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1. 发明授权

US08703124B2 Combination pharmaceutical composition and methods of treating diseases or conditions associated with the cardiovascular system 失效
标题翻译：组合药物组合物和治疗与心血管系统相关的疾病或病症的方法
公开(公告)号：US08703124B2
公开(公告)日：2014-04-22
申请号：US13135882
申请日：2011-07-15
申请人： Oleg Iliich Epshtein , Svetlana Alexandrovna Sergeeva , Liudmila Fyodorovna Dolgovyh , Vladimir Ivanovich Petrov
发明人： Oleg Iliich Epshtein , Svetlana Alexandrovna Sergeeva , Liudmila Fyodorovna Dolgovyh , Vladimir Ivanovich Petrov
IPC分类号： A61K39/395
CPC分类号： C07K16/2869 , A61K41/0004 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/40
摘要： The present application provides a pharmaceutical composition for administration to a patient suffering from at least one symptom of a cardiovascular condition, the composition comprising a) an activated-potentiated form of an antibody to angiotensin II AT1 receptor, and b) an activated-potentiated form of an antibody to endothelial NO-synthase.
摘要翻译：本申请提供了用于给患有心血管疾病的至少一种症状的患者施用的药物组合物，所述组合物包含a）活化增强形式的血管紧张素II AT1受体的抗体形式，以及b）活化增强形式的内皮NO合成酶的抗体。

2. 发明授权

US08865163B2 Pharmaceutical compositions and methods of treatment 有权
标题翻译：药物组合物和治疗方法
公开(公告)号：US08865163B2
公开(公告)日：2014-10-21
申请号：US13135893
申请日：2011-07-15
申请人： Oleg Iliich Epshtein , Svetlana Alexandrovna Sergeeva , Liudmila Fyodorovna Dolgovyh , Irina Anatolievna Kheyfets , Julia Leonidovna Dugina , Julia Alexandrovna Zabolotneva , Sergey Alexandrovich Tarasov
发明人： Oleg Iliich Epshtein , Svetlana Alexandrovna Sergeeva , Liudmila Fyodorovna Dolgovyh , Irina Anatolievna Kheyfets , Julia Leonidovna Dugina , Julia Alexandrovna Zabolotneva , Sergey Alexandrovich Tarasov
IPC分类号： A61K39/395 , C07K16/28 , C07K16/24 , A61K41/00 , A61Q19/06 , A61K8/64 , A61K39/00
CPC分类号： C07K16/28 , A61K8/64 , A61K41/0004 , A61K2039/505 , A61K2039/507 , A61K2039/545 , A61K2800/78 , A61Q19/06 , C07K16/24
摘要： The present invention provides pharmaceutical compositions comprising an activated potentiated form of an antibody to human cannabinoid receptor and use in the treatment of obesity and related metabolic disorders. The present invention further provides pharmaceutical compositions comprising an activated potentiated form of an antibody to human cannabinoid receptor and activated potentiated form of an antibody to protein S-100 for use in the treatment of addiction to psychoactive substances.The present invention provides methods for treating obesity and related metabolic disorders and substance abuse.
摘要翻译：本发明提供药物组合物，其包含活化的强化形式的抗人大麻素受体的抗体并用于治疗肥胖症和相关的代谢紊乱。本发明进一步提供药物组合物，其包含活化的增强形式的抗人类大麻素受体的抗体和对蛋白质S-100的抗体的活化增强形式，用于治疗对精神活性物质的成瘾。本发明提供了治疗肥胖症和相关的代谢紊乱和药物滥用的方法。

3. 发明申请

US20130017202A1 Pharmaceutical compositions and methods of treatment 有权
标题翻译：药物组合物和治疗方法
公开(公告)号：US20130017202A1
公开(公告)日：2013-01-17
申请号：US13135893
申请日：2011-07-15
申请人： Oleg Iliich Epshtein , Svetlana Alexandrovna Sergeeva , Liudmila Fyodorovna Dolgovyh , Irina Anatolievna Kheyfets , Julia Leonidovna Dugina , Julia Alexandrovna Zabolotneva , Sergey Alexandrovich Tarasov
发明人： Oleg Iliich Epshtein , Svetlana Alexandrovna Sergeeva , Liudmila Fyodorovna Dolgovyh , Irina Anatolievna Kheyfets , Julia Leonidovna Dugina , Julia Alexandrovna Zabolotneva , Sergey Alexandrovich Tarasov
IPC分类号： A61K39/395 , A61P25/30 , A61P3/04 , A61P3/00 , A61P25/34 , C07K16/28
CPC分类号： C07K16/28 , A61K8/64 , A61K41/0004 , A61K2039/505 , A61K2039/507 , A61K2039/545 , A61K2800/78 , A61Q19/06 , C07K16/24
摘要： The present invention provides pharmaceutical compositions comprising an activated potentiated form of an antibody to human cannabinoid receptor and use in the treatment of obesity and related metabolic disorders. The present invention further provides pharmaceutical compositions comprising an activated potentiated form of an antibody to human cannabinoid receptor and activated potentiated form of an antibody to protein S-100 for use in the treatment of addiction to psychoactive substances.The present invention provides methods for treating obesity and related metabolic disorders and substance abuse.
摘要翻译：本发明提供药物组合物，其包含活化的强化形式的抗人大麻素受体的抗体并用于治疗肥胖症和相关的代谢紊乱。本发明进一步提供药物组合物，其包含活化的增强形式的抗人类大麻素受体的抗体和对蛋白质S-100的抗体的活化增强形式，用于治疗对精神活性物质的成瘾。本发明提供了治疗肥胖症和相关的代谢紊乱和药物滥用的方法。

4. 发明申请

US20120251584A1 Combination pharmaceutical composition and methods of treating diseases or conditions associated with the cardiovascular system 失效
标题翻译：组合药物组合物和治疗与心血管系统相关的疾病或病症的方法
公开(公告)号：US20120251584A1
公开(公告)日：2012-10-04
申请号：US13135882
申请日：2011-07-15
申请人： Oleg Iliich Epshtein , Svetlana Alexandrovna Sergeeva , Liudmila Fyodorovna Dolgovyh , Vladmir Ivanovich Petrov
发明人： Oleg Iliich Epshtein , Svetlana Alexandrovna Sergeeva , Liudmila Fyodorovna Dolgovyh , Vladmir Ivanovich Petrov
IPC分类号： A61K39/395 , A61P9/12 , A61P7/02 , A61P9/04 , A61K9/00 , A61P9/00
CPC分类号： C07K16/2869 , A61K41/0004 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/40
摘要： The present application provides a pharmaceutical composition for administration to a patient suffering from at least one symptom of a cardiovascular condition, the composition comprising a) an activated-potentiated form of an antibody to angiotensin II AT1 receptor, and b) an activated-potentiated form of an antibody to endothelial NO-synthase.
摘要翻译：本申请提供了用于给患有心血管疾病的至少一种症状的患者施用的药物组合物，所述组合物包含a）活化增强形式的血管紧张素II AT1受体的抗体形式，以及b）活化增强形式的内皮NO合成酶的抗体。

5. 发明授权

US09308259B2 Medicinal agent for treating fatness, diabetes, and diseases associated with impaired glucose tolerance 有权
标题翻译：用于治疗肥胖，糖尿病和与糖耐量异常相关的疾病的药物
公开(公告)号：US09308259B2
公开(公告)日：2016-04-12
申请号：US12303648
申请日：2007-05-31
申请人： Oleg Iliich Epshtein , Svetlana Alexandrovna Sergeeva
发明人： Oleg Iliich Epshtein , Svetlana Alexandrovna Sergeeva
IPC分类号： A61K41/00 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2869 , A61K41/0004 , A61K2039/505
摘要： The inventive medicinal agent comprises antibodies against beta-subunit of insulin receptor in an activated form produced by means of repeated serial dilution and an external action performed according to homeopathic technology. The inventive method for producing a solid medicinal formulation for perorally treating fatness, diabetes, and other diseases associated with impaired glucose tolerance, consists in mixing the effective amount of carrier, which is showered in a fluidized layer by a water-alcohol dilution of antibodies in the form active against the beta-subunit of the insulin receptor produced by combining the repeated serial dilution, thereby reducing the concentration of antibodies, and an external action according to homeopathic technology, and is dried at a temperature equal to or less than 35° C., with pharmaceutically acceptable additives and in subsequently pelleting the mixture thus obtained by means of direct dry compression.
摘要翻译：本发明的药剂包含通过重复连续稀释产生的活化形式的胰岛素受体的β亚基抗体和根据顺势疗法技术进行的外部作用的抗体。用于产生用于经皮处理脂肪，糖尿病和与葡萄糖耐量异常相关的其它疾病的固体药物制剂的本发明的方法包括将有效量的载体混合在载体中，所述有效量的载体在流化层中通过抗体的水 - 醇稀释液通过组合重复的连续稀释产生的胰岛素受体的β亚单位活性的形式，从而降低抗体的浓度，以及根据顺势疗法技术的外部作用，并在等于或低于35℃的温度下干燥具有药学上可接受的添加剂，然后通过直接干压缩将由此获得的混合物造粒。

6. 发明申请

US20170119878A1 METHOD AND COMPOSITION FOR THE TREATMENT OF DISEASES CAUSED BY OR ASSOCIATED WITH HIV 审中-公开
公开(公告)号：US20170119878A1
公开(公告)日：2017-05-04
申请号：US15340191
申请日：2016-11-01
申请人： Oleg Iliich Epshtein
发明人： Oleg Iliich Epshtein , Andrey Valerievich Strygin
IPC分类号： A61K39/395 , A61K9/20 , A61K41/00 , C07K16/24 , C07K16/28 , A61K9/00 , A61K31/7072
CPC分类号： A61K39/3955 , A61K9/0053 , A61K9/20 , A61K31/506 , A61K31/7072 , A61K41/0004 , A61K45/00 , A61K45/06 , C07K16/249 , C07K16/2812 , C07K16/2815 , A61K2300/00
摘要： The invention provides a combination pharmaceutical composition comprising a) at least one activated-potentiated form of an antibody to at least one cytokine or at least an activated-potentiated form of an antibody to at least one receptor; and b) an effective amount of a nucleoside reverse transcriptase inhibitor, wherein said at least one cytokine or at least one receptor is participating in the regulation of immune process. Various embodiments and variants are contemplated.The invention also provides a method of treatment or prophylaxis of HIV, including AIDS, which includes administration of the combination pharmaceutical composition described in the specification to the patient in need thereof.

7. 发明申请

US20160220671A1 Method Of Administration To A Patient Suffering From Disturbances In Vascular Tone 审中-公开
标题翻译：对于患有血管内音障碍的病人的行为方法
公开(公告)号：US20160220671A1
公开(公告)日：2016-08-04
申请号：US15093462
申请日：2016-04-07
申请人： Oleg Iliich Epshtein
发明人： Oleg Iliich Epshtein , Andrey Vasilevich Martyushev
IPC分类号： A61K41/00 , C07K16/28
CPC分类号： A61K41/0004 , A61K39/395 , A61K2039/505 , C07K16/241 , C07K16/26 , C07K16/2869 , C07K16/2878 , C07K16/40
摘要： The method of treatment for diseases accompanied by disturbances of the vascular tone utilizes the use of ultra low doses of antibodies to a protein or a peptide involved in the vascular tone regulation or mediating the effects of other regulators; these antibodies are used in activated form produced by multiple subsequent dilution and external impact.
摘要翻译：用于伴随血管紧张度紊乱的疾病的治疗方法利用超低剂量抗体涉及血管调节调节的蛋白质或肽，或介导其他调节剂的作用; 这些抗体以多次后续稀释和外部冲击产生的活性形式使用。

8. 发明申请

US20160184256A1 METHOD OF TREATING DISORDERS OF THE CARDIOVASCULAR SYSTEM AND A PHARMACEUTICAL AGENT 审中-公开
标题翻译：治疗心血管系统疾病和药物代谢的方法
公开(公告)号：US20160184256A1
公开(公告)日：2016-06-30
申请号：US15059226
申请日：2016-03-02
申请人： Oleg Iliich Epshtein
发明人： Oleg Iliich Epshtein
IPC分类号： A61K31/277
CPC分类号： C07K16/44 , A61K31/277 , A61K39/39583 , A61K41/0004 , A61K2039/505 , A61K2039/545 , C07K16/00 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/243 , C07K16/245 , C07K16/246 , C07K16/248 , C07K16/249 , C07K16/26 , C07K16/28 , C07K16/2806 , C07K16/40 , C07K2317/73 , C07K2317/75 , C07K2317/77
摘要： A method of treating a pathological syndrome includes administration of an activated form of ultra-low doses of antibodies to an antigen, wherein said activated form is obtained by repeated consecutive dilution combined with external impact, and the antigen is a substance or a pharmaceutical agent exerting influence upon the mechanisms of formation of this particular pathological syndrome.Pharmaceutical agent for treating a pathological syndrome contains activated form of ultra-low doses of monoclonal, polyclonal or natural antibodies to an antigen, wherein said activated form is prepared by means of repeated consecutive dilution and external treatment, predominantly based on homeopathic technology, and said antigen is a substance or a drug acting as a direct cause of the pathological syndrome or involved in regulation of mechanisms of its formation. At that, activated forms of ultra-low doses of antibodies are raised against antigens of exogenous or endogenous origin, against autologous antigens, fetal antigens; anti-idiotypic antibodies are used too.
摘要翻译：治疗病理综合征的方法包括向抗原施用超低剂量抗体的活化形式，其中所述活化形式通过反复连续稀释与外部冲击结合获得，并且所述抗原是施用的物质或药剂影响这种特殊病理综合征的形成机制。用于治疗病理综合征的药物包含针对抗原的超低剂量的单克隆抗体，多克隆抗体或天然抗体的活化形式，其中所述活化形式通过重复连续稀释和外部治疗（主要基于顺势疗法技术）制备，所述抗原是作为病理综合征的直接原因或参与调节其形成机制的物质或药物。在此情况下，针对自身抗原，胎儿抗原，针对外源性或内源性抗原产生超低剂量抗体的活化形式; 也使用抗独特型抗体。

9. 发明授权

US08795657B2 Combination pharmaceutical composition and methods of treating diseases or conditions associated with respiratory disease or condition 有权
标题翻译：组合药物组合物和治疗与呼吸系统疾病或病症有关的疾病或病症的方法
公开(公告)号：US08795657B2
公开(公告)日：2014-08-05
申请号：US13135884
申请日：2011-07-15
申请人： Oleg Iliich Epshtein
发明人： Oleg Iliich Epshtein
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K39/3955 , A61K39/39583 , A61K41/0004 , A61K2039/505 , A61K2039/507 , C07K16/26 , C07K16/44
摘要： The present invention is concerned with a combination pharmaceutical composition comprising a) an activated-potentiated form of an antibody to bradykinin, b) an activated-potentiated form of an antibody to histamine and c) an activated-potentiated form of an antibody to morphine and method for treating and preventing upper respiratory tract conditions or disorders and the symptoms associated therewith by administration of the combination composition.
摘要翻译：本发明涉及组合药物组合物，其包含a）活化增强形式的缓激肽抗体，b）活化增强形式的组胺抗体，c）活化增强形式的吗啡抗体和用于治疗和预防上呼吸道状况或病症的方法以及通过给予组合组合物而引起的症状。

10. 发明申请

US20140079696A1 Method of increasing the effect of an activated-potentiated form of an antibody 审中-公开
标题翻译：增加活化增强形式抗体的作用的方法
公开(公告)号：US20140079696A1
公开(公告)日：2014-03-20
申请号：US13135901
申请日：2011-07-15
申请人： Oleg Iliich Epshtein
发明人： Oleg Iliich Epshtein
IPC分类号： A61K47/48 , A61K39/395
CPC分类号： C07K16/40 , A61K9/20 , A61K39/3955 , A61K41/0004 , A61K2039/507 , C07K16/18 , C07K16/2869
摘要： The preset invention provides a method of increasing the effect of an activated-potentiated form of an antibody to an endogenous biological molecule by combining said endogenous biological molecule with an activated-potentiated form of an antibody to endothelial NO-synthase.The present invention also provides a pharmaceutical composition comprising a) an activated-potentiated form of an antibody to an endogenous biological molecule, and b) an activated-potentiated form of an antibody to NO synthase.
摘要翻译：本发明提供了通过将所述内源性生物分子与内皮NO合成酶的活化增强形式的抗体组合来增加活化增强形式的抗体对内源性生物分子的作用的方法。本发明还提供一种药物组合物，其包含a）活化增强形式的内源性生物分子的抗体，和b）活化增强形式的NO合成酶抗体。

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