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1. 发明授权

US07101848B2 Bicyclic oligopeptides 有权
标题翻译：双环寡肽
公开(公告)号：US07101848B2
公开(公告)日：2006-09-05
申请号：US10621272
申请日：2003-07-17
申请人： Olivier Potterat , Ruediger Streicher , Klaus Wagner , Till Maurer , Juergen Mack , Stefan Peters
发明人： Olivier Potterat , Ruediger Streicher , Klaus Wagner , Till Maurer , Juergen Mack , Stefan Peters
IPC分类号： A61K38/12
CPC分类号： C07K14/003 , A61K38/00 , C07K7/56 , C07K14/605
摘要： The invention relates to a bicyclic oligopeptide or ester thereof having the capability to inhibit the glucagon receptor, comprised of: (a) a first cyclic group, which comprises at least one cysteine group and is formed by an amide bonding of the N-terminal amino acid with the second carboxylate group of a diacid amino acid, and (b) a second cyclic group which is formed by an amide bonding of an amino acid with the α-carboxylate group of said diacid amino acid, and by a disulfide bonding of the C-terminal cysteine and a cysteine group within the first cyclic group (a); and to the use of such bicyclic oligopeptides for the preparation of a medicament for the treatment or prevention of diseases, in which glucagon receptors are involved.
摘要翻译：本发明涉及具有抑制胰高血糖素受体能力的双环寡肽或其酯，其包括：（a）第一环状基团，其包含至少一个半胱氨酸基团，并且通过N-末端氨基的酰胺键形成酸与二酸氨基酸的第二羧酸盐基团反应，和（b）通过氨基酸与所述二酸氨基酸的α-羧酸酯基团的酰胺键形成的第二环状基团，以及通过二硫键第一个环状基团（a）中的C-末端半胱氨酸和半胱氨酸基团; 以及使用这种双环寡肽来制备用于治疗或预防涉及胰高血糖素受体的疾病的药物。

2. 发明授权

US06613879B1 FAP-activated anti-tumour compounds 有权
标题翻译： FAP激活的抗肿瘤化合物
公开(公告)号：US06613879B1
公开(公告)日：2003-09-02
申请号：US09553800
申请日：2000-04-21
申请人： Raymond A. Firestone , Wolfgang J. Rettig , Martin Lenter , Stefan Peters , Pilar Garin-Chesa , Juergen Mack , Dietmar Leipert , John E. Park , Leila A. Telan
发明人： Raymond A. Firestone , Wolfgang J. Rettig , Martin Lenter , Stefan Peters , Pilar Garin-Chesa , Juergen Mack , Dietmar Leipert , John E. Park , Leila A. Telan
IPC分类号： C07K508
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/65 , A61K47/67 , C07H15/252 , C07K5/06026 , C07K5/1019 , C07K5/1024
摘要： The invention relates to a prodrug that is capable of being converted into a drug by the catalytic action of human fibroblast activation protein (FAP&agr;), said prodrug having a cleavage site which is recognised by FAP&agr;, and said drug being cytotoxic or cytostatic under physiological conditions.
摘要翻译：本发明涉及能够通过人成纤维细胞活化蛋白（FAPalpha）的催化作用转化为药物的前体药物，所述前药具有被FAPalpha识别的切割位点，并且所述药物在生理条件下是细胞毒性或细胞生长抑制。

3. 发明申请

US20100298278A1 INHIBITORS OF BETA-SECRETASE FOR THE TREATMENT OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：用于治疗阿尔茨海默病的β-分泌酶的抑制剂
公开(公告)号：US20100298278A1
公开(公告)日：2010-11-25
申请号：US12063270
申请日：2006-08-08
申请人： Christian Eickmeier , Klaus Fuchs , Niklas Heine , Stefan Peters , Cornelia Dorner-Ciossek , Sandra Handschuh , Herbert Nar , Klaus Klinder
发明人： Christian Eickmeier , Klaus Fuchs , Niklas Heine , Stefan Peters , Cornelia Dorner-Ciossek , Sandra Handschuh , Herbert Nar , Klaus Klinder
IPC分类号： A61K31/549 , C07D417/12 , C07D285/16 , C07D277/28 , C07D211/96 , C07D295/26 , C07D265/10 , C07D413/12 , A61K31/426 , A61K31/4453 , A61K31/5375 , A61K31/535 , A61K31/445 , A61K31/473 , A61K31/55 , A61K31/439 , A61K31/437 , A61K31/65 , A61K31/496 , A61P25/28 , A61P3/10 , A61P9/10 , A61P1/18 , A61P25/00
CPC分类号： C07C307/10 , C07C2601/02 , C07D213/40 , C07D265/10 , C07D277/28 , C07D285/16 , C07D295/26 , C07D417/12
摘要： The invention relates to the substituted 1,2-ethylenediamines of general formula (I), wherein the groups R1 to R13, A, B, L and i are defined as in the description and the claims. The invention also relates to the use thereof in the treatment of Alzheimer's disease (AD) and similar diseases.
摘要翻译：本发明涉及通式（I）的取代的1,2-乙二胺，其中基团R 1至R 13，A，B，L和i如在说明书和权利要求书中所定义。本发明还涉及其在治疗阿尔茨海默病（AD）和类似疾病中的用途。

4. 发明授权

US07291642B2 Bradykinin-B1 antagonists, process for their preparation and their use as medicaments 有权
标题翻译：缓激肽B1拮抗剂，其制备方法及其用作药物
公开(公告)号：US07291642B2
公开(公告)日：2007-11-06
申请号：US11256573
申请日：2005-10-21
申请人： Iris Kauffmann-Hefner , Norbert Hauel , Henri Doods , Angelo Ceci , Stefan Peters
发明人： Iris Kauffmann-Hefner , Norbert Hauel , Henri Doods , Angelo Ceci , Stefan Peters
IPC分类号： A61K31/4164 , A61K31/4709 , A61K31/4439 , A61K31/501 , A61K31/5513 , A61K31/513 , A61K31/454 , C07D233/04 , C07D233/06
CPC分类号： C07D403/12 , C07D233/24 , C07D233/26 , C07D233/36 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention provides bradykinin-B1 antagonists of the formula in which A, Ar, G, Q, R1 and R4 are as defined in claim 1, their enantiomers, their diastereomers, their mixtures and their salts, in particular their physiologically acceptable salts with organic or inorganic acids or bases having useful properties, their preparation, medicaments comprising the pharmacologically effective compounds, their preparation and their use.
摘要翻译：本发明提供下式的缓激肽B1拮抗剂，其中A，Ar，G，Q，R 1和R 4如权利要求1所定义，其对映异构体，它们的非对映异构体，它们的混合物及其盐，特别是其具有有用性质的有机或无机酸或碱的生理上可接受的盐，它们的制备，包含药理学有效化合物的药物及其制备及其用途。

5. 发明授权

US09133904B2 Torsional vibration damper 有权
标题翻译：扭转振动阻尼器
公开(公告)号：US09133904B2
公开(公告)日：2015-09-15
申请号：US14115254
申请日：2012-03-27
申请人： Andreas Kranz , Dietmar Heidingsfeld , Dietmar Ritterbecks , Stefan Peters
发明人： Andreas Kranz , Dietmar Heidingsfeld , Dietmar Ritterbecks , Stefan Peters
IPC分类号： F16F15/12 , F16F15/121 , F16F15/131 , F16F15/134
CPC分类号： F16F15/121 , F16F15/131 , F16F15/13438 , F16F15/13453 , F16F15/13492 , Y10T74/2131
摘要： A torsional vibration damper has a drive-side transmission element; a damping device having a plurality of energy accumulators; a driven-side transmission element configured to be rotationally deflected coaxial to the drive-side transmission element and which is connected to the drive-side transmission element via the damping device; and sliding elements arranged in one of the drive-side transmission element and driven-side transmission element so as to be movable in a circumferential direction. The sliding elements have: (i) circumferential projections for the energy accumulators, these circumferential projections being directed toward adjacent sliding elements, and/or (ii) penetration spaces for circumferential projections provided at the adjacent sliding element. The energy accumulators are supported at the sliding elements, the sliding elements having in sequence in an axial direction at least one circumferential projection and/or at least one penetration space at their circumferential side which faces a sliding element adjacent in the circumferential direction.
摘要翻译：扭转振动阻尼器具有驱动侧传动元件; 具有多个蓄能器的阻尼装置; 被驱动侧传动元件，被配置为与驱动侧传动元件同轴地旋转偏转，并且经由阻尼装置连接到驱动侧传动元件; 以及布置在驱动侧传动元件和从动侧传动元件中的一个中的滑动元件，以便能够在圆周方向上移动。滑动元件具有：（i）用于蓄能器的周向突起，这些周向突起指向相邻的滑动元件，和/或（ii）设置在相邻滑动元件处的周向突起的穿透空间。蓄能器被支撑在滑动元件处，滑动元件沿轴向依次沿着圆周方向的至少一个周向突起和/或它们的圆周侧上的至少一个穿透空间，其面向与圆周方向相邻的滑动元件。

6. 发明授权

US09115093B2 Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity 有权
标题翻译：取代的双环二氢嘧啶酮及其作为嗜中性粒细胞弹性蛋白酶活性抑制剂的用途
公开(公告)号：US09115093B2
公开(公告)日：2015-08-25
申请号：US14184817
申请日：2014-02-20
申请人： Christian Gnamm , Thorsten Oost , Stefan Peters , Klaus Rudolf
发明人： Christian Gnamm , Thorsten Oost , Stefan Peters , Klaus Rudolf
IPC分类号： C07D239/70 , C07D403/12 , C07D401/12 , A61K31/517 , A61P19/02 , C07D239/82 , C07D401/04 , C07D403/06 , C07D407/06 , C07D407/12 , C07D409/04 , C07D409/12 , C07D413/06 , C07D471/04 , C07D487/04 , C07D493/10 , C07D498/04 , C07D498/10 , C07D405/14 , C07D403/04 , C07D405/04 , C07D405/06 , C07D405/12 , C07D413/12 , C07D417/06 , C07D487/10 , C07D491/10
CPC分类号： C07D239/82 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/06 , C07D407/12 , C07D409/04 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/10 , C07D493/10 , C07D498/04 , C07D498/10
摘要： This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.
摘要翻译：本发明涉及式1的取代双环二氢嘧啶酮及其作为嗜中性粒细胞弹性蛋白酶活性抑制剂的用途，含有它们的药物组合物及其用于治疗和/或预防肺，胃肠和泌尿生殖疾病，炎性疾病的药物的方法的皮肤和眼睛以及其他自身免疫性和过敏性疾病，同种异体移植排斥和肿瘤疾病。

7. 发明授权

US08859580B2 Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use 有权
标题翻译：苯并吡喃和相关支架的芳基和杂芳基羰基衍生物，含有这些化合物的药物及其应用
公开(公告)号：US08859580B2
公开(公告)日：2014-10-14
申请号：US12742680
申请日：2008-11-14
申请人： Frank Himmelsbach , Matthias Eckhardt , Bradford S. Hamilton , Armin Heckel , Joerg Kley , Thorsten Lehmann-Lintz , Herbert Nar , Stefan Peters , Annette Schuler-Metz , Matthias Zentgraf
发明人： Frank Himmelsbach , Matthias Eckhardt , Bradford S. Hamilton , Armin Heckel , Joerg Kley , Thorsten Lehmann-Lintz , Herbert Nar , Stefan Peters , Annette Schuler-Metz , Matthias Zentgraf
IPC分类号： C07D221/26 , C07D417/06 , C07D401/06 , C07D471/08 , C07D498/08 , C07D413/14 , C07D413/06 , C07D405/06 , C07D401/14 , C07D451/06 , C07D403/06
CPC分类号： C07D221/26 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D413/14 , C07D417/06 , C07D451/06 , C07D471/08 , C07D498/08
摘要： The present invention relates to compounds defined by formula I wherein the groups R1 to R3, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.
摘要翻译：本发明涉及由式I定义的化合物，其中R 1至R 3，X，m，n和o基团如权利要求1中所定义，具有有价值的药理学活性。特别地，化合物是11β-羟基类固醇脱氢酶（HSD）1的抑制剂，因此适用于治疗和预防可受该酶抑制影响的疾病，如代谢疾病，特别是2型糖尿病，肥胖症和血脂异常。

8. 发明授权

US08497281B2 Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline 有权
标题翻译：六氢茚基吡啶和八氢苯并喹啉的芳基和杂芳基羰基衍生物
公开(公告)号：US08497281B2
公开(公告)日：2013-07-30
申请号：US12940387
申请日：2010-11-05
申请人： Matthias Eckhardt , Stefan Peters , Herbert Nar , Frank Himmelsbach , Linghang Zhuang
发明人： Matthias Eckhardt , Stefan Peters , Herbert Nar , Frank Himmelsbach , Linghang Zhuang
IPC分类号： C07D401/06 , A61K31/352
CPC分类号： C07D221/10 , C07D221/06 , C07D221/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D417/06 , C07D471/04 , C07D498/04
摘要： The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
摘要翻译：本发明涉及由式I定义的化合物，其中变量R1，R2，R3，R4和m如权利要求1所定义，具有有价值的药理学活性。特别地，化合物是11β-羟基类固醇脱氢酶（HSD）1的抑制剂，因此适用于治疗和预防可受该酶抑制影响的疾病，如代谢疾病，特别是2型糖尿病，肥胖症和血脂异常。

9. 发明申请

US20110269791A1 Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use 有权
标题翻译：苯并呋喃和相关支架的脂环族羧酸衍生物，含有这些化合物的药物及其应用
公开(公告)号：US20110269791A1
公开(公告)日：2011-11-03
申请号：US12991722
申请日：2009-05-12
申请人： Stefan Peters , Matthias Eckhardt , Bradford S. Hamilton , Frank Himmelsbach , Joerg Kley , Thorsten Lehmann-Lintz
发明人： Stefan Peters , Matthias Eckhardt , Bradford S. Hamilton , Frank Himmelsbach , Joerg Kley , Thorsten Lehmann-Lintz
IPC分类号： A61K31/439 , A61K31/4985 , A61P3/10 , A61K31/397 , A61P3/00 , A61P3/06 , C07D471/04 , C07D221/26
CPC分类号： C07D221/26 , C07D221/22 , C07D401/06 , C07D401/08 , C07D401/12 , C07D405/06 , C07D405/12 , C07D471/18 , C07D491/08 , C07D491/18
摘要： The present invention relates to compounds defined by Formula (I), wherein the groups A, B, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.
摘要翻译：本发明涉及由式（I）定义的化合物，其中基团A，B，X，m，n和o如权利要求1中所定义，具有有价值的药理学活性。特别地，化合物是11β-羟基类固醇脱氢酶（HSD）1的抑制剂，因此适用于治疗和预防可受该酶抑制影响的疾病，如代谢疾病，特别是2型糖尿病，肥胖症和血脂异常。

10. 发明授权

US07713961B2 Substituted 1,2-ethylenediamines, methods for preparing them and uses thereof 有权
标题翻译：取代的1,2-乙二胺，其制备方法和用途
公开(公告)号：US07713961B2
公开(公告)日：2010-05-11
申请号：US11278059
申请日：2006-03-30
申请人： Christian Eickmeier , Stefan Peters , Klaus Fuchs , Niklas Heine , Sandra Handschuh , Cornelia Dorner-Ciossek , Klaus Klinder , Marcus Kostka
发明人： Christian Eickmeier , Stefan Peters , Klaus Fuchs , Niklas Heine , Sandra Handschuh , Cornelia Dorner-Ciossek , Klaus Klinder , Marcus Kostka
IPC分类号： A61K31/54 , A61K31/505 , A61K31/535 , C07D295/00 , C07C239/00 , A61K31/16 , C07D285/16 , C07D279/00
CPC分类号： C07K5/06026 , C07K5/06034 , C07K5/06191 , C07K5/0808 , C07K5/0812 , C07K5/0821
摘要： The present invention relates to substituted 1,2-ethylenediamines of general formula (I) wherein the groups R1 to R15, A, B, L, i as well as X1—X4 are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.
摘要翻译：本发明涉及通式（I）的取代的1,2-乙二胺，其中基团R 1至R 15，A，B，L，i以及X 1 -X 4如在说明书和权利要求书中所定义，以及其用于治疗阿尔茨海默病（AD）和类似疾病。

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