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1. 发明授权

US07371287B2 Substrate handling system 有权
标题翻译：基材处理系统
公开(公告)号：US07371287B2
公开(公告)日：2008-05-13
申请号：US10837842
申请日：2004-05-03
申请人： Norman L. Shaver , Timothy A. Ellis , David R. Hill
发明人： Norman L. Shaver , Timothy A. Ellis , David R. Hill
IPC分类号： C23C16/00 , C23F1/00 , H01L21/306
CPC分类号： B41C1/00 , B41C1/05 , B65H3/16 , B65H5/04 , B65H2301/44332 , B65H2406/11 , B65H2555/31 , B65H2701/1928 , Y10S414/141
摘要： A substrate handling system and method in which an air chuck produces a film of air between the substrate and the air chuck, a magnetic chuck attracts the substrate to the air chuck, and an actuator subsystem moves the magnetic chuck closer to and away from the air chuck to alternately pick up a substrate and release the substrate.
摘要翻译：一种基板处理系统和方法，其中空气卡盘在基板和空气卡盘之间产生空气膜，磁卡盘将基板吸引到空气卡盘，并且致动器子系统使磁卡盘更靠近和远离空气卡盘以交替地拾起基板并释放基板。

2. 发明授权

US08281853B1 Tool for use in well monitoring 有权
标题翻译：用于井监测的工具
公开(公告)号：US08281853B1
公开(公告)日：2012-10-09
申请号：US12317776
申请日：2008-12-29
申请人： David R. Hill , Sanford A. Burris
发明人： David R. Hill , Sanford A. Burris
IPC分类号： E21B47/04
CPC分类号： E21B43/121 , E21B47/042
摘要： A tool for use in well monitoring is described to insert devices for well fluid level control into a wellhead. The tool also permits removal of the devices for well fluid level control from an operating well for servicing. The tool also permits precise positioning of the components utilized to take measurements in the well annulus.
摘要翻译：描述了用于井监测的工具，用于将井液位控制装置插入井口。该工具还允许从用于维修的操作井中移除用于井液位控制的装置。该工具还允许用于在井环中进行测量的组件的精确定位。

3. 发明授权

US06437106B1 Process for preparing 6-o-substituted erythromycin derivatives 有权
标题翻译：制备6-O-取代的红霉素衍生物的方法
公开(公告)号：US06437106B1
公开(公告)日：2002-08-20
申请号：US09518281
申请日：2000-03-03
申请人： Eric J. Stoner , Matthew J. Peterson , Yi-Yin Ku , Russell D. Cink , Arthur J. Cooper , Mahendra N. Deshpande , Tim Grieme , Anthony R. Haight , David R. Hill , Margaret Chi-Ping Hsu , Steven A. King , Marvin Robert Leanna , Elaine C. Lee , Maureen A. McLaughlin , Howard E. Morton , James J. Napier , Daniel J. Plata , Prasad S. Raje , Michael Rasmussen , David Riley , Jien-Heh J. Tien , Steven J. Wittenberger
发明人： Eric J. Stoner , Matthew J. Peterson , Yi-Yin Ku , Russell D. Cink , Arthur J. Cooper , Mahendra N. Deshpande , Tim Grieme , Anthony R. Haight , David R. Hill , Margaret Chi-Ping Hsu , Steven A. King , Marvin Robert Leanna , Elaine C. Lee , Maureen A. McLaughlin , Howard E. Morton , James J. Napier , Daniel J. Plata , Prasad S. Raje , Michael Rasmussen , David Riley , Jien-Heh J. Tien , Steven J. Wittenberger
IPC分类号： C07H100
CPC分类号： C07H17/08
摘要： In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2′-substituted and optionally 4″-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
摘要翻译：一方面，本发明涉及一种制备6-O-取代的红霉素衍生物的方法，其包括在钯催化剂和膦的存在下使2'-取代的和任选的4'-取代的9-肟红霉素衍生物与烷基化剂反应。另一方面，本发明涉及使用钯催化的烷基化反应制备6-O-取代的红霉素酮内酯的方法。

4. 发明申请

US20120325456A1 Tool for Use in Well Monitoring 有权
标题翻译：用于井监测的工具
公开(公告)号：US20120325456A1
公开(公告)日：2012-12-27
申请号：US13604216
申请日：2012-09-05
申请人： David R. Hill
发明人： David R. Hill
IPC分类号： E21B43/12
CPC分类号： E21B43/127 , E21B43/121 , E21B47/0007 , E21B47/042
摘要： A system for matching the hydrocarbon reservoir inflow with the outflow of an artificial lift system utilizes an apparatus which makes real time fluid level determinations and inputs the observed fluid levels into a processor which controls the speed of a motor which operates a subsurface pump, so as to increase hydrocarbon production. The apparatus which makes real time fluid determinations is installed such that a gas emission port and a pressure wave receiving port are placed within the tubing-casing annulus.
摘要翻译：用于将烃储存器流入与人造举升系统的流出相匹配的系统利用了实现液位确定的装置，并将观察到的流体水平输入到控制操作地下泵的马达的速度的处理器中，以便增加碳氢化合物产量。实现实时流体测定的装置被安装成使得气体排出口和压力波接收端口被放置在管壳环形空间内。

5. 发明申请

US20090318689A1 Processes To Make Apoptosis Promoters 有权
标题翻译：制备细胞凋亡启动子的过程
公开(公告)号：US20090318689A1
公开(公告)日：2009-12-24
申请号：US12486361
申请日：2009-06-17
申请人： Thaddeus Stephan Franczyk, II , David R. Hill , Anthony Ralph Haight , Maureen Ann McLaughlin , Shashank Shekhar , Su Yu , Jianzhang Mei , Lei Wang
发明人： Thaddeus Stephan Franczyk, II , David R. Hill , Anthony Ralph Haight , Maureen Ann McLaughlin , Shashank Shekhar , Su Yu , Jianzhang Mei , Lei Wang
IPC分类号： C07D413/12
CPC分类号： C07D295/155 , C07D295/13 , Y02P20/55
摘要： Processes to make compounds, including N-acylsulfonamide apoptosis promoters are disclosed.
摘要翻译：公开了制备化合物，包括N-酰基磺酰胺凋亡启动子的方法。

6. 发明授权

US06315450B1 Diaphragm preload air bearing 失效
标题翻译：隔膜预紧空气轴承
公开(公告)号：US06315450B1
公开(公告)日：2001-11-13
申请号：US09241833
申请日：1999-02-01
申请人： Philip J. Hipol , David R. Hill
发明人： Philip J. Hipol , David R. Hill
IPC分类号： F16C2708
CPC分类号： F16C29/002 , F16C29/025 , F16C32/0666 , F16C32/067
摘要： A preload hydrostatic bearing includes a pad, a diaphragm and an adjustable member. The pad has a bearing structure, an inlet manifold, and a plurality of orifices. The orifices direct a fluid, such as air, from the inlet manifold toward the bearing surface. The diaphragm is mounted on the pad, and the adjustable member, which extends in an axial direction, is coupled proximate one end to a center portion of the diaphragm. The diaphragm transfers a preload in the axial direction to the adjustable member. This preload hydrostatic bearing has a high repeatability of performance, because a single diaphragm replaces prior art mechanical coupling devices, such as ball bearings, conical seats and spring washers, which undesirably are sources of friction and hysteresis.
摘要翻译：预压静液压轴承包括垫，隔膜和可调节构件。垫具有轴承结构，入口歧管和多个孔。孔口将诸如空气的流体从入口歧管引向支承表面。隔膜安装在垫上，并且沿轴向方向延伸的可调构件在一端靠近隔膜的中心部分。隔膜将轴向的预载荷传递到可调节构件。这种预压静液压轴承具有高性能的重复性，因为单个隔膜取代了现有技术的机械联接装置，例如球轴承，锥形座和弹簧垫圈，这不利地是摩擦和滞后的来源。

7. 发明授权

US08168784B2 Processes to make apoptosis promoters 有权
标题翻译：制备凋亡启动子的方法
公开(公告)号：US08168784B2
公开(公告)日：2012-05-01
申请号：US12486361
申请日：2009-06-17
申请人： Thaddeus Stephan Franczyk, II , David R. Hill , Anthony Ralph Haight , Maureen Ann McLaughlin , Shashank Shekhar , Su Yu , Jianzhang Mei , Lei Wang
发明人： Thaddeus Stephan Franczyk, II , David R. Hill , Anthony Ralph Haight , Maureen Ann McLaughlin , Shashank Shekhar , Su Yu , Jianzhang Mei , Lei Wang
IPC分类号： C07D413/12 , C07C47/42 , C07C49/403
CPC分类号： C07D295/155 , C07D295/13 , Y02P20/55
摘要： Processes to make compounds, including N-acylsulfonamide apoptosis promoters are disclosed.
摘要翻译：公开了制备化合物，包括N-酰基磺酰胺凋亡启动子的方法。

8. 发明授权

US5760216A Use of synthetic metalloporphyrins for preparation and prediction of drug metabolites 失效
标题翻译：使用合成金属卟啉来制备和预测药物代谢物
公开(公告)号：US5760216A
公开(公告)日：1998-06-02
申请号：US520842
申请日：1995-09-12
申请人： Mukund S. Chorghade , David H. Dolphin , David R. Hill , Fumio Hino , Elaine C. Lee
发明人： Mukund S. Chorghade , David H. Dolphin , David R. Hill , Fumio Hino , Elaine C. Lee
IPC分类号： G01N33/15 , B01J31/18 , C07B33/00 , C07D231/44 , C07D233/36 , C07D405/04 , C07D413/04 , C07D487/22 , C07B47/00 , C07C29/48 , C07D301/03
CPC分类号： B01J31/1815 , C07B33/00 , C07D231/44 , C07D233/36 , C07D405/04 , C07D413/04 , B01J2531/025 , B01J2531/16 , B01J2531/62 , B01J2531/72 , B01J2531/821 , B01J2531/842 , B01J2531/845 , B01J2531/847
摘要： A method for the systematic and efficient synthetic preparation and identification of metabolites of a pharmaceutical product in order to study possible toxic and/or otherwise biologically-active metabolites of such pharmaceutical products as early and conveniently as possible in the very expensive drug development process, comprising adding samples of the pharmaceutical product to a series of combinations of a synthetic metalloporphyrin (SMP) with a synthetic metalloporphyrin-co-oxidizing reagent in the presence of a suitable solvent, under specified conditions, in a manner such that each sample of pharmaceutical product is reacted with a different combination of synthetic metalloporphyrin, SMP-co-oxidizing reagent and solvent, followed by separation and isolation of the resulting oxidative products, then confirmation of the identity of metabolites from the pre-identified oxidative products by appropriate animal model studies, and subjecting the actual metabolites prepared in larger quantities by the above method to toxicologic, pathologic, histopathologic, mechanistic or genotoxic testing in order to identify toxic and/or otherwise metabolically-active beneficial or detrimental individual metabolites.
摘要翻译：一种用于系统和有效地合成制备和鉴定药物产品的代谢物的方法，以便在非常昂贵的药物开发过程中尽可能早地和方便地研究此类药物产品的有毒和/或其他生物活性代谢物，包括在合适的溶剂存在下，在规定的条件下，将药物产品的样品加入合成金属卟啉（SMP）与合成金属卟啉 - 辅助氧化剂的一系列组合，使得药物产品的每个样品为与合成金属卟啉，SMP-辅助氧化试剂和溶剂的不同组合反应，然后分离和分离所得的氧化产物，然后通过适当的动物模型研究从预先鉴定的氧化产物中鉴定代谢物的身份，以及对在较大的q中制备的实际代谢物进行处理通过上述方法对药物，病理，组织病理学，机械学或遗传毒性试验进行检测，以鉴别有毒和/或其他代谢活性的有益或有害的个体代谢物。

9. 发明授权

US4747451A Level sensor 失效
标题翻译：液位传感器
公开(公告)号：US4747451A
公开(公告)日：1988-05-31
申请号：US82840
申请日：1987-08-06
申请人： Harold P. Adams, Jr. , David R. Hill , Lee M. Richey , Andrew B. Maitland , William E. Banton , David C. Taylor
发明人： Harold P. Adams, Jr. , David R. Hill , Lee M. Richey , Andrew B. Maitland , William E. Banton , David C. Taylor
IPC分类号： E21B47/00 , E21B47/04 , E21B43/00 , F04B49/06
CPC分类号： E21B47/0008 , E21B47/042
摘要： A system for controlling production in an oil well comprises a first level sensor mounted upon the outer surface of the tubing near the lower end of the tubing and a second level sensor mounted upon the outer surface of the tubing above the first level sensor. The first level sensor is tuned to a first electrical signal frequency. The second level sensor is tuned to a second electrical signal frequency. A control device at spaced intervals transmits electrical signals of the first and second frequencies down the oil well and senses the liquid level by detecting impedance.
摘要翻译：用于控制油井中的生产的系统包括安装在靠近管道下端的管道的外表面上的第一级传感器和安装在第一级传感器上方的管道的外表面上的第二级传感器。第一级传感器被调谐到第一电信号频率。第二级传感器被调谐到第二电信号频率。以间隔间隔的控制装置将第一和第二频率的电信号传送到油井，并通过检测阻抗来感测液位。

10. 发明授权

US06441189B1 Process for the preparation of matrix metalloproteinase inhibitors 失效
标题翻译：制备基质金属蛋白酶抑制剂的方法
公开(公告)号：US06441189B1
公开(公告)日：2002-08-27
申请号：US10020326
申请日：2001-12-13
申请人： Anne E. Bailey , David R. Hill , Chi-nung W. Hsiao , Ravi Kurukulasuriya , Steve Wittenberger , Todd McDermott , Maureen A. McLaughlin
发明人： Anne E. Bailey , David R. Hill , Chi-nung W. Hsiao , Ravi Kurukulasuriya , Steve Wittenberger , Todd McDermott , Maureen A. McLaughlin
IPC分类号： C07D26306
CPC分类号： C07C239/20 , C07C213/00 , C07C217/34 , C07D205/08 , C07D233/38 , C07D233/78 , C07D263/24
摘要： The instant invention provides a process for the synthesis of matrix metalloproteinase inhibitors.
摘要翻译：本发明提供了合成基质金属蛋白酶抑制剂的方法。

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