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1. 发明授权

US06737425B1 N,N-substituted cyclic amine derivatives 失效
标题翻译： N，N-取代的环胺衍生物
公开(公告)号：US06737425B1
公开(公告)日：2004-05-18
申请号：US09743358
申请日：2001-01-29
申请人： Noboru Yamamoto , Makoto Komatsu , Yuichi Suzuki , Koki Kawano , Teiji Kimura , Koichi Ito , Satoshi Nagato , Yoshihiko Norimine , Tetsuhiro Niidome , Tetsuyuki Teramoto , Yoichi Iimura , Shinji Hatakeyama
发明人： Noboru Yamamoto , Makoto Komatsu , Yuichi Suzuki , Koki Kawano , Teiji Kimura , Koichi Ito , Satoshi Nagato , Yoshihiko Norimine , Tetsuhiro Niidome , Tetsuyuki Teramoto , Yoichi Iimura , Shinji Hatakeyama
IPC分类号： A61K31497
CPC分类号： C07D213/64 , C07D213/57 , C07D215/20 , C07D217/02 , C07D233/54 , C07D239/34 , C07D239/80 , C07D295/15 , C07D317/64 , C07D333/24 , C07D333/38
摘要： The invention provides an N,N-substituted cyclic amine compound represented by the following formula (VIII): wherein A represents an aryl group etc.; E represents a group represented by the formula —CO— or a group represented by the formula —CHOH—; G represents an oxygen atom etc.; J represents an aryl group which may be substituted; R1 represents a lower alkyl group etc.; Alk represents a linear or branched lower alkylene group; n, v, w, x and y are independent of each other and each represents 0 or 1; and p represents 2 or 3, or a pharmacologically acceptable salt thereof. The compound of the present invention or a salt thereof is effective to treat a disease against which calcium antagonism is effective. The disease may include acute ischemic stroke, cerebral apoplexy, cerebral infarction, head trauma, cerebral nerve cell death, Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, Huntington disease, cerebral circulatory metabolism disturbance, cerebral function disturbance, pain, spasm, schizophrenia, migraine, epilepsy, maniac-depressive psychosis, nerve degenerative diseases, cerebral ischemia, AIDS dementia complications, edema, anxiety disorder (generalized anxiety disorder) and diabetic neuropathy.
摘要翻译：本发明提供由下式（VIII）表示的N，N-取代的环胺化合物：其中A表示芳基等; E表示由式-CO-表示的基团或由式-CHOH-表示的基团; G表示氧原子等。 J表示可被取代的芳基; R 1表示低级烷基等。 Alk表示直链或支链低级亚烷基; n，v，w，x和y彼此独立，各自表示0或1; 和p表示2或3，或其药理学上可接受的盐。本发明的化合物或其盐可有效治疗钙拮抗作用有效的疾病。该疾病可能包括急性缺血性脑卒中，脑中风，脑梗塞，头部创伤，脑神经细胞死亡，阿尔茨海默病，帕金森病，肌萎缩性侧索硬化，亨廷顿病，脑循环代谢障碍，脑功能障碍，疼痛，痉挛，精神分裂症，偏头痛，癫痫，疯子抑郁精神病，神经退行性疾病，脑缺血，艾滋病痴呆并发症，水肿，焦虑症（广泛性焦虑症）和糖尿病性神经病变。

2. 发明授权

US06579881B2 Indoles 失效
标题翻译：吲哚
公开(公告)号：US06579881B2
公开(公告)日：2003-06-17
申请号：US09859517
申请日：2001-05-18
申请人： Noritaka Kitazawa , Kohshi Ueno , Keiko Takahashi , Teiji Kimura , Atsushi Sasaki , Koki Kawano , Tadashi Okabe , Makoto Komatsu , Manabu Matsunaga , Atsuhiko Kubota
发明人： Noritaka Kitazawa , Kohshi Ueno , Keiko Takahashi , Teiji Kimura , Atsushi Sasaki , Koki Kawano , Tadashi Okabe , Makoto Komatsu , Manabu Matsunaga , Atsuhiko Kubota
IPC分类号： A61K31435
CPC分类号： C07D231/12 , C07D211/26 , C07D211/74 , C07D217/04 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D491/04 , C07D513/04
摘要： A 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: wherein A, B, C, D, T, Y, and Z each represent a methine or a nitrogen linkage; R1, R2, R3, R4, and R5 each represent a substituent; n represents 0 or an integer of 1 to 3; m represents 0 or an integer of 1 to 6; and p represents an integer of 1 to 3. The compounds have serotonin antagonism. They are therefore clinically useful as medicaments, in particular, for treating, ameliorating, and preventing spastic paralysis. They are also useful as central muscle relaxants for ameliorating myotonia.
摘要翻译：由下式表示的1,4-取代环状胺衍生物或其药理学上可接受的盐：其中A，B，C，D，T，Y和Z各自表示次甲基或氮键; R1，R2，R3，R4和R5各自表示取代基; n表示0或1〜3的整数， m表示0或1〜6的整数， p表示1〜3的整数。这些化合物具有5-羟色胺拮抗作用。因此，它们在临床上可用作药物，特别是用于治疗，改善和预防痉挛性麻痹。它们也可用作改善肌强直的中枢肌肉松弛剂。

3. 发明授权

US07071201B2 Quinoline derivatives 失效
标题翻译：喹啉衍生物
公开(公告)号：US07071201B2
公开(公告)日：2006-07-04
申请号：US09846259
申请日：2001-05-02
申请人： Noritaka Kitazawa , Kohshi Ueno , Keiko Takahashi , Teiji Kimura , Atsushi Sasaki , Koki Kawano , Tadashi Okabe , Makoto Komatsu , Manabu Matsunaga , Atsuhiko Kubota
发明人： Noritaka Kitazawa , Kohshi Ueno , Keiko Takahashi , Teiji Kimura , Atsushi Sasaki , Koki Kawano , Tadashi Okabe , Makoto Komatsu , Manabu Matsunaga , Atsuhiko Kubota
IPC分类号： A61K31/435 , A61K31/55 , C07D211/68 , C07D401/00
CPC分类号： C07D231/12 , C07D211/26 , C07D211/74 , C07D217/04 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D491/04 , C07D513/04
摘要： A novel compound of the formula: wherein A, B, C, D, T, Y, and Z represent each methine or nitrogen; R1, R2, R3, R4, and R5 represent each a substituent; n represents 0 or an integer of 1 to 3; m represents 0 or an integer of 1 to 6; and p represents an integer of 1 to 3; and pharmacologically acceptable salts thereof. The compound has a serotonin antagonism and is clinically useful as medicament, in particular, for treating, ameliorating and preventing spastic paralysis or central muscle relaxants for ameliorating myotonia.
摘要翻译：下式的新化合物：其中A，B，C，D，T，Y和Z代表每个次甲基或氮; R 1，R 2，R 3，R 4和R 5，表示取代基; n表示0或1〜3的整数， m表示0或1〜6的整数， p表示1〜3的整数，及其药理学上可接受的盐。该化合物具有5-羟色胺拮抗作用，并且在临床上可用作药物，特别是用于治疗，改善和预防痉挛性麻痹或中枢肌肉松弛剂以改善肌强直。

4. 发明授权

US06448243B1 1,4-substituted cyclic amine derivatives 失效
标题翻译： 1,4-取代的环胺衍生物
公开(公告)号：US06448243B1
公开(公告)日：2002-09-10
申请号：US09367227
申请日：1999-08-11
申请人： Noritaka Kitazawa , Kohshi Ueno , Keiko Takahashi , Teiji Kimura , Atsushi Sasaki , Koki Kawano , Tadashi Okabe , Makoto Komatsu , Manabu Matsunaga , Atsuhiko Kubota
发明人： Noritaka Kitazawa , Kohshi Ueno , Keiko Takahashi , Teiji Kimura , Atsushi Sasaki , Koki Kawano , Tadashi Okabe , Makoto Komatsu , Manabu Matsunaga , Atsuhiko Kubota
IPC分类号： C07D40100
CPC分类号： C07D231/12 , C07D211/26 , C07D211/74 , C07D217/04 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D491/04 , C07D513/04
摘要： A novel 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: (wherein A, B, C, D, T, Y and Z represent each methine or nitrogen; R1, R2, R3, R4 and R5 represent each a substituent; n represents 0 or an integer of 1 to 3; m represents 0 or an integer of 1 to 6; and p represents an integer of 1 to 3.) The compound has a serotonin antagonism and is clinically useful as medicament, in particular, for treating, ameliorating and preventing spastic paralysis or central muscle relaxants for ameliorating myotonia.
摘要翻译：由下式表示的新的1,4-取代环胺衍生物或其药理学上可接受的盐：（其中A，B，C，D，T，Y和Z表示次甲基或氮; R1，R2，R3，R4 R5表示取代基，n表示0或1〜3的整数，m表示0或1〜6的整数，p表示1〜3的整数。）该化合物具有5-羟色胺拮抗作用，临床有用作为药物，特别是用于治疗，改善和预防痉挛性麻痹或用于改善肌强直的中枢肌肉松弛剂。

5. 发明授权

US06281214B1 Biphenyl derivatives 失效
标题翻译：联苯衍生物
公开(公告)号：US06281214B1
公开(公告)日：2001-08-28
申请号：US09166229
申请日：1998-10-05
申请人： Kozo Akasaka , Masahiro Yonaga , Akiharu Kajiwara , Kunizo Higurashi , Kohshi Ueno , Satoshi Nagato , Makoto Komatsu , Noritaka Kitazawa , Masataka Ueno , Yoshiharu Yamanishi , Yoshimasa Machida , Yuki Komatsu , Naoyuki Shimomura , Norio Minami , Toshikazu Shimizu , Atsushi Nagaoka
发明人： Kozo Akasaka , Masahiro Yonaga , Akiharu Kajiwara , Kunizo Higurashi , Kohshi Ueno , Satoshi Nagato , Makoto Komatsu , Noritaka Kitazawa , Masataka Ueno , Yoshiharu Yamanishi , Yoshimasa Machida , Yuki Komatsu , Naoyuki Shimomura , Norio Minami , Toshikazu Shimizu , Atsushi Nagaoka
IPC分类号： A61K31495
CPC分类号： C07D213/30 , C07C2601/02 , C07D213/26 , C07D213/38 , C07D213/50 , C07D213/70 , C07D295/02 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D295/205 , C07D295/26 , C07D307/14 , C07D307/52 , C07D319/06 , C07D339/08 , C07F7/1804
摘要： A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof: wherein R1, R2, R3, R4, and R5 are defined in the specification, is clinically useful for treating and ameliorating mental disorders such as cerebrovascular disorder, aggressive behavior due to senile dementia, mental excitation, poriomania, delirium, hallucination, hyperkinesia, schizophrenia, emotional disturbance, depression, neurosis, psychophysiologic disorder and anxiety neurosis. The compounds exhibit dopamine 2 receptor antagonism and/or serotonin 2 receptor antagonism.
摘要翻译：由下式（I）表示的联苯衍生物或其药理学上可接受的盐：其中R1，R2，R3，R4和R5在说明书中定义，在临床上可用于治疗和改善精神障碍如脑血管障碍，侵袭性老年性痴呆，精神激素，por妄症，del妄，幻觉，运动过度，精神分裂症，情绪障碍，抑郁症，神经症，心理生理障碍和焦虑神经症的行为。该化合物表现出多巴胺2受体拮抗作用和/或5-羟色胺2受体拮抗作用。

6. 发明授权

US5849912A Biphenyl derivatives 失效
标题翻译：联苯衍生物
公开(公告)号：US5849912A
公开(公告)日：1998-12-15
申请号：US855790
申请日：1997-05-12
申请人： Kozo Akasaka , Masahiro Yonaga , Akiharu Kajiwara , Kunizo Higurashi , Kohshi Ueno , Satoshi Nagato , Makoto Komatsu , Noritaka Kitazawa , Masataka Ueno , Yoshiharu Yamanishi , Yoshimasa Machida , Yuki Komatsu , Naoyuki Shimomura , Norio Minami , Toshikazu Shimizu , Atsushi Nagaoka
发明人： Kozo Akasaka , Masahiro Yonaga , Akiharu Kajiwara , Kunizo Higurashi , Kohshi Ueno , Satoshi Nagato , Makoto Komatsu , Noritaka Kitazawa , Masataka Ueno , Yoshiharu Yamanishi , Yoshimasa Machida , Yuki Komatsu , Naoyuki Shimomura , Norio Minami , Toshikazu Shimizu , Atsushi Nagaoka
IPC分类号： C07D295/03 , A61K31/495 , A61P25/18 , C07D213/26 , C07D213/30 , C07D213/38 , C07D213/50 , C07D213/70 , C07D295/02 , C07D295/04 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D295/205 , C07D295/26 , C07D307/14 , C07D307/52 , C07D319/06 , C07D339/08 , C07F7/18 , C07D401/06
CPC分类号： C07D213/30 , C07D213/26 , C07D213/38 , C07D213/50 , C07D213/70 , C07D295/02 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D295/205 , C07D295/26 , C07D307/14 , C07D307/52 , C07D319/06 , C07D339/08 , C07F7/1856 , C07C2101/02
摘要： A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are defined in the specification, is clinically useful for treating and ameliorating mental disorders such as cerebrovascular disorder, aggressive behavior due to senile dementia, mental excitation, poriomania, delirium, hallucination, hyperkinesia, schizophrenia, emotional disturbance, depression, neurosis, psychophysiologic disorder and anxiety neurosis. The compounds exhibit dopamine 2 receptor antagonism and/or serotonin 2 receptor antagonism.
摘要翻译：由下式（I）表示的联苯衍生物或其药学上可接受的盐：其中R 1，R 2，R 3，R 4和R 5在本说明书中定义，其在临床上可用于治疗和改善精神障碍脑血管障碍，老年性痴呆，精神激动，心脏虚弱，del妄，幻觉，运动过度，精神分裂症，情绪障碍，抑郁，神经症，心理生理障碍和焦虑神经症引起的侵略行为。该化合物表现出多巴胺2受体拮抗作用和/或5-羟色胺2受体拮抗作用。

7. 发明授权

US09285763B2 Cap, powder container, developer supply device, and image forming apparatus 有权
公开(公告)号：US09285763B2
公开(公告)日：2016-03-15
申请号：US14579963
申请日：2014-12-22
申请人： Makoto Komatsu , Tsukuru Kai , Tadashi Hayakawa , Hiroshi Hosokawa , Daichi Yamaguchi , Junichi Matsumoto
发明人： Makoto Komatsu , Tsukuru Kai , Tadashi Hayakawa , Hiroshi Hosokawa , Daichi Yamaguchi , Junichi Matsumoto
IPC分类号： G03G15/08 , G03G21/16
CPC分类号： G03G21/1676 , G03G15/0867 , G03G15/0868 , G03G15/0872 , G03G15/0877 , G03G15/0881 , G03G15/0886 , G03G2215/0668 , G03G2215/069 , Y10S222/01
摘要： A cap is configured to be attached to a developer container that discharges developer contained in the container body out of the container body through a discharge port defined in a portion of the container body. The cap includes a first attaching member and a second attaching member that are detachably assembled into one piece. When the first attaching member or the second attaching member receives a rotary force, the first attaching member and the second attaching member are separated from each other, and only the first attaching member is released from the container body.

8. 发明授权

US08886095B2 Powder container, powder supply device and image-forming apparatus 有权
标题翻译：粉末容器，粉末供给装置和成像装置
公开(公告)号：US08886095B2
公开(公告)日：2014-11-11
申请号：US13367534
申请日：2012-02-07
申请人： Makoto Komatsu , Tsukuru Kai , Hiroshi Hosokawa , Junichi Matsumoto , Tadashi Hayakawa
发明人： Makoto Komatsu , Tsukuru Kai , Hiroshi Hosokawa , Junichi Matsumoto , Tadashi Hayakawa
IPC分类号： G03G15/08
CPC分类号： G03G15/087
摘要： A powder container which is mounted on an image-forming apparatus body, and houses a powder includes a container body configured to carry the powder housed inside thereof from a first end side to a second end side by rotating, and discharge the powder outside from the second end side, a gear formed in an outer circumference of the container body, and a cover which is mounted on the gear to cover at least a tooth section of the gear.
摘要翻译：安装在图像形成装置主体上并容纳粉末的粉末容器包括：容器主体，其被配置为通过旋转从第一端侧向第二端侧承载容纳在其内的粉末，并将粉末从第二端侧，形成在容器主体的外周中的齿轮，以及安装在齿轮上以覆盖齿轮的至少齿部的盖。

9. 发明申请

US20140241741A1 CORRECTION CONTROL METHOD AND IMAGE FORMING APPARATUS 审中-公开
标题翻译：校正控制方法和图像形成装置
公开(公告)号：US20140241741A1
公开(公告)日：2014-08-28
申请号：US14167100
申请日：2014-01-29
申请人： Makoto Komatsu , Shinji Kato
发明人： Makoto Komatsu , Shinji Kato
IPC分类号： G03G15/00 , G03G15/16 , G03G15/08
CPC分类号： G03G15/0849 , G03G15/0853 , G03G21/203 , G03G2215/00126 , G03G2215/0129
摘要： A correction control method includes performing correction control to bring a control value to a target value or a change through a prediction control system that previously applies a predetermined amount of correction and a predetermined timing. The prediction control system is constructed without performing data offset processing for deriving the predetermined amount of correction and the predetermined timing.
摘要翻译：校正控制方法包括执行校正控制以通过预先应用预定量的校正和预定定时的预测控制系统将控制值带到目标值或变化。构建预测控制系统，而不进行用于导出预定量的校正和预定定时的数据偏移处理。

10. 发明申请

US20130272750A1 POWDER CONTAINER, POWDER SUPPLY DEVICE AND IMAGE FORMING APPARATUS 有权
标题翻译：粉末容器，粉末供应装置和图像形成装置
公开(公告)号：US20130272750A1
公开(公告)日：2013-10-17
申请号：US13991250
申请日：2011-12-02
申请人： Junichi Matsumoto , Tsukuru Kai , Hiroshi Hosokawa , Makoto Komatsu , Tadashi Hayakawa , Yuzuru Ozawa
发明人： Junichi Matsumoto , Tsukuru Kai , Hiroshi Hosokawa , Makoto Komatsu , Tadashi Hayakawa , Yuzuru Ozawa
IPC分类号： G03G15/08
CPC分类号： G03G15/0886 , G03G15/0832 , G03G15/0865 , G03G15/0872 , G03G15/0879 , G03G2215/0132
摘要： Provided is a powder container having a new structure capable of stable discharge and transport of a powder contained in a container by enabling the powder to be reliably discharged to the outside of the package while preventing the powder from spilling and flying out of the container. The powder container has a container body (138) for transporting powder contained therein from a first end side (138a) to a second end side (138b) thereof by self-rotating; a nozzle receiver (139) having a nozzle receiving hole (insertion section) (139a) arranged inside the second end side of the container body and configured to allow a transport nozzle (162) having a powder receiving inlet (170) to be inserted therein, and a supply port 139b arranged in at least a part of the nozzle receiver (139) and configured to supply the powder in the container body (138) to the powder receiving inlet (170): and a shutter (140) supported by the nozzle receiver 139 and configured to open and close the nozzle receiving hole (insertion section) 139a by sliding in response to insertion of the transport nozzle 162 into the nozzle receiver (139).
摘要翻译：本发明提供一种粉末容器，其具有通过使粉末能够可靠地排出到包装外部而能够稳定地排出和运送容器中的粉末的结构，同时防止粉末溢出并从容器中飞出。该粉末容器具有：容纳体，用于通过自转旋转从第一端侧（138a）向第二端侧（138b）输送其中所含的粉末; 喷嘴接收器（139），其具有布置在容器主体的第二端侧内侧的喷嘴接收孔（插入部）（139a），并且构造成允许具有粉末接收入口（170）的输送喷嘴（162）插入其中以及布置在喷嘴接收器（139）的至少一部分中并被配置为将粉末容纳在容器主体（138）中的粉末供应到粉末接收入口（170）的供应口139b，以及由所述容器主体喷嘴接收器139，并且构造成响应于将输送喷嘴162插入喷嘴接收器（139）而滑动来打开和关闭喷嘴接收孔（插入部）139a。

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