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1. 发明授权

US5811450A Thiepane compounds 失效
公开(公告)号：US5811450A
公开(公告)日：1998-09-22
申请号：US740568
申请日：1996-10-31
申请人： Norbert W. Bischofberger , Choung U. Kim , Steven H. Krawczyk , Lawrence R. McGee , Michael J. Postich , Wenjin Yang
发明人： Norbert W. Bischofberger , Choung U. Kim , Steven H. Krawczyk , Lawrence R. McGee , Michael J. Postich , Wenjin Yang
IPC分类号： A61K31/38 , C07D337/00
CPC分类号： C07D337/04 , C07D417/06 , C07D495/04
摘要： Tri- and tetra substituted thiepane compositions having use as immunogens, therapeutics, diagnostics and for other industrial purposes are disclosed. The compositions inhibit proteolytic activity of viral enzymes and are useful for the inhibition of such enzymes as well as in assays for the detection of such enzymes. Embodiments in which antigenic polypeptides are bonded to the compositions are useful in raising antibodies against the thiepane haptens or the polypeptide. Labeled thiepanes of this invention are useful as diagnostic reagents.

2. 发明授权

US6034118A Thiepane compounds 失效
标题翻译：噻哩啶化合物
公开(公告)号：US6034118A
公开(公告)日：2000-03-07
申请号：US552429
申请日：1995-11-03
申请人： Norbert W. Bischofberger , Choung U. Kim , Steven H. Krawczyk , Lawrence R. McGee , Michael J. Postich , Wenjin Yang
发明人： Norbert W. Bischofberger , Choung U. Kim , Steven H. Krawczyk , Lawrence R. McGee , Michael J. Postich , Wenjin Yang
IPC分类号： C07D337/04 , C07D495/04 , A61K31/38 , C07D337/00
CPC分类号： C07D337/04 , C07D495/04
摘要： Tri- and tetra substituted thiepane compositions having use as immunogens, therapeutics, diagnostics and for other industrial purposes are disclosed. The compositions inhibit proteolytic activity of viral enzymes and are useful for the inhibition of such enzymes as well as in assays for the detection of such enzymes. Embodiments in which antigenic polypeptides are bonded to the compositions are useful in raising antibodies against the thiepane haptens or the polypeptide. Labeled thiepanes of this invention are useful as diagnostic reagents.
摘要翻译：公开了用作免疫原，治疗学，诊断和用于其它工业目的的三取代和四取代的硫代吡喃组合物。组合物抑制病毒酶的蛋白水解活性，并且可用于抑制这些酶以及用于检测这些酶的测定。其中抗原性多肽与组合物结合的实施方案可用于产生针对硫替平半抗原或多肽的抗体。本发明的标记的thiepane可用作诊断试剂。

3. 发明授权

US4892865A Pyrrolo[2,3-d]pyrimidine nucleosides as antiviral agents 失效
标题翻译：吡咯并[2,3-d]嘧啶核苷作为抗病毒剂
公开(公告)号：US4892865A
公开(公告)日：1990-01-09
申请号：US127487
申请日：1987-12-01
申请人： Leroy B. Townsend , John C. Drach , Steven H. Krawczyk
发明人： Leroy B. Townsend , John C. Drach , Steven H. Krawczyk
IPC分类号： C07H19/16
CPC分类号： A61K31/70 , C07H19/16
摘要： This invention relates to the use of certain substituted pyrrolo[2,3-d]-pyrimidine nucleosides in the treatment of viral infections, in particular those caused by human immunodeficiency virus type 1, herpes simplex virus type 1 and human cytomegalovirus. These substituted compounds retain antiviral properties present in their parent compounds yet exhibit significantly decreased levels of cytotoxicity.
摘要翻译：本发明涉及某些取代的吡咯并[2,3-d] - 嘧啶核苷在治疗病毒感染中的用途，特别是由1型人类免疫缺陷病毒1型，单细胞病毒1型和人巨细胞病毒引起的那些。这些取代的化合物保留了其母体化合物中存在的抗病毒性质，但表现出显着降低的细胞毒性水平。

4. 发明授权

US07579332B2 Nucleobase phosphonate analogs for antiviral treatment 有权
标题翻译：用于抗病毒治疗的核碱基膦酸酯类似物
公开(公告)号：US07579332B2
公开(公告)日：2009-08-25
申请号：US10903288
申请日：2004-07-30
申请人： Steven H. Krawczyk
发明人： Steven H. Krawczyk
IPC分类号： C07F9/6561 , C07F9/6512 , A61K31/675 , A61P31/18
CPC分类号： C07F9/65616 , A61K31/675
摘要： The invention provides compounds with activity against infectious diseases. The compounds of the invention may inhibit retroviral reverse transcriptases and thus inhibit the replication, of the virus. The compounds of the invention may be useful for treating human patients infected with a human retrovirus, such as human immunodeficiency virus (strains of HIV-l or HIV-2) or human T-cell leukemia virus (HTLV-1 or HTLV-II) which results in acquired immunodeficiency syndrome (AIDS) and/or related diseases. Representative of the invention is a compound of the following formula, with the substituents defined herein:
摘要翻译：本发明提供具有抗感染性疾病活性的化合物。本发明的化合物可以抑制逆转录病毒逆转录酶，从而抑制病毒的复制。本发明的化合物可用于治疗感染人类逆转录病毒如人类免疫缺陷病毒（HIV-1或HIV-2的菌株）或人类T细胞白血病病毒（HTLV-1或HTLV-II）的人类患者，导致获得性免疫缺陷综合征（AIDS）和/或相关疾病。本发明的代表是具有本文定义的取代基的下式的化合物：

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