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1. 发明授权

US08933117B2 Crystals of substituted cycloalkene derivatives 有权
标题翻译：取代环烯烃衍生物的晶体
公开(公告)号：US08933117B2
公开(公告)日：2015-01-13
申请号：US13825875
申请日：2011-09-22
申请人： Nobuyuki Ohkawa , Kouki Iida , Takayoshi Nagasaki
发明人： Nobuyuki Ohkawa , Kouki Iida , Takayoshi Nagasaki
IPC分类号： A01N43/26 , A61K31/355 , C07D317/72 , A61K31/357
CPC分类号： C07D317/72 , A61K31/357
摘要： To provide potassium salts of substituted cycloalkene derivatives, which suppress the production of an inflammatory mediator caused by intracellular signal transduction or cell activation induced by endotoxin, and crystals thereof. The present invention provides potassium (2-chloro-4-fluorophenyl){[(2R,3R,8R)-7-(ethoxycarbonyl)-2,3-bis(hydroxymethyl)-1,4-dioxaspiro[4.5]deca-6-en-8-yl]sulfonyl}azanide and potassium (2-bromo-4-fluorophenyl){[(2R,3R,8R)-7-(ethoxycarbonyl)-2,3-bis(hydroxymethyl)-1,4-dioxaspiro[4.5]deca-6-en-8-yl]sulfonyl}azanide, each of which suppresses the production of an inflammatory mediator caused by intracellular signal transduction or cell activation induced by endotoxin, crystals thereof, and a pharmaceutical containing any of the same, and a prophylactic and/or therapeutic agent for sepsis containing any of the same.
摘要翻译：提供抑制由内毒素诱导的细胞内信号转导或细胞活化引起的炎症介质的产生的取代环烯烃衍生物的钾盐及其结晶。本发明提供了（2-氯-4-氟苯基）{[（2R，3R，8R）-7-（乙氧基羰基）-2,3-双（羟甲基）-1,4-二氧杂螺[4.5]十碳六（2-溴-4-氟苯基）{[（2R，3R，8R）-7-（乙氧基羰基）-2,3-双（羟甲基）二氧杂螺[4.5]十碳-6-烯-8-基]磺酰基}吖庚因，其各自抑制由内毒素诱导的细胞内信号转导或细胞活化引起的炎性介质的产生，其晶体和含有任何以及含有任何相同的败血症的预防和/或治疗剂。

2. 发明申请

US20140073689A9 Crystals of Substituted Cycloalkene Derivatives 有权
标题翻译：取代的环烯烃衍生物的晶体
公开(公告)号：US20140073689A9
公开(公告)日：2014-03-13
申请号：US13825875
申请日：2011-09-22
申请人： Nobuyuki Ohkawa , Kouki Iida , Takayoshi Nagasaki
发明人： Nobuyuki Ohkawa , Kouki Iida , Takayoshi Nagasaki
IPC分类号： C07D317/72
CPC分类号： C07D317/72 , A61K31/357
摘要： To provide potassium salts of substituted pyrrolidine derivatives, which suppress the production of an inflammatory mediator caused by intracellular signal transduction or cell activation induced by endotoxin, and crystals thereof. The present invention provides potassium(2-chloro-4-fluorophenyl){[(2R,3R,8R)-7-(ethoxycarbonyl)-2,3-bis(hydroxymethyl)-1,4-dioxaspiro[4.5]deca-6-en-8-yl]sulfonyl}azanide and potassium(2-bromo-4-fluorophenyl){[(2R,3R,8R)-7-(ethoxycarbonyl)-2,3-bis(hydroxymethyl)-1,4-dioxaspiro[4.5]deca-6-en-8-yl]sulfonyl}azanide, each of which suppresses the production of an inflammatory mediator caused by intracellular signal transduction or cell activation induced by endotoxin, crystals thereof, and a pharmaceutical containing any of the same, and a prophylactic and/or therapeutic agent for sepsis containing any of the same.
摘要翻译：提供抑制由内毒素诱导的细胞内信号转导或细胞活化引起的炎性介质的产生的取代的吡咯烷衍生物的钾盐及其结晶。本发明提供了（2-氯-4-氟苯基）{[（2R，3R，8R）-7-（乙氧基羰基）-2,3-双（羟甲基）-1,4-二氧杂螺[4.5]十碳六（2-溴-4-氟苯基）{[（2R，3R，8R）-7-（乙氧基羰基）-2,3-双（羟甲基）二氧杂螺[4.5]十碳-6-烯-8-基]磺酰基}吖庚因，其各自抑制由内毒素诱导的细胞内信号转导或细胞活化引起的炎性介质的产生，其晶体和含有以及含有任何相同的败血症的预防和/或治疗剂。

3. 发明申请

US20130178521A1 Crystals of Substituted Cycloalkene Derivatives 有权
标题翻译：取代的环烯烃衍生物的晶体
公开(公告)号：US20130178521A1
公开(公告)日：2013-07-11
申请号：US13825875
申请日：2011-09-22
申请人： Nobuyuki Ohkawa , Kouki Iida , Takayoshi Nagasaki
发明人： Nobuyuki Ohkawa , Kouki Iida , Takayoshi Nagasaki
IPC分类号： C07D317/72
CPC分类号： C07D317/72 , A61K31/357
摘要： To provide potassium salts of substituted pyrrolidine derivatives, which suppress the production of an inflammatory mediator caused by intracellular signal transduction or cell activation induced by endotoxin, and crystals thereof. The present invention provides potassium(2-chloro-4-fluorophenyl){[(2R,3R,8R)-7-(ethoxycarbonyl)-2,3-bis(hydroxymethyl)-1,4-dioxaspiro[4.5]deca-6-en-8-yl]sulfonyl}azanide and potassium(2-bromo-4-fluorophenyl){[(2R,3R,8R)-7-(ethoxycarbonyl)-2,3-bis(hydroxymethyl)-1,4-dioxaspiro[4.5]deca-6-en-8-yl]sulfonyl}azanide, each of which suppresses the production of an inflammatory mediator caused by intracellular signal transduction or cell activation induced by endotoxin, crystals thereof, and a pharmaceutical containing any of the same, and a prophylactic and/or therapeutic agent for sepsis containing any of the same.
摘要翻译：提供抑制由内毒素诱导的细胞内信号转导或细胞活化引起的炎性介质的产生的取代的吡咯烷衍生物的钾盐及其结晶。本发明提供了（2-氯-4-氟苯基）{[（2R，3R，8R）-7-（乙氧基羰基）-2,3-双（羟甲基）-1,4-二氧杂螺[4.5]十碳六（2-溴-4-氟苯基）{[（2R，3R，8R）-7-（乙氧基羰基）-2,3-双（羟甲基）二氧杂螺[4.5]十碳-6-烯-8-基]磺酰基}吖庚因，其各自抑制由内毒素诱导的细胞内信号转导或细胞活化引起的炎性介质的产生，其晶体和含有以及含有任何相同的败血症的预防和/或治疗剂。

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