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1. 发明申请

US20070078119A1 Storage system for texaphyrin pharmaceutical formulations 审中-公开
标题翻译：泰克萨菲瑞药物制剂的储存系统
公开(公告)号：US20070078119A1
公开(公告)日：2007-04-05
申请号：US11241549
申请日：2005-09-30
申请人： Norbert Purro , Hugo Madden , Suzanne Nguyen
发明人： Norbert Purro , Hugo Madden , Suzanne Nguyen
IPC分类号： A61K31/555 , B65D85/42
CPC分类号： A61K9/0019 , A61J1/14 , A61K31/555 , A61K31/70 , B65D77/0426 , B65D81/30
摘要： A packaging system is described for a drug that provides protection from contamination, crystallization and/or degradation of the drug during storage of the system prior to its use. The packaging of the drug does not significantly absorb, react with, or otherwise adversely affect the therapeutic effectiveness of the drug or other excipients or components during storage of the system prior to its use. The packaging system is also used for preserving a drug, particularly a drug containing high-purity texaphyrin metal complexes, by providing a product packaging system that prevents, limits or otherwise controls degradation reactions that can result from exposure to oxygen and/or light.
摘要翻译：描述了用于药物的包装系统，其在使用前在系统的储存期间提供防止污染，结晶和/或降解的药物。药物的包装在使用前在系统储存期间不会显着吸收，反应或不利地影响药物或其它赋形剂或组分的治疗有效性。包装系统还用于通过提供防止，限制或以其它方式控制可能由于暴露于氧气和/或光引起的降解反应的产品包装系统来保存药物，特别是含有高纯度泰克萨菲瑞金属络合物的药物。

2. 发明申请

US20110046100A1 Texaphyrin solutions and pharmaceutical formulations 审中-公开
标题翻译： Texaphyrin溶液和药物制剂
公开(公告)号：US20110046100A1
公开(公告)日：2011-02-24
申请号：US12939780
申请日：2010-11-04
申请人： Norbert Purro , Hugo Madden , Suzanne Kretchmar Nguyen
发明人： Norbert Purro , Hugo Madden , Suzanne Kretchmar Nguyen
IPC分类号： A61K31/555 , A61P35/00
CPC分类号： A61K9/0019 , A61J1/14 , A61K31/555 , A61K31/70 , B65D77/0426 , B65D81/30
摘要： A packaging system is described for a drug that provides protection from contamination, crystallization and/or degradation of the drug during storage of the system prior to its use. The packaging of the drug does not significantly absorb, react with, or otherwise adversely affect the therapeutic effectiveness of the drug or other excipients or components during storage of the system prior to its use. The packaging system is also used for preserving a drug, particularly a drug containing high-purity texaphyrin metal complexes, by providing a product packaging system that prevents, limits or otherwise controls degradation reactions that can result from exposure to oxygen and/or light.
摘要翻译：描述了用于药物的包装系统，其在使用前在系统的储存期间提供防止污染，结晶和/或降解的药物。药物的包装在使用前在系统储存期间不会显着吸收，反应或不利地影响药物或其它赋形剂或组分的治疗有效性。包装系统还用于通过提供防止，限制或以其它方式控制可能由于暴露于氧气和/或光引起的降解反应的产品包装系统来保存药物，特别是含有高纯度泰克萨菲瑞金属络合物的药物。

3. 发明申请

US20070072838A1 High-purity texaphyrin metal complexes 审中-公开
标题翻译：高纯度泰克萨菲芬金属配合物
公开(公告)号：US20070072838A1
公开(公告)日：2007-03-29
申请号：US11235475
申请日：2005-09-26
申请人： Hugo Madden , Greg Hemmi , Tarak Mody
发明人： Hugo Madden , Greg Hemmi , Tarak Mody
IPC分类号： A61K31/555 , C07F5/00 , C07D487/22
CPC分类号： C07F5/00 , A61K31/555 , A61K45/00 , C07C41/16 , C07C43/2055 , C07C205/37 , C07D487/22 , C07F5/003
摘要： Disclosed herein are the methods and compositions for the improved synthesis of texaphyrin metal complexes. The improved synthesis results in high-purity compositions of texaphyrin metal complexes in which more than about 98% of the texaphyrin metal complexes in the composition have the same structure and/or the same molecular weight. Further described herein are pharmaceutical compositions comprising such high-purity compositions, and the use of such high-purity compositions in the treatment of cancer and cardiovascular diseases and disorders.
摘要翻译：本文公开了用于改进合成特沙弗林金属络合物的方法和组合物。改进的合成导致特沙弗林金属络合物的高纯度组合物，其中组合物中超过约98％的特沙弗林金属络合物具有相同的结构和/或相同的分子量。本文进一步描述的是包含这种高纯度组合物的药物组合物，以及这些高纯度组合物在治疗癌症和心血管疾病和病症中的用途。

4. 发明授权

US08410263B2 High-purity texaphyrin metal complexes 有权
标题翻译：高纯度泰克萨菲芬金属配合物
公开(公告)号：US08410263B2
公开(公告)日：2013-04-02
申请号：US12611896
申请日：2009-11-03
申请人： Hugo Madden , Greg Hemmi , Tarak Mody
发明人： Hugo Madden , Greg Hemmi , Tarak Mody
IPC分类号： C07D225/06 , C07D487/22 , C07C43/205 , C07C205/06
CPC分类号： C07F5/00 , A61K31/555 , A61K45/00 , C07C41/16 , C07C43/2055 , C07C205/37 , C07D487/22 , C07F5/003
摘要： Disclosed herein are the methods and compositions for the improved synthesis of texaphyrin metal complexes. The improved synthesis results in high-purity compositions of texaphyrin metal complexes in which more than about 98% of the texaphyrin metal complexes in the composition have the same structure and/or the same molecular weight. Further described herein are pharmaceutical compositions comprising such high-purity compositions, and the use of such high-purity compositions in the treatment of cancer and cardiovascular diseases and disorders.
摘要翻译：本文公开了用于改进合成特沙弗林金属络合物的方法和组合物。改进的合成导致特沙弗林金属络合物的高纯度组合物，其中组合物中超过约98％的特沙弗林金属络合物具有相同的结构和/或相同的分子量。本文进一步描述的是包含这种高纯度组合物的药物组合物，以及这些高纯度组合物在治疗癌症和心血管疾病和病症中的用途。

5. 发明申请

US20080063605A1 Method of Enhancing Visualization of Atherosclerotic Plaque 审中-公开
标题翻译：增强动脉粥样硬化斑块可视化的方法
公开(公告)号：US20080063605A1
公开(公告)日：2008-03-13
申请号：US11579759
申请日：2005-05-19
申请人： Wai-Fung Cheong , Hugo Madden , Greg Hemmi
发明人： Wai-Fung Cheong , Hugo Madden , Greg Hemmi
IPC分类号： A61B5/055
CPC分类号： A61K49/106
摘要： The invention relates to a method and a corresponding device for multipurposely supporting a randomly shaped and/or possibly complex with respect to a rigid base (11) part (1) by fixing a working reference, wherein the inventive method consist in interposing at least one deformable constant-volume chamber (3) which is sealed and filled with incompressible particles (4) between a maintainable part and the rigid base (11) and in lowing pressure inside the deformable constant-volume chamber (3) by means of a vacuum source (5) connectable thereto, thereby enabling the particles (4) to be amalgamated into a solid block which thrusts at least partly on the rigid base (11) and maintains the part (1) by fitting the shape thereof.
摘要翻译：本发明涉及一种方法和相应的装置，用于通过固定工作参考物多相关地支撑相对于刚性基座部件（1）的随机成形和/或可能复合的装置，其中本发明的方法包括至少一个可变形恒定容积室（3），其通过真空源密封并在可维护部件和刚性基座（11）之间并且在可变形恒定容积室（3）内的低压下填充不可压缩颗粒（4）（5），从而使得颗粒（4）能够被合并成固体块，其至少部分地推动在刚性基座（11）上并且通过装配其形状来保持部件（1）。

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