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1. 发明申请

US20140275199A1 SUBSTITUTED 3-(BIPHENYL-3-YL)-4-HYDROXY-8-METHOXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONE 有权
标题翻译：取代的3-（联苯-3-基）-4-羟基-8-甲氧基-1-氮杂[4.5] DEC-3-EN-2-ONE
公开(公告)号：US20140275199A1
公开(公告)日：2014-09-18
申请号：US14236279
申请日：2012-07-31
申请人： Ningshu Liu , Kai Thede , Ursula Mönning , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Reiner Fischer
发明人： Ningshu Liu , Kai Thede , Ursula Mönning , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Reiner Fischer
IPC分类号： C07D209/54 , A61K31/403
CPC分类号： C07D209/54 , A61K31/403
摘要： The invention relates to substituted 3-(biphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-ones, in particular for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of neoplastic disorders.
摘要翻译：本发明涉及取代的3-（联苯-3-基）-4-羟基-8-甲氧基-1-氮杂螺[4.5]癸-3-烯-2-酮，特别是用于治疗目的，用于药物组合物，它们在治疗中的用途，特别是用于预防和治疗肿瘤性疾病。

2. 发明申请

US20140011853A1 SUBSTITUTED 3-(BIPHENYL-3-YL)-8,8-DIFLUORO-4-HYDROXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONES FOR THERAPY 有权
标题翻译：取代的3-（联苯-3-基）-8,8-二氟-4-羟基-1-氮杂[4.5] DEC-3-EN-2-ONES治疗
公开(公告)号：US20140011853A1
公开(公告)日：2014-01-09
申请号：US13985940
申请日：2012-02-14
申请人： Ningshu Liu , Kai Thede , Ursula Mönning , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Reiner Fischer
发明人： Ningshu Liu , Kai Thede , Ursula Mönning , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Reiner Fischer
IPC分类号： A61K31/403 , A61K45/06 , C07D209/54
CPC分类号： A01N43/38 , A01N43/12 , A61K31/403 , A61K45/06 , C07D209/54
摘要： The invention relates to substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones of the formula (Ia) for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of tumour disorders.The invention also relates to novel compounds of the formula (I) in which W, X, Y, Z, A, B, D and G have the meanings given above, to a plurality of processes and intermediates for their preparation, and to their use as pesticides and/or herbicides and/or fungicides. The invention also relates to selectively herbicidal compositions comprising, firstly, the halogen-substituted spirocyclic ketoenols and, secondly, a crop plant compatibility-improving compound.The present invention furthermore relates to the boosting of the action of crop protection compositions comprising, in particular, halogen-substituted spirocyclic ketoenols, through the addition of ammonium salts or phosphonium salts and optionally penetrants, to the corresponding compositions, to processes for producing them and to their application in crop protection as pesticides and/or fungicides and/or for preventing unwanted plant growth.
摘要翻译：为了治疗目的，本发明涉及式（Ia）的取代的3-（联苯-3-基）-8,8-二氟-4-羟基-1-氮杂螺[4.5]癸-3-烯-2-酮，药物组合物及其在治疗中的用途，特别是用于预防和治疗肿瘤病症。本发明还涉及其中W，X，Y，Z，A，B，D和G具有上述含义的式（I）的新化合物，涉及多种制备方法和中间体，以及它们用作农药和/或除草剂和/或杀真菌剂。本发明还涉及选择性除草组合物，其包含首先是卤素取代的螺环酮醇，其次是作物植物相容性改善化合物。本发明还涉及通过将铵盐或鏻盐和任选的渗透剂加入到相应的组合物中来增强作物保护组合物的作用，包括特别是卤素取代的螺环酮醇，用于生产它们的方法和在农作物保护中作为农药和/或杀真菌剂的应用和/或用于防止不期望的植物生长。

3. 发明授权

US09278925B2 Substituted 3-(biphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one 有权
标题翻译：取代的3-（联苯-3-基）-4-羟基-8-甲氧基-1-氮杂螺[4.5]癸-3-烯-2-酮
公开(公告)号：US09278925B2
公开(公告)日：2016-03-08
申请号：US14236279
申请日：2012-07-31
申请人： Ningshu Liu , Kai Thede , Ursula Mönning , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Reiner Fischer
发明人： Ningshu Liu , Kai Thede , Ursula Mönning , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Reiner Fischer
IPC分类号： C07D207/18 , C07D209/54 , A61K31/403
CPC分类号： C07D209/54 , A61K31/403
摘要： The invention relates to substituted 3-(biphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-ones, in particular for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of neoplastic disorders.
摘要翻译：本发明涉及取代的3-（联苯-3-基）-4-羟基-8-甲氧基-1-氮杂螺[4.5]癸-3-烯-2-酮，特别是用于治疗目的，用于药物组合物，它们在治疗中的用途，特别是用于预防和治疗肿瘤性疾病。

4. 发明授权

US09000026B2 Substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones for therapy 有权
标题翻译：取代3-（联苯-3-基）-8,8-二氟-4-羟基-1-氮杂螺[4.5]癸-3-烯-2-酮治疗
公开(公告)号：US09000026B2
公开(公告)日：2015-04-07
申请号：US13985940
申请日：2012-02-14
申请人： Ningshu Liu , Kai Thede , Ursula Mönning , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Reiner Fischer
发明人： Ningshu Liu , Kai Thede , Ursula Mönning , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Reiner Fischer
IPC分类号： A61K31/4015 , C07D209/54 , A01N43/38 , A61K31/403 , A61K45/06 , A01N43/12
CPC分类号： A01N43/38 , A01N43/12 , A61K31/403 , A61K45/06 , C07D209/54
摘要： The invention relates to substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones of the formula (Ia) for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of tumor disorders.The invention also relates to novel compounds of the formula (I) in which W, X, Y, Z, A, B, D and G have the meanings given above, to a plurality of processes and intermediates for their preparation, and to their use as pesticides and/or herbicides and/or fungicides. The invention also relates to selectively herbicidal compositions comprising, firstly, the halogen-substituted spirocyclic ketoenols and, secondly, a crop plant compatibility-improving compound.The present invention furthermore relates to the boosting of the action of crop protection compositions comprising, in particular, halogen-substituted spirocyclic ketoenols, through the addition of ammonium salts or phosphonium salts and optionally penetrants, to the corresponding compositions, to processes for producing them and to their application in crop protection as pesticides and/or fungicides and/or for preventing unwanted plant growth.
摘要翻译：为了治疗目的，本发明涉及式（Ia）的取代的3-（联苯-3-基）-8,8-二氟-4-羟基-1-氮杂螺[4.5]癸-3-烯-2-酮，药物组合物及其在治疗中的用途，特别是用于预防和治疗肿瘤病症。本发明还涉及其中W，X，Y，Z，A，B，D和G具有上述含义的式（I）的新化合物，涉及多种制备方法和中间体，以及它们用作农药和/或除草剂和/或杀真菌剂。本发明还涉及选择性除草组合物，其包含首先是卤素取代的螺环酮醇，其次是作物植物相容性改善化合物。本发明还涉及通过将铵盐或鏻盐和任选的渗透剂加入到相应的组合物中来增强作物保护组合物的作用，包括特别是卤素取代的螺环酮醇，制备它们的方法和在农作物保护中作为农药和/或杀真菌剂的应用和/或用于防止不期望的植物生长。

5. 发明授权

US09212140B2 (5s,8s)-3-(4′-chlor-3′-fluor-4-methlybiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5] dec-3-en-2-one (compound A) for treatment 有权
标题翻译：（5s，8s）-3-（4'-氯-3'-氟-4-甲基联苯-3-基）-4-羟基-8-甲氧基-1-氮杂螺[4.5]癸-3-烯-2-酮一（化合物A）用于治疗
公开(公告)号：US09212140B2
公开(公告)日：2015-12-15
申请号：US13983165
申请日：2012-02-03
申请人： Ningshu Liu , Kai Thede , Philip Lienau , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Maher Najjar , Knut Eis , Reiner Fischer , Wahed Ahmed Moradi
发明人： Ningshu Liu , Kai Thede , Philip Lienau , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Maher Najjar , Knut Eis , Reiner Fischer , Wahed Ahmed Moradi
IPC分类号： A61K31/4015 , A61K31/403 , A61K45/06 , A01N43/12 , A01N43/38 , C07D209/54
CPC分类号： C07D209/54 , A61K31/4015 , A61K45/06
摘要： The invention relates to (5s,8s)-3-(4′-chloro-3′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of tumour disorders.
摘要翻译：本发明涉及（5s，8s）-3-（4'-氯-3'-氟-4-甲基联苯-3-基）-4-羟基-8-甲氧基-1-氮杂螺[4.5] en-2-one用于治疗目的，用于药物组合物及其在治疗中的用途，特别是用于预防和治疗肿瘤病症。

6. 发明申请

US20140031407A1 (5S,8S)-3-(4'-CHLOR-3'-FLUOR-4-METHLYBIPHENYL-3-YL)-4-HYDROXY-8-METHOXY-1-AZASPIRO[4.5]DEC-3-EN-2-ONE (COMPOUND A) FOR TREATMENT 有权
标题翻译：（5S，8S）-3-（4'-氯-3'-氟-4-甲基联苯-3-基）-4-羟基-8-甲氧基-1-氮杂[4.5] DEC-3-EN- 一（化合物A）治疗
公开(公告)号：US20140031407A1
公开(公告)日：2014-01-30
申请号：US13983165
申请日：2012-02-03
申请人： Ningshu Liu , Kai Thede , Philip Lienau , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Maher Najjar , Knut Eis , Reiner Fischer , Wahed Ahmed Moradi
发明人： Ningshu Liu , Kai Thede , Philip Lienau , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Maher Najjar , Knut Eis , Reiner Fischer , Wahed Ahmed Moradi
IPC分类号： C07D209/54
CPC分类号： C07D209/54 , A61K31/4015 , A61K45/06
摘要： The invention relates to (5s,8s)-3-(4′-chloro-3′-fluoro-4-methylbiphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of tumour disorders.
摘要翻译：本发明涉及（5s，8s）-3-（4'-氯-3'-氟-4-甲基联苯-3-基）-4-羟基-8-甲氧基-1-氮杂螺[4.5] en-2-one用于治疗目的，用于药物组合物及其在治疗中的用途，特别是用于预防和治疗肿瘤病症。

7. 发明申请

US20130040935A1 CYCLIC KETO-ENOLS FOR THERAPY 审中-公开
标题翻译：循环治疗方法
公开(公告)号：US20130040935A1
公开(公告)日：2013-02-14
申请号：US13578914
申请日：2011-02-08
申请人： Ningshu Liu , Kai Thede , Philip Lienau , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Maher Najjar , Knut Eis , Reiner Fischer , Wahed Ahmed Moradi
发明人： Ningshu Liu , Kai Thede , Philip Lienau , Arne Scholz , Christoph-Stephan Hilger , Ulf Bömer , Maher Najjar , Knut Eis , Reiner Fischer , Wahed Ahmed Moradi
IPC分类号： A61K31/4015 , C07D209/54 , C07D207/38 , C07D513/04 , C07D209/96 , C07D491/113 , C07D307/94 , C07D307/33 , C07D498/04 , A61K31/407 , A61K31/403 , A61K31/542 , A61K31/365 , A61K31/382 , A61K31/553 , A61P35/00 , C07D491/107
CPC分类号： C07D493/10 , C07D207/38 , C07D209/54 , C07D513/04
摘要： The invention relates to 5′-biphenyl-substituted cyclic ketoenols for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of tumour disorders.
摘要翻译：本发明涉及用于治疗目的的5'-联苯取代的环酮醇酯，药物组合物及其在治疗中的用途，特别是用于预防和治疗肿瘤病症。

8. 发明申请

US20120129833A1 CYCLIC KETOENOLS FOR THERAPY 审中-公开
标题翻译：环孢素治疗药物
公开(公告)号：US20120129833A1
公开(公告)日：2012-05-24
申请号：US13213436
申请日：2011-08-19
申请人： Ningshu LIU , Kai Thede , Philip Lienau , Arne Scholz , Maher Najjar , Ulf Bomer , Knut Eis , Reiner Fischer
发明人： Ningshu LIU , Kai Thede , Philip Lienau , Arne Scholz , Maher Najjar , Ulf Bomer , Knut Eis , Reiner Fischer
IPC分类号： A61K31/553 , A61K31/407 , A61P3/04 , A61P3/10 , A61P3/06 , A61P1/16 , A61P9/00 , C07D209/54 , A61K31/403 , C07D207/38 , A61K31/4015 , C07D491/113 , C07D307/94 , A61K31/365 , C07D493/10 , C07D487/04 , A61K31/5025 , C07D498/04 , A61K31/4162 , C07D231/34 , A61K31/4152 , C07D221/20 , A61K31/438 , C07D491/107
CPC分类号： C07D207/38 , C07D209/54 , C07D221/20 , C07D231/34 , C07D307/94 , C07D487/04 , C07D491/107 , C07D491/113 , C07D498/04
摘要： The invention relates to 5′-biphenyl-substituted cyclic ketoenols for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of diabetes, obesity, hyperlipidaemia, fatty livers and of disorders of the cardiovascular system.
摘要翻译：本发明涉及用于治疗目的的5'-联苯取代的环酮酮醇，药物组合物及其在治疗中的用途，特别是用于预防和治疗糖尿病，肥胖症，高脂血症，脂肪肝和心血管系统疾病。

9. 发明授权

US09809542B2 Spiroheterocyclically substituted tetramic acid derivatives 有权
公开(公告)号：US09809542B2
公开(公告)日：2017-11-07
申请号：US13024969
申请日：2011-02-10
申请人： Reiner Fischer , Arnd Voerste , Isolde Häuser-Hahn , Stefan Lehr , Elmar Gatzweiler , Ulrich Görgens , Ines Heinemann
发明人： Reiner Fischer , Arnd Voerste , Isolde Häuser-Hahn , Stefan Lehr , Elmar Gatzweiler , Ulrich Görgens , Ines Heinemann
IPC分类号： C07D211/94 , C07D471/10
CPC分类号： C07D211/94 , C07D471/10
摘要： The invention relates to novel compounds of the formula (I) in which W, X, Y, Z, A and G have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides and/or fungicides. Moreover, the invention relates to selectively herbicidal compositions comprising, firstly, the spiroheterocyclically substituted tetramic acid derivatives and, secondly, a crop plant compatibility-improving compound.The present invention furthermore relates to the boosting of the action of crop protection compositions comprising in particular spiroheterocyclically substituted tetramic acid derivatives through the addition of ammonium or phosphonium salts and optionally penetrants, to the corresponding compositions, to processes for their preparation and to their use in crop protection as insecticides and/or acaricides and/or fungicides and/or for preventing unwanted vegetation.

10. 发明授权

US09259003B2 Insecticides based on neonicotinoids and safeners 有权
标题翻译：基于新烟碱类和安全剂的杀虫剂
公开(公告)号：US09259003B2
公开(公告)日：2016-02-16
申请号：US11632184
申请日：2005-07-18
申请人： Reiner Fischer , Wolfram Andersch , Heike Hungenberg , Wolfgang Thielert , Lothar Willms
发明人： Reiner Fischer , Wolfram Andersch , Heike Hungenberg , Wolfgang Thielert , Lothar Willms
IPC分类号： A01N25/34 , A01N43/40 , A01N43/78 , A01P7/00 , A01N43/88 , A01N43/08 , A01N47/40 , A01N51/00
CPC分类号： A01N47/40 , A01N51/00 , A01N25/32 , A01N41/06 , A01N43/56 , A01N43/80 , A01N2300/00
摘要： Insecticidal compositions, characterized by an effective amount of a combination of active compounds comprising (a) at least one compound of the formula (I) in which Het, A, R and X are as defined in the description, and (b) at least one crop plant compatibility-improving compound from the group of compounds listed in the description, which are used for controlling arthropods, and also methods for controlling arthropods by treating plants and their seed with the compositions.
摘要翻译：杀虫组合物的特征在于有效量的活性化合物的组合，其包含（a）至少一种式（I）化合物，其中Het，A，R和X如说明书中所定义，和（b）至少用于控制节肢动物的描述中列出的化合物组的一种作物植物相容性改善化合物，以及通过用组合物处理植物及其种子来控制节肢动物的方法。

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