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1. 发明授权

US06456901B1 Hybrid robot motion task level control system 有权
标题翻译：混合机器人运动任务级控制系统
公开(公告)号：US06456901B1
公开(公告)日：2002-09-24
申请号：US09838894
申请日：2001-04-20
申请人： Ning Xi , Jindong Tan
发明人： Ning Xi , Jindong Tan
IPC分类号： G06F1900
CPC分类号： B25J9/1607
摘要： A hybrid control system is provided for controlling the movement of a robot. The hybrid control system includes a singularity detector; a task level controller that receives a motion plan and determines a first set of control commands which are defined in a task space; and a joint level controller that receives the motion plan and determines a second set of control commands which are defined in a joint space. The singularity detector monitors the movement of the robot and detects robot movement in a region about a singularity configuration. When robot movement occurs outside of this region, the task level controller is operable to issue the first set of control commands to the robot. When the robot movement occurs inside of this region, the joint level controller is operable to issue the second set of control commands to the robot. In this way, the hybrid control system ensures feasible robot motion in the neighborhood of and at kinematic singularity configuration.
摘要翻译：提供了一种用于控制机器人运动的混合控制系统。混合控制系统包括奇点检测器; 任务级别控制器，其接收运动计划并确定在任务空间中定义的第一组控制命令; 以及联合级别控制器，其接收运动计划并确定在联合空间中限定的第二组控制命令。奇点检测器监视机器人的运动并检测机器人在关于奇异构型的区域中的运动。当机器人移动发生在该区域之外时，任务级别控制器可操作以向机器人发出第一组控制命令。当机器人移动发生在该区域内时，联合液位控制器可操作以向机器人发出第二组控制命令。以这种方式，混合控制系统确保在运动学奇异性配置附近和运动学上的可行机器人运动。

2. 发明授权

US09573953B2 Heteroaromatic compounds as PI3 kinase modulators and methods of use 有权
标题翻译：杂环化合物作为PI3激酶调节剂和使用方法
公开(公告)号：US09573953B2
公开(公告)日：2017-02-21
申请号：US14181670
申请日：2014-02-15
申请人： Ning Xi
发明人： Ning Xi
IPC分类号： C07D487/04 , C07D471/04 , A61K31/444 , A61K45/06 , A61K31/519
CPC分类号： C07D487/04 , A61K31/444 , A61K31/4545 , A61K31/519 , A61K45/06 , C07D471/04 , A61K2300/00
摘要： The present invention provides heteroaromatic derivatives and pharmaceutical acceptable salts and formulations thereof useful in modulating the protein kinase activity, especially phosphatidylinositol 3-kinases (PI3 kinases) and mTOR, and in modulating inter- and/or intra-cellular signaling activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
摘要翻译：本发明提供了可用于调节蛋白激酶活性的杂芳族衍生物及其药学上可接受的盐和制剂，特别是磷脂酰肌醇3-激酶（PI3激酶）和mTOR，以及调节细胞间和/或细胞内信号活动如增殖，分化，凋亡，迁移和侵袭。本发明还提供包含这些化合物的药学上可接受的组合物和使用该组合物治疗哺乳动物，特别是人类中过度增殖性疾病的方法。

3. 发明申请

US20130282174A1 JUMPING ROBOT 有权
标题翻译：摔跤机器人
公开(公告)号：US20130282174A1
公开(公告)日：2013-10-24
申请号：US13832284
申请日：2013-03-15
申请人： Ning Xi , Jianguo Zhao , Bingtuan Gao , Jing Xu , Matt Mutka , Li Xiao
发明人： Ning Xi , Jianguo Zhao , Bingtuan Gao , Jing Xu , Matt Mutka , Li Xiao
IPC分类号： B25J9/16
CPC分类号： B25J9/1682 , B25J9/104 , Y10S901/01
摘要： A jumping robot is provided. In another aspect, a jumping robot weighs less than 50 grams, jumps at least 20 cm high and has a maximum linear dimension of 10 cm. A further aspect provides a robot that employs an electromagnetic actuator that actuates at least two of: jumping, steering, self-righting, and/or mid-air orientation control.
摘要翻译：提供跳跃机器人。在另一方面，跳跃机器人重量小于50克，跳跃至少20厘米高，最大直线尺寸为10厘米。另一方面提供了一种使用致动器的电磁致动器的机器人，其致动：跳跃，转向，自对准和/或空中取向控制中的至少两个。

4. 发明授权

US08476434B2 Protein kinase modulators and method of use 有权
标题翻译：蛋白激酶调节剂及其使用方法
公开(公告)号：US08476434B2
公开(公告)日：2013-07-02
申请号：US12952156
申请日：2010-11-22
申请人： Stephanie D. Geuns-Meyer , Brian L. Hodous , Stuart C. Chaffee , Paul Tempest , Ning Xi , Phillip R. Olivieri , Joseph L. Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Brian K. Albrecht , Vinod F. Patel , Victor J. Cee , Karina Romero , Hanh Nho Nguyen , Holly L. Deak , Rebecca E. Johnson
发明人： Stephanie D. Geuns-Meyer , Brian L. Hodous , Stuart C. Chaffee , Paul Tempest , Ning Xi , Phillip R. Olivieri , Joseph L. Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Brian K. Albrecht , Vinod F. Patel , Victor J. Cee , Karina Romero , Hanh Nho Nguyen , Holly L. Deak , Rebecca E. Johnson
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , A61K31/4427 , A61K31/506 , A61K31/54 , A61P19/02 , A61P35/00
CPC分类号： C07D213/73 , C07D239/42 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D471/04
摘要： The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other proliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.
摘要翻译：本发明涉及具有通式I的化合物，其中A，B，D，E，G，H1-5和R1-4在本文中定义，以及能够调节各种蛋白激酶受体酶的合成中间体，从而影响与这些激酶的活性相关的各种疾病状态和状况。例如，化合物能够调节激酶，从而影响血管发生过程并治疗血管生成相关疾病和其它增殖性疾病，包括癌症和炎症。本发明还包括药物组合物，包括该化合物，以及治疗与蛋白激酶活性有关的疾病状态的方法。

5. 发明授权

US08426585B2 Compounds comprising a spiro-ring 有权
标题翻译：包含螺环的化合物
公开(公告)号：US08426585B2
公开(公告)日：2013-04-23
申请号：US13587936
申请日：2012-08-17
申请人： Ning Xi
发明人： Ning Xi
IPC分类号： A61P35/04 , C07D403/14 , C07D413/14 , C07D471/04
CPC分类号： A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D471/04 , C07D491/107 , C07D493/10 , C07D495/04 , C07D498/04 , C07D519/00
摘要： The present invention provides novel compounds useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
摘要翻译：本发明提供了可用于调节蛋白酪氨酸激酶活性和调节细胞间和/或细胞内信号传导的新化合物。本发明还提供包含这些化合物的药学上可接受的组合物和使用该组合物治疗哺乳动物，特别是人类中过度增殖性疾病的方法。

6. 发明申请

US20120315247A1 COMPOUNDS COMPRISING A SPIRO-RING AND METHODS OF USE 有权
标题翻译：包含螺旋环的化合物及其使用方法
公开(公告)号：US20120315247A1
公开(公告)日：2012-12-13
申请号：US13587936
申请日：2012-08-17
申请人： Ning Xi
发明人： Ning Xi
IPC分类号： A61K31/4709 , C07D401/12 , A61K31/704 , A61K31/664 , A61K31/573 , A61K31/7048 , A61K31/513 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K38/21 , A61K31/4745 , A61K39/395 , A61K31/4995 , A61P35/00 , A61P9/10 , A61P35/04 , C12N9/99 , C07D401/14
CPC分类号： A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D471/04 , C07D491/107 , C07D493/10 , C07D495/04 , C07D498/04 , C07D519/00
摘要： The present invention provides novel compounds useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
摘要翻译：本发明提供了可用于调节蛋白酪氨酸激酶活性和调节细胞间和/或细胞内信号传导的新化合物。本发明还提供包含这些化合物的药学上可接受的组合物和使用该组合物治疗哺乳动物，特别是人类中过度增殖性疾病的方法。

7. 发明授权

US08232294B2 Amino ester derivatives, sailts thereof and methods of use 有权
标题翻译：氨基酯衍生物，帆船及使用方法
公开(公告)号：US08232294B2
公开(公告)日：2012-07-31
申请号：US12728153
申请日：2010-03-19
申请人： Ning Xi
发明人： Ning Xi
IPC分类号： C07D215/38 , A61K31/04
CPC分类号： C07D215/20 , A61K31/4709 , A61K31/573 , A61K31/661 , A61K31/704 , A61K31/708 , A61K39/395 , A61K45/06 , C07D209/54 , C07D215/22 , C07D401/12 , C07D401/14 , C07D405/14 , C07K16/18 , A61K2300/00
摘要： The present invention provides amino ester compounds, salts, and pharmaceutical formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
摘要翻译：本发明提供用于调节蛋白酪氨酸激酶活性以及调节细胞间和/或细胞内信号传导的氨基酯化合物，其盐和药物制剂。本发明还提供包含这些化合物的药学上可接受的组合物和使用该组合物治疗哺乳动物，特别是人类中过度增殖性疾病的方法。

8. 发明申请

US20120148531A1 FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE 有权
标题翻译：熔融杂环衍生物及其使用方法
公开(公告)号：US20120148531A1
公开(公告)日：2012-06-14
申请号：US13309488
申请日：2011-12-01
申请人： Brian K. ALBRECHT , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
发明人： Brian K. ALBRECHT , David Bauer , Steven Bellon , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Randall W. Hungate , Tae-Seong Kim , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie Springer , Markian Stec , Ning Xi , Kevin Yang
IPC分类号： A61K31/5025 , A61K31/5377 , A61K38/21 , A61P35/00 , A61P35/04 , C07D487/04 , A61K31/538
CPC分类号： A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

9. 发明申请

US20120065185A1 SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE 有权
标题翻译：取代的烷基胺衍生物及其使用方法
公开(公告)号：US20120065185A1
公开(公告)日：2012-03-15
申请号：US13297213
申请日：2011-11-15
申请人： Guoqing CHEN , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph L. Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan
发明人： Guoqing CHEN , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph L. Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan
IPC分类号： A61K31/4436 , A61K31/4709 , A61K31/4725 , A61P3/00 , A61P7/00 , A61P35/00 , A61P31/00 , A61K31/444 , A61K31/5377
CPC分类号： C07D213/82 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/538 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/00 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like.
摘要翻译：所选择的杂环化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。本发明包括新型化合物，类似物，前药及其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。

10. 发明授权

US08088794B2 Substituted amide derivatives and methods of use 有权
标题翻译：取代的酰胺衍生物和使用方法
公开(公告)号：US08088794B2
公开(公告)日：2012-01-03
申请号：US12945575
申请日：2010-11-12
申请人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
发明人： Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
IPC分类号： A61K31/47 , C07D453/02
CPC分类号： C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

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