专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050176783A1 Substituted aromatic-ring compounds, process for producing the same and use 有权
公开(公告)号：US20050176783A1
公开(公告)日：2005-08-11
申请号：US11094210
申请日：2005-03-31
申请人： Norikazu Tamura , Takashi Ichikawa , Masayuki Il
发明人： Norikazu Tamura , Takashi Ichikawa , Masayuki Il
IPC分类号： C07C317/44 , C07D309/28 , C07D211/70 , A61K31/192 , A61K31/455
CPC分类号： C07C317/44 , C07C2601/10
摘要： A compound of the formula: wherein R1 is an aliphatic hydrocarbon group optionally having substituent(s), an aromatic hydrocarbon group optionally having substituent(s), a heterocyclic group optionally having substituent(s), a group of the formula: OR1a wherein R1a is a hydrogen atom or an aliphatic hydrocarbon group optionally having substituent(s), or a group of the formula: wherein R1b and R1c are the same or different and each is a hydrogen atom or an aliphatic hydrocarbon group optionally having substituent(s), X is a methylene group, a nitrogen atom, a sulfur atom or an oxygen atom, Y is an optionally substituted methylene group or an optionally substituted nitrogen atom, ring A is a 5 to 8-membered ring optionally substituted further by 1 to 4 substituent(s) selected from (1) an aliphatic hydrocarbon group optionally having substituent(s), (2) an aromatic hydrocarbon group optionally having substituent(s), (3) a group of the formula: OR2 wherein R2 is a hydrogen atom, or an aliphatic hydrocarbon group optionally having substituent(s) and (4) a halogen atom, Ar is an aromatic hydrocarbon group optionally having substituent(s), a group of the formula: is a group of the formula: or the formula: m is an integer of 0 to 2, n is an integer of 1 to 3, and the sum of m and n is not more than 4, provided that when X is a methylene group, Y is an optionally substituted methylene group, and a salt thereof have an inhibitory activity on nitric oxide (NO) production and cytokine production, and are useful as an agent for the prophylaxis and/or treatment of diseases, such as cardiac disease, autoimmune disease, inflammatory disease, central nervous system disease, infectious disease, sepsis, septic shock and the like.

IPRDB

热门服务

关于我们

友情链接

联系方式