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1. 发明申请

US20070142325A1 Starch 审中-公开
标题翻译：淀粉
公开(公告)号：US20070142325A1
公开(公告)日：2007-06-21
申请号：US11701612
申请日：2007-02-02
申请人： Nils Gustavsson , Monica Jonsson , Per Berden , Timo Laakso , Mats Reslow
发明人： Nils Gustavsson , Monica Jonsson , Per Berden , Timo Laakso , Mats Reslow
IPC分类号： A61K31/718 , C08B31/00
CPC分类号： A61K31/718 , C08B30/04 , C08B30/14
摘要： Production of purified, parenterally administrable starch by washing starch containing more than 85% amylopectin in order to remove surface-localized proteins, lipids and endotoxins, subjecting the starch to a molecular weight reduction by acid hydrolysis, and optionally removing residual water-soluble proteins. Purified starch and microparticles based on such starch.
摘要翻译：通过洗涤含有超过85％的支链淀粉的淀粉来制备纯化的，肠胃外可施用的淀粉，以去除表面定位的蛋白质，脂质和内毒素，通过酸水解使淀粉进行分子量降低，并任选地除去残留的水溶性蛋白质。基于这种淀粉的纯化淀粉和微粒。

2. 发明申请

US20070122484A1 Parenterally administrable microparticles 审中-公开
标题翻译：肠胃外给药的微粒
公开(公告)号：US20070122484A1
公开(公告)日：2007-05-31
申请号：US11644514
申请日：2006-12-22
申请人： Monica Jonsson , Timo Laakso , Mats Reslow
发明人： Monica Jonsson , Timo Laakso , Mats Reslow
IPC分类号： A61K31/718 , A61K9/14
CPC分类号： A61K9/5031 , A61K9/5089
摘要： A process for producing microparticles containing biologically active substance, in which process an aqueous solution of the said substance is prepared, this solution is mixed with an aqueous solution of PEG such that the substance is concentrated and/or solidified, the substance is optionally washed, the substance is mixed with an aqueous starch solution, the composition obtained is mixed, after the admixture of the starch solution, with a polymer solution, thereby forming an emulsion of starch droplets in the polymer solution, the starch droplets are solidified into microparticles, the microparticles are dried and a release-controlling shell is optionally applied to these. Novel microparticles which are obtainable by means of this process.
摘要翻译：一种制备含有生物活性物质的微粒的方法，其中制备所述物质的水溶液，将该溶液与PEG的水溶液混合，使得物质被浓缩和/或固化，物质任选地被洗涤，将该物质与淀粉水溶液混合，将得到的组合物在淀粉溶液混合后与聚合物溶液混合，由此在聚合物溶液中形成淀粉液滴的乳液，淀粉液滴固化成微粒，将微粒干燥，并且任选地将这些释放控制壳施加于其上。通过该方法可获得的新型微粒。

3. 发明授权

US08017152B2 Cores and microcapsules suitable for parenteral administration as well as process for their manufacture 失效
标题翻译：适用于肠胃外给药的核心和微胶囊以及其制造方法
公开(公告)号：US08017152B2
公开(公告)日：2011-09-13
申请号：US11439602
申请日：2006-05-24
申请人： Nils Ove Gustafsson , Monica Jonsson , Timo Laakso
发明人： Nils Ove Gustafsson , Monica Jonsson , Timo Laakso
IPC分类号： A61K9/14 , A61K9/46
CPC分类号： A61K9/0024 , A61K9/1623 , A61K9/1641 , A61K9/1652 , A61K9/1658 , A61K9/5015 , A61K9/5031 , A61K9/5073
摘要： Process for producing parenterally administrable cores. The cores are intermediates suitable for manufacturing sustained release preparations. Microcapsules incorporating a core and a shell and pharmaceutical compositions incorporating such cores and microcapsules are also provided.
摘要翻译：用于生产肠胃外给药的核心的方法。核心是适于制造持续释放制剂的中间体。还提供了包含核心和壳的微胶囊以及掺入这种核心和微胶囊的药物组合物。

4. 发明授权

US06120787A Sustained release particles 失效
标题翻译：持续释放颗粒
公开(公告)号：US06120787A
公开(公告)日：2000-09-19
申请号：US51709
申请日：1998-04-17
申请人： Nils-Ove Gustafsson , Timo Laakso , Peter Fyhr , Monica Jonsson
发明人： Nils-Ove Gustafsson , Timo Laakso , Peter Fyhr , Monica Jonsson
IPC分类号： A61K9/16 , A61K9/50 , A61K9/52 , A61K38/28 , B01J19/00 , A61F2/00
CPC分类号： A61K9/5031 , A61K9/1647 , A61K9/1652
摘要： A method of preparing parenterally administrable sustained release microparticles, which comprises preparing core particles in an aqueous medium that is essentially free from organic solvent, a biologically active substance being entrapped therein during or after said preparation, drying the core particles and coating the same with a release-controlling polymer by air suspension technique so as to create a shell on the core particles without any detrimental exposure of the active substance to organic solvent. Microparticles obtainable by such a method also are provided.
摘要翻译： PCT No.PCT / SE96 / 01091 Sec。 371日期：1998年4月17日 102（e）1998年4月17日PCT PCT 1996年9月3日PCT公布。出版物WO97 / 14408 日本1997年04月24日制备肠胃外给药的缓释微粒的方法，其包括在基本上不含有机溶剂的水性介质中制备核心颗粒，在制备期间或之后将生物活性物质包埋在其中，干燥核心颗粒和通过空气悬浮技术用释放控制聚合物涂覆它们，以便在核心颗粒上形成壳体，而不会有害的将活性物质暴露于有机溶剂。还提供了可通过这种方法获得的微粒。

5. 发明申请

US20060269606A1 Cores and microcapsules suitable for parenteral administration as well as process for their manufacture 失效
标题翻译：适用于肠胃外给药的核心和微胶囊以及其制造方法
公开(公告)号：US20060269606A1
公开(公告)日：2006-11-30
申请号：US11439602
申请日：2006-05-24
申请人： Nils Gustafsson , Monica Jonsson , Timo Laakso
发明人： Nils Gustafsson , Monica Jonsson , Timo Laakso
IPC分类号： A61K9/24
CPC分类号： A61K9/0024 , A61K9/1623 , A61K9/1641 , A61K9/1652 , A61K9/1658 , A61K9/5015 , A61K9/5031 , A61K9/5073
摘要： Process for producing parenterally administrable cores. The cores are intermediates suitable for manufacturing sustained release preparations. Microcapsules incorporating a core and a shell and pharmaceutical compositions incorporating such cores and microcapsules are also provided.
摘要翻译：用于生产肠胃外给药的核心的方法。核心是适于制造持续释放制剂的中间体。还提供了包含核心和壳的微胶囊以及掺入这种核心和微胶囊的药物组合物。

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