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1. 发明授权

US06207653B1 Use of heparin or heparan sulphate in combination with chitosan for the prevention or treatment of infections caused by herpes virus 失效
标题翻译：使用肝素或硫酸乙酰肝素与壳聚糖联合用于预防或治疗由疱疹病毒引起的感染
公开(公告)号：US06207653B1
公开(公告)日：2001-03-27
申请号：US09230021
申请日：1999-01-19
申请人： Olle Larm , Marcus Back , Tomas Bergström
发明人： Olle Larm , Marcus Back , Tomas Bergström
IPC分类号： A01K4304
CPC分类号： A61K45/06 , A61K31/715
摘要： The use of heparin or heparan sulphate in combination with chitosan for the manufacture of a medicament for the prevention or treatment of infections caused by herpes virus in mammal including man; and a process for the treatment of infectious diseases caused by herpes viruses.
摘要翻译：使用肝素或硫酸乙酰肝素与壳聚糖组合用于制备用于预防或治疗由哺乳动物包括人在内的疱疹病毒引起的感染的药物; 以及用于治疗由疱疹病毒引起的传染病的方法。

2. 发明申请

US20100249689A1 DEVICE AND METHOD FOR RESTORATION OF THE CONDITION OF BLOOD 有权
标题翻译：用于恢复血液条件的装置和方法
公开(公告)号：US20100249689A1
公开(公告)日：2010-09-30
申请号：US12665156
申请日：2008-06-18
申请人： Olle Larm , Tomas Bergström , Jones Axelsson , Lars Adolfsson , Robert S. Ward , Keith Mccrea
发明人： Olle Larm , Tomas Bergström , Jones Axelsson , Lars Adolfsson , Robert S. Ward , Keith Mccrea
IPC分类号： A61M1/14 , B05D5/00 , B01D39/16 , B01D63/02 , B01D61/24
CPC分类号： A61M1/3679 , A61K31/70 , B01J20/3272 , B01J20/3274 , Y02A50/411
摘要： The present invention relates to a device for extracorporeal removal of harmful agents from blood or blood components, comprising full length heparin immobilized on a solid substrate by covalent end point attachment. The present invention also relates to a method for extracorporeal removal of a harmful agent from mammalian blood or blood components. The present invention further relates to a process for covalent end point attachment of full length heparin to a solid substrate.
摘要翻译：本发明涉及一种用于从血液或血液成分体外去除有害物质的装置，其包括通过共价终点附着固定在固体基质上的全长肝素。本发明还涉及从哺乳动物血液或血液成分体外去除有害物质的方法。本发明还涉及将全长肝素与固体底物共价连接的方法。

3. 发明授权

US09173989B2 Method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from blood 有权
标题翻译：用于体外去除病原微生物，炎症细胞或来自血液的炎性蛋白质的方法
公开(公告)号：US09173989B2
公开(公告)日：2015-11-03
申请号：US12086126
申请日：2006-12-13
申请人： Olle Larm , Tomas Bergström
发明人： Olle Larm , Tomas Bergström
IPC分类号： A61K35/14 , A01N1/02 , A61M1/36 , A61K31/70
CPC分类号： A61M1/3679 , A61K31/70 , A61M2202/0413 , A61M2202/203 , A61M2202/206 , Y02A50/411 , Y02A50/414 , Y02A50/473
摘要： The present invention relates to a method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from mammalian blood/use of a device comprising a carbohydrate immobilized on a solid substrate, said carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, for extracorporeal removal of said pathogenic microbe, inflammatory cell or inflammatory protein from mammalian blood/use of a carbohydrate having a binding affinity for a pathogenic microbe, an inflammatory cell or an inflammatory protein, wherein said carbohydrate is immobilized on a solid substrate, in the preparation of a device for treatment of a condition caused or aggravated by said pathogenic microbe, inflammatory cell or inflammatory protein/and a method for treatment of a mammalian subject suffering from a condition caused or aggravated by a pathogenic microbe, an inflammatory cell or an inflammatory protein.
摘要翻译：本发明涉及从哺乳动物血液中体外去除致病微生物，炎性细胞或炎性蛋白的方法，其使用包含固定在固体底物上的碳水化合物的装置，所述碳水化合物对致病微生物具有结合亲和力，炎性细胞或炎症蛋白，用于从哺乳动物血液体外去除所述致病微生物，炎性细胞或炎症蛋白/使用对致病微生物，炎性细胞或炎性蛋白具有结合亲和力的碳水化合物，其中所述碳水化合物为固定在固体基质上，在制备用于治疗所述致病微生物，炎性细胞或炎性蛋白质引起或加重的病症的装置中，以及用于治疗患有由病原体引起或加剧的病症的哺乳动物受试者的方法微生物，炎性细胞或炎症蛋白。

4. 发明授权

US08663148B2 Device and method for restoration of the condition of blood 有权
标题翻译：恢复血液状况的装置及方法
公开(公告)号：US08663148B2
公开(公告)日：2014-03-04
申请号：US12665156
申请日：2008-06-18
申请人： Olle Larm , Tomas Bergström , Jonas Axelsson , Lars Adolfsson , Robert S. Ward , Keith McCrea
发明人： Olle Larm , Tomas Bergström , Jonas Axelsson , Lars Adolfsson , Robert S. Ward , Keith McCrea
IPC分类号： A61M1/14 , C08B37/10
CPC分类号： A61M1/3679 , A61K31/70 , B01J20/3272 , B01J20/3274 , Y02A50/411
摘要： The present invention relates to a device for extracorporeal removal of harmful agents from blood or blood components, comprising full length heparin immobilized on a solid substrate by covalent end point attachment. The present invention also relates to a method for extracorporeal removal of a harmful agent from mammalian blood or blood components. The present invention further relates to a process for covalent end point attachment of full length heparin to a solid substrate.
摘要翻译：本发明涉及一种用于从血液或血液成分体外去除有害物质的装置，其包括通过共价终点附着固定在固体基质上的全长肝素。本发明还涉及从哺乳动物血液或血液成分体外去除有害物质的方法。本发明还涉及将全长肝素与固体底物共价连接的方法。

5. 发明授权

US08389468B2 Approach to the treatment of compartment syndrome 有权
公开(公告)号：US08389468B2
公开(公告)日：2013-03-05
申请号：US13025702
申请日：2011-02-11
申请人： Hans-Arne Hansson , Stefan Lange , Eva Jennische , Tomas Bergström
发明人： Hans-Arne Hansson , Stefan Lange , Eva Jennische , Tomas Bergström
IPC分类号： A61K38/16 , A61K38/08 , A61K38/00
CPC分类号： A61K38/1709
摘要： The present invention relates to the use of an antisecretory protein or a derivative, homologue, and/or fragment thereof, having antisecretory activity, and/or a pharmaceutically active salt thereof, for the manufacture of a pharmaceutical composition and/or a medical food for the treatment and/or prevention of compartment syndrome. A compartment syndrome may be caused by or a cause of a variety of other conditions which are also encompassed by the present invention, such as viral and bacterial infections. Furthermore, the invention relates to a method for the treatment and/or prevention of compartment syndrome in a mammal in need thereof.

6. 发明授权

US08309513B2 Approach to the treatment of compartment syndrome 有权
标题翻译：方法治疗隔室综合征
公开(公告)号：US08309513B2
公开(公告)日：2012-11-13
申请号：US12289389
申请日：2008-10-27
申请人： Hans-Arne Hansson , Stefan Lange , Eva Jennische , Tomas Bergström
发明人： Hans-Arne Hansson , Stefan Lange , Eva Jennische , Tomas Bergström
IPC分类号： A61K38/16 , A61K38/08 , A61K38/00
CPC分类号： A61K38/1709
摘要： The present invention relates to the use of an antisecretory protein or a derivative, homologue, and/or fragment thereof, having antisecretory activity, and/or a pharmaceutically active salt thereof, for the manufacture of a pharmaceutical composition and/or a medical food for the treatment and/or prevention of compartment syndrome. A compartment syndrome may be caused by or a cause of a variety of other conditions which are also encompassed by the present invention, such as viral and bacterial infections. Furthermore, the invention relates to a method for the treatment and/or prevention of compartment syndrome in a mammal in need thereof.
摘要翻译：本发明涉及具有抗分泌活性的抗分泌蛋白或其衍生物，同系物和/或其片段，和/或其药物活性盐在制备药物组合物和/或医疗食品中的用途隔室综合征的治疗和/或预防。隔室综合征可能是由本发明也包括的各种其他病症引起的原因或原因，例如病毒和细菌感染。此外，本发明涉及在有需要的哺乳动物中治疗和/或预防隔室综合征的方法。

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