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1. 发明申请

US20090258012A1 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISORDERS 审中-公开
标题翻译：用于治疗炎症性疾病的组合物和方法
公开(公告)号：US20090258012A1
公开(公告)日：2009-10-15
申请号：US12409617
申请日：2009-03-24
申请人： Olga Ignatovich , Rudolf Maria Theodora de Wildt , Benjamin Woolven , Steven Grant , Philip C. Jones , Amrik Basran , Neil Brewis
发明人： Olga Ignatovich , Rudolf Maria Theodora de Wildt , Benjamin Woolven , Steven Grant , Philip C. Jones , Amrik Basran , Neil Brewis
IPC分类号： A61K39/395 , A61P19/02
CPC分类号： C07K16/468 , A61K47/6879 , C07K16/005 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/30 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2319/00
摘要： The invention relates to compositions and methods for treating inflammatory disorders. More specifically, the invention relates to antibody compositions and their use in the treatment of inflammatory disorders.
摘要翻译：本发明涉及用于治疗炎症性疾病的组合物和方法。更具体地，本发明涉及抗体组合物及其在治疗炎症性疾病中的用途。

2. 发明申请

US20050271663A1 Compositions and methods for treating inflammatory disorders 审中-公开
标题翻译：用于治疗炎性疾病的组合物和方法
公开(公告)号：US20050271663A1
公开(公告)日：2005-12-08
申请号：US10925366
申请日：2004-08-24
申请人： Olga Ignatovich , Rudolf de Wildt , Benjamin Woolven , Steven Grant , Philip Jones , Amrik Basran , Neil Brewis
发明人： Olga Ignatovich , Rudolf de Wildt , Benjamin Woolven , Steven Grant , Philip Jones , Amrik Basran , Neil Brewis
IPC分类号： A61K39/395 , A61K47/48 , A61K49/00 , C07H21/04 , C07K16/00 , C07K16/18 , C07K16/22 , C07K16/24 , C07K16/40
CPC分类号： C07K16/468 , A61K47/6879 , C07K16/005 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/30 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2319/00
摘要： The invention relates to compositions and methods for treating inflammatory disorders. More specifically, the invention relates to antibody compositions and their use in the treatment of inflammatory disorders.
摘要翻译：本发明涉及用于治疗炎症性疾病的组合物和方法。更具体地，本发明涉及抗体组合物及其在治疗炎症性疾病中的用途。

3. 发明申请

US20060073141A1 Compositions and methods for treating inflammatory disorders 审中-公开
标题翻译：用于治疗炎性疾病的组合物和方法
公开(公告)号：US20060073141A1
公开(公告)日：2006-04-06
申请号：US11098758
申请日：2005-04-04
申请人： Olga Ignatovich , Rudolf de Wildt , Benjamin Woolven , Steven Grant , Philip Jones , Amrik Basran , Neil Brewis
发明人： Olga Ignatovich , Rudolf de Wildt , Benjamin Woolven , Steven Grant , Philip Jones , Amrik Basran , Neil Brewis
IPC分类号： A61K39/395 , C07K16/44
CPC分类号： C07K16/22 , A61K47/60 , A61K47/6879 , A61K2039/505 , C07K16/18 , C07K16/241 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/92 , C07K2319/00
摘要： The invention relates to compositions and methods for treating inflammatory disorders. More specifically, the invention relates to antibody compositions and their use in the treatment of inflammatory disorders.
摘要翻译：本发明涉及用于治疗炎症性疾病的组合物和方法。更具体地，本发明涉及抗体组合物及其在治疗炎症性疾病中的用途。

4. 发明申请

US20100081792A1 Ligand 审中-公开
标题翻译：配体
公开(公告)号：US20100081792A1
公开(公告)日：2010-04-01
申请号：US11981821
申请日：2007-10-31
申请人： Steven Grant , Amrik Basran , Olga Ignatovich , Rudolph Maria T. De Wildt , Philip Jones , Neil Brewis , Ben Woolven , Elena De Angelis , Lucy J. Holt , Greg Winter , Ian Tomlinson , Kevin Moulder
发明人： Steven Grant , Amrik Basran , Olga Ignatovich , Rudolph Maria T. De Wildt , Philip Jones , Neil Brewis , Ben Woolven , Elena De Angelis , Lucy J. Holt , Greg Winter , Ian Tomlinson , Kevin Moulder
IPC分类号： C07K16/00
CPC分类号： C07K16/468 , A61K47/60 , A61K2039/505 , C07K14/415 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/2866 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C07K2319/00
摘要： The invention provides a dual-specific ligand comprising a first and second single variable domain, each having binding specificity for a antigenic target. The invention also provides for a single variable domain monomer ligand that specifically binds to an antigenic target.
摘要翻译：本发明提供了双特异性配体，其包含第一和第二单可变结构域，每一结构域对抗原靶具有结合特异性。本发明还提供了与抗原靶特异性结合的单个可变域单体配体。

5. 发明授权

US09127059B2 Anti P2X7 receptor antibodies and fragments thereof 有权
标题翻译：抗P2X7受体抗体及其片段
公开(公告)号：US09127059B2
公开(公告)日：2015-09-08
申请号：US13391619
申请日：2010-08-20
申请人： Julian Alexander Barden , Neil Brewis , Philip Jones , Steven Grant
发明人： Julian Alexander Barden , Neil Brewis , Philip Jones , Steven Grant
IPC分类号： C07K16/28
CPC分类号： C07K16/28 , C07K16/30 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/74 , C07K2317/76 , C07K2317/92
摘要： The invention relates to an antigen binding site for binding to a P2X7 receptor, the antigen binding site being defined by general formula 1: FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4
摘要翻译：本发明涉及用于结合P2X7受体的抗原结合位点，抗原结合位点由通式1定义：FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

6. 发明申请

US20130171146A1 DUAL-SPECIFIC IL-1A/ IL-1B ANTIBODIES 审中-公开
标题翻译：双特异性IL-1A / IL-1B抗体
公开(公告)号：US20130171146A1
公开(公告)日：2013-07-04
申请号：US13591027
申请日：2012-08-21
申请人： Chung-ming Hsieh , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Michael Roguska , Ian Tomlinson , Carrie Enever , Steven Grant , Mihriban Tuna
发明人： Chung-ming Hsieh , Bradford L. McRae , Yuliya Kutskova , John E. Memmott , Michael Roguska , Ian Tomlinson , Carrie Enever , Steven Grant , Mihriban Tuna
IPC分类号： C07K16/46 , A61K45/06 , C07K16/24 , A61K39/395
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , C07K16/245 , C07K2317/569 , C07K2317/92
摘要： The invention provides an isolated, dual-specific antibody, or an antigen-binding portion thereof, which is specific for human IL-1α and human IL-1β. The dual specific antibodies of the invention also neutralize both human IL-1α and human IL-1β. The invention also provides domain antibodies (dAbs) specific for human IL-1α and human IL-1β.
摘要翻译：本发明提供了对人IL-1α和人IL-1β特异的分离的双重特异性抗体或其抗原结合部分。本发明的双重特异性抗体也中和人IL-1α和人IL-1beta。本发明还提供了对人IL-1α和人IL-1β特异性的结构域抗体（dAb）。

7. 发明申请

US20090297524A1 Compositions monovalent for CD40L binding and methods of use 有权
标题翻译：用于CD40L结合的单价组合物和使用方法
公开(公告)号：US20090297524A1
公开(公告)日：2009-12-03
申请号：US11663247
申请日：2005-09-16
申请人： Steven Grant , Haiqun Liu , Kevin Moulder
发明人： Steven Grant , Haiqun Liu , Kevin Moulder
IPC分类号： A61K39/395 , C07K16/28 , A61P37/00
CPC分类号： C07K16/2875 , C07K2317/565 , C07K2317/569 , C07K2317/76
摘要： The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L activity while avoiding potential undesirable effects that can occur with antibodies capable of divalent or multivalent binding of CD40L. In one aspect, a monovalent anti-CD40L antibody polypeptide consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD40L, preferably without substantially agonizing CD40 and/or CD40L activity. In another aspect, the monovalent anti-CD40L antibody polypeptide is a human antibody polypeptide. The invention further encompasses methods of antagonizing CD40/CD40L interactions in an individual and methods of treating diseases or disorders involving CD40/CD40L interactions, the methods involving administering a monovalent anti-CD40L antibody polypeptide to the individual.
摘要翻译：本发明涉及单价结合CD40L的抗体多肽。针对CD40L结合的单价抗体多肽可以抑制CD40L活性，同时避免可能与能够进行CD40L二价或多价结合的抗体发生的不良反应。一方面，单价抗CD40L抗体多肽由特异性结合和拮抗CD40L的活性的单个免疫球蛋白可变区组成或包含，优选不具有实质上激动的CD40和/或CD40L活性。另一方面，单价抗CD40L抗体多肽是人抗体多肽。本发明还包括拮抗个体中CD40 / CD40L相互作用的拮抗作用的方法以及治疗涉及CD40 / CD40L相互作用的疾病或病症的方法，涉及向个体施用单价抗CD40L抗体多肽的方法。

8. 发明申请

US20050211180A1 Aquarium tank 审中-公开
标题翻译：水族箱
公开(公告)号：US20050211180A1
公开(公告)日：2005-09-29
申请号：US11090669
申请日：2005-03-25
申请人： Steven Grant
发明人： Steven Grant
IPC分类号： A01K63/00 , A01K63/06
CPC分类号： A01K63/003 , A01K63/06
摘要： This invention relates to a unique ornamental aquarium design that incorporates a cylinder shaped unit, a base, and a top section. The base's lighting unit will project upward a wide variety of colored lights, including white light, into the tank. The unit will plug into a standard outlet. A mechanism is included on the base to allow for the lights to be rotated either automatically or one color at a time. The housing unit or tank has a broad opening for inserting fish, decorative objects or an air filtration device. The top is designed to allow for an air filtration device to be inserted through the top and into the tank.
摘要翻译：本发明涉及一种独特的装饰性水族馆设计，其包括圆筒形单元，底座和顶部。基地的照明单元将向上投射各种各样的彩色灯，包括白光，进入坦克。本机将插入标准插座。底座上包含一个机构，可以自动旋转灯光或一次旋转一种颜色。外壳单元或槽具有用于插入鱼，装饰物品或空气过滤装置的宽敞开口。顶部设计成允许空气过滤装置通过顶部插入罐中。

9. 发明授权

US08092800B2 Antibodies against Candida antigens 失效
标题翻译：针对念珠菌抗原的抗体
公开(公告)号：US08092800B2
公开(公告)日：2012-01-10
申请号：US11886492
申请日：2006-03-10
申请人： Antonio Cassone , Flavia de Bernardis , Steven Grant , Haiqun Liu
发明人： Antonio Cassone , Flavia de Bernardis , Steven Grant , Haiqun Liu
IPC分类号： A61K39/00 , A61K39/395 , A61K39/38
CPC分类号： C07K16/14 , A61K2039/505 , A61K2039/54 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/569 , C07K2317/76
摘要： This invention relates to domain antibodies. In particular, it relates to domain antibodies (dAbs) that recognize virulence traits of Candida spp. and confer passive protection against candidiasis.
摘要翻译：本发明涉及结构域抗体。特别涉及识别假丝酵母属的毒力特征的结构域抗体（dAb）。并给予针对念珠菌病的被动保护。

10. 发明申请

US20110172400A1 COMPOSITIONS MONOVALENT FOR CD40L BINDING AND METHODS OF USE 审中-公开
标题翻译： CD40L结合物的组合物单一使用方法和使用方法
公开(公告)号：US20110172400A1
公开(公告)日：2011-07-14
申请号：US12941870
申请日：2010-11-08
申请人： Steven Grant , Haiqun Liu , Kevin Moulder
发明人： Steven Grant , Haiqun Liu , Kevin Moulder
IPC分类号： C07K16/18
CPC分类号： C07K16/2875 , C07K2317/565 , C07K2317/569 , C07K2317/76
摘要： The invention relates to antibody polypeptides that monovalently bind CD4OL. Antibody polypeptides that are monovalent for binding of CD4OL can inhibit CD4OL activity while avoiding potential undesirable effects that can occur with antibodies capable of divalent or multivalent binding of DC4OL. in one aspect, a monovalent anti-CD4OL antibody polypeptide consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of DC4OL, preferably without substantially agonizing CD40 activity. In another aspect, the monovalent anti-CD4OL antibody polypeptide is a human antibody polypeptide. The invention further encompasses methods of antagonizing CD40/CD4OL interactions in an individual and methods of treating diseases or disorders involving CD40/DC4OL interactions, the methods involving administering a monovalent anti-CD4OL antibody polypeptide to the individual.
摘要翻译：本发明涉及单价结合CD4OL的抗体多肽。用于结合CD4OL的单价抗体多肽可以抑制CD4OL活性，同时避免可能与能够进行DC4OL的二价或多价结合的抗体发生的不良反应。在一个方面，单价抗-T1OL抗体多肽由特异性结合并拮抗DC4OL的活性的单个免疫球蛋白可变区组成或包含，优选不具有实质上激动的CD40活性。另一方面，单价抗-TOLOL抗体多肽是人抗体多肽。本发明还包括拮抗个体中CD40 / CD4OL相互作用的拮抗作用的方法以及治疗涉及CD40 / DC4OL相互作用的疾病或病症的方法，所述方法包括对个体施用单价抗-TOLOL抗体多肽。

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