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1. 发明授权

US09012166B2 Method for assaying histone methylation enzyme activity 有权
标题翻译：测定组蛋白甲基化酶活性的方法
公开(公告)号：US09012166B2
公开(公告)日：2015-04-21
申请号：US13639334
申请日：2011-04-15
申请人： Norikazu Nishino , Yasushi Takemoto , Akihiro Ito , Minoru Yoshida
发明人： Norikazu Nishino , Yasushi Takemoto , Akihiro Ito , Minoru Yoshida
IPC分类号： G01N21/78 , C12Q1/37 , C12Q1/48 , G01N33/68 , C07D311/18 , C07D311/82 , C07D473/32
CPC分类号： C12Q1/37 , C07D311/18 , C07D311/82 , C07D473/32 , C12Q1/48 , G01N33/6875 , G01N2500/00 , Y02P20/55
摘要： Provided are a method for measuring histone methyltransferase activity, a method for screening for compounds that inhibit histone methyltransferase activity, a reagent kit for measuring histone methyltransferase activity, and a kit for screening for compounds that inhibit histone methyltransferase activity. A substrate compound represented by general formula (I): R1-X-K-R2 (I), or a salt thereof, wherein R1 represents a hydrogen atom or a protecting group for an amino terminus; X represents a peptide consisting of 0 or 1 or more amino acid residues; K represents a lysine residue; and R2 represents a dye label linked via an amide bond to the carbonyl terminus of a lysine residue, wherein the cleavage of the amide bond by peptidase changes the fluorescence property or chromogenic property of the dye label, and the methylation of the ε amino group of the lysine residue by the histone methyltransferase decreases susceptibility to peptidase, is used.
摘要翻译：提供了测定组蛋白甲基转移酶活性的方法，用于筛选抑制组蛋白甲基转移酶活性的化合物的方法，用于测定组蛋白甲基转移酶活性的试剂盒和用于筛选抑制组蛋白甲基转移酶活性的化合物的试剂盒。由通式（I）表示的底物化合物：R1-X-K-R2（I）或其盐，其中R1表示氢原子或氨基末端的保护基; X表示由0或1个或更多个氨基酸残基组成的肽; K表示赖氨酸残基; R2表示通过酰胺键与赖氨酸残基的羰基末端连接的染料标记，其中通过肽酶切割酰胺键改变染料标记的荧光性质或显色性质，以及染料标记的甲基化。使用组蛋白甲基转移酶的赖氨酸残基的氨基降低对肽酶的易感性。

2. 发明申请

US20130029878A1 Method for Assaying Histone Methylation Enzyme Activity 有权
标题翻译：分析组蛋白甲基化酶活性的方法
公开(公告)号：US20130029878A1
公开(公告)日：2013-01-31
申请号：US13639334
申请日：2011-04-15
申请人： Norikazu Nishino , Yasushi Takemoto , Akihiro Ito , Minoru Yoshida
发明人： Norikazu Nishino , Yasushi Takemoto , Akihiro Ito , Minoru Yoshida
IPC分类号： G01N21/64 , C40B30/08 , C07K2/00 , G01N21/78
CPC分类号： C12Q1/37 , C07D311/18 , C07D311/82 , C07D473/32 , C12Q1/48 , G01N33/6875 , G01N2500/00 , Y02P20/55
摘要： Provided are a method for measuring histone methyltransferase activity, a method for screening for compounds that inhibit histone methyltransferase activity, a reagent kit for measuring histone methyltransferase activity, and a kit for screening for compounds that inhibit histone methyltransferase activity. A substrate compound represented by general formula (I): R1—X—K—R2 (I), or a salt thereof, wherein R1 represents a hydrogen atom or a protecting group for an amino terminus; X represents a peptide consisting of 0 or 1 or more amino acid residues; K represents a lysine residue; and R2 represents a dye label linked via an amide bond to the carbonyl terminus of a lysine residue, wherein the cleavage of the amide bond by peptidase changes the fluorescence property or chromogenic property of the dye label, and the methylation of the ε amino group of the lysine residue by the histone methyltransferase decreases susceptibility to peptidase, is used.
摘要翻译：提供了测定组蛋白甲基转移酶活性的方法，用于筛选抑制组蛋白甲基转移酶活性的化合物的方法，用于测定组蛋白甲基转移酶活性的试剂盒和用于筛选抑制组蛋白甲基转移酶活性的化合物的试剂盒。由通式（I）表示的底物化合物：R1-X-K-R2（I）或其盐，其中R1表示氢原子或氨基末端的保护基; X表示由0或1个或更多个氨基酸残基组成的肽; K表示赖氨酸残基; R2表示通过酰胺键与赖氨酸残基的羰基末端连接的染料标记，其中通过肽酶切割酰胺键改变染料标记的荧光性质或显色性质，以及染料标记的甲基化。使用组蛋白甲基转移酶的赖氨酸残基的氨基降低对肽酶的易感性。

3. 发明授权

US09899952B2 Electric power steering control device 有权
公开(公告)号：US09899952B2
公开(公告)日：2018-02-20
申请号：US13980407
申请日：2011-04-21
申请人： Yasushi Takemoto , Kazushi Kimura
发明人： Yasushi Takemoto , Kazushi Kimura
IPC分类号： H02P29/60 , H02P29/68 , H02P29/00 , B62D5/04
CPC分类号： H02P29/68 , B62D5/0496 , H02P29/60
摘要： A electric power steering control device equipped with a motor having a resolver detection unit includes: an ambient temperature detector for detecting ambient temperature around a portion generating heat by current flow; a motor temperature detector for, based on a signal from the resolver detection unit of the motor, estimating the temperature of the portion generating heat; and an abnormality determiner for comparing the temperature detected by the ambient temperature detector with the temperature detected by the motor temperature detector and determining that the ambient temperature detector is abnormal.

4. 发明授权

US08010278B2 Control apparatus for internal combustion engine 有权
标题翻译：内燃机控制装置
公开(公告)号：US08010278B2
公开(公告)日：2011-08-30
申请号：US12437958
申请日：2009-05-08
申请人： Shinji Kunisada , Yasushi Takemoto
发明人： Shinji Kunisada , Yasushi Takemoto
IPC分类号： F02D41/00 , B60T7/12
CPC分类号： F02D41/0025 , F02D19/0623 , F02D19/084 , F02D19/088 , F02D41/1488 , F02D41/1498 , F02D2200/0612 , Y02T10/36
摘要： An engine is operated with air-fuel ratio F/B control interrupted, by regarding an alcohol concentration value ALC1 inputted from outside as a tentative concentration value, and by detecting the rotation-speed fluctuation amount of an engine, the appropriateness of the tentative concentration value is determined. In the case where it is determined that the tentative concentration value is appropriate, an estimated alcohol concentration value ALC2 stored in a storage means is replaced by the tentatively changed alcohol concentration value ALC1.
摘要翻译：通过关于从外部输入的酒精浓度值ALC1作为暂定浓度值，通过检测发动机的转速波动量来检测发动机的空燃比F / B控制中断的发动机，暂定浓度的适当性值被确定。在确定临时浓度值适当的情况下，存储在存储装置中的估计的醇浓度值ALC2被暂时改变的醇浓度值ALC1代替。

5. 发明申请

US20130285587A1 ELECTRIC POWER STEERING CONTROL DEVICE 有权
标题翻译：电动转向控制装置
公开(公告)号：US20130285587A1
公开(公告)日：2013-10-31
申请号：US13980407
申请日：2011-04-21
申请人： Yasushi Takemoto , Kazushi Kimura
发明人： Yasushi Takemoto , Kazushi Kimura
IPC分类号： H02P29/00
CPC分类号： H02P29/68 , B62D5/0496 , H02P29/60
摘要： A electric power steering control device equipped with a motor having a resolver detection unit comprises: an ambient temperature detecting means (33) for detecting ambient temperature around a portion generating heat by current flow; a motor temperature detecting means (32) for, based on a signal from the resolver detection unit (13) of the motor (4), estimating the temperature of the portion generating heat; and an abnormality determining means (34) for comparing the temperature detected by the ambient temperature detecting means with the temperature detected by the motor temperature detecting means and determining that the ambient temperature detecting means is abnormal.
摘要翻译：一种配备有具有旋转变压器检测单元的电动机的电动助力转向控制装置，包括：环境温度检测装置，用于检测通过电流产生热的部分周围的环境温度; 电动机温度检测装置，用于基于来自电动机（4）的旋转变压器检测单元（13）的信号，估计产生热量的部分的温度; 以及用于将由环境温度检测装置检测的温度与由电动机温度检测装置检测的温度进行比较并确定环境温度检测装置异常的异常确定装置（34）。

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