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1. 发明授权

US06504523B1 Active matrix LCD device 有权
标题翻译：有源矩阵液晶显示装置
公开(公告)号：US06504523B1
公开(公告)日：2003-01-07
申请号：US09723492
申请日：2000-11-28
申请人： Noriaki Sugawara , Kimikazu Matsumoto , Kunimasa Itakura , Tatsuya Shiki , Toshikazu Shimizu , Shoichi Kuroha , Shinichi Nishida
发明人： Noriaki Sugawara , Kimikazu Matsumoto , Kunimasa Itakura , Tatsuya Shiki , Toshikazu Shimizu , Shoichi Kuroha , Shinichi Nishida
IPC分类号： G09G336
CPC分类号： G02F1/134363 , G02F1/133514 , G09G3/3614 , G09G3/3648 , G09G2300/0434 , G09G2320/0247 , G09G2330/021
摘要： An active-matrix LCD device drives the LCD panel by using a dot reversible driving technique. The switching between two sets of input signals or two resolution modes is conducted by applying a DC voltage between the pixel electrode and the common electrode in each pixel before restart of the image display of a switched signal. The DC voltage has the same polarity among the pixels in the pixel array to thereby reduce the flicker after the restart of the image display.
摘要翻译：有源矩阵LCD设备通过使用点可逆驱动技术来驱动LCD面板。在重新开始切换信号的图像显示之前，通过在像素电极和公共电极之间施加直流电压来进行两组输入信号或两种分辨率模式之间的切换。 DC电压在像素阵列中的像素之间具有相同的极性，从而在图像显示重新开始之后减少闪烁。

2. 发明申请

US20080227815A1 Crystal of Indole Derivative Having Piperidine Ring and Process for Production Thereof 审中-公开
标题翻译：具有哌啶环的吲哚衍生物的晶体及其制备方法
公开(公告)号：US20080227815A1
公开(公告)日：2008-09-18
申请号：US11913931
申请日：2006-05-11
申请人： Takahisa Sakaguchi , Yuichi Suzuki , Koichi Ito , Jun Niijima , Mamoru Miyazawa , Toshikazu Shimizu , Masaharu Gotoda , Naoko Suzuki , Takashi Hasebe
发明人： Takahisa Sakaguchi , Yuichi Suzuki , Koichi Ito , Jun Niijima , Mamoru Miyazawa , Toshikazu Shimizu , Masaharu Gotoda , Naoko Suzuki , Takashi Hasebe
IPC分类号： A61K31/454 , C07D405/14 , A61P25/18 , A61P25/30
CPC分类号： C07D405/14
摘要： A crystal of 1-[1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)-ethyl]piperidin-4-yl]-N-methyl-1H-indole-6-carboxamide fumarate which has peaks at chemical shifts of about 124.0 ppm and about 26.8 ppm in a 13C solid NMR spectrum.
摘要翻译： 1- [1- [2-（7-甲氧基-2,2-二甲基-4-氧代色满-8-基） - 乙基]哌啶-4-基] -N-甲基-1H-吲哚-6- 富马酸甲酰胺，在13 C固体NMR光谱中具有约124.0ppm和约26.8ppm的化学位移的峰。

3. 发明授权

US5565883A Active matrix liquid crystal display unit capable of suppressing flicker and cross talk 失效
标题翻译：有源矩阵液晶显示单元能够抑制闪烁和串扰
公开(公告)号：US5565883A
公开(公告)日：1996-10-15
申请号：US266111
申请日：1994-06-27
申请人： Toshikazu Shimizu
发明人： Toshikazu Shimizu
IPC分类号： G02F1/133 , G02F1/136 , G02F1/1368 , G09G3/20 , G09G3/36
CPC分类号： G09G3/3648 , G09G2320/0209 , G09G2320/0247 , G09G3/2011 , G09G3/2018 , G09G3/3614
摘要： In an active matrix liquid crystal display unit for displaying data on a liquid crystal panel in response to a control signal, a drain driver is supplied with the control signal to supply a first alternating voltage signal of a predetermined phase to odd-numbered drain buses for drain electrodes of thin-film transistors arranged in a matrix of the panel and to supply even-numbered drain buses with a second alternating voltage signal having a reversed phase which is reversed relative to the predetermined phase. A gate driver supplies the gate buses with electric power cyclically in cycles. Preferably, the first and the second alternating voltage signals have a common period which is equal to a time interval during which the electric power is supplied successively to two adjacent ones of the gate buses. This avoids flicker and cross talk in a display of the data. More preferably, the first and the second alternating voltage signals are given either in each cycle or in a preselected plurality of cycles one of a predetermined number of voltages to cope with a greater number of steps of a tone of the display.
摘要翻译：在用于响应于控制信号在液晶面板上显示数据的有源矩阵液晶显示单元中，为漏极驱动器提供控制信号，以将预定相位的第一交流电压信号提供给奇数编号的漏极总线以面板的矩阵形式布置的薄膜晶体管的漏电极，并且为具有反相的第二交流电压信号提供偶数的漏极总线，所述第二交流电压信号相对于预定相位反相。栅极驱动器以周期性循环供电电源。优选地，第一和第二交流电压信号具有等于将电力连续提供给两个相邻栅极总线的时间间隔的公共周期。这避免了数据显示中的闪烁和串扰。更优选地，第一和第二交流电压信号在每个周期中以预定的多个周期中的一个预定数量的电压中给出，以应对显示器的色调的更多数量的步骤。

4. 发明授权

US06676468B2 Method of producing a spark plug 有权
标题翻译：火花塞的制造方法
公开(公告)号：US06676468B2
公开(公告)日：2004-01-13
申请号：US09985356
申请日：2001-11-02
申请人： Hiroya Ishiguro , Kozo Takamura , Toshikazu Shimizu
发明人： Hiroya Ishiguro , Kozo Takamura , Toshikazu Shimizu
IPC分类号： H01T2102
CPC分类号： H01T21/02
摘要： In producing a spark plug including a central electrode having a first chip including noble metal and an earth electrode having a second chip including the noble metal, a spark gap being disposed between the first and second chips, a chip including the noble metal. The chip is welded to an end of the central electrode and to an end of the earth electrode. The welded chip is cut to form the first and second chips and the spark gap.
摘要翻译：在制造包括具有包括贵金属的第一芯片的中心电极和具有包括贵金属的第二芯片的接地电极的火花塞时，设置在第一和第二芯片之间的火花隙，包括贵金属的芯片。该芯片焊接到中心电极的一端和接地电极的端部。焊接的芯片被切割以形成第一和第二芯片和火花隙。

5. 发明授权

US5849912A Biphenyl derivatives 失效
标题翻译：联苯衍生物
公开(公告)号：US5849912A
公开(公告)日：1998-12-15
申请号：US855790
申请日：1997-05-12
申请人： Kozo Akasaka , Masahiro Yonaga , Akiharu Kajiwara , Kunizo Higurashi , Kohshi Ueno , Satoshi Nagato , Makoto Komatsu , Noritaka Kitazawa , Masataka Ueno , Yoshiharu Yamanishi , Yoshimasa Machida , Yuki Komatsu , Naoyuki Shimomura , Norio Minami , Toshikazu Shimizu , Atsushi Nagaoka
发明人： Kozo Akasaka , Masahiro Yonaga , Akiharu Kajiwara , Kunizo Higurashi , Kohshi Ueno , Satoshi Nagato , Makoto Komatsu , Noritaka Kitazawa , Masataka Ueno , Yoshiharu Yamanishi , Yoshimasa Machida , Yuki Komatsu , Naoyuki Shimomura , Norio Minami , Toshikazu Shimizu , Atsushi Nagaoka
IPC分类号： C07D295/03 , A61K31/495 , A61P25/18 , C07D213/26 , C07D213/30 , C07D213/38 , C07D213/50 , C07D213/70 , C07D295/02 , C07D295/04 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D295/205 , C07D295/26 , C07D307/14 , C07D307/52 , C07D319/06 , C07D339/08 , C07F7/18 , C07D401/06
CPC分类号： C07D213/30 , C07D213/26 , C07D213/38 , C07D213/50 , C07D213/70 , C07D295/02 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D295/205 , C07D295/26 , C07D307/14 , C07D307/52 , C07D319/06 , C07D339/08 , C07F7/1856 , C07C2101/02
摘要： A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are defined in the specification, is clinically useful for treating and ameliorating mental disorders such as cerebrovascular disorder, aggressive behavior due to senile dementia, mental excitation, poriomania, delirium, hallucination, hyperkinesia, schizophrenia, emotional disturbance, depression, neurosis, psychophysiologic disorder and anxiety neurosis. The compounds exhibit dopamine 2 receptor antagonism and/or serotonin 2 receptor antagonism.
摘要翻译：由下式（I）表示的联苯衍生物或其药学上可接受的盐：其中R 1，R 2，R 3，R 4和R 5在本说明书中定义，其在临床上可用于治疗和改善精神障碍脑血管障碍，老年性痴呆，精神激动，心脏虚弱，del妄，幻觉，运动过度，精神分裂症，情绪障碍，抑郁，神经症，心理生理障碍和焦虑神经症引起的侵略行为。该化合物表现出多巴胺2受体拮抗作用和/或5-羟色胺2受体拮抗作用。

6. 发明授权

US5583229A Process for the preparation of imidazopyridine derivatives 失效
标题翻译：咪唑并吡啶衍生物的制备方法
公开(公告)号：US5583229A
公开(公告)日：1996-12-10
申请号：US256869
申请日：1994-08-05
申请人： Yoshio Urawa , Ken Furukawa , Toshikazu Shimizu , Yoji Yamagishi , Tomio Tsurugi , Tomio Ichino
发明人： Yoshio Urawa , Ken Furukawa , Toshikazu Shimizu , Yoji Yamagishi , Tomio Tsurugi , Tomio Ichino
IPC分类号： C07C63/72 , C07C65/105 , C07C69/732 , C07C69/76 , C07D213/73 , C07D213/75 , C07D263/10 , C07D263/12 , C07D263/14 , C07D309/12 , C07D413/12 , C07D471/04
CPC分类号： C07D213/73 , C07C63/72 , C07C65/105 , C07C69/732 , C07C69/76 , C07D213/75 , C07D263/10 , C07D263/12 , C07D263/14 , C07D309/12 , C07D413/12 , C07D471/04 , Y02P20/55
摘要： The present invention provides an industrially advantageous process for preparing a 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo[4,5-b]pyridine derivative represented by the following formula (II) which is a precursor of an antagonist against an angiotensin II receptor useful as an antihypertensive drug, a biphenyl derivative which is a precursor of the substituent of the pyridine derivative, a process for the preparation thereof, and an intermediate useful for the preparation of the biphenyl derivative: ##STR1##
摘要翻译： PCT No.PCT / JP93 / 01776 Sec。 371日期：1994年8月5日 102（e）日期1994年8月5日PCT 1993年12月7日PCT公布。公开号WO94 / 13666 日期：1994年6月23日本发明提供了制备由下式（II）表示的2-烷基-3-（联苯-4-基）甲基-3H-咪唑并[4,5-b]吡啶衍生物的工业上有利的方法），其是用作抗高血压药物的血管紧张素II受体的拮抗剂的前体，作为吡啶衍生物的取代基的前体的联苯衍生物，其制备方法和可用于制备联苯衍生物：（II）

7. 发明授权

US08704435B2 Spark plug of internal combustion engine having an earth electrode having an exposed side surface on a projecting part 有权
标题翻译：具有在突出部分上具有暴露侧表面的接地电极的内燃机的火花塞
公开(公告)号：US08704435B2
公开(公告)日：2014-04-22
申请号：US13540701
申请日：2012-07-03
申请人： Satoru Kadowaki , Toshikazu Shimizu
发明人： Satoru Kadowaki , Toshikazu Shimizu
IPC分类号： H01T13/32 , H01T13/39
CPC分类号： H01T13/39 , H01T13/32
摘要： A spark plug has a cylindrical housing case, a cylindrical glass insulator, a center electrode, and an earth electrode fixed to the cylindrical housing case. The earth electrode has a projected part which is projected toward the center electrode. The projected part has a facing surface which faces the center electrode and is most close to the center electrode in a spark discharge gap. This gap is formed between the center electrode and the earth electrode. The facing surface is covered with a plating layer. A base material, with which the earth electrode is made, is exposed on a side surface of the projected part around the facing surface of the projected part. The base material of the earth electrode is made of Ni alloy containing not less than 90 wt % Ni, and preferably, Ni within a range of 90 wt % to 98 wt %.
摘要翻译：火花塞具有圆柱形壳体，圆柱形玻璃绝缘体，中心电极和固定到圆柱形壳体的接地电极。接地电极具有向中心电极突出的突出部分。投影部分具有面对中心电极并且在火花放电间隙中最接近中心电极的面对表面。该间隙形成在中心电极和接地电极之间。面对表面被镀层覆盖。制造接地电极的基材在突出部分的相对表面周围的侧面上露出。接地电极的基材由含有不小于90重量％Ni，优选Ni在90重量％至98重量％的范围内的Ni合金制成。

8. 发明授权

US06281214B1 Biphenyl derivatives 失效
标题翻译：联苯衍生物
公开(公告)号：US06281214B1
公开(公告)日：2001-08-28
申请号：US09166229
申请日：1998-10-05
申请人： Kozo Akasaka , Masahiro Yonaga , Akiharu Kajiwara , Kunizo Higurashi , Kohshi Ueno , Satoshi Nagato , Makoto Komatsu , Noritaka Kitazawa , Masataka Ueno , Yoshiharu Yamanishi , Yoshimasa Machida , Yuki Komatsu , Naoyuki Shimomura , Norio Minami , Toshikazu Shimizu , Atsushi Nagaoka
发明人： Kozo Akasaka , Masahiro Yonaga , Akiharu Kajiwara , Kunizo Higurashi , Kohshi Ueno , Satoshi Nagato , Makoto Komatsu , Noritaka Kitazawa , Masataka Ueno , Yoshiharu Yamanishi , Yoshimasa Machida , Yuki Komatsu , Naoyuki Shimomura , Norio Minami , Toshikazu Shimizu , Atsushi Nagaoka
IPC分类号： A61K31495
CPC分类号： C07D213/30 , C07C2601/02 , C07D213/26 , C07D213/38 , C07D213/50 , C07D213/70 , C07D295/02 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D295/205 , C07D295/26 , C07D307/14 , C07D307/52 , C07D319/06 , C07D339/08 , C07F7/1804
摘要： A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof: wherein R1, R2, R3, R4, and R5 are defined in the specification, is clinically useful for treating and ameliorating mental disorders such as cerebrovascular disorder, aggressive behavior due to senile dementia, mental excitation, poriomania, delirium, hallucination, hyperkinesia, schizophrenia, emotional disturbance, depression, neurosis, psychophysiologic disorder and anxiety neurosis. The compounds exhibit dopamine 2 receptor antagonism and/or serotonin 2 receptor antagonism.
摘要翻译：由下式（I）表示的联苯衍生物或其药理学上可接受的盐：其中R1，R2，R3，R4和R5在说明书中定义，在临床上可用于治疗和改善精神障碍如脑血管障碍，侵袭性老年性痴呆，精神激素，por妄症，del妄，幻觉，运动过度，精神分裂症，情绪障碍，抑郁症，神经症，心理生理障碍和焦虑神经症的行为。该化合物表现出多巴胺2受体拮抗作用和/或5-羟色胺2受体拮抗作用。

9. 发明授权

US6130498A Spark plug with specific measured parameters 有权
标题翻译：火花塞具有特定的测量参数
公开(公告)号：US6130498A
公开(公告)日：2000-10-10
申请号：US207661
申请日：1998-12-09
申请人： Toshikazu Shimizu , Yasushi Kawashima
发明人： Toshikazu Shimizu , Yasushi Kawashima
IPC分类号： H01T13/39 , H01T13/41 , H01T13/20
CPC分类号： H01T13/39 , H01T13/41
摘要： A spark plug has an insulator having a through hole extending in an axial direction thereof and an insulator leg portion at an end thereof, a resistor disposed in the through hole, a central electrode disposed in the through hole to face a central electrode side end face of the resistor and protruding from an insulator end face of the insulator leg portion, and a housing holding the insulator. A length between the insulator end face and the central electrode side end face of the resistor is equal to or larger than 1.5 times as large as a length of the insulator leg portion in the axial direction. Accordingly, temperature at a contact portion between the resistor and the central electrode is prevented from being increased, resulting in long life of the spark plug.
摘要翻译：火花塞具有绝缘体，该绝缘体具有沿其轴向延伸的通孔和在其一端的绝缘体腿部，设置在通孔中的电阻器，设置在通孔中的中心电极，以面对中心电极侧端面并且从绝缘体腿部的绝缘体端面突出并且保持绝缘体的壳体。电阻器的绝缘体端面和中心电极侧端面之间的长度等于或大于绝缘子腿部在轴向方向上的长度的1.5倍。因此，防止电阻器和中心电极之间的接触部分的温度升高，导致火花塞寿命长。

10. 发明授权

US5559236A Intermediates for substituted biphenylmethylmidazopyridine angiotensin II antagonists 失效
标题翻译：取代联苯甲基咪唑并吡啶血管紧张素II拮抗剂的中间体
公开(公告)号：US5559236A
公开(公告)日：1996-09-24
申请号：US471465
申请日：1995-06-06
申请人： Yoshio Urawa , Ken Furukawa , Toshikazu Shimizu , Yoji Yamagishi , Tomio Tsurugi , Tomio Ichino
发明人： Yoshio Urawa , Ken Furukawa , Toshikazu Shimizu , Yoji Yamagishi , Tomio Tsurugi , Tomio Ichino
IPC分类号： C07C63/72 , C07C65/105 , C07C69/732 , C07C69/76 , C07D213/73 , C07D213/75 , C07D263/10 , C07D263/12 , C07D263/14 , C07D309/12 , C07D413/12 , C07D471/04 , C07D413/10
CPC分类号： C07D213/73 , C07C63/72 , C07C65/105 , C07C69/732 , C07C69/76 , C07D213/75 , C07D263/10 , C07D263/12 , C07D263/14 , C07D309/12 , C07D413/12 , C07D471/04 , Y02P20/55
摘要： The present invention provides an industrially advantageous process for preparing a 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo[4,5-b]pyridine derivative represented by the following formula (II) which is a precursor of an antagonist against an angiotensin II receptor useful as an antihypertensive drug, a biphenyl derivative which is a precursor of the substituent of the pyridine derivative, a process for the preparation thereof, and an intermediate useful for the preparation of the biphenyl derivative: ##STR1## The 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo-[4,5-b]pyridine derivative can be prepared in a high yield according to the present invention from a 2-amino-5-halogeno-3-nitropyridine derivative through amidation, N-alkylation and reductive cyclization. The halogen atom introduced at the 5-position as a protective group against nitration can be eliminated simultaneously in the step which is conducted thereafter. Thus, this process is industrially advantageous. Further, the biphenyl derivative of the present invention is excellent in reactivity and purity of the product, thus being an intermediate suitable for the industrial production.
摘要翻译：本发明提供了制备由下式（II）表示的2-烷基-3-（联苯-4-基）甲基-3H-咪唑并[4,5-b]吡啶衍生物的工业上有利的方法，其为前体可用作抗高血压药物的血管紧张素II受体的拮抗剂，作为吡啶衍生物的取代基的前体的联苯衍生物，其制备方法和用于制备联苯衍生物的中间体：（II）2-烷基-3-（联苯-4-基）甲基-3H-咪唑并[4,5-b]吡啶衍生物可以按照本发明从2-氨基 -5-卤代-3-硝基吡啶衍生物通过酰胺化，N-烷基化和还原环化。在其后进行的步骤中可以同时消除在5位引入作为硝化保护基的卤素原子。因此，该方法在工业上是有利的。此外，本发明的联苯衍生物的产物的反应性和纯度优异，因此是适于工业化生产的中间体。

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