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1. 发明授权

US07436562B2 Scanning examination apparatus, lens unit, and objective-lens adaptor 有权
标题翻译：扫描检查装置，镜头单元和物镜适配器
公开(公告)号：US07436562B2
公开(公告)日：2008-10-14
申请号：US11375042
申请日：2006-03-15
申请人： Nobuyuki Nagasawa , Yoshihisa Tanikawa , Kazuhiko Osa , Yoshiharu Saito
发明人： Nobuyuki Nagasawa , Yoshihisa Tanikawa , Kazuhiko Osa , Yoshiharu Saito
IPC分类号： G02B26/08 , G02B21/06
CPC分类号： G02B21/006 , A61B5/0059 , A61B5/0068 , G02B21/0012 , G02B21/0028 , G02B26/0816
摘要： It is possible to easily and accurately confirm the position of an optical axis of an objective lens relative to an examination site on a specimen, and positioning of the objective relative to the specimen can be carried out rapidly in a preparation stage. The invention provides scanning examination apparatus comprising a first light source; a light scanning unit configured to scan light from the first light source on a specimen; an objective lens configured to form an image of the light scanned in the light scanning unit at the specimen; a light-detecting unit configured to detect return light emitted from the specimen; a second light source configured to emit visible light; a deflecting optical element, disposed between the light scanning unit and the objective lens, for making visible light emitted from the second light source enter the objective lens along an optical axis of the objective lens; and a beam-shaping unit configured to form the visible light from the second light source, which is irradiated onto a surface of the specimen via the objective lens using the deflecting optical element, into a pattern that enables the optical axis of the objective lens to be indicated.
摘要翻译：可以容易且准确地确认物镜的光轴相对于检体的检查部位的位置，能够在准备阶段快速地进行物体相对于检体的定位。本发明提供一种扫描检查装置，包括：第一光源; 光扫描单元，被配置为在样本上扫描来自第一光源的光; 物镜，被配置为在所述样本处形成在所述光扫描单元中扫描的光的图像; 光检测单元，被配置为检测从所述样本发射的返回光; 配置为发射可见光的第二光源; 设置在光扫描单元和物镜之间的偏转光学元件，用于使从第二光源发出的可见光沿着物镜的光轴进入物镜; 以及光束整形单元，被配置为将来自所述第二光源的可见光通过所述偏转光学元件通过所述物镜照射到所述样本的表面上，使得能够使所述物镜的光轴被指示。

2. 发明申请

US20060214095A1 Scanning examination apparatus, lens unit, and objective-lens adaptor 有权
标题翻译：扫描检查装置，镜头单元和物镜适配器
公开(公告)号：US20060214095A1
公开(公告)日：2006-09-28
申请号：US11375042
申请日：2006-03-15
申请人： Nobuyuki Nagasawa , Yoshihisa Tanikawa , Kazuhiko Osa , Yoshiharu Saito
发明人： Nobuyuki Nagasawa , Yoshihisa Tanikawa , Kazuhiko Osa , Yoshiharu Saito
IPC分类号： H01J40/14 , H01J3/14 , H01J5/16
CPC分类号： G02B21/006 , A61B5/0059 , A61B5/0068 , G02B21/0012 , G02B21/0028 , G02B26/0816
摘要： It is possible to easily and accurately confirm the position of an optical axis of an objective lens relative to an examination site on a specimen, and positioning of the objective relative to the specimen can be carried out rapidly in a preparation stage. The invention provides scanning examination apparatus comprising a first light source; a light scanning unit configured to scan light from the first light source on a specimen; an objective lens configured to form an image of the light scanned in the light scanning unit at the specimen; a light-detecting unit configured to detect return light emitted from the specimen; a second light source configured to emit visible light; a deflecting optical element, disposed between the light scanning unit and the objective lens, for making visible light emitted from the second light source enter the objective lens along an optical axis of the objective lens; and a beam-shaping unit configured to form the visible light from the second light source, which is irradiated onto a surface of the specimen via the objective lens using the deflecting optical element, into a pattern that enables the optical axis of the objective lens to be indicated.
摘要翻译：可以容易且准确地确认物镜的光轴相对于检体的检查部位的位置，能够在准备阶段快速地进行物体相对于检体的定位。本发明提供一种扫描检查装置，包括：第一光源; 光扫描单元，被配置为在样本上扫描来自第一光源的光; 物镜，被配置为在所述样本处形成在所述光扫描单元中扫描的光的图像; 光检测单元，被配置为检测从所述样本发射的返回光; 配置为发射可见光的第二光源; 设置在光扫描单元和物镜之间的偏转光学元件，用于使从第二光源发出的可见光沿着物镜的光轴进入物镜; 以及光束整形单元，被配置为将来自所述第二光源的可见光通过所述偏转光学元件通过所述物镜照射到所述样本的表面上，使得能够使所述物镜的光轴被指示。

3. 发明申请

US20060050276A1 Dark box apparatus for fluoroscopy, fluoroscopy system, and fluoroscopy method 有权
标题翻译：用于荧光透视，荧光透视系统和荧光透视法的暗盒装置
公开(公告)号：US20060050276A1
公开(公告)日：2006-03-09
申请号：US11213906
申请日：2005-08-30
申请人： Kei Tsuyuki , Kazuhiko Osa , Nobuyuki Nagasawa
发明人： Kei Tsuyuki , Kazuhiko Osa , Nobuyuki Nagasawa
IPC分类号： G01N21/64
CPC分类号： G01N21/6458 , G01N21/6456
摘要： Noise in a fluorescence image acquired during fluoroscopy is eliminated to present a clear fluorescence image, and the relative positional relationship between the fluoroscopy unit and the specimen can be recognized even while fluoroscopy is in progress. A dark box apparatus for fluoroscopy includes: a dark-box main body enclosing a specimen and a fluoroscopy unit for illuminating the specimen with excitation light with a first spectral band and for detecting fluorescence with a second spectral band generated by the specimen; an illumination light source disposed in the dark-box main body to emit light with a third spectral band different from the first spectral band and the second spectral band; and an observation window disposed in the dark-box main body, the observation window being capable of transmitting light with a fourth spectral band which includes at least part of the third spectral band and does not include the first spectral band and the second spectral band.
摘要翻译：在荧光透视期间获取的荧光图像中的噪声被消除以呈现清晰的荧光图像，并且即使在进行荧光透视时也能够识别透视单元和样本之间的相对位置关系。用于荧光透视的暗盒装置包括：包围样本的暗盒主体和用于用具有第一光谱带的激发光照射样本并用于用由样本产生的第二光谱带检测荧光的荧光透视单元; 照明光源，其设置在所述暗盒主体内，以与所述第一光谱带和所述第二光谱带不同的第三光谱带发光; 以及设置在暗箱主体中的观察窗，所述观察窗能够透射具有包括所述第三光谱带的至少一部分的第四光谱带的光，并且不包括所述第一光谱带和所述第二光谱带。

4. 发明申请

US20080116395A1 Dark box apparatus for fluoroscopy, fluoroscopy system, and fluroscopy method 审中-公开
标题翻译：用于荧光透视，荧光透视系统和荧光法的暗盒装置
公开(公告)号：US20080116395A1
公开(公告)日：2008-05-22
申请号：US12005893
申请日：2007-12-27
申请人： Kei Tsuyuki , Kazuhiko Osa , Nobuyuki Nagasawa
发明人： Kei Tsuyuki , Kazuhiko Osa , Nobuyuki Nagasawa
IPC分类号： G01N21/00
CPC分类号： G01N21/6458 , G01N21/6456
摘要： Noise in a fluorescence image acquired during fluoroscopy is eliminated to present a clear fluorescence image, and the relative positional relationship between the fluoroscopy unit and the specimen can be recognized even while fluoroscopy is in progress. A dark box apparatus for fluoroscopy includes: a dark-box main body enclosing a specimen and a fluoroscopy unit for illuminating the specimen with excitation light with a first spectral band and for detecting fluorescence with a second spectral band generated by the specimen; an illumination light source disposed in the dark-box main body to emit light with a third spectral band different from the first spectral band and the second spectral band; and an observation window disposed in the dark-box main body, the observation window being capable of transmitting light with a fourth spectral band which includes at least part of the third spectral band and does not include the first spectral band and the second spectral band.
摘要翻译：在荧光透视期间获取的荧光图像中的噪声被消除以呈现清晰的荧光图像，并且即使在进行荧光透视时也能够识别透视单元和样本之间的相对位置关系。用于荧光透视的暗盒装置包括：包围样本的暗盒主体和用于用具有第一光谱带的激发光照射样本并用于用由样本产生的第二光谱带检测荧光的荧光透视单元; 照明光源，其设置在所述暗盒主体内，以与所述第一光谱带和所述第二光谱带不同的第三光谱带发光; 以及设置在暗箱主体中的观察窗，所述观察窗能够透射具有包括所述第三光谱带的至少一部分的第四光谱带的光，并且不包括所述第一光谱带和所述第二光谱带。

5. 发明授权

US07339667B2 Dark box apparatus for fluoroscopy, fluoroscopy system, and fluoroscopy method 有权
标题翻译：用于荧光透视，荧光透视系统和荧光透视法的暗盒装置
公开(公告)号：US07339667B2
公开(公告)日：2008-03-04
申请号：US11726885
申请日：2007-03-23
申请人： Kei Tsuyuki , Kazuhiko Osa , Nobuyuki Nagasawa
发明人： Kei Tsuyuki , Kazuhiko Osa , Nobuyuki Nagasawa
IPC分类号： G01N21/64
CPC分类号： G01N21/6458 , G01N21/6456
摘要： Noise in a fluorescence image acquired during fluoroscopy is eliminated to present a clear fluorescence image, and the relative positional relationship between the fluoroscopy unit and the specimen can be recognized even while fluoroscopy is in progress. A dark box apparatus for fluoroscopy includes: a dark-box main body enclosing a specimen and a fluoroscopy unit for illuminating the specimen with excitation light with a first spectral band and for detecting fluorescence with a second spectral band generated by the specimen; an illumination light source disposed in the dark-box main body to emit light with a third spectral band different from the first spectral band and the second spectral band; and an observation window disposed in the dark-box main body, the observation window being capable of transmitting light with a fourth spectral band which includes at least part of the third spectral band and does not include the first spectral band and the second spectral band.
摘要翻译：在荧光透视期间获取的荧光图像中的噪声被消除以呈现清晰的荧光图像，并且即使在进行荧光透视时也能够识别透视单元和样本之间的相对位置关系。用于荧光透视的暗盒装置包括：包围样本的暗盒主体和用于用具有第一光谱带的激发光照射样本并用于用由样本产生的第二光谱带检测荧光的荧光透视单元; 照明光源，其设置在所述暗盒主体内，以与所述第一光谱带和所述第二光谱带不同的第三光谱带发光; 以及设置在暗箱主体中的观察窗，所述观察窗能够透射具有包括所述第三光谱带的至少一部分的第四光谱带的光，并且不包括所述第一光谱带和所述第二光谱带。

6. 发明申请

US20070177142A1 Dark box apparatus for fluoroscopy, fluoroscopy system, and fluoroscopy method 有权
标题翻译：用于荧光透视，荧光透视系统和荧光透视法的暗盒装置
公开(公告)号：US20070177142A1
公开(公告)日：2007-08-02
申请号：US11726885
申请日：2007-03-23
申请人： Kei Tsuyuki , Kazuhiko Osa , Nobuyuki Nagasawa
发明人： Kei Tsuyuki , Kazuhiko Osa , Nobuyuki Nagasawa
IPC分类号： G01N21/64
CPC分类号： G01N21/6458 , G01N21/6456
摘要： Noise in a fluorescence image acquired during fluoroscopy is eliminated to present a clear fluorescence image, and the relative positional relationship between the fluoroscopy unit and the specimen can be recognized even while fluoroscopy is in progress. A dark box apparatus for fluoroscopy includes: a dark-box main body enclosing a specimen and a fluoroscopy unit for illuminating the specimen with excitation light with a first spectral band and for detecting fluorescence with a second spectral band generated by the specimen; an illumination light source disposed in the dark-box main body to emit light with a third spectral band different from the first spectral band and the second spectral band; and an observation window disposed in the dark-box main body, the observation window being capable of transmitting light with a fourth spectral band which includes at least part of the third spectral band and does not include the first spectral band and the second spectral band.
摘要翻译：在荧光透视期间获取的荧光图像中的噪声被消除以呈现清晰的荧光图像，并且即使在进行荧光透视时也能够识别透视单元和样本之间的相对位置关系。用于荧光透视的暗盒装置包括：包围样本的暗盒主体和用于用具有第一光谱带的激发光照射样本并用于用由样本产生的第二光谱带检测荧光的荧光透视单元; 照明光源，其设置在所述暗盒主体内，以与所述第一光谱带和所述第二光谱带不同的第三光谱带发光; 以及设置在暗箱主体中的观察窗，所述观察窗能够透射具有包括所述第三光谱带的至少一部分的第四光谱带的光，并且不包括所述第一光谱带和所述第二光谱带。

7. 发明授权

US07215426B2 Dark box apparatus for fluoroscopy, fluoroscopy system, and fluoroscopy method 有权
公开(公告)号：US07215426B2
公开(公告)日：2007-05-08
申请号：US11213906
申请日：2005-08-30
申请人： Kei Tsuyuki , Kazuhiko Osa , Nobuyuki Nagasawa
发明人： Kei Tsuyuki , Kazuhiko Osa , Nobuyuki Nagasawa
IPC分类号： G01N21/64
CPC分类号： G01N21/6458 , G01N21/6456
摘要： Noise in a fluorescence image acquired during fluoroscopy is eliminated to present a clear fluorescence image, and the relative positional relationship between the fluoroscopy unit and the specimen can be recognized even while fluoroscopy is in progress. A dark box apparatus for fluoroscopy includes: a dark-box main body enclosing a specimen and a fluoroscopy unit for illuminating the specimen with excitation light with a first spectral band and for detecting fluorescence with a second spectral band generated by the specimen; an illumination light source disposed in the dark-box main body to emit light with a third spectral band different from the first spectral band and the second spectral band; and an observation window disposed in the dark-box main body, the observation window being capable of transmitting light with a fourth spectral band which includes at least part of the third spectral band and does not include the first spectral band and the second spectral band.

8. 发明申请

US20070115543A1 Examination method and examination apparatus 审中-公开
标题翻译：检查方法和检查仪器
公开(公告)号：US20070115543A1
公开(公告)日：2007-05-24
申请号：US11651680
申请日：2007-01-09
申请人： Nobuyuki Nagasawa , Yasunori Makara , Hiroya Fukuyama , Yoshihisa Tanikawa
发明人： Nobuyuki Nagasawa , Yasunori Makara , Hiroya Fukuyama , Yoshihisa Tanikawa
IPC分类号： G02B21/00
CPC分类号： A61B5/0059 , A61B5/0064 , A61B5/6835 , A61B5/6844 , A61B5/6886 , A61B2503/40 , G02B21/0032 , G02B21/0076 , G02B21/16
摘要： An easily viewable examination image in which blurring occurring in an image is reduced without operating an examination optical system in real time matching the motion of a specimen is obtained. There is provided an examination method comprising, prior to examining an examination site of a specimen, acquiring an image of the specimen surface of an examination region including the examination site, over a predetermined time range; extracting a plurality of feature points by processing the acquired image of the specimen surface; calculating a motion trajectory for each of the extracted feature points over the time range; and disposing an optical axis of an examination optical system at a position where the motion trajectory of a feature point disposed in the examination site is minimized.
摘要翻译：获得其中在图像中发生模糊的轻松可见的检查图像，而不用实际地检查检体光学系统来匹配检体的运动。提供了一种检查方法，其包括在检查样本的检查部位之前，在预定时间范围内获取包括检查部位的检查区域的样本表面的图像; 通过处理获得的样本表面的图像来提取多个特征点; 在时间范围内计算每个提取的特征点的运动轨迹; 并且将检查光学系统的光轴布置在设置在检查部位的特征点的运动轨迹最小化的位置。

9. 发明申请

US20060193496A1 Examination method and examination-assisting tool 审中-公开
标题翻译：考试方法和考核辅助工具
公开(公告)号：US20060193496A1
公开(公告)日：2006-08-31
申请号：US11334708
申请日：2006-01-17
申请人： Nobuyuki Nagasawa , Yoshihisa Tanikawa
发明人： Nobuyuki Nagasawa , Yoshihisa Tanikawa
IPC分类号： G06K9/00
CPC分类号： G02B21/365 , G02B7/08 , G02B21/0012 , G02B21/244
摘要： The invention enables clear, low-blur examination images to be acquired without operating an examination optical system in real time to match the motion of a specimen. The invention provides an examination method comprising fixing an indicator member that is visible from outside to a surface of the specimen, which is disposed within an examination region of a microscope; acquiring a plurality of images of the surface of the specimen, including the indicator member, at predetermined time intervals; processing the plurality of acquired images to calculate a motion trajectory of the indicator member; and fixing an optical axis of an examination optical system at a position where the motion trajectory of the indicator portion at the examination site of the specimen is minimized, to carry out examination.
摘要翻译：本发明能够实现清晰，低模糊的检查图像，而不需要实时检查检查光学系统来匹配样本的运动。本发明提供了一种检查方法，包括将从外部可见的指示器构件固定到放置在显微镜检查区域内的样本表面; 以预定的时间间隔获取包括指示器构件的样本表面的多个图像; 处理多个获取的图像以计算指示器构件的运动轨迹; 将检查光学系统的光轴固定在试样的检查部位的指示部的运动轨迹最小的位置，进行检查。

10. 发明授权

US07804642B2 Scanning examination apparatus 有权
标题翻译：扫描检查仪
公开(公告)号：US07804642B2
公开(公告)日：2010-09-28
申请号：US11913833
申请日：2006-05-16
申请人： Nobuyuki Nagasawa , Masahiro Oba , Tetsuya Koike , Yoshihisa Tanikawa , Yujin Arai
发明人： Nobuyuki Nagasawa , Masahiro Oba , Tetsuya Koike , Yoshihisa Tanikawa , Yujin Arai
IPC分类号： G02B21/06
CPC分类号： G02B21/002 , G02B21/008 , G02B21/365
摘要： A scanning examination apparatus 1 is provided, the apparatus including a detachable objective lens 6 or 6′, a scanner 3 for two-dimensionally scanning light F from a specimen 100 focused by the objective lens 6 or 6′, a scanner control device 13 for controlling the operation of the scanner 3, and an optical detector 9 for detecting light scanned by the scanner 3, wherein the scanner control device 13 changes the scanning direction of the light F depending on an image formation mode of the light F at the objective lens 6 or 6′ which is attached.
摘要翻译：提供了一种扫描检查装置1，该装置包括一个可拆卸的物镜6或6'，用于从由物镜6或6'聚焦的样本100二维地扫描光F的扫描器3，用于控制扫描仪3的操作，以及用于检测由扫描器3扫描的光的光学检测器9，其中扫描仪控制装置13根据物镜上的光F的图像形成模式改变光F的扫描方向 6或6'。

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