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    • 3. 发明授权
    • Compositions for topical application comprising a peroxide and retinoid
    • 用于局部应用的组合物,其包含过氧化物和类视色素
    • US08617580B2
    • 2013-12-31
    • US13495701
    • 2012-06-13
    • Ofer ToledanoHanan SertchookNatalia LobodaHaim Bar-SimantovLeora ShapiroRaed Abu-Reziq
    • Ofer ToledanoHanan SertchookNatalia LobodaHaim Bar-SimantovLeora ShapiroRaed Abu-Reziq
    • A61Q19/02A61P17/10
    • A61K9/0014A61K9/28A61K47/34
    • The invention relates to a composition for topical application comprising as an active ingredient a peroxide and a retinoid wherein one of said peroxide and retinoid is in the form of first microparticles comprising a solid particulate matter of the active ingredient coated by a metal oxide layer and the other of said peroxide and retinoid is present in an uncoated free form or in a coated form of the active ingredient. The invention further relates to method for treating a surface condition in a subject using said composition, a method for preparing a composition exhibiting improved stability, and a kit comprising: (a) a first composition comprising a peroxide as a first active ingredient; and (b) a second composition comprising a retinoid as a second active ingredient; at least one of said first and said second active ingredient being coated by a metal oxide layer.
    • 本发明涉及用于局部应用的组合物,其包含作为活性成分的过氧化物和类视色素,其中所述过氧化物和类视色素之一为第一微粒的形式,其包含由金属氧化物层包被的活性成分的固体颗粒物质, 所述过氧化物和类视色素中的另一种以未包衣的游离形式或活性成分的包衣形式存在。 本发明还涉及使用所述组合物治疗受试者的表面状况的方法,制备显示出改善的稳定性的组合物的方法,以及试剂盒,其包含:(a)第一组合物,其包含作为第一活性成分的过氧化物; 和(b)第二组合物,其包含类视黄醇作为第二活性成分; 所述第一和第二活性成分中的至少一个被金属氧化物层包覆。