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1. 发明授权

US09790504B2 Anti-tumor therapy 有权
公开(公告)号：US09790504B2
公开(公告)日：2017-10-17
申请号：US14893690
申请日：2014-05-21
申请人： Nikolai Khodarev , Ravi Sood , Bernard Roizman , Ralph R. Weichselbaum
发明人： Nikolai Khodarev , Ravi Sood , Bernard Roizman , Ralph R. Weichselbaum
IPC分类号： C12N15/113 , C07H21/02 , A61K48/00 , A61K31/506 , A61K31/519 , A61K31/713 , A61K45/06 , C12Q1/68
CPC分类号： C12N15/1137 , A61K31/506 , A61K31/519 , A61K31/713 , A61K45/06 , C12N15/113 , C12N2310/14 , C12N2320/12 , C12N2320/30 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Panels, compositions, and methods for treating cancer in a subject in need thereof are disclosed involving one or more genes the suppression of which renders the cancer chemosensitive and/or radiosensitive.

2. 发明申请

US20160367627A1 ANTI-TUMOR THERAPY 审中-公开
标题翻译：抗肿瘤治疗
公开(公告)号：US20160367627A1
公开(公告)日：2016-12-22
申请号：US14901929
申请日：2014-06-24
申请人： Nikolai Khodarev , Ravi Sood , Bernard Roizman , Ralph R. Weichselbaum
发明人： Nikolai Khodarev , Ravi Sood , Bernard Roizman , Ralph R. Weichselbaum
IPC分类号： A61K38/17 , A61K45/06
CPC分类号： A61K38/177 , A61K31/506 , A61K45/06
摘要： Compositions, kits and methods for treating cancer in a subject in need thereof are disclosed involving one or more inhibitors of the JAK/STAT pathway which renders the cancer chemosensitive and/or radiosensitive.
摘要翻译：公开了用于治疗有需要的受试者中的癌症的组合物，试剂盒和方法，涉及一种或多种使癌症化学敏感和/或放射敏感的JAK / STAT通路抑制剂。

3. 发明申请

US20160222387A1 ANTI-TUMOR THERAPY 有权
标题翻译：抗肿瘤治疗
公开(公告)号：US20160222387A1
公开(公告)日：2016-08-04
申请号：US14893690
申请日：2014-05-21
申请人： Nikolai Khodarev , Ravi Sood , Bernard Roizman , Ralph R. Weichselbaum
发明人： Nikolai Khodarev , Ravi Sood , Bernard Roizman , Ralph R. Weichselbaum
IPC分类号： C12N15/113 , C12Q1/68 , A61K31/506 , A61K31/519 , A61K45/06 , A61K31/713
CPC分类号： C12N15/1137 , A61K31/506 , A61K31/519 , A61K31/713 , A61K45/06 , C12N15/113 , C12N2310/14 , C12N2320/12 , C12N2320/30 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Panels, compositions, and methods for treating cancer in a subject in need thereof are disclosed involving one or more genes the suppression of which renders the cancer chemosensitive and/or radiosensitive.
摘要翻译：公开了涉及一种或多种抑制癌症化学敏感和/或辐射敏感的基因的治疗癌症的组合物，组合物和方法。

4. 发明申请

US20110274661A1 Attentuated Herpesvirus Encoding a Mek Pathway Polypeptide 审中-公开
标题翻译：注意疱疹病毒编码Mek途径多肽
公开(公告)号：US20110274661A1
公开(公告)日：2011-11-10
申请号：US13058780
申请日：2009-08-07
申请人： Alice P. Poon , Ralph R. Weichselbaum , Bernard Roizman
发明人： Alice P. Poon , Ralph R. Weichselbaum , Bernard Roizman
IPC分类号： A61K35/76 , A61M37/00 , A61P19/02 , A61P27/02 , C12N7/04 , A61P35/00
CPC分类号： C07K14/005 , A61K35/763 , A61K48/0058 , C12N7/00 , C12N9/1205 , C12N15/85 , C12N15/86 , C12N2710/16622 , C12N2710/16632 , C12N2710/16643 , C12N2710/16661 , C12N2710/16662 , C12N2830/002 , C12N2830/60
摘要： The disclosure provides materials and methods for the treatment of cells exhibiting a cell proliferative disorder with a herpes simplex virus having a deficiency in the expression of active ICP34.5 and comprising an expression control element effective in modulating at least one component of the MEK pathway to ensure that infected cells are MEK+. Cell proliferative diseases, disorders or conditions, such as cancers, rheumatoid arthritis and macular degeneration, are amenable to treatment using these HSVs. Further provided are methods for preventing such cell proliferative disorders by administering the HSVs as well as methods for ameliorating a symptom associated with a cell proliferative disorder by administering such HSVs.
摘要翻译：本公开提供用于治疗具有细胞增殖性病症的细胞的材料和方法，所述单纯疱疹病毒具有活性ICP34.5的表达缺陷，并且包含有效调节至少一种MEK途径成分的表达控制元件，确保受感染的细胞是MEK +。细胞增殖性疾病，疾病或病症，如癌症，类风湿关节炎和黄斑变性，适用于使用这些HSV的治疗。还提供了通过施用HSV来预防这种细胞增殖性疾病的方法以及通过施用这种HSV来改善与细胞增殖性病症相关的症状的方法。

5. 发明申请

US20110002890A1 Treatment of tumors with genetically engineered herpes virus 失效
标题翻译：用遗传工程疱疹病毒治疗肿瘤
公开(公告)号：US20110002890A1
公开(公告)日：2011-01-06
申请号：US12802443
申请日：2010-06-07
申请人： Ralph R. Weichselbaum , Bernard Roizman , Richard J. Whitley
发明人： Ralph R. Weichselbaum , Bernard Roizman , Richard J. Whitley
IPC分类号： A61K35/76 , A61P35/00
CPC分类号： C07K14/005 , A61K35/763 , C12N2710/16622 , C12N2710/16632
摘要： Disclosed are methods for treating cancer by administering an effective amount of a modified Herpes simplex virus.
摘要翻译：公开了通过施用有效量的改良的单纯疱疹病毒来治疗癌症的方法。

6. 发明授权

US08318691B2 Treatment of tumors with genetically engineered herpes virus 失效
标题翻译：用遗传工程疱疹病毒治疗肿瘤
公开(公告)号：US08318691B2
公开(公告)日：2012-11-27
申请号：US12802443
申请日：2010-06-07
申请人： Ralph R. Weichselbaum , Bernard Roizman , Richard J. Whitley
发明人： Ralph R. Weichselbaum , Bernard Roizman , Richard J. Whitley
IPC分类号： A61K48/00
CPC分类号： C07K14/005 , A61K35/763 , C12N2710/16622 , C12N2710/16632
摘要： Disclosed are methods for treating cancer by administering an effective amount of a modified Herpes simplex virus.
摘要翻译：公开了通过施用有效量的改良的单纯疱疹病毒来治疗癌症的方法。

7. 发明授权

US06846670B2 Genetically engineered herpes virus for the treatment of cardiovascular disease 有权
标题翻译：遗传工程疱疹病毒用于治疗心血管疾病
公开(公告)号：US06846670B2
公开(公告)日：2005-01-25
申请号：US09995475
申请日：2001-11-28
申请人： Lewis B. Schwartz , Ralph R. Weichselbaum , Bernard Roizman
发明人： Lewis B. Schwartz , Ralph R. Weichselbaum , Bernard Roizman
IPC分类号： C12N15/09 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K45/00 , A61K48/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P37/02 , A61P43/00 , C12N7/04 , C12N15/869 , C12N15/00
CPC分类号： C12N15/86 , A61K48/00 , A61K48/0058 , C12N7/00 , C12N2710/16643 , C12N2710/16661
摘要： The present invention provides methods of expressing a nucleic acid or producing a proteinaceous composition encoded by a nucleic acid in vascular and cardiovascular cells by administration of a herpesvirus vector. The present invention provides methods of producing a therapeutic benefit in vascular and cardiovascular tissue by administration of a herpesvirus vector. In additional aspects, the invention concerns combination therapies for vascular and cardiovascular diseases comprising administration of a herpesvirus vector and treatment with at least one addition pharmacological agent or surgical procedure.
摘要翻译：本发明提供了通过施用疱疹病毒载体在血管和心血管细胞中表达核酸或产生由核酸编码的蛋白质组合物的方法。本发明提供了通过施用疱疹病毒载体在血管和心血管组织中产生治疗益处的方法。在另外的方面，本发明涉及用于血管和心血管疾病的组合疗法，包括施用疱疹病毒载体和用至少一种加药理学剂或外科手术进行治疗。

8. 发明申请

US20110046211A1 COMBINATION THERAPY OF HEDGEHOG INHIBITORS, RADIATION AND CHEMOTHERAPEUTIC AGENTS 审中-公开
标题翻译： HEDGEHOG抑制剂，辐射和化学治疗剂的联合治疗
公开(公告)号：US20110046211A1
公开(公告)日：2011-02-24
申请号：US12913459
申请日：2010-10-27
申请人： Ralph R. Weichselbaum , Zahra Shafaee , Wei Du
发明人： Ralph R. Weichselbaum , Zahra Shafaee , Wei Du
IPC分类号： A61K31/337 , A61P35/00 , C12N5/02
CPC分类号： A61K31/56 , A61K31/337 , A61K31/4355 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： The present invention relates to therapeutic combinations and methods of inhibiting the proliferation of cancerous cells, the abnormal growth of cells, and tumor cell growth using the combination of a hedgehog inhibitor with chemotherapy and/or radiation therapy. The present invention also relates to methods of enhancing the antiproliferative effect of chemotherapy and/or radiation therapy in a mammalian cancer patient undergoing either chemotherapy or radiation or a combination of radiation and chemotherapy by co-administering a therapeutically amount of a hedgehog inhibitor, concurrently or sequentially, with the chemotherapy and/or radiation therapy.
摘要翻译：本发明涉及使用刺猬蛋白抑制剂与化疗和/或放射治疗的组合来抑制癌细胞增殖，细胞异常生长和肿瘤细胞生长的治疗组合和方法。本发明还涉及通过共同施用治疗量的刺猬蛋白抑制剂同时或同时施用化学疗法和/或放射治疗在化疗或放射的哺乳动物癌症患者或辐射和化学疗法的组合中增强抗增殖作用的方法依次进行化疗和/或放射治疗。

9. 发明授权

US5641755A Regulation of x-ray mediated gene expression 失效
标题翻译：调节X线介导的基因表达
公开(公告)号：US5641755A
公开(公告)日：1997-06-24
申请号：US278452
申请日：1994-07-20
申请人： Ralph R. Weichselbaum , Dennis E. Hallahan , Donald W. Kufe
发明人： Ralph R. Weichselbaum , Dennis E. Hallahan , Donald W. Kufe
IPC分类号： A61K31/40 , A61K41/00 , A61K48/00
CPC分类号： A61K31/40 , A61K31/70 , A61K41/0019 , A61K41/0023
摘要： Treatment of cells with ionizing radiation is associated with the production of arachidonic acid. Inhibition of phospholipase A2 abolishes radiation-mediated arachidonate production, protein kinase C induction and tumor necrosis factor gene expression. The addition of inhibitors of lipoxygenase, such as ketoconazole, prior to irradiation reduces the expression of of tumor necrosis factor while maintaining the expression of other radiation inducible genes, such as Egr-1 and c-jun. In contrast, indomethacin, an inhibitor of cyclooxygenase, enhanced the expression of tumor necrosis factor as well as other radiation inducible genes. The results show that lipoxygenase inhibitors are useful in the treatment of radiation-induced mucositis, dermatitis, pneumonitis, proctitis, and esophagitis. which may be due to the production of cytokines such as TNF.
摘要翻译：用电离辐射处理细胞与花生四烯酸的生产有关。磷脂酶A2的抑制消除辐射介导的花生四烯酸生成，蛋白激酶C诱导和肿瘤坏死因子基因表达。在照射之前加入脂氧合酶抑制剂如酮康唑可降低肿瘤坏死因子的表达，同时保持其他放射诱导基因如Egr-1和c-jun的表达。相比之下，吲哚美辛是环氧合酶抑制剂，增强了肿瘤坏死因子以及其他辐射诱导基因的表达。结果表明，脂氧合酶抑制剂可用于治疗放射诱导的粘膜炎，皮炎，肺炎，直肠炎和食道炎。这可能是由于产生诸如TNF的细胞因子。

10. 发明授权

US08597949B2 Methods and compositions for modulating RAD51 and homologous recombination 有权
公开(公告)号：US08597949B2
公开(公告)日：2013-12-03
申请号：US12671147
申请日：2008-07-28
申请人： Philip P. Connell , Douglas K. Bishop , Ralph R. Weichselbaum
发明人： Philip P. Connell , Douglas K. Bishop , Ralph R. Weichselbaum
IPC分类号： C12N15/00 , C12N5/00
CPC分类号： A61K31/5377 , A61K31/00 , A61K31/18 , A61K31/415 , A61K31/4178 , A61K31/4406 , A61K31/4409 , A61K45/06 , A61K2300/00
摘要： The present invention concerns methods and compositions involving inhibitors and enhancers of RAD51, a protein involved in homologous recombination. In some embodiments, the present invention concerns methods for stimulating homologous recombination, which has a number of significant research and clinical applications. In certain other embodiments, there are methods for protecting cells using a compound that enhances RAD51 activity. Such enhancers may also be employed to prevent or reduce damage to cells that may be caused by DNA damaging agents. In other embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 enhancer or inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation.

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