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1. 发明授权

US06821781B1 Method for selecting transformed plant cells using ethionine and cystathionine gamma synthase as the selection agent and marker gene 失效
标题翻译：使用乙硫氨酸和胱硫醚γ合酶作为选择剂和标记基因选择转化的植物细胞的方法
公开(公告)号：US06821781B1
公开(公告)日：2004-11-23
申请号：US09936454
申请日：2001-09-13
申请人： Nilgun E. Tumer , Thomas Leustek
发明人： Nilgun E. Tumer , Thomas Leustek
IPC分类号： C12N504
CPC分类号： C12N9/1085 , C12N9/88 , C12N15/8209 , C12N15/821 , C12N15/8243 , C12N15/8253
摘要： Disclosed are transgenic plants having edible portions that produce methional during processing. The plants contain increased methionine levels such that upon processing of the edible portion(s), methional levels are increased and lead to food products that possess improved flavor stability and/or quality. Plants of the Solanaceous family e.g., potato, tomato and eggplant, and other methional-producing plants including maize and soybean, are preferred plants. Several ways of genetically engineering plants to produce increased free Met levels are disclosed, with introduction of a non-native nucleic acid encoding cystathionine gamma synthase (CGS) and tissue-specific expression of an anti-sense S-adenosyl-methionine synthetase being preferred. Also disclosed are methods for selecting transformed plant cells using ethionine and CGS as the selection agent and marker gene respectively.
摘要翻译：公开了具有在处理过程中产生化学物质的可食用部分的转基因植物。植物含有增加的甲硫氨酸水平，使得在加工可食用部分时，甲基水平增加并导致具有改善的风味稳定性和/或质量的食品。茄科家族的植物，例如马铃薯，番茄和茄子，以及其它包括玉米和大豆在内的产甲植物是优选的植物。通过引入编码胱硫醚γ合成酶（CGS）的非天然核酸和反义S-腺苷 - 甲硫氨酸合成酶的组织特异性表达，公开了遗传工程植物产生增加的游离Met水平的几种方式。还公开了分别使用乙硫氨酸和CGS作为选择剂和标记基因选择转化的植物细胞的方法。

2. 发明授权

US08026410B2 Transgenic plants expressing L3 delta proteins are resistant to trichothecene fungal toxins 失效
标题翻译：表达L3δ蛋白的转基因植物对单端孢霉真菌毒素具有抗性
公开(公告)号：US08026410B2
公开(公告)日：2011-09-27
申请号：US12384050
申请日：2009-03-30
申请人： Nilgun E. Tumer , Rong Di
发明人： Nilgun E. Tumer , Rong Di
IPC分类号： C12N15/09 , C12N15/82 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8282
摘要： Disclosed are specific mutants of L3 and transgenic plants that produce them. The plants exhibit increased resistance to fungal toxins that target ribosomal L3 protein. Also disclosed are transgenic plants that co-produce L3 mutant and an RIP protein, and exhibit increased resistance to various fungal toxins and viruses, while reducing toxicity normally associated with production of the RIP. Uses of the L3 mutants in animals are further disclosed.
摘要翻译：公开了L3和转基因植物的特异性突变体。植物表现出对靶核糖体L3蛋白质的真菌毒素的抗性增加。还公开了共同产生L3突变体和RIP蛋白的转基因植物，并且显示出对各种真菌毒素和病毒的增强的抗性，同时降低通常与RIP生产相关的毒性。进一步公开了动物中L3突变体的用途。

3. 发明申请

US20110061129A1 Disease Resistant Transgenic Plants 审中-公开
标题翻译：抗病转基因植物
公开(公告)号：US20110061129A1
公开(公告)日：2011-03-10
申请号：US12919613
申请日：2009-03-02
申请人： Nilgun E. Tumer , Mohamed Anwar Bin Umer , John McLaughlin
发明人： Nilgun E. Tumer , Mohamed Anwar Bin Umer , John McLaughlin
IPC分类号： C12N15/87 , A01H5/00
CPC分类号： C07K14/415 , C12N15/8282
摘要： Provided are transgenic plants, seed and plant parts which display increased resistance to fungal disease or mycotoxin. Also provided are methods of making transgenic plants with increased resistance to fungal disease or mycotoxin.
摘要翻译：提供转基因植物，种子和植物部分，显示对真菌病或真菌毒素的抗性增加。还提供了使具有增加的对真菌病或霉菌毒素抗性的转基因植物的方法。

4. 发明授权

US4970168A Virus-resistant plants 失效
标题翻译：抗病毒植物
公开(公告)号：US4970168A
公开(公告)日：1990-11-13
申请号：US302498
申请日：1989-01-27
申请人： Nilgun E. Tumer
发明人： Nilgun E. Tumer
IPC分类号： C07K14/08 , C12N15/82
CPC分类号： C07K14/005 , C12N15/8283 , C12N2770/40022
摘要： Transgenic plants are disclosed which are resistant to virus infection by Potato Virus X and Potato Virus Y. Plant genes and transformation vectors are also disclosed. Potato plants, for example, Russet Burbank variety, are made resistant to dual infection by Potato Virus X and Potato Virus Y by transforming the plant to express the coat proteins of the two viruses.
摘要翻译：公开了抗马铃薯病毒X和马铃薯病毒Y的病毒感染的转基因植物。还公开了植物基因和转化载体。马铃薯植物，例如Russet Burbank品种，通过转化植物以表达两种病毒的外壳蛋白而被马铃薯病毒X和马铃薯病毒Y的双重感染抗性。

5. 发明授权

US08753642B2 Method of treating hepatitis C virus 有权
标题翻译：治疗丙型肝炎病毒的方法
公开(公告)号：US08753642B2
公开(公告)日：2014-06-17
申请号：US12449076
申请日：2008-01-18
申请人： Rong Di , Nilgun E. Tumer
发明人： Rong Di , Nilgun E. Tumer
IPC分类号： C07K14/00
CPC分类号： A61K38/168
摘要： A method of treating or inhibiting hepatitic C virus (HCV). The method comprises administering an effective amount of at least one pokeweed antiviral protein (PAP) mutant alone or in combination with other anti-HCV agents.
摘要翻译：一种治疗或抑制肝细胞C病毒（HCV）的方法。该方法包括单独施用有效量的至少一种pokeweed抗病毒蛋白（PAP）突变体或与其它抗HCV药剂组合施用。

6. 发明申请

US20100298238A1 NONTOXIC SHIGA-LIKE TOXIN MUTANT COMPOSITIONS AND METHODS 审中-公开
标题翻译：非特异性SHIGA类似毒素组合物和方法
公开(公告)号：US20100298238A1
公开(公告)日：2010-11-25
申请号：US12682104
申请日：2008-10-08
申请人： Nilgun E. Tumer , Rong Di
发明人： Nilgun E. Tumer , Rong Di
IPC分类号： A61K38/16 , C07K14/25 , C07H21/04 , C12N15/70 , C12N1/21 , A61P31/04 , A61P7/00
CPC分类号： C07K14/25 , A61K39/00 , A61K39/0002
摘要： Disclosed are nontoxic mutants of Shiga-like toxin (Stx1 or Stx2), nucleic acids encoding them, compositions containing the mutants and methods of using the mutants in connection with hemolytic euremic syndrome (HUS). Also disclosed are methods of treating HUS using L3 protein fragments, the nontoxic Stx1 or Stx2 mutants, or combinations thereof.
摘要翻译：公开了志贺样毒素（Stx1或Stx2）的无毒突变体，编码它们的核酸，含有突变体的组合物和使用与溶血性尿毒症综合征（HUS）有关的突变体的方法。还公开了使用L3蛋白片段，无毒Stx1或Stx2突变体或其组合治疗HUS的方法。

7. 发明申请

US20100120680A1 METHOD OF TREATING HEPATITIS C VIRUS 有权
标题翻译：治疗乙型肝炎病毒的方法
公开(公告)号：US20100120680A1
公开(公告)日：2010-05-13
申请号：US12449076
申请日：2008-01-18
申请人： Rong Di , Nilgun E. Tumer
发明人： Rong Di , Nilgun E. Tumer
IPC分类号： A61K38/16 , C07K14/415 , A61P31/14
CPC分类号： A61K38/168
摘要： A method of treating or inhibiting hepatitic C virus (HCV). The method comprises administering an effective amount of at least one pokeweed antiviral protein (PAP) mutant alone or in combination with other anti-HCV agents.
摘要翻译：一种治疗或抑制肝细胞C病毒（HCV）的方法。该方法包括单独施用有效量的至少一种pokeweed抗病毒蛋白（PAP）突变体或与其它抗HCV药剂组合施用。

8. 发明授权

US06146628A Biotherapeutic agents comprising recombinant PAP and PAP mutants 失效
标题翻译：包含重组PAP和PAP突变体的生物治疗剂
公开(公告)号：US06146628A
公开(公告)日：2000-11-14
申请号：US501253
申请日：1995-07-11
申请人： Fatih M. Uckun , Nilgun E. Tumer
发明人： Fatih M. Uckun , Nilgun E. Tumer
IPC分类号： A61K47/48 , A61P35/00 , C07K14/415 , C07K16/28 , A61K39/395 , A61K39/40 , A61K39/42 , A61K39/44
CPC分类号： A61K47/48469 , C07K14/415 , C07K16/2803 , A61K2039/505 , C07K2317/74
摘要： Biotherapeutic agents are provided which comprise recombinant PAP or a biologically equivalent variant or mutant thereof, linked to a targeting moiety which are effective for the treatment of certain human diseases. The invention further provides a process for producing the biotherapeutic agents as well as a method which utilizes the disclosed biotherapeutic agents to systemically treat cancer patients.
摘要翻译：提供了包含与靶向部分连接的重组PAP或其生物学等效变体或突变体的生物治疗剂，其有效治疗某些人类疾病。本发明还提供了生产生物治疗剂的方法以及利用所公开的生物治疗剂全身治疗癌症患者的方法。

9. 发明申请

US20100285046A1 Nontoxic ricin mutant compositions and methods 审中-公开
标题翻译：无毒蓖麻毒素突变体组成及方法
公开(公告)号：US20100285046A1
公开(公告)日：2010-11-11
申请号：US12310833
申请日：2007-09-05
申请人： Nilgun E. Tumer , Xiao-Ping Li , Marianne Baricevic
发明人： Nilgun E. Tumer , Xiao-Ping Li , Marianne Baricevic
IPC分类号： A61K39/00 , A61K31/7088 , C07H21/04 , C07K14/415 , A61K38/16 , A61P35/00
CPC分类号： C07K14/415 , A61K39/00
摘要： Disclosed are nontoxic ricin mutants and uses in connection with vaccines and cancer therapy.
摘要翻译：公开了无毒的蓖麻毒蛋白突变体和与疫苗和癌症治疗有关的用途。

10. 发明授权

US06627736B1 Pap mutants that exhibit anti-viral and/or anti-fungal activity in plants 失效
标题翻译：在植物中表现出抗病毒和/或抗真菌活性的Pap突变体
公开(公告)号：US06627736B1
公开(公告)日：2003-09-30
申请号：US09639456
申请日：2000-08-15
申请人： Nilgun E. Tumer
发明人： Nilgun E. Tumer
IPC分类号： A01H500
CPC分类号： C07K14/415 , C12N15/8282 , C12N15/8283
摘要： Disclosed are PAP mutants having reduced phytotoxicity compared to wild-type PAP, and which confer broad spectrum resistance to viruses and/or fungi in plants. One group of PAP mutants is characterized by at least one amino acid substitution in the N-terminus of mature PAP, such as the Glycine 75 residue or the Glutamic acid 97 residue; two groups of additional PAP mutants are characterized by truncations in the N-terminal region of mature PAP and truncations or amino acid substitutions in the C-terminal region of mature PAP, respectively; and a further group are enzymatically inactive which still exhibit anti-fungal properties. Also disclosed are DNA molecules encoding the PAP mutants, mutant PAP DNA constructs, and transgenic seed and plants containing the DNAs. Further disclosed are methods for identifying PAP mutants having reduced phytotoxicity, as well as isolated and purified PAP mutants identified by the method.
摘要翻译：公开了与野生型PAP相比具有降低的植物毒性的PAP突变体，并且赋予植物中病毒和/或真菌广谱抗性。一组PAP突变体的特征在于成熟PAP的N末端至少一个氨基酸取代，如甘氨酸75残基或谷氨酸97残基; 两组额外的PAP突变体的特征在于成熟PAP的N末端区域的截短和成熟PAP的C末端区域的截短或氨基酸取代; 并且另外一组酶是无活性的，其仍然表现出抗真菌性质。还公开了编码PAP突变体，突变体PAP DNA构建体和含有DNA的转基因种子和植物的DNA分子。还公开了用于鉴定具有降低的植物毒性的PAP突变体的方法，以及通过该方法鉴定的分离和纯化的PAP突变体的方法。

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