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1. 发明申请

US20120238460A1 RANTES LEVELS AS A DIAGNOSTIC AND THERAPEUTIC FOR ACUTE GRAFT VERSUS HOST DISEASE 审中-公开
标题翻译： RANTES水平作为诊断和治疗急性冠状动脉疾病
公开(公告)号：US20120238460A1
公开(公告)日：2012-09-20
申请号：US12739976
申请日：2008-11-10
申请人： Ofer Levy , Eva Guinan , Eugenie Suter
发明人： Ofer Levy , Eva Guinan , Eugenie Suter
IPC分类号： C40B30/04
CPC分类号： G01N33/6863 , G01N2333/523 , G01N2800/245 , G01N2800/50
摘要： Disclosed herein are methods for determining the likelihood of a subject to develop Acute graft versus host disease (aGVHD) upon receiving myeloablative allogeneic hematopoietic stem cell transplantation (HSCT). One such method comprises assaying for baseline plasma concentration of RANTES in a sample obtained from the subject, and comparing the baseline plasma concentration of RANTES to a predetermined level. The method may further comprise assaying for day 7 plasma concentration of RANTES in sample obtained from the subject, and comparing the day 7 plasma concentration of RANTES to a predetermined level. Another such method comprises assaying for day 7 plasma concentration of RANTES in a sample obtained from the subject, and comparing the day 7 plasma concentration of RANTES to a predetermined level. Another such method comprises assaying for donor plasma concentration of RANTES in a sample obtained from a donor of the hemtopoietic stem cells, and comparing the donor plasma concentration of RANTES to a predetermined level, wherein a donor plasma concentration of RANTES less than the predetermined level indicates a likelihood of the subject to develop aGVHD upon receiving myeloablative allogeneic HSCT from that donor. Other methods include assaying for day 0, or for day 7, plasma concentration of MCP-1 in a sample obtained from the subject, and comparing the day 0 or day 7, plasma concentration of MCP-1 to a predetermined level.
摘要翻译：本文公开了用于确定受试者在接受清髓性同种异体造血干细胞移植（HSCT）时发展为急性移植物抗宿主病（aGVHD）的可能性的方法。一种这样的方法包括测定从受试者获得的样品中RANTES的基线血浆浓度，并将RANTES的基线血浆浓度与预定水平进行比较。该方法还可以包括测定从受试者获得的样品中RANTES的第7天血浆浓度，并将RANTES的第7天血浆浓度与预定水平进行比较。另一种这样的方法包括测定从受试者获得的样品中RANTES的第7天血浆浓度，并将RANTES的第7天血浆浓度与预定水平进行比较。另一种这样的方法包括测定从造血干细胞的供体获得的样品中RANTES的供体血浆浓度，并将RANTES的供体血浆浓度与预定水平进行比较，其中RANTES的供体血浆浓度小于预定水平表明接受来自该供体的清髓性同种异体HSCT的受试者可能发生GVHD。其他方法包括测定从受试者获得的样品中的第0天或第7天MCP-1的血浆浓度，并将MCP-1的血浆浓度与第0天或第7天的血浆浓度进行比较。

2. 发明授权

US09770483B2 BPI and its congeners as radiation mitigators and radiation protectors 有权
公开(公告)号：US09770483B2
公开(公告)日：2017-09-26
申请号：US14009201
申请日：2012-04-05
申请人： Eva Guinan , Ofer Levy
发明人： Eva Guinan , Ofer Levy
IPC分类号： A61K38/17 , C07K14/47 , A61K45/06 , A61K31/4709 , A61K31/496 , A61K31/5383
CPC分类号： A61K38/1751 , A61K31/4709 , A61K31/496 , A61K31/5383 , A61K45/06 , A61K2300/00
摘要： Described herein is a method of mitigating, in a subject (individual), tissue injury resulting from exposure to radiation (accidental/unintentional or intentional, such as therapeutic), chemoradiotherapy, disease, toxin, or drug or biologic mediated therapy.

3. 发明申请

US20140142024A1 BPI AND ITS CONGENERS AS RADIATION MITIGATORS AND RADIATION PROTECTORS 有权
标题翻译： BPI及其作为辐射减轻剂和辐射防护剂的恒温器
公开(公告)号：US20140142024A1
公开(公告)日：2014-05-22
申请号：US14009201
申请日：2012-04-05
申请人： Eva Guinan , Ofer Levy
发明人： Eva Guinan , Ofer Levy
IPC分类号： A61K38/17 , A61K31/496
CPC分类号： A61K38/1751 , A61K31/4709 , A61K31/496 , A61K31/5383 , A61K45/06 , A61K2300/00
摘要： Described herein is a method of mitigating, in a subject (individual), tissue injury resulting from exposure to radiation (accidental/unintentional or intentional, such as therapeutic), chemoradiotherapy, disease, toxin, or drug or biologic mediated therapy.
摘要翻译：本文描述的是在受试者（个体）中减轻由暴露于辐射（偶然/非故意或有意的，例如治疗），放化疗，疾病，毒素或药物或生物介导治疗引起的组织损伤的方法。

4. 发明授权

US09626274B2 Instruction and logic for tracking access to monitored regions 有权
公开(公告)号：US09626274B2
公开(公告)日：2017-04-18
申请号：US14580676
申请日：2014-12-23
申请人： Ahmad Yasin , Rajshree A. Chabukswar , Ofer Levy , Michael W. Chynoweth , Charlie J. Hewett
发明人： Ahmad Yasin , Rajshree A. Chabukswar , Ofer Levy , Michael W. Chynoweth , Charlie J. Hewett
IPC分类号： G06F11/00 , G06F11/34 , G06F11/30 , G06F9/38
CPC分类号： G06F11/3471 , G06F9/30076 , G06F9/38 , G06F11/3024 , G06F11/3037 , G06F11/3466 , G06F11/348 , G06F2201/81 , G06F2201/88
摘要： A processor includes a front end, a decoder, a retirement unit, and a performance monitoring unit. The front end includes a decoder with logic to receive a tracking instruction to enable tracking of execution of a region of memory. The instruction is to define an address range of the region. The retirement includes logic to retire the tracking instruction and candidate instructions. The performance monitoring unit includes logic to determine that the candidate instructions are associated with an entrance and an exit to the address range, and to generate an alert based on the candidate instructions association with the entrance and the exit.

5. 发明申请

US20140380027A1 ELAPSED CYCLE TIMER IN LAST BRANCH RECORDS 有权
标题翻译：最近分支记录中的ELAPSED循环定时器
公开(公告)号：US20140380027A1
公开(公告)日：2014-12-25
申请号：US13922421
申请日：2013-06-20
申请人： Ahmad Yasin , Michael W. Chynoweth , Ofer Levy , Jason W. Brandt , Angela Schmid
发明人： Ahmad Yasin , Michael W. Chynoweth , Ofer Levy , Jason W. Brandt , Angela Schmid
IPC分类号： G06F9/30
CPC分类号： G06F9/3806 , G06F9/30058 , G06F9/30098 , G06F11/3419 , G06F11/348 , G06F2201/865 , G06F2201/88
摘要： A processing device implementing an elapsed cycle timer in last branch records (LBRs) is disclosed. A processing device of the disclosure includes a last branch record (LBR) counter to iterate with each cycle of the processing device and an LBR structure communicably coupled to the LBR counter. The LBR structure comprises a plurality of LBR entries. Furthermore, an LBR entry of the plurality of LBR entries comprises an address instruction pointer (IP) of a branch instruction executed by the processing device, an address IP of a target of the branch instruction, and an elapsed time field that stores a value of the LBR counter when the LBR entry is created.
摘要翻译：公开了一种在最后的分支记录（LBR）中实现经过周期定时器的处理装置。本公开的处理装置包括与处理装置的每个周期重复的最后一个分支记录（LBR）计数器和可通信地耦合到LBR计数器的LBR结构。 LBR结构包括多个LBR条目。此外，多个LBR条目的LBR条目包括由处理装置执行的分支指令的地址指令指针（IP），分支指令的目标的地址IP以及存储分支指令的值的经过时间字段当创建LBR条目时，LBR计数器。

6. 发明申请

US20140056811A1 NEW CELL-PENETRATING PEPTIDES AND USES THEREOF 审中-公开
标题翻译：新细胞穿刺肽及其用途
公开(公告)号：US20140056811A1
公开(公告)日：2014-02-27
申请号：US13976502
申请日：2011-12-26
申请人： Etai Jacob , Amir Toporik , Ronen Shemesh , Ofer Levy
发明人： Etai Jacob , Amir Toporik , Ronen Shemesh , Ofer Levy
IPC分类号： A61K47/48
CPC分类号： C07K14/78 , A61K47/62 , C07K14/47 , C07K2319/01
摘要： The present invention is related to peptides, which are suitable for use as cell-penetrating peptides (CPPs), variants thereof and/or complexes, fusion molecules and/or conjugates comprising same, use thereof for manufacture of compositions for diagnosing, treating and/or preventing of medical conditions.
摘要翻译：本发明涉及适合用作细胞穿透肽（CPP），其变体和/或复合物，包含其的融合分子和/或缀合物的肽，其用于制备用于诊断，治疗和/ 或预防医疗状况。

7. 发明授权

US08529943B2 Angiopoietin derived peptides 有权
标题翻译：促血管生成素衍生肽
公开(公告)号：US08529943B2
公开(公告)日：2013-09-10
申请号：US13054914
申请日：2009-07-20
申请人： Yossef Kliger , Itamar Borukhov , Ofer Levy , Zohar Tiran , Assaf Wool , Ehud Schreiber , Anat Amir , Zurit Levine , Amir Toporik
发明人： Yossef Kliger , Itamar Borukhov , Ofer Levy , Zohar Tiran , Assaf Wool , Ehud Schreiber , Anat Amir , Zurit Levine , Amir Toporik
IPC分类号： C07K14/515 , C07K14/00 , C07K7/06 , C07K7/08 , C07K16/46 , A61K38/16 , A61K38/08 , A61K38/10
CPC分类号： C07K14/515 , A61K38/14 , A61K38/1891 , A61K45/06 , C07K9/00 , C07K9/001
摘要： Provided are angiopoietin-derived peptides or homologs or derivatives thereof, pharmaceutical composition including them, a use thereof for therapy and for the manufacture of a medicament, a method of treating a wide range of conditions, disorders and diseases therewith, nucleotide sequences encoding them, antibodies directed to epitopes thereof and fusion proteins including them.
摘要翻译：提供来自血管生成素的肽或其同系物或衍生物，包含它们的药物组合物，其用于治疗和制备药物的用途，治疗各种病症，疾病和疾病的方法，编码它们的核苷酸序列，针对其表位的抗体和包括它们的融合蛋白。

8. 发明申请

US20110311450A1 POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS 审中-公开
标题翻译：多肽和多核苷酸，以及作为药物和生物学药物目标的用途
公开(公告)号：US20110311450A1
公开(公告)日：2011-12-22
申请号：US13131879
申请日：2009-12-08
申请人： Zurit Levine , Avi Rosenberg , Galit Rotman , Amit Novik , Amir Toporik , Yaron Kinar , Sergey Nemzer , Shira Walach , Eve Montia , Shirley Sameach-Greenwald , Liat Dassa , Merav Beiman , Anat Cohen-Dayag , Ofer Levy
发明人： Zurit Levine , Avi Rosenberg , Galit Rotman , Amit Novik , Amir Toporik , Yaron Kinar , Sergey Nemzer , Shira Walach , Eve Montia , Shirley Sameach-Greenwald , Liat Dassa , Merav Beiman , Anat Cohen-Dayag , Ofer Levy
IPC分类号： A61K49/00 , C12N9/96 , A61P35/00 , A61K39/395 , C40B30/04 , G01N33/574 , C07K16/30 , C12N5/078
CPC分类号： C07K16/28 , A61K38/00 , A61K39/39558 , A61K2039/505 , C07K14/47 , C07K16/30 , C07K16/3015 , C07K16/3038 , C07K16/3053 , C07K16/3061 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12Q1/6886 , C12Q2600/136 , G01N33/57484 , G01N33/577 , G01N2333/47
摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KRTCAP3, FAM26F, MGC52498, FAM70A or TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages. This invention further relates to extracellular domains of KRTCAP3, FAM26F, MGC52498, FAM70A and TMEM154 proteins and variants, and therapeutic usages thereof.
摘要翻译：本发明涉及用于产生免疫和非免疫的治疗剂和疾病诊断的新靶标。更具体地，本发明提供针对在癌症中差异表达的KRTCAP3，FAM26F，MGC52498，FAM70A或TMEM154抗原以及诊断和治疗用途的治疗性抗体。本发明还涉及KRTCAP3，FAM26F，MGC52498，FAM70A和TMEM154蛋白质和变体的细胞外结构域及其治疗用途。

9. 发明申请

US20090327663A1 Power Aware Retirement 有权
标题翻译：电力意识退休
公开(公告)号：US20090327663A1
公开(公告)日：2009-12-31
申请号：US12215526
申请日：2008-06-27
申请人： Zeev Sperber , Rafi Marom , Ofer Levy
发明人： Zeev Sperber , Rafi Marom , Ofer Levy
IPC分类号： G06F9/30
CPC分类号： G06F1/3203 , G06F1/3287 , G06F9/3855 , G06F9/3857 , G06F9/3865 , Y02D10/124 , Y02D10/171 , Y02D50/20
摘要： In one embodiment, the present invention includes a retirement unit to receive and retire executed instructions. The retirement unit may include a first array to receive information at allocation and a second array to receive information after execution. The retirement unit may further include logic to calculate an event associated with an executed instruction if information associated with the executed instruction is stored in an on-demand portion of at least one of arrays. Other embodiments are described and claimed.
摘要翻译：在一个实施例中，本发明包括用于接收和退出执行的指令的退休单元。退休单元可以包括用于在分配时接收信息的第一阵列和用于在执行之后接收信息的第二阵列。如果与所执行的指令相关联的信息被存储在阵列中的至少一个的按需部分中，退休单元还可以包括用于计算与执行的指令相关联的事件的逻辑。描述和要求保护其他实施例。

10. 发明授权

US5842996A Automatic tourniquet system 失效
标题翻译：自动止血带系统
公开(公告)号：US5842996A
公开(公告)日：1998-12-01
申请号：US530317
申请日：1996-01-22
申请人： Frank Vincenz Jonas Gruenfeld , Alexander Opatowsky , Joel Engel , Yehouda David , Ofer Levy
发明人： Frank Vincenz Jonas Gruenfeld , Alexander Opatowsky , Joel Engel , Yehouda David , Ofer Levy
IPC分类号： A61B5/022 , A61B17/135 , A61B5/00
CPC分类号： A61B5/02233 , A61B17/135
摘要： An automatic tourniquet system (10) including variable pressure cuff apparatus (60) for applying a variable pressure to a limb or artery of a patient in order to occlude blood flow thereat and control apparatus (40) for determining the operative pressure of the variable pressure cuff (20) apparatus and including apparatus for estimating the minimum effective cuff pressure required for complete occlusion.
摘要翻译： PCT No.PCT / EP94 / 01044 Sec。 371日期1996年1月22日 102（e）日期1996年1月22日PCT 1994年3月31日PCT公布。公开号WO94 / 22364 1994年10月13日公开了一种自动止血带系统（10），包括用于向患者的肢体或动脉施加可变压力以便阻塞血液流量的可变压力袖带装置（60），以及用于确定手术可变压力袖带（20）装置的压力，并且包括用于估计完全闭塞所需的最小有效袖带压力的装置。

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