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1. 发明授权

US08022205B2 Pyrimidine derivatives as PI3K inhibitor and use thereof 有权
标题翻译：嘧啶衍生物作为PI3K抑制剂及其用途
公开(公告)号：US08022205B2
公开(公告)日：2011-09-20
申请号：US12376039
申请日：2007-08-07
申请人： Nobuo Shimma , Hirosato Ebiike , Jun Ohwada , Hatsuo Kawada , Kenji Morikami , Mitsuaki Nakamura , Miyuki Yoshida , Nobuya Ishii , Masami Hasegawa , Shun Yamamoto , Kohei Koyama
发明人： Nobuo Shimma , Hirosato Ebiike , Jun Ohwada , Hatsuo Kawada , Kenji Morikami , Mitsuaki Nakamura , Miyuki Yoshida , Nobuya Ishii , Masami Hasegawa , Shun Yamamoto , Kohei Koyama
IPC分类号： C07D401/04 , C07D401/12 , C07D405/04 , C07D413/12
CPC分类号： C07D487/04
摘要： A drug is provided that is useful as a preventive or therapeutic for cancer as a result of having superior PI3K inhibitory effects as well as superior stability in the body and water-solubility.A compound, or pharmaceutically acceptable salt thereof, represented by formula (I): [wherein, X represents a single bond, etc.; Y represents a single bond, etc. (provided that X and Y are not simultaneously single bonds); Z represents a hydrogen atom, etc.; m represents an integer of 1 or 2; and R1 represents a cyclic substituent].
摘要翻译：由于具有优异的PI3K抑制作用以及在体内具有优异的稳定性和水溶性，因此提供了可用作癌症的预防或治疗剂的药物。由式（I）表示的化合物或其药学上可接受的盐：[其中，X表示单键等; Y表示单键等（X和Y不同时为单键）。 Z表示氢原子等; m表示1或2的整数; 并且R 1表示环状取代基]。

2. 发明申请

US20100069629A1 PYRIMIDINE DERIVATIVES AS PI3K INHIBITOR AND USE THEREOF 有权
标题翻译：吡嗪衍生物作为PI3K抑制剂及其用途
公开(公告)号：US20100069629A1
公开(公告)日：2010-03-18
申请号：US12376039
申请日：2007-08-07
申请人： Nobuo Shimma , Hirosato Ebiike , Jun Ohwada , Hatsuo Kawada , Kenji Morikami , Mitsuaki Nakamura , Miyuki Yoshida , Nobuya Ishii , Masami Hasegawa , Shun Yamamoto , Kohei Koyama
发明人： Nobuo Shimma , Hirosato Ebiike , Jun Ohwada , Hatsuo Kawada , Kenji Morikami , Mitsuaki Nakamura , Miyuki Yoshida , Nobuya Ishii , Masami Hasegawa , Shun Yamamoto , Kohei Koyama
IPC分类号： C07D413/14 , A61P35/00
CPC分类号： C07D487/04
摘要： A drug is provided that is useful as a preventive or therapeutic for cancer as a result of having superior PI3K inhibitory effects as well as superior stability in the body and water-solubility.A compound, or pharmaceutically acceptable salt thereof, represented by formula (I): [wherein, X represents a single bond, etc.; Y represents a single bond, etc. (provided that X and Y are not simultaneously single bonds); Z represents a hydrogen atom, etc.; m represents an integer of 1 or 2; and R1 represents a cyclic substituent].
摘要翻译：由于具有优异的PI3K抑制作用以及在体内具有优异的稳定性和水溶性，因此提供了可用作癌症的预防或治疗剂的药物。由式（I）表示的化合物或其药学上可接受的盐：[其中，X表示单键等; Y表示单键等（X和Y不同时为单键）。 Z表示氢原子等; m表示1或2的整数; 并且R 1表示环状取代基]。

3. 发明申请

US20110306615A1 NOVEL IMIDAZOLIDINE DERIVATIVE AND USE THEREOF 失效
公开(公告)号：US20110306615A1
公开(公告)日：2011-12-15
申请号：US11662289
申请日：2005-09-09
申请人： Kazutaka Tachibana , Haruhiko Sato , Masateru Ohta , Mitsuaki Nakamura , Takuya Shiraishi , Hitoshi Yoshino , Takashi Emura , Akie Honma , Etsuro Onuma , Hiromitsu Kawata , Kenji Taniguchi
发明人： Kazutaka Tachibana , Haruhiko Sato , Masateru Ohta , Mitsuaki Nakamura , Takuya Shiraishi , Hitoshi Yoshino , Takashi Emura , Akie Honma , Etsuro Onuma , Hiromitsu Kawata , Kenji Taniguchi
IPC分类号： A61K31/454 , C07D233/74 , C07D417/10 , C07D403/12 , C07D233/86 , C07D413/12 , A61K31/4166 , A61K31/428 , A61K31/496 , A61K31/4439 , A61K31/5377 , A61P35/00 , A61P13/08 , A61Q7/00 , A61P15/00 , A61P17/10 , C07D401/04
CPC分类号： C07D417/04 , C07D211/58 , C07D233/74 , C07D233/86 , C07D277/82 , C07D401/04
摘要： According to the present invention, a compound represented by formula (I): wherein Q is: A is a hydrogen atom, a halogen atom, —ORa or a C1-4 alkyl group which may be substituted by one or more halogen atoms; E is independently selected from a C1-6 alkyl group; m is selected from integers from 0 to 3; R2 and R3 are independently selected from a C1-6 alkyl group; X1 and X2 are independently selected from O and S; Y is selected from an arylene group and a divalent 5- or 6-membered monocyclic or 8- to 10-membered condensed heterocyclic group, wherein the arylene group and the heterocyclic group may be substituted by 1 to 3 substituents independently selected from E1; E1 is independently selected from a hydroxyl group, a halogen atom, a C1-4 alkyl group, a cyano group, a C1-4 alkoky group, a carbamoyl group, a C1-4 alkylcarbamoyl group, a di(C1-4 alkyl)carbamoyl group, an amino group, a C1-4 alkylamino group, a di(C1-4 alkylamino group, a sulfamoyl group, a C1-4 alkylsulfamoyl group and a di(C1-4 alkyl)sulfamoyl group; Z is —CON(—Ra)—, —CO—, —COO—, —NRa—C(═NH)NRb—, —NRa—C(═N—CN)NRb—, —N(—Ra)COO—, —C(═NH)—, —SO2—, —SO2N(—Ra)—, —SO2NR1—, —N(—Ra)CO—, —N(—Ra)CON(—Rb)—, —N(COR1)CO—, —N(—Ra)SO2—, —N(SO2R1)SO2—, —N(—Ra)— or —N(—Ra)SO2N(—Rb)—; R1 is independently a hydrogen atom, a hydroxyl group, a C1-6 alkyl group which may be substituted by one or more substituents, a heterocyclic group which may be substituted by one or more substituents, an aryl group which may be substituted by one or more substituents, a C3-8 cycloalkyl group which may be substituted by one or more substituents or a C3-8 cycloalkenyl group which may be substituted by one or more substituents, or a salt, prodrug or solvate thereof is provided. Furthermore, a pharmaceutical composition containing the compound, and the like are also provided.

4. 发明授权

US06292593B1 Image synthesizing device and method 失效
标题翻译：图像合成装置及方法
公开(公告)号：US06292593B1
公开(公告)日：2001-09-18
申请号：US09269031
申请日：1999-03-18
申请人： Kazuyuki Nako , Mitsuaki Nakamura , Masashi Hirosawa , Hiroshi Akagi , Yoshihiro Kitamura
发明人： Kazuyuki Nako , Mitsuaki Nakamura , Masashi Hirosawa , Hiroshi Akagi , Yoshihiro Kitamura
IPC分类号： G06K936
CPC分类号： G06T5/006 , G06T7/30 , H04N1/3876
摘要： A one-dimensional image synthesizing unit 3 images an subject, and produces a plurality of image-to-be-combined signals expressing images-to-be-combined having overlapped regions. A central processing unit 5 first obtains matching of images of the subject for each of adjacent images-to-be-combined for all image-to-be-combined signals by center and large block matching processes, and detects the deviations of overlapped regions from the obtained matching. Next, in a small block matching process, on the basis of the deviations of the overlapped regions, a plurality of reference blocks and search regions are made to correspond to each other and are set in the respective overlapped regions, and the deviations of the images of the subject are detected in a unit of each search region in more detail than the deviations detected by the large block matching process. Finally, each of the images-to-be-combined is partially geometrically deformed so as to cancel the deviation of the image of the subject, the reference block and the search block are made coincident with each other, and all image-to-be-combined signals are combined to superimpose the respective images-to-be-combined, so that combined image signals are obtained.
摘要翻译：一维图像合成单元3对被摄体进行成像，并且生成表示具有重叠区域的待组合图像的多个图像组合信号。中央处理单元5通过中心和大块匹配处理首先获得与待组合的所有图像信号相对应的每个相邻图像的对象的图像的匹配，并且检测重叠区域的偏差获得匹配。接下来，在小块匹配处理中，基于重叠区域的偏差，使多个参考块和搜索区域彼此对应并设置在各个重叠区域中，并且图像的偏差以与大块匹配处理检测到的偏差更详细地检测每个搜索区域的单位。最后，要组合的每个图像被部分地几何变形，以便消除被摄体的图像的偏差，使得参考块和搜索块彼此一致，并且所有图像将被组合的信号被组合以叠加要组合的各个图像，从而获得组合的图像信号。

5. 发明授权

US07246670B2 Work vehicle with hydrostatic steering system 有权
标题翻译：具有静液压转向系统的工作车辆
公开(公告)号：US07246670B2
公开(公告)日：2007-07-24
申请号：US11040594
申请日：2005-01-21
申请人： Kazuhiko Hayashi , Mitsuaki Nakamura
发明人： Kazuhiko Hayashi , Mitsuaki Nakamura
IPC分类号： B62D6/08
CPC分类号： F16H61/468 , B62D5/07 , B62D11/183 , E02F9/2235 , E02F9/225 , E02F9/2253 , E02F9/2296 , F16H61/431 , F16H61/433 , F16H2059/467
摘要： A work vehicle with a hydrostatic steering system is disclosed which is capable of performing optimum control of the absorption torque of a hydraulic pump according to running load; capable of preferentially ensuring turning performance and implement speed when running load is relatively low; and capable of ensuring desired turning performance even when running load is relatively high. To this end, a bulldozer with a hydrostatic steering system, wherein the power of a hydraulic motor driven by pressure oil fed from a hydraulic pump operated by an engine is transmitted to right and left crawler tracks through a differential steering means composed of planetary gear trains etc., is designed to control the absorption torque of the hydraulic pump according to the speed ratio of a torque converter calculated by a speed ratio operation unit.
摘要翻译：公开了一种具有静液压转向系统的工作车辆，其能够根据运行载荷对液压泵的吸收转矩进行最佳控制; 能够优先确保转向性能，运行负载时执行转速相对较低; 并且即使当运行负载相对较高时也能够确保期望的转向性能。为此，具有静液压转向系统的推土机，其中由从由发动机操作的液压泵供给的压力油驱动的液压马达的动力通过由行星齿轮系组成的差速转向装置传递到左右履带履带被设计成根据由变速比运算单元计算的变矩器的转速比来控制液压泵的吸收转矩。

6. 发明授权

US07018993B2 Antiandrogenic agent 失效
标题翻译：抗雄激素剂
公开(公告)号：US07018993B2
公开(公告)日：2006-03-28
申请号：US10312730
申请日：2001-07-02
申请人： Masateru Ohta , Nobuaki Kato , Mitsuaki Nakamura , Kazutaka Tachibana
发明人： Masateru Ohta , Nobuaki Kato , Mitsuaki Nakamura , Kazutaka Tachibana
IPC分类号： A61K31/56 , C07J1/00
CPC分类号： C07J41/0038 , A61K31/565 , C07J1/00 , C07J1/0022 , C07J41/00 , Y02P20/55
摘要： A compound pf general formula (I): wherein, for example, X1 and X2 independently represent a hydrogen atom. Ra represents a hydrogen atom or a protecting group for a hydroxyl group. Rb and Rc form an optionally protected —(C═O)— together with the 3-position carbon atom attached to Rb and Rc, and the broken line forms a single bond or double bond together with the solid line, or a pharmaceutically acceptable salt of the compound or a prodrug thereof.
摘要翻译：化合物pf通式（I）：其中，例如X 1和X 2独立地表示氢原子。 R a表示氢原子或羟基的保护基。 R b和R c形成任选保护的 - （CO） - 连接到R b和R b上的3位碳原子，并且虚线与实线一起形成单键或双键，或该化合物或其前药的药学上可接受的盐。

7. 发明申请

US20060018515A1 Biometric data collating apparatus, biometric data collating method and biometric data collating program product 审中-公开
标题翻译：生物特征数据整理设备，生物特征数据整理方法和生物特征数据整理程序产品
公开(公告)号：US20060018515A1
公开(公告)日：2006-01-26
申请号：US11169758
申请日：2005-06-30
申请人： Yasufumi Itoh , Manabu Yumoto , Manabu Onozaki , Mitsuaki Nakamura
发明人： Yasufumi Itoh , Manabu Yumoto , Manabu Onozaki , Mitsuaki Nakamura
IPC分类号： G06K9/00
CPC分类号： G06K9/6228 , G06K9/00087
摘要： In collation determination of an input biometric data and a plurality of reference data stored in advance, when a biometric data collating apparatus according to the invention determines that the reference data matching with the biometric data is present, the biometric data collating apparatus updates a current reference order ordidx of the reference data determined as matching data to Order[0] representing a leading place in a collation order table.
摘要翻译：在预先存储的输入生物体数据和多个参考数据的核对确定中，当根据本发明的生物统计数据对照装置确定存在与生物统计数据匹配的参考数据时，生物体数据对照装置更新当前参考将作为匹配数据确定的参考数据的顺序ordidx指定为排序规则表中的前导位置的Order [0]。

8. 发明授权

US5353686A Hydraulic circuit for four-position closed-center selector valve controlled by pressure proportional control valve 失效
标题翻译：用于压力比例控制阀控制的四位闭式中心选择阀液压回路
公开(公告)号：US5353686A
公开(公告)日：1994-10-11
申请号：US067785
申请日：1993-05-25
申请人： Mitsuaki Nakamura
发明人： Mitsuaki Nakamura
IPC分类号： E02F9/22 , E02F9/20 , F15B11/00 , F15B11/05 , F15B11/08 , F15B11/16 , F15B13/042 , F15B13/10 , F15B13/06
CPC分类号： E02F9/2004 , F15B13/0422 , Y10T137/86582 , Y10T137/87072
摘要： A hydraulic circuit, having a four-position closed-center valve (6) controlled by a proportional control valve (22), can facilitate the vertical position control and operating speed control of a blade with a simple structure, while providing that the floating condition of the blade can be precisely recognized by the position of a control lever (20a). The spool (41) of the four-position selector valve (6) has a "hold" position which is given by the closed-center position. Opposite ends of the spool (41) receive a pilot pressure from the pressure proportional control valve (22), one position being obtained by applying pilot pressure to a first end of the spool (41), and two positions being obtained by applying pilot pressure to the second end of the spool (41). One of the latter two positions is a "floating" position, while the other two positions are the "up" position and the "down" position. The control lever (20a) for the pressure proportional control valve (22) can have a detent device for fixing the control lever at the "floating" position.
摘要翻译：具有由比例控制阀（22）控制的四位置中心阀（6）的液压回路可以以简单的结构促进叶片的垂直位置控制和操作速度控制，同时提供浮动状态可以通过控制杆（20a）的位置精确地识别刀片。四位选择阀（6）的阀芯（41）具有由闭合中心位置给出的“保持”位置。阀芯（41）的相对端接受来自压力比例控制阀（22）的先导压力，通过向阀芯（41）的第一端施加先导压力而获得一个位置，并且通过施加先导压力到所述线轴（41）的第二端。后两个位置之一是“浮动”位置，而另外两个位置是“向上”位置和“向下”位置。用于压力比例控制阀（22）的控制杆（20a）可以具有用于将控制杆固定在“浮动”位置的制动装置。

9. 发明授权

US07502381B2 Network terminal, network system, method of controlling network terminal, and program 失效
标题翻译：网络终端，网络系统，网络终端控制方法和程序
公开(公告)号：US07502381B2
公开(公告)日：2009-03-10
申请号：US10814144
申请日：2004-04-01
申请人： Mitsuaki Nakamura
发明人： Mitsuaki Nakamura
IPC分类号： H04L12/54 , H04B7/212 , H04L12/403 , H04J3/00 , H04J3/06
CPC分类号： H04J3/0641 , H04B7/2678 , H04J3/0652 , H04W56/00 , H04W84/20
摘要： A network terminal of the present invention includes: a synchronization information frame receiving section for receiving a synchronization information frame from a master terminal; a network information managing section for maintaining the network by being synchronized with the synchronization information frame; a synchronization information frame missing detection section for detecting the missing of the synchronization information frame from the master terminal; a priority list storing section for storing a priority list which defines a synchronization information frame transmission start time in such a manner as to differentiate synchronization information frame transmission start times between the network terminals; and a synchronization information frame transmission section for, in a case where the network terminal acts as a new master terminal of the network system, periodically outputting a synchronization information frame, from the synchronization information frame transmission start time in accordance with the priority list, synchronization information frame transmitting section starting to output the synchronization information frame after the missing of the synchronization information frame is detected.
摘要翻译：本发明的网络终端包括：同步信息帧接收单元，用于从主终端接收同步信息帧; 网络信息管理部分，用于通过与所述同步信息帧同步来维护所述网络; 用于从所述主终端检测所述同步信息帧的丢失的同步信息帧缺失检测部分; 优先级列表存储部分，用于存储定义同步信息帧发送开始时间的优先级列表，以便区分网络终端之间的同步信息帧发送开始时间; 以及同步信息帧发送部，用于在网络终端作为网络系统的新的主终端的情况下，根据优先级列表从同步信息帧发送开始时间周期性地输出同步信息帧，同步在检测到同步信息帧的缺失之后开始输出同步信息帧的信息帧发送部。

10. 发明授权

US07271188B2 Imidazolidine derivatives 失效
标题翻译：咪唑烷衍生物
公开(公告)号：US07271188B2
公开(公告)日：2007-09-18
申请号：US10560281
申请日：2004-06-11
申请人： Kazutaka Tachibana , Haruhiko Sato , Masateru Ohta , Mitsuaki Nakamura , Takuya Shiraishi , Ikuhiro Imaoka , Hitoshi Yoshino , Masahiro Nagamuta , Hiromitsu Kawata
发明人： Kazutaka Tachibana , Haruhiko Sato , Masateru Ohta , Mitsuaki Nakamura , Takuya Shiraishi , Ikuhiro Imaoka , Hitoshi Yoshino , Masahiro Nagamuta , Hiromitsu Kawata
IPC分类号： A61K31/4166 , C07D233/86 , C07C311/03
CPC分类号： C07D233/86
摘要： The present invention provides a compound represented by formula (I):[Formula 1] wherein n is an integer selected from 1 to 20, and R1 and R2, which may be the same or different, each represent a hydrogen atom, or a linear or branched C1-C6 alkyl group, or a salt, a prodrug or a solvate thereof, as well as a drug, a pharmaceutical composition containing the compound, and the like.
摘要翻译：本发明提供由式（I）表示的化合物：[式1]其中n是选自1至20，R 1和R 2的整数，其中可以相同或不同，各自表示氢原子或直链或支链C 1 -C 6烷基，或其盐，前药或溶剂合物，以及药物，含有该化合物的药物组合物等。

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