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1. 发明申请

US20090162340A1 STABLE GALENIC FREEZE-DRIED PHARMACEUTICAL PREPARATION OF RECOMBINANT CARBOHYDRATE-BINDING POLYPEPTIDES 审中-公开
标题翻译：重组碳氢化合物结合多糖的稳定的冷冻干燥药物制备
公开(公告)号：US20090162340A1
公开(公告)日：2009-06-25
申请号：US12327345
申请日：2008-12-03
申请人： Oliver Gloger , Bernd W. Muller , Klaus Witthohn
发明人： Oliver Gloger , Bernd W. Muller , Klaus Witthohn
IPC分类号： A61K38/47 , A61P39/00
CPC分类号： A61K9/19 , A61K9/0019 , A61K38/168 , A61K47/02 , A61K47/18 , A61K47/183 , A61K47/26 , A61K47/36
摘要： The invention relates to a method for the production of a medicament containing a polypeptide comprising at least one recombinant carbohydrate-binding polypeptide, or a functional fragment or derivative of said carbohydrate-binding polypeptide in a form stable for storage. The polypeptide mentioned comprises polypeptides or functional derivatives thereof, which are fused with cytotoxically effective peptides to give fusion proteins, or which are linked to another polypeptide having a cytotoxic activity. Moreover, the invention describes further formulating of the disclosed medicaments to medicaments with different pharmaceutical forms.
摘要翻译：本发明涉及一种生产含有多肽的药物的方法，所述多肽包含至少一种重组碳水化合物结合多肽，或所述碳水化合物结合多肽的功能性片段或衍生物，其形式稳定存放。所提及的多肽包括多肽或其功能性衍生物，其与细胞毒性有效的肽融合以产生融合蛋白，或与另外具有细胞毒活性的多肽相连。此外，本发明描述了将所公开的药物进一步配制成具有不同药物形式的药物。

2. 发明授权

US08377654B2 Stable galenic freeze-dried pharmaceutical preparation of recombinant carbohydrate-binding polypeptides 有权
标题翻译：稳定的盖仑冷冻干燥的重组碳水化合物结合多肽的药物制剂
公开(公告)号：US08377654B2
公开(公告)日：2013-02-19
申请号：US13102670
申请日：2011-05-06
申请人： Oliver Gloger , Bernd W. Muller , Klaus Witthohn
发明人： Oliver Gloger , Bernd W. Muller , Klaus Witthohn
IPC分类号： C12P21/06 , A61K9/19
CPC分类号： A61K9/19 , A61K9/0019 , A61K38/168 , A61K47/02 , A61K47/18 , A61K47/183 , A61K47/26 , A61K47/36
摘要： The invention relates to a method for the production of a medicament containing a polypeptide comprising at least one recombinant carbohydrate-binding polypeptide, or a functional fragment or derivative of said carbohydrate-binding polypeptide in a form stable for storage. The polypeptide mentioned comprises polypeptides or functional derivatives thereof, which are fused with cytotoxically effective peptides to give fusion proteins, or which are linked to another polypeptide having a cytotoxic activity. Moreover, the invention describes further formulating of the disclosed medicaments to medicaments with different pharmaceutical forms.
摘要翻译：本发明涉及一种生产含有多肽的药物的方法，所述多肽包含至少一种重组碳水化合物结合多肽，或所述碳水化合物结合多肽的功能性片段或衍生物，其形式稳定存放。所提及的多肽包括多肽或其功能性衍生物，其与细胞毒性有效的肽融合以产生融合蛋白，或与另外具有细胞毒活性的多肽相连。此外，本发明描述了将所公开的药物进一步配制成具有不同药物形式的药物。

3. 发明申请

US20110217283A1 STABLE GALENIC FREEZE-DRIED PHARMACEUTICAL PREPARATION OF RECOMBINANT CARBOHYDRATE-BINDING POLYPEPTIDES 有权
标题翻译：重组碳氢化合物结合多糖的稳定的冷冻干燥药物制备
公开(公告)号：US20110217283A1
公开(公告)日：2011-09-08
申请号：US13102670
申请日：2011-05-06
申请人： Oliver Gloger , Bernd W. Müller , Klaus Witthohn
发明人： Oliver Gloger , Bernd W. Müller , Klaus Witthohn
IPC分类号： A61K38/47 , A61K38/02 , A61P39/00
CPC分类号： A61K9/19 , A61K9/0019 , A61K38/168 , A61K47/02 , A61K47/18 , A61K47/183 , A61K47/26 , A61K47/36
摘要： The invention relates to a method for the production of a medicament containing a polypeptide comprising at least one recombinant carbohydrate-binding polypeptide, or a functional fragment or derivative of said carbohydrate-binding polypeptide in a form stable for storage. The polypeptide mentioned comprises polypeptides or functional derivatives thereof, which are fused with cytotoxically effective peptides to give fusion proteins, or which are linked to another polypeptide having a cytotoxic activity. Moreover, the invention describes further formulating of the disclosed medicaments to medicaments with different pharmaceutical forms.
摘要翻译：本发明涉及一种生产含有多肽的药物的方法，所述多肽包含至少一种重组碳水化合物结合多肽，或所述碳水化合物结合多肽的功能性片段或衍生物，其形式稳定存放。所提及的多肽包括多肽或其功能性衍生物，其与细胞毒性有效的肽融合以产生融合蛋白，或与另外具有细胞毒活性的多肽相连。此外，本发明描述了将所公开的药物进一步配制成具有不同药物形式的药物。

4. 发明申请

US20070021396A1 Oral contraception with trimegestone 审中-公开
标题翻译：口服避孕药与曲美孕酮
公开(公告)号：US20070021396A1
公开(公告)日：2007-01-25
申请号：US11348545
申请日：2006-02-06
申请人： Oliver Gloger , Heinrich Kugelmann , Maria Popova
发明人： Oliver Gloger , Heinrich Kugelmann , Maria Popova
IPC分类号： A61K31/57 , A61K31/56
CPC分类号： A61K31/565 , A61K31/57 , A61K31/575
摘要： The invention relates to a method for contraception comprising the administration of trimegestone to a woman of child-bearing age on at least 21 successive days, beginning on day 1 of the menstrual cycle, wherein on at least one of the at least 21 successive days the daily dose of trimegestone is more than 500 μg.
摘要翻译：本发明涉及一种用于避孕的方法，包括从月经周期的第1天开始至少连续21天向育龄妇女施用曲美孕酮，其中在至少连续21天中的至少一个中曲美孕酮的日剂量超过500杯。

5. 发明授权

US08666134B2 Method for the fully automatic segmentation of an organ, in particular the renal parenchyma, from volume data sets in medical imaging 失效
标题翻译：用于从医学成像中的体数据集中全面自动分割器官的方法，特别是肾实质
公开(公告)号：US08666134B2
公开(公告)日：2014-03-04
申请号：US13440677
申请日：2012-04-05
申请人： Oliver Gloger
发明人： Oliver Gloger
IPC分类号： G06K9/00
CPC分类号： G01R33/5608 , G06T7/11 , G06T7/136 , G06T7/143 , G06T2207/10088 , G06T2207/20036 , G06T2207/20076 , G06T2207/20081 , G06T2207/20161 , G06T2207/20192 , G06T2207/30084
摘要： A method is disclosed for segmenting an organ from volume data sets in medical imaging. A likelihood data set is generated. A binary data set is generated with the aid of a threshold value method, in which the organ region is eroded step by step. When the organ region is separated into a number of subregions, only one of the subregions, which is most likely to contain the organ, is selected for further erosion in each instance. This subregion is identified from geometrical features of the organ, which are known from the training data sets. In the likelihood data set the likelihood values of voxels of the subregions separated in the binary data set are reduced, so that a correspondingly corrected likelihood data set results. On the basis of this corrected likelihood data set the organ from the likelihood data set is segmented.
摘要翻译：公开了一种用于在医学成像中从体数据集分割器官的方法。生成似然数据集。借助阈值法生成二进制数据集，其中器官区域逐步被侵蚀。当器官区域分成多个子区域时，在每种情况下仅选择最可能含有器官的子区域中的一个以进一步侵蚀。该子区域是从训练数据集中已知的器官的几何特征来识别的。在似然数据集中，二进制数据集中分离的子区域的体素的似然值减小，从而得到相应校正的似然数据集。基于这种校正的可能性数据集，来自似然数据集的器官被分割。

6. 发明申请

US20130091679A1 Device And Method For Assembling Sets Of Instruments 审中-公开
标题翻译：仪器组装装置及方法
公开(公告)号：US20130091679A1
公开(公告)日：2013-04-18
申请号：US13650719
申请日：2012-10-12
申请人： Oliver Gloger , Omid Abri
发明人： Oliver Gloger , Omid Abri
IPC分类号： B23P21/00 , B23P11/00
CPC分类号： G06Q10/0875 , A61B90/90 , G06Q50/22 , G16H40/63 , Y10T29/49769 , Y10T29/53087
摘要： The invention relates to a device for assembling sets of instruments, having a data processing installation and a fine identification unit. The data processing installation has a display unit, a database, a first interface and an evaluation unit. The fine identification unit has a first support for placing the instruments of a set of instruments thereon and a first camera. The first camera is arranged and oriented such that it can capture image data from instruments to be identified and arranged on the first support from at least one perspective, and the data processing installation is designed such that it uses the first interface to receive image data from the first camera and can store the received image data in the database. It can further visually identify a respective instrument by use of the evaluation unit. The invention also relates to an according method for assembling sets of instruments.
摘要翻译：本发明涉及一种用于组装仪器的装置，具有数据处理装置和精细识别单元。数据处理装置具有显示单元，数据库，第一接口和评估单元。精细识别单元具有用于将一组仪器的仪器放置在其上的第一支撑件和第一相机。第一相机被布置和定向成使得其可以从至少一个角度捕获要被识别和布置在第一支架上的装置的图像数据，并且数据处理装置被设计成使得其使用第一接口从第一台相机，并可将接收到的图像数据存储在数据库中。它可以通过使用评估单元进一步目视识别相应的仪器。本发明还涉及一种用于组装仪器的相关方法。

7. 发明授权

US08447085B2 Method for segmenting an organ in volume data records from magnetic resonance imaging 失效
标题翻译：从磁共振成像分割体数据记录器官的方法
公开(公告)号：US08447085B2
公开(公告)日：2013-05-21
申请号：US12860204
申请日：2010-08-20
申请人： Oliver Gloger
发明人： Oliver Gloger
IPC分类号： G06K9/00
CPC分类号： G06T7/11 , G06T7/143 , G06T7/187 , G06T2200/04 , G06T2207/10088 , G06T2207/20076 , G06T2207/20081 , G06T2207/30056
摘要： A method is disclosed for segmenting an organ, more particularly the liver, in n-channel volume data records from magnetic resonance imaging. In at least one embodiment of the method, probability distributions are generated on the basis of segmentation results from n-channel training data records, which probability distributions specify probabilities of positions of voxels and intensity values, which have been reduced from n-dimensions to one dimension with the aid of discriminant reduction, of voxels in the training data records belonging to the organ. At least one 3D probability data record is then generated from the n-channel volume data records on the basis of the probability distributions, in which 3D probability data record each voxel is assigned a probability of belonging to the organ. A maximum value of the 3D probability data record is set as the start point for the segmentation, and the organ is subsequently segmented on the basis of the 3D probability data record using a region-growing technique. The method allows very reliable fully-automatic segmentation of the organ.
摘要翻译：公开了一种用于在来自磁共振成像的n通道体积数据记录中分割器官，特别是肝脏的方法。在该方法的至少一个实施例中，基于来自n个信道训练数据记录的分割结果生成概率分布，该概率分布指定已经从n维减少到一个的体素的位置的概率和强度值借助于判别式缩减维度，属于该器官的训练数据记录中的体素。然后，基于概率分布从n个通道体数据记录中生成至少一个3D概率数据记录，其中3D概率数据记录每个体素分配属于机关的概率。将3D概率数据记录的最大值设置为分割的开始点，随后使用区域生长技术基于3D概率数据记录分割器官。该方法允许器官非常可靠的全自动分割。

8. 发明申请

US20120259582A1 Device And Method For Identifying Instruments 审中-公开
标题翻译：识别仪器的装置和方法
公开(公告)号：US20120259582A1
公开(公告)日：2012-10-11
申请号：US13440441
申请日：2012-04-05
申请人： Oliver Gloger
发明人： Oliver Gloger
IPC分类号： G06F15/00 , G01N5/00
CPC分类号： B25J11/00 , A61B90/90 , A61B2090/065 , G01G19/40
摘要： The invention relates to a device for identifying instruments comprising at least one weight sensor, a data processing system, which has an interface, at least one database and an processing unit, and a visualization unit. Weight distribution data of instruments can be determined and compared by the device. This allows identifying individual instruments. The invention further relates to according methods for detecting a weight distribution of an individual instrument and for identifying an individual instrument, as well as to a method for assembling instrument sets.
摘要翻译：本发明涉及一种用于识别仪器的装置，包括至少一个重量传感器，具有界面的数据处理系统，至少一个数据库和处理单元以及可视化单元。可以通过设备确定和比较仪器的重量分布数据。这允许识别单个仪器。本发明还涉及用于检测单个仪器的重量分布和用于识别单个仪器的相关方法，以及用于组装仪器组的方法。

9. 发明申请

US20110044523A1 METHOD FOR SEGMENTING AN ORGAN IN VOLUME DATA RECORDS FROM MAGNETIC RESONANCE IMAGING 失效
标题翻译：从磁共振成像中分离体积数据记录中的有机体的方法
公开(公告)号：US20110044523A1
公开(公告)日：2011-02-24
申请号：US12860204
申请日：2010-08-20
申请人： Oliver Gloger
发明人： Oliver Gloger
IPC分类号： G06T15/00
CPC分类号： G06T7/11 , G06T7/143 , G06T7/187 , G06T2200/04 , G06T2207/10088 , G06T2207/20076 , G06T2207/20081 , G06T2207/30056
摘要： A method is disclosed for segmenting an organ, more particularly the liver, in n-channel volume data records from magnetic resonance imaging. In at least one embodiment of the method, probability distributions are generated on the basis of segmentation results from n-channel training data records, which probability distributions specify probabilities of positions of voxels and intensity values, which have been reduced from n-dimensions to one dimension with the aid of discriminant reduction, of voxels in the training data records belonging to the organ. At least one 3D probability data record is then generated from the n-channel volume data records on the basis of the probability distributions, in which 3D probability data record each voxel is assigned a probability of belonging to the organ. A maximum value of the 3D probability data record is set as the start point for the segmentation, and the organ is subsequently segmented on the basis of the 3D probability data record using a region-growing technique. The method allows very reliable fully-automatic segmentation of the organ.
摘要翻译：公开了一种用于在来自磁共振成像的n通道体积数据记录中分割器官，特别是肝脏的方法。在该方法的至少一个实施例中，基于来自n个信道训练数据记录的分割结果生成概率分布，该概率分布指定已经从n维减少到一个的体素的位置的概率和强度值借助于判别式缩减维度，属于该器官的训练数据记录中的体素。然后，基于概率分布从n个通道体数据记录中生成至少一个3D概率数据记录，其中3D概率数据记录每个体素分配属于机关的概率。将3D概率数据记录的最大值设置为分割的开始点，随后使用区域生长技术基于3D概率数据记录分割器官。该方法允许器官非常可靠的全自动分割。

10. 发明申请

US20130093877A1 Device And Method For Identifying Anomalies On Instruments 有权
标题翻译：识别仪器异常的装置和方法
公开(公告)号：US20130093877A1
公开(公告)日：2013-04-18
申请号：US13650751
申请日：2012-10-12
申请人： Oliver Gloger
发明人： Oliver Gloger
IPC分类号： H04N7/18
CPC分类号： G01N21/94 , A61B90/90 , G01N21/8851
摘要： The present invention relates to a device for identifying anomalies on medical instruments, having a data processing installation and an instrument analysing unit. The data processing installation has a display unit, a database, a first interface and an evaluation unit and the instrument analysing unit has a support and at least one camera. The at least one camera is arranged and oriented such that it can capture image data from medical instruments arranged on the support from at least one perspective, and the data processing installation is designed such that it uses the first interface to receive image data from the at least one camera and can store the received image data in the database. Further, it can use the evaluation unit to examine said image data for regions which have anomalies. In addition, the invention also relates to an according method.
摘要翻译：本发明涉及一种用于识别医疗器械异常的装置，具有数据处理装置和仪器分析单元。数据处理装置具有显示单元，数据库，第一接口和评估单元，并且仪器分析单元具有支撑件和至少一个相机。所述至少一个相机被布置和定向成使得其可以从至少一个角度从布置在所述支架上的医疗仪器捕获图像数据，并且所述数据处理装置被设计成使得其使用所述第一接口从所述第一接口接收图像数据至少一个相机，并且可以将接收到的图像数据存储在数据库中。此外，可以使用评估单元检查具有异常的区域的所述图像数据。此外，本发明还涉及一种相关方法。

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