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1. 发明授权

US06326386B1 Benzamide derivatives as thrombin inhibitors 失效
标题翻译：苯甲酰胺衍生物作为凝血酶抑制剂
公开(公告)号：US06326386B1
公开(公告)日：2001-12-04
申请号：US09678610
申请日：2000-10-04
申请人： Nigel Stephen Watson , Martin Pass , Vipulkumar Patel
发明人： Nigel Stephen Watson , Martin Pass , Vipulkumar Patel
IPC分类号： C07D21302
CPC分类号： C07D213/74 , A61K31/4409 , A61K31/4439 , C07D401/12 , C07D405/12 , C07D417/12
摘要： The invention relates to a novel class of amide derivatives which act as thrombin inhibitors as described by formula (I), where R1 and R2, independently represent a group (a) or R1 and R2 together form a C3-7 heterocycloalkyl or heterocycloalkenyl group which may be optionally substituted by C1-6 alkyl, C1-4 alkoxy, halogen, carboxylic acid or a C1-4 carboxylic acid ester group; R3 represents hydrogen, C1-3 alkyl, halogen, or C1-2 alkoxy; R4, R5 and R6 independently represent hydrogen, or halogen; R7 represents hydrogen or C1-6 alkyl; R8 represents hydrogen, C3-7 cycloalkyl, C3-7 cycloalkenyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkenyl, aryl or heteroaryl, which groups are optionally substituted by one or more groups selected from halogen, hydroxy, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 acyloxy, NR9R10, NHCOR11, NHSO2R12, COR13, CO2R14, CONR15R16, and SO2NHR17; X represents a bond, a C1-6 alkyl chain, or a C3-6 alkenyl chain, where one or two nitrogen, oxygen, or sulfur atoms may be optionally contained within each chain, and the chains are optionally substituted by one or more groups selected from halogen, hydroxy, CN, C1-6 alkyl, C1-6 alkoxy, C1-6 acyloxy, NR9R10, NHCOR11, NHSO2R12, COR13, CO2R14, CONR15R16, and SO2NHR17; R9-R17 represent hydrogen, C1-6 alkyl, or R9 and R10 or R15 and R16 form a C3-7 heterocycloalkyl ring, or R12 additionally may represent trifluoromethyl; and pharmaceutically acceptable derivatives or solvates thereof, to processes for their preparation; and their use in the treatment of clinical conditions susceptible to amelioration by administration of a thrombin inhibitor.
摘要翻译：本发明涉及作为如式（I）所述的凝血酶抑制剂的新一类酰胺衍生物，其中R 1和R 2独立地表示基团（a）或R 1和R 2一起形成C 3-7杂环烷基或杂环烯基，其中可以任选地被C 1-6烷基，C 1-4烷氧基，卤素，羧酸或C 1-4羧酸酯基取代; R 3表示氢，C 1-3烷基，卤素或C 1-2烷氧基; R4，R5和R6独立地表示氢或卤素; R 7表示氢或C 1-6烷基; R8表示氢，C3-7环烷基，C3-7环烯基，C3-7杂环烷基，C3-7杂链烯基，芳基或杂芳基，这些基团任选被一个或多个选自卤素，羟基，CN，C 1-6烷基的基团取代，C 1-6烷氧基，C 1-6酰氧基，NR 9 R 10，NHCOR 11，NHSO 2 R 12，COR 13，CO 2 R 14，CONR 15 R 16和SO 2 NHR 17; X表示键，C 1-6烷基链或C 3-6烯基链，其中每个链中可任选地含有一个或两个氮，氧或硫原子，并且该链任选被一个或多个基团取代选自卤素，羟基，CN，C 1-6烷基，C 1-6烷氧基，C 1-6酰氧基，NR 9 R 10，NHCOR 11，NHSO 2 R 12，COR 13，CO 2 R 14，CONR 15 R 16和SO 2 NHR 17; R9-R17表示氢，C1-6烷基或R9，R10或R15和R16形成C

2. 发明授权

US09341792B2 Vent structures for encapsulated components on an SOI-based photonics platform 有权
标题翻译：基于SOI的光子平台上封装元件的通气结构
公开(公告)号：US09341792B2
公开(公告)日：2016-05-17
申请号：US13154699
申请日：2011-06-07
申请人： Mary Nadeau , John Fangman , Duane Stackhouse , Craig Young , David Piede , Vipulkumar Patel
发明人： Mary Nadeau , John Fangman , Duane Stackhouse , Craig Young , David Piede , Vipulkumar Patel
IPC分类号： G02B6/12 , G02B6/42 , H01S5/022 , H01S5/0683
CPC分类号： G02B6/4256 , H01L2224/48111 , H01L2224/48227 , H01L2924/16152 , H01L2924/16195 , H01S5/0222 , H01S5/02248 , H01S5/02288 , H01S5/0683
摘要： An silicon-on-insulator (SOI)-based photonics platform is formed to including a venting structure for encapsulating the active and passive optical components formed on the SOI-based photonics platform. The venting structure is used to allow for the encapsulated components to “breathe” such that water vapor and gasses will pass through the package and not condensate on any of the encapsulated optical surfaces. The venting structure is configured to also to prevent dust, liquids and other particulate material from entering the package.
摘要翻译：形成基于绝缘体上硅（SOI）的光子平台，以包括用于封装形成在基于SOI的光子平台上的有源和无源光学部件的排气结构。通气结构用于允许封装的部件“呼吸”，使得水蒸气和气体将通过包装而不是任何封装的光学表面上的冷凝物。排气结构还用于防止灰尘，液体和其它颗粒物质进入包装。

3. 发明授权

US07706644B2 Offset launch mode from nanotaper waveguide into multimode fiber 有权
标题翻译：从纳米孔波导到多模光纤的偏移发射模式
公开(公告)号：US07706644B2
公开(公告)日：2010-04-27
申请号：US12218367
申请日：2008-07-15
申请人： Mark Webster , Prakash Gothoskar , Vipulkumar Patel , David Piede
发明人： Mark Webster , Prakash Gothoskar , Vipulkumar Patel , David Piede
IPC分类号： G02B6/26
CPC分类号： G02B6/30 , G02B6/3598 , G02B6/3636 , G02B6/3652 , G02B6/3692 , G02B6/4249
摘要： One or more nanotaper coupling waveguides formed within an optical substrate allows for straightforward, reproducible offset launch conditions to be achieved between an incoming signal and the core region of a multimode fiber (which may be disposed along an alignment fixture formed in the optical substrate), fiber array or other multimode waveguiding structure. Offset launching of a single mode signal into a multimode fiber couples the signal into favorable spatial modes which reduce the presence of differential mode dispersion along the fiber. This approach to providing single mode signal coupling into legacy multimode fiber is considered to be an improvement over the prior art which required the use of an interface element between a single mode fiber and multimode fiber, limiting the number of propagating signals and applications for the legacy multimode fiber. An optical switch may be used to select the specific nanotaper(s) for coupling into the multimode fiber.
摘要翻译：形成在光学衬底内的一个或多个纳米锥耦合波导允许在多模光纤（其可以沿着形成在光学衬底中的对准夹具设置）的入射信号和芯区域之间实现简单，可再现的偏移发射条件，光纤阵列或其他多模波导结构。偏移将单模信号发射到多模光纤中将信号耦合到有利的空间模式，这降低了沿着光纤的差分色散的存在。将单模信号耦合提供给传统多模光纤的这种方法被认为是对需要使用单模光纤和多模光纤之间的接口元件的现有技术的改进，限制了传播信号的数量和遗留的应用多模光纤可以使用光学开关来选择用于耦合到多模光纤的特定纳米锥。

4. 发明授权

US07447395B2 Silicon modulator offset tuning arrangement 有权
标题翻译：硅调制器偏移调谐布置
公开(公告)号：US07447395B2
公开(公告)日：2008-11-04
申请号：US11810591
申请日：2007-06-06
申请人： Robert Keith Montgomery , Margaret Ghiron , Prakash Gothoskar , Paulius Mindaugas Mosinskis , Vipulkumar Patel , Kalpendu Shastri , Mark Webster
发明人： Robert Keith Montgomery , Margaret Ghiron , Prakash Gothoskar , Paulius Mindaugas Mosinskis , Vipulkumar Patel , Kalpendu Shastri , Mark Webster
IPC分类号： G02B6/12 , G02F1/295
CPC分类号： G02F1/025 , G02F1/0147 , G02F1/225 , G02F2201/126
摘要： A silicon-based optical modulator structure includes one or more separate localized heating elements for changing the refractive index of an associated portion of the structure and thereby providing corrective adjustments to address unwanted variations in device performance. Heating is provided by thermo-optic devices such as, for example, silicon-based resistors, silicide resistors, forward-biased PN junctions, and the like, where any of these structures may easily be incorporated with a silicon-based optical modulator. The application of a DC voltage to any of these structures will generate heat, which then transfers into the waveguiding area. The increase in local temperature of the waveguiding area will, in turn, increase the refractive index of the waveguiding in the area. Control of the applied DC voltage results in controlling the refractive index.
摘要翻译：基于硅的光学调制器结构包括一个或多个单独的局部加热元件，用于改变结构的相关部分的折射率，从而提供校正调整以解决器件性能的不期望的变化。加热由诸如硅基电阻器，硅化物电阻器，正向偏置PN结等的热光器件提供，其中这些结构中的任何一种可以容易地与硅基光学调制器结合。对这些结构中的任何一个施加直流电压将产生热量，然后传递到波导区域。波导区域的局部温度的增加又将增加该区域中波导的折射率。施加的直流电压的控制导致控制折射率。

5. 发明申请

US20070129354A1 Biphenyl carboxylic amide p38 kinase inhibitors 失效
标题翻译：联苯羧酰胺p38激酶抑制剂
公开(公告)号：US20070129354A1
公开(公告)日：2007-06-07
申请号：US10551502
申请日：2004-04-07
申请人： Nicola Aston , Paul Bamborough , Katherine Jones , Vipulkumar Patel , Stephen Swanson , Ann Walker
发明人： Nicola Aston , Paul Bamborough , Katherine Jones , Vipulkumar Patel , Stephen Swanson , Ann Walker
IPC分类号： A61K31/54 , A61K31/5377 , A61K31/495 , A61K31/445 , A61K31/426 , A61K31/421 , A61K31/4164 , A61K31/40 , A61K31/165
CPC分类号： C07D271/06 , C07C235/42 , C07C235/46 , C07C237/30 , C07C237/42 , C07C275/42 , C07C311/04 , C07C311/15 , C07C2601/02 , C07D295/088 , C07D295/185
摘要： Compound of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
摘要翻译：式（I）化合物或其药学上可接受的衍生物及其作为药物的用途，特别是作为p38激酶抑制剂。

6. 发明申请

US20060177173A1 Vertical stacking of multiple integrated circuits including SOI-based optical components 审中-公开
标题翻译：包括基于SOI的光学元件的多个集成电路的垂直堆叠
公开(公告)号：US20060177173A1
公开(公告)日：2006-08-10
申请号：US11346718
申请日：2006-02-03
申请人： Kalpendu Shastri , Vipulkumar Patel , David Piede , John Fangman
发明人： Kalpendu Shastri , Vipulkumar Patel , David Piede , John Fangman
IPC分类号： G02B6/12 , G02B6/26 , G02B6/42 , G02B6/10
CPC分类号： G02B6/42 , G02B6/4214 , G02B6/43 , G02F1/025 , H01L31/12
摘要： A vertical stack of integrated circuits includes at least one CMOS electronic integrated circuit (IC), an SOI-based opto-electronic integrated circuit structure, and an optical input/output coupling element. A plurality of metalized vias may be formed through the thickness of the stack so that electrical connections can be made between each integrated circuit. Various types of optical input/output coupling can be used, such as prism coupling, gratings, inverse tapers, and the like. By separating the optical and electrical functions onto separate ICs, the functionalities of each may be modified without requiring a re-design of the remaining system. By virtue of using SOI-based opto-electronics with the CMOS electronic ICs, a portion of the SOI structure may be exposed to provide access to the waveguiding SOI layer for optical coupling purposes.
摘要翻译：集成电路的垂直堆叠包括至少一个CMOS电子集成电路（IC），基于SOI的光电集成电路结构以及光输入/输出耦合元件。可以通过堆叠的厚度形成多个金属化通孔，使得可以在每个集成电路之间进行电连接。可以使用各种类型的光输入/输出耦合，例如棱镜耦合，光栅，逆锥等。通过将光学和电气功能分离到单独的IC上，可以修改每个功能，而不需要重新设计剩余的系统。通过使用具有CMOS电子IC的基于SOI的光电子器件，SOI结构的一部分可能被暴露以提供对波导SOI层的访问以用于光学耦合目的。

7. 发明申请

US20060160886A1 Chemical compounds 失效
公开(公告)号：US20060160886A1
公开(公告)日：2006-07-20
申请号：US11384094
申请日：2006-03-17
申请人： Chuen Chan , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Caroline Whitworth , Robert Young
发明人： Chuen Chan , Julie Hamblin , Henry Kelly , Nigel King , Andrew Mason , Vipulkumar Patel , Stefan Senger , Gita Shah , Nigel Watson , Helen Weston , Caroline Whitworth , Robert Young
IPC分类号： A61K31/4025 , A61K31/4015 , C07D403/02
CPC分类号： A61K9/0031 , A61K9/0019 , A61K9/0024 , A61K9/0043 , A61K9/0056 , A61K9/0073 , A61K9/0095 , A61K9/02 , A61K9/12 , A61K31/4025 , A61K31/454 , A61K38/00 , C07K5/06034 , C07K5/06139 , C07K5/06191
摘要： The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.

8. 发明授权

US07003196B2 External grating structures for interfacing wavelength-division-multiplexed optical sources with thin optical waveguides 有权
标题翻译：用于将波分复用光源与薄光波导接口连接的外部光栅结构
公开(公告)号：US07003196B2
公开(公告)日：2006-02-21
申请号：US10935145
申请日：2004-09-07
申请人： Margaret Ghiron , Prakash Gothoskar , Robert Keith Montgomery , Vipulkumar Patel , Soham Pathak , Kalpendu Shastri , Katherine A. Yanushefski
发明人： Margaret Ghiron , Prakash Gothoskar , Robert Keith Montgomery , Vipulkumar Patel , Soham Pathak , Kalpendu Shastri , Katherine A. Yanushefski
IPC分类号： G02B6/34
CPC分类号： G02B6/12007 , G02B6/122 , G02B6/29311 , G02B6/34
摘要： A coupling arrangement for allowing multiple wavelengths to be coupled into and out of a relatively thin silicon optical waveguide layer utilizes a diffractive optical element, in the form of a volume phase grating, in combination with a prism coupling structure. The diffractive optical element is formed to comprise a predetermined modulation index sufficient to diffract the various wavelengths through angles associated with improving the coupling efficiency of each wavelength into the silicon waveguide. The diffractive optical element may be formed as a separate element, or formed as an integral part of the coupling facet of the prism coupler.
摘要翻译：用于允许多个波长耦合到相对薄的硅光波导层中的耦合布置利用体积相位光栅的形式的衍射光学元件与棱镜耦合结构组合。衍射光学元件被形成为包括足以将各种波长衍射成与提高每个波长到硅波导的耦合效率相关联的角度的预定调制指数。衍射光学元件可以形成为单独的元件，或者形成为棱镜耦合器的耦合面的整体部分。

9. 发明申请

US20050194990A1 Wafer-level opto-electronic testing apparatus and method 有权
标题翻译：晶圆级光电测试仪器及方法
公开(公告)号：US20050194990A1
公开(公告)日：2005-09-08
申请号：US11075430
申请日：2005-03-08
申请人： Prakash Gothoskar , Margaret Ghiron , Robert Montgomery , Vipulkumar Patel , Kalpendu Shastri , Soham Pathak , David Piede , Katherine Yanushefski
发明人： Prakash Gothoskar , Margaret Ghiron , Robert Montgomery , Vipulkumar Patel , Kalpendu Shastri , Soham Pathak , David Piede , Katherine Yanushefski
IPC分类号： G01R31/26
CPC分类号： G02B6/30 , G02B6/34 , G02B2006/12107
摘要： A wafer-level testing arrangement for opto-electronic devices formed in a silicon-on-insulator (SOI) wafer structure utilizes a single opto-electronic testing element to perform both optical and electrical testing. Beam steering optics may be formed on the testing element and used to facilitate the coupling between optical probe signals and optical coupling elements (e.g., prism couplers, gratings) formed on the top surface of the SOI structure. The optical test signals are thereafter directed into optical waveguides formed in the top layer of the SOI structure. The opto-electronic testing element also comprises a plurality of electrical test pins that are positioned to contact a plurality of bondpad test sites on the opto-electronic device and perform electrical testing operations. The optical test signal results may be converted into electrical representations within the SOI structure and thus returned to the testing element as electrical signals.
摘要翻译：用于在绝缘体上硅（SOI）晶片结构中形成的光电器件的晶片级测试装置利用单个光电测试元件执行光学和电学测试。光束转向光学元件可以形成在测试元件上，并且用于促进光学探针信号与形成在SOI结构的顶表面上的光耦合元件（例如，棱镜耦合器，光栅）之间的耦合。此后，光学测试信号被引导到形成在SOI结构的顶层中的光波导中。光电测试元件还包括多个电测试引脚，其被定位成接触光电器件上的多个接合焊盘测试点并执行电测试操作。光学测试信号结果可以转换为SOI结构内的电气表示，并因此作为电信号返回到测试元件。

10. 发明申请

US20050189591A1 Active manipulation of light in a silicon-on-insulator (SOI) structure 有权
标题翻译：主动操纵绝缘体上硅（SOI）结构中的光
公开(公告)号：US20050189591A1
公开(公告)日：2005-09-01
申请号：US11069852
申请日：2005-02-28
申请人： Prakash Gothoskar , Margaret Ghiron , Robert Montgomery , Vipulkumar Patel , Kalpendu Shastri , Soham Pathak , Katherine Yanushefski
发明人： Prakash Gothoskar , Margaret Ghiron , Robert Montgomery , Vipulkumar Patel , Kalpendu Shastri , Soham Pathak , Katherine Yanushefski
IPC分类号： G02B6/12 , H01L27/15
CPC分类号： G02B6/12004 , G02F1/025 , G02F1/292 , G02F2001/294
摘要： An arrangement for actively controlling, in two dimensions, the manipulation of light within an SOI-based optical structure utilizes doped regions formed within the SOI layer and a polysilicon layer of a silicon-insulator-silicon capacitive (SISCAP) structure. The regions are oppositely doped so as to form an active device, where the application of a voltage potential between the oppositely doped regions functions to modify the refractive index in the affected area and alter the properties of an optical signal propagating through the region. The doped regions may be advantageously formed to exhibit any desired “shaped” (such as, for example, lenses, prisms, Bragg gratings, etc.), so as to manipulate the propagating beam as a function of the known properties of these devices. One or more active devices of the present invention may be included within a SISCAP formed, SOI-based optical element (such as, for example, a Mach-Zehnder interferometer, ring resonator, optical switch, etc.) so as to form an active, tunable element.
摘要翻译：用于主动地控制SOI基光学结构内的光的操纵的布置利用形成在SOI层内的掺杂区域和硅绝缘体 - 硅电容（SISCAP）结构的多晶硅层。这些区域相反地掺杂以形成有源器件，其中在相对掺杂区域之间施加电压电位用于改变受影响区域中的折射率并改变传播通过该区域的光信号的特性。可以有利地形成掺杂区域以呈现任何期望的“成形”（例如，透镜，棱镜，布拉格光栅等），以便根据这些器件的已知特性来操纵传播光束。本发明的一个或多个有源器件可以包括在形成SISCAP的SOI基光学元件（例如，诸如Mach-Zehnder干涉仪，环形谐振器，光学开关等）中，以形成活跃的，可调元素。

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