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1. 发明申请

US20200158799A1 PHOTONIC BAND-GAP RESONATOR FOR MAGNETIC RESONANCE APPLICATIONS 审中-公开
公开(公告)号：US20200158799A1
公开(公告)日：2020-05-21
申请号：US16626714
申请日：2018-06-27
申请人： North Carolina State University
发明人： Alexander Nevzorov , Alexej I. Smirnov , Sergey Milikisiyants
IPC分类号： G01R33/34 , G01R33/341
摘要： Aspects of photonic band gap resonators for magnetic resonance are described. In one example, an apparatus includes a 1D structure having a plurality of layers. A respective thickness of the individual layers is one-quarter of a respective wavelength of a target magnetic resonance frequency within the individual layers of the plurality of layers, or a multiple thereof. A first layer has a first dielectric constant, and a second layer that is adjacent to the first layer has a second dielectric constant. A defect includes a sample. The defect has a thickness that is approximately up to one-half of a wavelength of the target magnetic resonance frequency within the defect.

2. 发明申请

US20170029377A1 SITE-SPECIFIC DYNAMIC NUCLEAR POLARIZATION NMR AGENTS 审中-公开
标题翻译：现场特定动态核极化NMR试剂
公开(公告)号：US20170029377A1
公开(公告)日：2017-02-02
申请号：US15222428
申请日：2016-07-28
申请人： North Carolina State University
发明人： Alexej I. Smirnov , Maxim Anatolyevich Voynov
IPC分类号： C07D211/94 , G01N24/08
CPC分类号： C07D211/94 , G01N24/12 , G01R33/62
摘要： Dynamic nuclear polarization (DNP) agents are provided for DNP nuclear magnetic resonance of analytes. The DNP agents can have the structure A-X-L-R, where A is none or an amphiphilic group; X is a coupling group capable of site-specific binding with the analyte or, when A is an amphiphilic group, capable of site-specific binding with the amphiphilic group; L is a bond or a linker group; and R is a poly-radical group. The poly-radical can be a di-radical, a tri-radical, a tetra-radical, or a combination thereof. Methods of NMR measurement of an analyte comprising an NMR-detectable nucleus are provided. The methods can include the steps of providing a frozen sample containing the analyte and a DNP agent; applying radiation having a frequency that excites electron spin transitions in the DNP agent at an intensity to polarize the NMR-detectable nucleus; and detecting a signal from nuclear spin transitions in the NMR-detectable nucleus.
摘要翻译：为分析物的DNP核磁共振提供动态核极化（DNP）试剂。 DNP试剂可以具有结构A-X-L-R，其中A不是或两亲基团; X是能够与分析物进行位点特异性结合的偶联基团，或当A是两亲基团时，能够与两亲基团进行位点特异性结合; L是键或连接基; 并且R是多基团基团。多基团可以是二基团，三基团，四基团或其组合。提供了包含NMR可检测核的分析物的NMR测量方法。所述方法可以包括提供含有分析物和DNP试剂的冷冻样品的步骤; 施加具有在DNP试剂中激发电子自旋跃迁的频率的辐射，其强度使核磁共振可检测核极化; 并检测核可检测核中核自旋跃迁的信号。

3. 发明授权

US11119165B2 Photonic band-gap resonator for magnetic resonance applications 有权
公开(公告)号：US11119165B2
公开(公告)日：2021-09-14
申请号：US16626714
申请日：2018-06-27
申请人： North Carolina State University
发明人： Alexander Nevzorov , Alexej I. Smirnov , Sergey Milikisiyants
IPC分类号： G01R33/34 , G01R33/341 , G01R33/30
摘要： Aspects of photonic band gap resonators for magnetic resonance are described. In one example, an apparatus includes a 1D structure having a plurality of layers. A respective thickness of the individual layers is one-quarter of a respective wavelength of a target magnetic resonance frequency within the individual layers of the plurality of layers, or a multiple thereof. A first layer has a first dielectric constant, and a second layer that is adjacent to the first layer has a second dielectric constant. A defect includes a sample. The defect has a thickness that is approximately up to one-half of a wavelength of the target magnetic resonance frequency within the defect.

4. 发明授权

US10414729B2 Site-specific dynamic nuclear polarization NMR agents 有权
公开(公告)号：US10414729B2
公开(公告)日：2019-09-17
申请号：US15222428
申请日：2016-07-28
申请人： North Carolina State University
发明人： Alexej I. Smirnov , Maxim Anatolyevich Voynov
IPC分类号： C07D211/94 , C07D211/56 , G01N24/12 , G01R33/62
摘要： Dynamic nuclear polarization (DNP) agents are provided for DNP nuclear magnetic resonance of analytes. The DNP agents can have the structure A-X-L-R, where A is none or an amphiphilic group; X is a coupling group capable of site-specific binding with the analyte or, when A is an amphiphilic group, capable of site-specific binding with the amphiphilic group; L is a bond or a linker group; and R is a poly-radical group. The poly-radical can be a di-radical, a tri-radical, a tetra-radical, or a combination thereof. Methods of NMR measurement of an analyte comprising an NMR-detectable nucleus are provided. The methods can include the steps of providing a frozen sample containing the analyte and a DNP agent; applying radiation having a frequency that excites electron spin transitions in the DNP agent at an intensity to polarize the NMR-detectable nucleus; and detecting a signal from nuclear spin transitions in the NMR-detectable nucleus.

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