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1. 发明授权

US08744553B2 Real-time radiation treatment planning system 有权
标题翻译：实时辐射治疗计划系统
公开(公告)号：US08744553B2
公开(公告)日：2014-06-03
申请号：US13625662
申请日：2012-09-24
申请人： Nucletron Operations B.V.
发明人： Johann Kindlein , Dimos Baltas , Georgios Sakas , Frans Kulpers , Hans Martin Schot
IPC分类号： A61B5/05
CPC分类号： A61N5/1031 , A61N5/1001 , A61N5/1007 , A61N5/1039 , A61N2005/1012 , A61N2005/1032 , A61N2005/1074 , G06F19/00 , G06F19/3481
摘要： The invention relates to a real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body using hollow needles. According to embodiments of the invention, the system may include a processing means processing means-configured to perform a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm, with respect to one or more specific organs within the pre-selected anatomical portion and with respect to the needles, for converting the image data obtained with an imaging means into a three-dimensional image of the anatomical portion, using at least one single or multi-objective anatomy-based genetic optimization algorithm. For pre-planning or virtual simulation purposes, the processing means is arranged to determine in real time the optimal number and position of at least one of the needles, positions of energy emitting sources within the needles, and the dwell times of the energy emitting sources at the positions. For post-planning purposes, the processing means is arranged to determine, based on three-dimensional image information, in real time the real needle positions and the dwell times of the energy emitting sources for the positions.
摘要翻译：本发明涉及一种实时放射治疗计划系统，用于使用空心针对动物体的预先选择的解剖部分进行放射治疗。根据本发明的实施例，系统可以包括处理装置处理装置，其被配置为相对于预先选择的解剖部分内的一个或多个特定器官执行三维成像算法和三维图像分割算法并且相对于针，用于使用至少一个单目标或多目标基于解剖的遗传优化算法将用成像装置获得的图像数据转换成解剖部分的三维图像。对于预先规划或虚拟模拟目的，处理装置被布置成实时确定针中的至少一个针的最佳数量和位置，针内的能量发射源的位置以及能量发射源的停留时间在职位。为了规划后的目的，处理装置被布置成基于三维图像信息实时确定位置的能量发射源的实际针位置和停留时间。

2. 发明申请

US20150105606A1 Real Time Radiation Treatment Planning System 审中-公开
标题翻译：实时辐射治疗计划系统
公开(公告)号：US20150105606A1
公开(公告)日：2015-04-16
申请号：US14260009
申请日：2014-04-23
申请人： Nucletron Operations B.V.
发明人： Johann Kindlein , Dimos Baltas , Georgios Sakas , Frans Kuipers , Hans Martin Schot
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/1001 , A61N5/1007 , A61N5/1039 , A61N2005/1012 , A61N2005/1032 , A61N2005/1074 , G06F19/00 , G06F19/3481
摘要： The invention relates to a real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body using hollow needles. According to embodiments of the invention, the system may include a processing means processing means-configured to perform a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm, with respect to one or more specific organs within the pre-selected anatomical portion and with respect to the needles, for converting the image data obtained with an imaging means into a three-dimensional image of the anatomical portion, using at least one single or multi-objective anatomy-based genetic optimization algorithm. For pre-planning or virtual simulation purposes, the processing means is arranged to determine in real time the optimal number and position of at least one of the needles, positions of energy emitting sources within the needles, and the dwell times of the energy emitting sources at the positions. For post-planning purposes, the processing means is arranged to determine, based on three-dimensional image information, in real time the real needle positions and the dwell times of the energy emitting sources for the positions.
摘要翻译：本发明涉及一种实时放射治疗计划系统，用于使用空心针对动物体的预先选择的解剖部分进行放射治疗。根据本发明的实施例，系统可以包括处理装置处理装置，其被配置为相对于预先选择的解剖部分内的一个或多个特定器官执行三维成像算法和三维图像分割算法并且相对于针，用于使用至少一个单目标或多目标基于解剖的遗传优化算法将用成像装置获得的图像数据转换成解剖部分的三维图像。对于预先规划或虚拟模拟目的，处理装置被布置成实时确定针中的至少一个针的最佳数量和位置，针内的能量发射源的位置以及能量发射源的停留时间在职位。为了规划后的目的，处理装置被布置成基于三维图像信息实时确定位置的能量发射源的实际针位置和停留时间。

3. 发明授权

US09381377B2 Real time radiation treatment planning system 有权
标题翻译：实时辐射治疗计划系统
公开(公告)号：US09381377B2
公开(公告)日：2016-07-05
申请号：US14260009
申请日：2014-04-23
申请人： Nucletron Operations B.V.
发明人： Johann Kindlein , Dimos Baltas , Georgios Sakas , Frans Kuipers , Hans Martin Schot
IPC分类号： A61B5/05 , A61N5/10
CPC分类号： A61N5/1031 , A61N5/1001 , A61N5/1007 , A61N5/1039 , A61N2005/1012 , A61N2005/1032 , A61N2005/1074 , G06F19/00 , G06F19/3481
摘要： The invention relates to a real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body using hollow needles. According to embodiments of the invention, the system may include a processing means processing means-configured to perform a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm, with respect to one or more specific organs within the pre-selected anatomical portion and with respect to the needles, for converting the image data obtained with an imaging means into a three-dimensional image of the anatomical portion, using at least one single or multi-objective anatomy-based genetic optimization algorithm. For pre-planning or virtual simulation purposes, the processing means is arranged to determine in real time the optimal number and position of at least one of the needles, positions of energy emitting sources within the needles, and the dwell times of the energy emitting sources at the positions. For post-planning purposes, the processing means is arranged to determine, based on three-dimensional image information, in real time the real needle positions and the dwell times of the energy emitting sources for the positions.
摘要翻译：本发明涉及一种实时放射治疗计划系统，用于使用空心针对动物体的预先选择的解剖部分进行放射治疗。根据本发明的实施例，系统可以包括处理装置处理装置，其被配置为相对于预先选择的解剖部分内的一个或多个特定器官执行三维成像算法和三维图像分割算法并且相对于针，用于使用至少一个单目标或多目标基于解剖的遗传优化算法将用成像装置获得的图像数据转换成解剖部分的三维图像。对于预先规划或虚拟模拟目的，处理装置被布置成实时确定针中的至少一个针的最佳数量和位置，针内的能量发射源的位置以及能量发射源的停留时间在职位。为了规划后的目的，处理装置被布置成基于三维图像信息实时确定位置的能量发射源的实际针位置和停留时间。

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