专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4421914A Thiazolo[3,2-a]pyrimidines, derivatives thereof, processes for production thereof, and pharmaceutical use thereof 失效
公开(公告)号：US4421914A
公开(公告)日：1983-12-20
申请号：US311329
申请日：1981-10-14
申请人： Noriaki Okamura , Takeshi Toru , Takeo Oba , Toshio Tanaka , Kiyoshi Bannai , Kenzo Watanabe , Seizi Kurozumi , Tatsuyuki Naruchi , Keiji Komoriya
发明人： Noriaki Okamura , Takeshi Toru , Takeo Oba , Toshio Tanaka , Kiyoshi Bannai , Kenzo Watanabe , Seizi Kurozumi , Tatsuyuki Naruchi , Keiji Komoriya
IPC分类号： C07D513/04 , C07D513/14 , A61K31/505
CPC分类号： C07D513/04
摘要： A compound selected from thiazolo[3,2-a]pyrimidines or their enolate derivatives represented by the following general formula ##STR1## wherein R.sup.1 and R.sup.2 are identical or different, and each represents a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 3 to 10 carbon atoms, a substituted or unsubstituted phenyl group, a substituted or unsubstituted cycloaliphatic group having 3 to 8 carbon atoms, a substituted or unsubstituted phenylalkyl group or a substituted or unsubstituted acyl group having 2 to 7 carbon atoms, provided that R.sup.1 and R.sup.2 are not simultaneously hydrogen atoms or substituted or unsubstituted acyl groups having 2 to 7 carbon atoms; and R.sup.1 and R.sup.2, when taken together, may form, with the nitrogen atom to which they are bonded, a 5- or 6-membered ring which may further contain one or more hetero atoms;and acid addition salts of these compounds.The thiazolo[3,2-a]pyrimidines may be prepared by a process comprising (a) reacting a malonic acid derivative of the following general formula ##STR2## wherein R.sup.1 and R.sup.2 are as defined with regard to formula (I), and R.sup.4 and R.sup.5 are identical or different and each represents an alkyl group having 1 to 6 carbon atoms,with 2-aminothiazoline under heat, if desired in the presence of an inert organic solvent, to induce cyclocondensation, or (b) performing said condensation reaction in the presence of an alkali metal alkoxide, if desired in the presence of an inert organic solvent, and neutralizing the resulting enolate with an acid; and if desired, reacting the reaction product of (a) or (b) with an acid.The present invention provides also several processes for preparing enolate derivatives thereof.The thiazolo[3,2-a]pyrimidines, their enolate derivatives and acid addition compounds thereof are useful for regulating the immune function of a warm-blooded animal.

2. 发明授权

US4383996A Derivative of thiazolo[3,2-a]pyrimidine and a process for the preparation thereof and a drug containing it 失效
标题翻译：噻唑并[3,2-a]嘧啶的衍生物及其制备方法和含有它的药物
公开(公告)号：US4383996A
公开(公告)日：1983-05-17
申请号：US339460
申请日：1981-12-28
申请人： Takeo Oba , Kiyoshi Bannai , Toshio Tanaka , Kenzo Watanabe , Tatsuyuki Naruchi , Keiji Komoriya , Seizi Kurozumi , Kenji Hoshina
发明人： Takeo Oba , Kiyoshi Bannai , Toshio Tanaka , Kenzo Watanabe , Tatsuyuki Naruchi , Keiji Komoriya , Seizi Kurozumi , Kenji Hoshina
IPC分类号： C07D513/04 , A61K31/505
CPC分类号： C07D513/04 , Y10S514/825 , Y10S514/885
摘要： A derivative of thiazolo [3,2-a] pyrimidine expressed by formula (I) ##STR1## (where R indicates a phenyl group or a benzyl group which has a halogen atom, a lower alkyl or lower alkyloxy group as a substituent group, an alicyclic group or an arylethyl group), and a process for the preparation of a compound of formula (I) comprising cyclizing a compound expressed by formula (II) by application of heat ##STR2## (where a definition of R is as same as that given in case of formula (I) and R' indicates a halogen atom or lower alkyloxy group). A drug which contains this compound as active ingredient is useful for curing autoimmune diseases such as rheumatoid arthritis, nephritis, etc.
摘要翻译： PCT No.PCT / JP80 / 00090 Sec。 371日期：1981年12月28日 102（e）日期1981年12月28日PCT提交1980年4月28日PCT公布。公开号WO81 / 03174 1981年11月12日，由式（I）表示的噻唑并[3,2-a]嘧啶衍生物（I）（其中R表示苯基或具有卤素原子的苄基，较低烷基或低级烷氧基作为取代基，脂环基或芳乙基），以及制备式（I）化合物的方法，其包括使式（II）表示的化合物通过加热（II）（其中R的定义与式（I）的情况相同，R'表示卤素原子或低级烷氧基）。含有该化合物作为活性成分的药物可用于治疗自身免疫性疾病如类风湿性关节炎，肾炎等。

3. 发明授权

US4466980A Thiaprostaglandin E.sub.1 derivatives, process for production thereof, and pharmaceutical use thereof 失效
标题翻译： Thiaprostaglandin E1衍生物，其制备方法及其药物用途
公开(公告)号：US4466980A
公开(公告)日：1984-08-21
申请号：US316902
申请日：1981-10-30
申请人： Toshio Tanaka , Takeshi Toru , Takeo Oba , Noriaki Okamura , Kenzo Watanabe , Kiyoshi Bannai , Atsuo Hazato , Seizi Kurozumi , Fukuyoshi Kamimoto , Akira Ohtsu
发明人： Toshio Tanaka , Takeshi Toru , Takeo Oba , Noriaki Okamura , Kenzo Watanabe , Kiyoshi Bannai , Atsuo Hazato , Seizi Kurozumi , Fukuyoshi Kamimoto , Akira Ohtsu
IPC分类号： C07C405/00 , C07D309/12 , C07C177/00 , A61K31/557
CPC分类号： C07C405/0033 , C07D309/12
摘要： A novel compound selected from the group consisting of 7-(or 6- or 4-)thiaprostaglandin E.sub.1 derivatives of the formula (I). ##STR1## wherein A represents --CH.sub.2 -- or ##STR2## in which n is 0, 1 or 2, provided that only one A cut of three is ##STR3## R.sup.1 -R.sup.7 and G are as defined in the specification, the 15-epimers of said thiaprostaglandin E.sub.1 derivatives, the enatiomers of said thiaprostaglandin E.sub.1 derivatives or their 15-epimers, and mixtures of these compounds.A 7-thiaprostaglandin E.sub.1 derivative and/or its optical isomer may be prepared by reacting a 2-organo-2-cyclopentenone (II) with an organic copper-lithium compound (III) to effect conjugation reaction. A 6-thiaprostaglandin E.sub.1 derivative and/or its optical isomer may be prepared by subjecting an .alpha.,.beta.-unsaturated ketone (IV) and a thiol (V) to the Michael addition reaction. And, 4-thiaprostaglandin derivative and/or its optical isomer may also be prepared by the Michael addition reaction from a 2-allyl substituted cyclopentanone (VI) and a thiol (VIII).Some compounds ((I)-1) amongst the compounds of the formula (I) and/or their optical isomer are useful for controlling vascular actions such as angina pectoris, vasodilation etc.
摘要翻译：选自式（I）的7-（或6-或4-）赖氨酸前列腺素E1衍生物的新化合物。（I）其中A表示-CH 2 - 或，其中n为0,1或2，条件是三个只有一个A切割是R 1 -R 7，G如说明书中所定义，所述thiaprostaglandin E1衍生物的15-差向异构体，所述thiaprostaglandin E1衍生物或它们的15-差向异构体的对映体，以及这些化合物的混合物。 7-硫代前列腺素E1衍生物和/或其旋光异构体可以通过2-有机-2-环戊烯酮（II）与有机铜 - 锂化合物（III）反应来制备共轭反应。 6-硫代前列腺素E1衍生物和/或其旋光异构体可以通过使α，β-不饱和酮（IV）和硫醇（V）进行迈克尔加成反应来制备。并且，也可以通过从2-烯丙基取代的环戊酮（VI）和硫醇（VIII）的迈克尔加成反应制备4-硫代前列腺素衍生物和/或其旋光异构体。式（I）化合物和/或其旋光异构体中的一些化合物（（I）-1）可用于控制血管作用，例如心绞痛，血管舒张等。

4. 发明授权

US4605645A 5-fluoro-2'-deoxyuridine derivatives and a process for the preparation thereof 失效
标题翻译： 5-氟-2'-脱氧尿苷衍生物及其制备方法
公开(公告)号：US4605645A
公开(公告)日：1986-08-12
申请号：US448087
申请日：1982-12-09
申请人： Kenzo Watanabe , Yoshinori Kato , Masahiko Saito , Takeo Oba , Hisashi Fukushima , Takeshi Hara
发明人： Kenzo Watanabe , Yoshinori Kato , Masahiko Saito , Takeo Oba , Hisashi Fukushima , Takeshi Hara
IPC分类号： C07H19/10 , C07H15/12 , C07H17/00
CPC分类号： C07H19/10 , Y02P20/55
摘要： 5-fluoro-2'-deoxyuridine derivatives expressed by general formula (1) and their pharmacologically permissible salts ##STR1## wherein A indicates a saturated or unsaturated divalent aliphatic hydrocarbon group having 1 to 30 carbon atoms; the letter n indicates 0 or 1, and when n is 0, it indicates that Y is directly bound to an oxygen atom; Y represents a hydrogen atom, phenyl group, or substituted phenyl group; however, when Y is a hydrogen atom, n is 1; R indicates a hydrogen atom or alcohol-protecting group.These compounds have a very strong antitumor activity.
摘要翻译：由通式（1）表示的5-氟-2'-脱氧尿苷衍生物及其药理学允许的盐（1）其中A表示具有1至30个碳原子的饱和或不饱和的二价脂族烃基; 字母n表示0或1，当n为0时，表示Y与氧原子直接结合; Y表示氢原子，苯基或取代的苯基; 然而，当Y为氢原子时，n为1; R表示氢原子或醇保护基。这些化合物具有非常强的抗肿瘤活性。

5. 发明授权

US5251586A Valve mechanism for an internal combustion engine 失效
标题翻译：内燃机的阀机构
公开(公告)号：US5251586A
公开(公告)日：1993-10-12
申请号：US858674
申请日：1992-03-27
申请人： Kazuhiro Koga , Takashi Yamamoto , Shinji Kamimaru , Kenzo Watanabe
发明人： Kazuhiro Koga , Takashi Yamamoto , Shinji Kamimaru , Kenzo Watanabe
IPC分类号： F01L1/26 , F01L1/34
CPC分类号： F01L1/267
摘要： A valve mechanism has a low-speed cam and a high-speed cam, a low-speed rocker arm operatively connected with a valve and a high-speed rocker arm. A changeover pin is provided for connecting the low-speed rocker arm and the high-speed rocker arm to each other so as to be rocked together by the high-speed cam. The changeover pin is slidably mounted in the high-speed rocker arm. A flat engaging face is formed on a front portion of the changeover pin so as to be engaged with a shaft provided for connecting both of the rocker arms.
摘要翻译：阀机构具有低速凸轮和高速凸轮，与阀和高速摇臂可操作地连接的低速摇臂。提供一个转换销，用于将低速摇臂和高速摇臂相互连接，以便通过高速凸轮摇摆在一起。转换销可滑动地安装在高速摇臂中。平面接合面形成在转换销的前部，以便与设置成连接两个摇臂的轴相啮合。

6. 发明授权

US5020488A Valve mechanism for an internal combustion engine 失效
标题翻译：内燃机的阀机构
公开(公告)号：US5020488A
公开(公告)日：1991-06-04
申请号：US596770
申请日：1990-10-12
申请人： Kenzo Watanabe
发明人： Kenzo Watanabe
IPC分类号： F01L1/26
CPC分类号： F01L1/267 , Y10T74/20582 , Y10T74/20882
摘要： A valve mechanism has a low-speed cam and a high-speed cam, a low-speed rocker arm operatively connected a valve and a high-speed rocker arm. A changeover device is provided for connecting the low-speed and high-speed rocker arm with each other so as to be rocked together by the high-speed cam. A roller follower is rotatably mounted on a shaft provided in the low-speed rocker arm. The high-speed rocker arm has a slipper engaging with the high-speed cam. The changeover device has a piston slidably mounted in the high-speed rocker arm so as to connect the high-speed rocker arm with the low-speed rocker arm.
摘要翻译：阀机构具有低速凸轮和高速凸轮，可操作地连接阀和高速摇臂的低速摇臂。提供一种切换装置，用于将低速和高速摇臂彼此连接，以便通过高速凸轮摇摆在一起。滚子从动件可旋转地安装在设置在低速摇臂中的轴上。高速摇臂具有与高速凸轮接合的拖鞋。切换装置具有可滑动地安装在高速摇臂中的活塞，以将高速摇臂与低速摇臂连接。

7. 发明授权

US4055963A Heating system 失效
标题翻译：加热系统
公开(公告)号：US4055963A
公开(公告)日：1977-11-01
申请号：US590203
申请日：1975-06-25
申请人： Kunihiro Shoji , Akihiro Yokota , Kenzo Watanabe
发明人： Kunihiro Shoji , Akihiro Yokota , Kenzo Watanabe
IPC分类号： F25B13/00
CPC分类号： F25B13/00 , F25B2313/023 , F25B2313/02732 , F25B2313/02741
摘要： Improvements in a heating system which heats a fluid medium by a heat exchanger and delivers it to an indoor coil or coils for space heating. Refrigerant, such as fluorohydrocarbons for refrigerators, is utilized as the heating medium. The heat exchanger is supplied with heat from a heat source, such as hot water from a boiler, at a temperature higher than that of air around the exchanger. The refrigerant in liquid form is heated while being vaporized in the heat exchanger at a pressure greater than the saturation pressure corresponding to the ambient air temperature. The medium thus gasified to a high pressure and temperature is drawn into a circulating pump and then delivered to the indoor coil or coils, where it is condensed to a liquid with heat dissipation. In this way a great heating capacity is attained with the heating medium at a low rate of circulation. The suction of high-pressure heating medium enables the circulating pump of a small capacity to accomplish not only a high rate of transfer of the heating medium but also a decrease of the compression ratio. These beneficial effects combine to permit substantial reduction of the pump power consumption.
摘要翻译：改进加热系统，其通过热交换器加热流体介质并将其输送到室内线圈或用于空间加热的线圈。制冷剂，如用于冰箱的氟代烃，被用作加热介质。热交换器从热源（例如来自锅炉的热水）以比交换器周围的空气高的温度供给热量。液体形式的制冷剂在热交换器中被加热，压力大于对应于周围空气温度的饱和压力。将如此气化成高压和温度的介质吸入循环泵中，然后输送到室内线圈或线圈，在那里它被冷凝成具有散热的液体。以这种方式，以低的循环速度使加热介质达到极大的加热能力。高压加热介质的吸入使得容量小的循环泵不仅可以实现高介质的传送速率，而且可以降低压缩比。这些有益效果结合起来可以显着降低泵的功率消耗。

8. 发明授权

US5971045A Veneer lathe 失效
标题翻译：单板车床
公开(公告)号：US5971045A
公开(公告)日：1999-10-26
申请号：US122868
申请日：1998-07-27
申请人： Kenzo Watanabe
发明人： Kenzo Watanabe
IPC分类号： B27L5/02 , B27L5/04
CPC分类号： B27L5/025
摘要： A veneer lathe comprising a knife (2) for peeling a log (1), which is secured rotatably to a knife stock, and a roller bar (3) disposed to press a circumferential surface of the log (1) at an upstream side, in relative to said knife (2), of a rotational direction of the log (1). The roller bar (3) has a diameter of not more than 30 mm, and is provided on the circumferential surface thereof with a large number of projections (5) whose height is not higher than the circumferential surface of the roller bar (3). The roller bar (3) is sustained in a sliding bearing (9) and adapted to receive a rotational force from a driving source. The roller bar (3) functions not only as a pressure bar but also as a power transmitting media to rotate the log (1), thereby preventing the generation of lathe check of veneer to be produced.
摘要翻译：一种单板车床，包括用于剥离可旋转地固定在刀库上的木材（1）的刀（2）和设置成在上游侧挤压木材（1）的圆周表面的滚柱（3）相对于所述刀（2），所述对数（1）的旋转方向。滚柱（3）的直径不大于30mm，并且在其圆周表面上设有高度不高于滚柱（3）的圆周表面的大量突起（5）。滚柱（3）被保持在滑动轴承（9）中并且适于接收来自驱动源的旋转力。滚柱（3）不仅用作压力杆，而且还用作动力传递介质来旋转原木（1），从而防止生产单板的车床检查。

9. 发明授权

US5005540A Valve timing control system for an internal combustion engine 失效
标题翻译：内燃机气门正时控制系统
公开(公告)号：US5005540A
公开(公告)日：1991-04-09
申请号：US541711
申请日：1990-06-21
申请人： Kenzo Watanabe
发明人： Kenzo Watanabe
IPC分类号： F01L13/00 , F01L9/02
CPC分类号： F01L9/025
摘要： A hydraulic valve lifter is disposed between a cam and a valve. The hydraulic valve lifter comprises a cylindrical lifter body, a cam piston slidably mounted in the lifter body, and a lifter piston slidably mounted in the lifter body. The cam piston engages with the cam and the lifter piston engages with the valve. A hydraulic circuit is provided for supplying oil to an oil chamber in the valve lifter. An electromagnetic relief valve is provided in a relief passage for draining the oil chamber. The relief valve is closed in accordance with engine operating conditions, thereby controlling the valve timing.
摘要翻译：液压阀提升器设置在凸轮和阀之间。液压气门挺杆包括圆柱形升降机主体，可滑动地安装在升降机主体中的凸轮活塞和可滑动地安装在升降机主体中的升降活塞。凸轮活塞与凸轮接合，提升活塞与阀门接合。提供了一种用于向阀提升器中的油室供油的液压回路。在用于排出油室的释放通道中设置电磁释放阀。安全阀按照发动机运转状态关闭，从而控制气门正时。

10. 发明授权

US4765380A Drive roller assembly of veneer lathe for rotating log and veneer lathe 失效
标题翻译：用于旋转木材和单板车床的单板车床的驱动辊组件
公开(公告)号：US4765380A
公开(公告)日：1988-08-23
申请号：US23944
申请日：1987-03-10
申请人： Kenzo Watanabe
发明人： Kenzo Watanabe
IPC分类号： B27B25/02 , B27L5/02
CPC分类号： B27L5/025 , B27B25/02
摘要： A roller assembly of a veneer lathe for rotating a log is disclosed. It comprises a rotatable element, an elastic element provided on the rotatable element, and a plurality of ring shaped members each having a periphery for being urgedly contacted the periphery of a log. The ring shaped members are spacedly provided on the rotatable element with the elastic element interposed therebetween. A veneer lathe including the above-mentioned roller assembly is also disclosed.
摘要翻译：公开了一种用于旋转原木的单板车床的辊组件。它包括可旋转元件，设置在可旋转元件上的弹性元件，以及多个环形构件，每个环形构件具有周向用于与木材的外周接触。环形构件间隔地设置在可旋转元件上，弹性元件插入其间。还公开了包括上述辊组件的单板车床。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式