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2. 发明授权

US4514560A Aggregating polysaccharide derived from aureobacidium 失效
标题翻译：来自金黄色葡萄球菌的聚集多糖
公开(公告)号：US4514560A
公开(公告)日：1985-04-30
申请号：US353968
申请日：1982-03-02
申请人： Satoru Shinohara , Noboru Fujii , Kiyohisa Imada , Genichi Kadota , Hideo Ueno
发明人： Satoru Shinohara , Noboru Fujii , Kiyohisa Imada , Genichi Kadota , Hideo Ueno
IPC分类号： G01N31/00 , A23L29/00 , A23L29/20 , A23L29/269 , A61K31/715 , A61P1/12 , A61P7/00 , A61P35/00 , B01D21/01 , C08B37/00 , C12P19/04 , C12P19/26 , C12R1/645
CPC分类号： A61K31/715 , A23L29/271 , C12P19/04 , Y10S435/911
摘要： A polysaccharide contains D-glucose as main constitutive sugar according to gas chromatography carried out through methylation in accordance with the Hakomori's method; and hydrolysis and to paper chromatography carried out through acid hydrolysis shows G.sup.1 .fwdarw.:.fwdarw..sup.3 G.sup.1 .fwdarw.:.fwdarw..sup.3 G.sub.6.sup.1 .fwdarw.=0.38-0.43:0.14-0.24:0.38-0.43 in gas chromatographic mass spectrometry (GC-MS method); has the signal of C.sub.1 at 103 ppm as measured from a .sup.13 C-nuclear magnetic resonance spectrum; shows characteristic absorption at 1720 cm.sup.-1 -1760 cm.sup.-1 and 890 cm.sup.-1 in an infrared absorption spectrum; has number average molecular weight between 50,000 and 500,000 as measured by the osmotic pressure; has a specific rotation [.alpha.].sub.D.sup.25 between +20 and +70; consists 42.0 to 45.0% of carbon, 5.7 to 6.7% of hydrogen, 0 to 1.0% of nitrogen, 0.2 to 0.8% of ash content and the rest of oxygen according to the results of an elementary analysis; contains 4.0 to 6.0% of phosphoric acid in total as measured by a fluorescent X-ray analysis, the Allen's improved method, and the Deniges-Atkins method after carbonic acid melting; shows a color reaction of saccharides through an .alpha.-naphthol-sulfuric acid reaction, an indole-sulfuric acid reaction and a phenol-sulfuric acid reaction; is negative in a ninhydrin reaction, a carbazole-sulfuric acid reaction and an Elson-Morgan's reaction; is soluble in dimethyl sulfoxide (DMSO); swells well, though not readily soluble in water; and is insoluble in ethanol, pyridine, chloroform and other organic solvents.
摘要翻译：根据Hakomori方法通过甲基化进行的气相色谱法，多糖含有D-葡萄糖作为主要组成糖; 通过酸水解进行水解和纸层析，显示气相色谱质谱（GC-MS法）中的G1 - →3G11-> = 0.38-0.43：0.14-0.24：0.38-0.43。 ; 从13C核磁共振谱测得的信号为103ppm; 在红外吸收光谱中显示在1720cm-1-1760cm -1和890cm -1处的特征吸收; 通过渗透压测定的数均分子量在50,000和500,000之间; 具有+20和+70之间的特定旋转αD25; 根据元素分析的结果，含有42.0〜45.0％的碳，5.7〜6.7％的氢，0〜1.0％的氮，0.2〜0.8％的灰分和余量的氧; 通过荧光X射线分析，艾伦改进方法和碳酸溶解后的丹尼斯 - 阿特金斯法测定，总共含有4.0〜6.0％的磷酸; 通过α-萘酚 - 硫酸反应，吲哚 - 硫酸反应和苯酚 - 硫酸反应显示出糖的显色反应; 在茚三酮反应，咔唑 - 硫酸反应和Elson-Morgan反应中是负的; 可溶于二甲基亚砜（DMSO）; 溶胀好，虽然不易溶于水; 并且不溶于乙醇，吡啶，氯仿等有机溶剂。

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