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    • 2. 发明申请
    • STABLE OIL SUSPENSIONS WITH ENHANCED BIOAVAILABILITY AND COMPOSITIONS THEREOF
    • 稳定的油悬浮液,具有增强的生物可利用性及其组合物
    • US20160143332A1
    • 2016-05-26
    • US14631093
    • 2015-02-25
    • OmniActive Health Technologies Limited
    • Jayant DESHPANDELaxman KATEPrakash BHANUSE
    • A23L1/30A23D9/007A23L1/00
    • A23D9/007A23L33/10A23L33/105A23L33/115A23L33/12A23L33/15A23L33/155A23P10/20A23P10/30A23P10/35A61K9/10A61K9/4875A61K36/37A61K47/44
    • Stable oil suspensions are described that have enhanced bioavailability and contain lipophilic nutrients uniformly dispersed in a solid hydrophilic carrier and suspended in an oil medium. A process for preparation of stable oil suspensions of lipophilic nutrients and compositions of these suspensions such as soft gelatin capsules are also described. The oil suspensions include soluble granules of lipophilic nutrients suspended in oil. Soluble granules include lipophilic nutrients dispersed uniformly in a solid hydrophilic carrier with one or more food grade excipient. Stable oil suspensions of the invention include at least 1% to about 50% lipophilic nutrient. These oil suspensions are resistant to oxidation and exhibit enhanced stability and bioavailability as compared to soluble granules and to marketed comparative products. Oil suspensions herein can be encapsulated in soft gel capsules or filled in sachets to administer conveniently to patients.
    • 描述了稳定的油悬浮液,其具有增强的生物利用度并且包含均匀分散在固体亲水载体中并悬浮在油介质中的亲脂性营养物质。 还描述了制备亲脂性营养物的稳定油悬浮液的方法和这些悬浮液如软明胶胶囊的组合物。 油悬浮液包括悬浮在油中的亲脂性营养物质的可溶性颗粒。 可溶性颗粒包括用一种或多种食品级赋形剂均匀分散在固体亲水载体中的亲脂性营养物质。 本发明的稳定的油悬浮液包括至少1%至约50%的亲脂性营养物质。 与可溶性颗粒和市售的比较产品相比,这些油悬浮液具有抗氧化作用并且表现出增强的稳定性和生物利用度。 本文的油悬浮液可以包封在软胶囊中或填充小袋以方便地给患者施用。
    • 3. 发明申请
    • COMPOSITION OF OILY, PUNGENT AND ODORIFEROUS SUBSTANCES AND A PROCESS OF PREPARATION THEREOF
    • 油,ENT ENT US US US OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF OF
    • US20150209400A1
    • 2015-07-30
    • US14463249
    • 2014-08-19
    • OmniActive Health Technologies Limited
    • Jayant DESHPANDEGirish ACHLIYAPravin NALAWADEPrakash BHANUSESwapnil KHAMBORKAR
    • A61K36/81A23L2/52A61K9/50
    • A composition of oily, pungent and odoriferous substances and a process for preparation thereof are described, in particular an extended and sustained release of a stable, free flowing, solid composition of one or more of substances such as capsicum, black pepper, ginger, mustard, cinnamon, garlic, onion, paprika, turmeric and the like, extracts thereof, and/or components thereof, and a process for preparation thereof are described. For example, compositions comprise a substance such as capsicum containing capsaicinoid components, which include for example capsaicin, dihydro-capsaicin, and/or nor-dihydro-capsaicin. The composition can eliminate the discomfort by facilitating intestinal absorption of the active ingredient and thereby minimizing/eliminating the discomfort caused by the residual unabsorbed active ingredient, and can be particularly suitable for formulating into consumable dry syrups, tablets, capsules, liquid syrups, health drinks, diet drinks, fruit juices, and/or soft drinks, which can be useful in reduction of body weight.
    • 描述了油性,刺鼻和有气味物质的组合物及其制备方法,特别是延长和持续释放一种或多种物质如辣椒,黑胡椒,姜,芥末的稳定的自由流动的固体组合物 ,肉桂,大蒜,洋葱,辣椒粉,姜黄等,其提取物和/或其成分及其制备方法。 例如,组合物包含诸如辣椒素的辣椒素成分的物质,其包括例如辣椒素,二氢辣椒素和/或去氢二氢辣椒素。 组合物可以通过促进活性成分的肠吸收而消除不适,从而最小化/消除由残留的未吸收的活性成分引起的不适,并且特别适用于配制成消耗性干糖浆,片剂,胶囊,液体糖浆,保健饮料 ,饮食饮料,果汁和/或软饮料,其可用于减轻体重。