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1. 发明授权

US09766239B2 Synbodies for detection of human norovirus 有权
公开(公告)号：US09766239B2
公开(公告)日：2017-09-19
申请号：US14776434
申请日：2014-03-12
申请人： Nidhi Gupta , Chris Diehnelt , Charles Arntzen , Stephen Johnston
发明人： Nidhi Gupta , Chris Diehnelt , Charles Arntzen , Stephen Johnston
IPC分类号： C07K16/08 , G01N33/569 , C07K14/00
CPC分类号： G01N33/56983 , C07K14/001 , C07K16/08 , C07K2318/20 , G01N2333/08 , G01N2469/10 , G01N2800/26
摘要： Synbodies specific for Norovirus and coupled with a substrate provide Norovirus binding and detection platforms (FIG. 1). A Norovirus capturing platform, comprising one or more synbodies selected from the group consisting of synbodies 6-6, 92-92, 93-93, and 94-94 coupled to a substrate, has been found to found to bind with either GII.4 Minerva or both GII.4 Minerva and GII.4 Sydney# strains of norovirus.

2. 发明授权

US10011649B2 High affinity synbodies for influenza 有权
公开(公告)号：US10011649B2
公开(公告)日：2018-07-03
申请号：US14913089
申请日：2014-08-25
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , Christopher Diehnelt , Nidhi Gupta , Valeriy Domenyuk , Zhan-Gong Zhao , Stephen Johnston
发明人： Christopher Diehnelt , Nidhi Gupta , Valeriy Domenyuk , Zhan-Gong Zhao , Stephen Johnston
IPC分类号： C07K16/28 , A61K38/00 , A61K39/395 , A61K39/00 , G01N33/53 , C07K16/10 , C07K14/11 , C07K14/00 , G01N33/569
CPC分类号： C07K16/1018 , A61K38/00 , C07K14/001 , C07K14/11 , C07K2318/20 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： Composition of synbodies that bind influenza. The synbodies are composed of two peptides joined on a scaffold.

3. 发明授权

US08420666B2 Pyrazolo (3, 4-B) pyridine derivatives as phosphodiesterase inhibitors 有权
标题翻译：吡唑并（3,4-B）吡啶衍生物作为磷酸二酯酶抑制剂
公开(公告)号：US08420666B2
公开(公告)日：2013-04-16
申请号：US12531043
申请日：2008-03-14
申请人： Sonali Rudra , Nidhi Gupta , Lalit Kumar Baregama , Ritu Agarwal , Vinayak Vasantrao Khairnar , Mandadapu Raghu Ramaiah , Venkata P. Palle , Sarala Balachandran , Atul Kondaskar , Manohar Salla , Abhijit Ray , Sunanda G. Dastidar , Lalitha Vijaykrishnan
发明人： Sonali Rudra , Nidhi Gupta , Lalit Kumar Baregama , Ritu Agarwal , Vinayak Vasantrao Khairnar , Mandadapu Raghu Ramaiah , Venkata P. Palle , Sarala Balachandran , Atul Kondaskar , Manohar Salla , Abhijit Ray , Sunanda G. Dastidar , Lalitha Vijaykrishnan
IPC分类号： C07D513/02 , C07D515/02 , A01N43/42 , A61K31/44
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed herein having the structure of Formula 1: can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4/PDE type 7 inhibitors are provided.
摘要翻译：本发明涉及磷酸二酯酶（PDE）4型，磷酸二酯酶（PDE）7型和双重PDE型4 / PDE型7型抑制剂。本文公开的具有式1结构的化合物可用于治疗，预防，抑制或抑制CNS疾病，例如多发性硬化; 各种病理状况如影响免疫系统的疾病，包括艾滋病，移植排斥反应，自身免疫性疾病如T细胞相关疾病，例如类风湿性关节炎; 炎性疾病如呼吸道炎症疾病，包括慢性阻塞性肺疾病（COPD），哮喘，支气管炎，过敏性鼻炎，成人呼吸窘迫综合征（ARDS）和其他炎性疾病，包括但不限于银屑病，休克，特应性皮炎，嗜酸性肉芽肿，过敏性结膜炎，骨关节炎; 胃肠道炎症性疾病如克罗恩病，结肠炎，胰腺炎以及不同类型的癌症，包括白血病; 特别是在人类。提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为PDE 4型，PDE型7和双重PDE型4 / PDE 7型抑制剂的用途。

4. 发明授权

US09529788B1 System for assisting creation of messages by providing selectable templates 有权
标题翻译：通过提供可选择的模板来协助创建消息的系统
公开(公告)号：US09529788B1
公开(公告)日：2016-12-27
申请号：US13652357
申请日：2012-10-15
申请人： Nidhi Gupta , Jeff Ligh , Song SunMin Sunny
发明人： Nidhi Gupta , Jeff Ligh , Song SunMin Sunny
IPC分类号： G06F17/00 , G06F17/21 , G06F17/24
CPC分类号： G06F17/243 , G06F17/212 , G06F17/248
摘要： Embodiments of the present invention are directed to a system for assisting creation of messages by providing selectable templates. The system includes an application configured to provide a form which receives information. The form is configured based on a template, such as a default template or an alternate template. A user is able to switch between templates any time during the process of completing the form. The templates share one or more common fields. The application is configured to persist user data associated with at least one of the one or more common fields. The application is also configured to refresh/update the form with relevant fields and editable content associated with a template, and any persisted user data upon selection of that template. In some embodiments, the alternate templates include templates based on posts previously completed by the user and/or canned templates which are category-specific.
摘要翻译：本发明的实施例涉及一种通过提供可选模板来辅助消息创建的系统。该系统包括被配置为提供接收信息的表单的应用。该表单是基于模板配置的，例如默认模板或备用模板。在完成表单的过程中，用户可以随时在模板之间切换。模板共享一个或多个常见字段。该应用被配置为持续与一个或多个公共字段中的至少一个相关联的用户数据。该应用还被配置为刷新/更新与相关字段和与模板相关联的可编辑内容的表单，以及在选择该模板时的任何持久化的用户数据。在一些实施例中，替代模板包括基于先前由用户完成的帖子和/或类别特定的模板。

5. 发明申请

US20110130403A1 PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS 审中-公开
标题翻译：吡咯并[3,4-B]吡啶衍生物作为磷酸二酯酶抑制剂
公开(公告)号：US20110130403A1
公开(公告)日：2011-06-02
申请号：US12531045
申请日：2008-03-13
申请人： Sonali Rudra , Nidhi Gupta , Lalit Kumar Baregama , Ritu Agarwal , Mandadapu Raghuramaiah , Vinayak Vasantrao Khairnar , Venkata P. Palle , Sarala Balachandran , Abhijit Ray , Sunada G. Dastidar , Lalitha Vijaykrishnan
发明人： Sonali Rudra , Nidhi Gupta , Lalit Kumar Baregama , Ritu Agarwal , Mandadapu Raghuramaiah , Vinayak Vasantrao Khairnar , Venkata P. Palle , Sarala Balachandran , Abhijit Ray , Sunada G. Dastidar , Lalitha Vijaykrishnan
IPC分类号： A61K31/437 , C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/53 , A61P29/00 , A61P37/06 , A61P25/00
CPC分类号： C07D471/04
摘要： The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed hereinf having the structure of Formula I: can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE t e 4/PDE t e 7 inhibitors are rovided.
摘要翻译：本发明涉及磷酸二酯酶（PDE）4型，磷酸二酯酶（PDE）7型和双重PDE型4 / PDE型7型抑制剂。本文公开的具有式I结构的化合物可用于治疗，预防，抑制或抑制CNS疾病，例如多发性硬化; 各种病理状况如影响免疫系统的疾病，包括艾滋病，移植排斥反应，自身免疫性疾病如T细胞相关疾病，例如类风湿性关节炎; 炎性疾病如呼吸道炎症疾病，包括慢性阻塞性肺疾病（COPD），哮喘，支气管炎，过敏性鼻炎，成人呼吸窘迫综合征（ARDS）和其他炎性疾病，包括但不限于银屑病，休克，特应性皮炎，嗜酸性肉芽肿，过敏性结膜炎，骨关节炎; 胃肠道炎症性疾病如克罗恩病，结肠炎，胰腺炎以及不同类型的癌症，包括白血病; 特别是在人类。制备所公开的化合物的方法，包含所公开的化合物的药物组合物及其作为PDE 4型，PDE型7和双重PDE 4 / PDE 7抑制剂的用途是有争议的。

6. 发明申请

US20100292196A1 PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS 有权
标题翻译：吡咯烷（3,4-B）吡啶衍生物作为磷酸二酯酶抑制剂
公开(公告)号：US20100292196A1
公开(公告)日：2010-11-18
申请号：US12531043
申请日：2008-03-14
申请人： Sonali Rudra , Nidhi Gupta , Lalit Kumar Baregama , Ritu Agarwal , Vinayak Vasantrao Khairnar , Mandadapu Raghu Ramaiah , Venkata P. Palle , Sarala Balachandran , Atul Kondaskar , Manohar Salla , Abhijit Ray , Sunanda G. Dastidar , Lalitha Vijaykrishnan
发明人： Sonali Rudra , Nidhi Gupta , Lalit Kumar Baregama , Ritu Agarwal , Vinayak Vasantrao Khairnar , Mandadapu Raghu Ramaiah , Venkata P. Palle , Sarala Balachandran , Atul Kondaskar , Manohar Salla , Abhijit Ray , Sunanda G. Dastidar , Lalitha Vijaykrishnan
IPC分类号： A61K31/573 , C07D519/00 , A61K31/437 , C07D471/04 , A61P17/00 , A61P19/00 , A61P11/00 , A61P35/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed herein having the structure of Formula 1: can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4/PDE type 7 inhibitors are provided.
摘要翻译：本发明涉及磷酸二酯酶（PDE）4型，磷酸二酯酶（PDE）7型和双重PDE型4 / PDE型7型抑制剂。本文公开的具有式1结构的化合物可用于治疗，预防，抑制或抑制CNS疾病，例如多发性硬化; 各种病理状况如影响免疫系统的疾病，包括艾滋病，移植排斥反应，自身免疫性疾病如T细胞相关疾病，例如类风湿性关节炎; 炎性疾病如呼吸道炎症疾病，包括慢性阻塞性肺疾病（COPD），哮喘，支气管炎，过敏性鼻炎，成人呼吸窘迫综合征（ARDS）和其他炎性疾病，包括但不限于银屑病，休克，特应性皮炎，嗜酸性肉芽肿，过敏性结膜炎，骨关节炎; 胃肠道炎症性疾病如克罗恩病，结肠炎，胰腺炎以及不同类型的癌症，包括白血病; 特别是在人类。提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为PDE 4型，PDE型7和双重PDE型4 / PDE 7型抑制剂的用途。

7. 发明申请

US20100029728A1 PHOSPHODIESTERASE INHIBITORS 审中-公开
标题翻译：磷酸二酯酶抑制剂
公开(公告)号：US20100029728A1
公开(公告)日：2010-02-04
申请号：US12442336
申请日：2007-09-22
申请人： Sarala Balachandran , Nidhi Gupta , Vinayak Vasantrao Khairnar , Sonali Rudra , Venkata P. Palle , Sunanda G. Dastidar
发明人： Sarala Balachandran , Nidhi Gupta , Vinayak Vasantrao Khairnar , Sonali Rudra , Venkata P. Palle , Sunanda G. Dastidar
IPC分类号： A61K31/4245 , C07D413/04 , A61P29/00 , A61P25/00 , A61P11/06 , A61P11/08 , A61P11/00 , A61P17/06 , A61P27/02 , A61P19/02
CPC分类号： C07D261/18 , C07D413/04
摘要： The present invention relates to phosphodiesterase (PDE) type IV selective inhibitors. Compounds disclosed herein can be useful in the treatment of CNS diseases, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and their use as PDE type IV selective inhibitors, are provided.
摘要翻译：本发明涉及磷酸二酯酶（PDE）IV型选择性抑制剂。本文公开的化合物可用于治疗CNS疾病，AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS）嗜酸粒细胞性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是人类。提供制备所公开化合物的方法，含有所公开化合物的药物组合物及其作为PDE IV型选择性抑制剂的用途。

8. 发明申请

US20080009535A1 Inhibitors of phosphodiesterase type-IV 审中-公开
标题翻译：磷酸二酯酶IV型抑制剂
公开(公告)号：US20080009535A1
公开(公告)日：2008-01-10
申请号：US11390491
申请日：2006-03-27
申请人： Sarala Balachandran , Nidhi Gupta , Nagarajan Muthukaman , Vinayak Khairnar , Sarika Ramnani , Lalit Baregama , Saswati Chakladar , Mandadapu Raghu Ramaiah , Ritu Agarwal , Sunanda Dastidar , Abhijit Ray
发明人： Sarala Balachandran , Nidhi Gupta , Nagarajan Muthukaman , Vinayak Khairnar , Sarika Ramnani , Lalit Baregama , Saswati Chakladar , Mandadapu Raghu Ramaiah , Ritu Agarwal , Sunanda Dastidar , Abhijit Ray
IPC分类号： A61K31/424 , A61P11/00 , A61P11/06 , A61P17/06 , A61P29/00 , A61P31/12 , C07D261/04
CPC分类号： C07D261/20 , C07D413/12 , C07D498/10
摘要： The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.
摘要翻译：本发明涉及异恶唑啉衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。特别地，本文公开的化合物可用于治疗AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS）嗜酸粒细胞肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是在人类中。本发明还涉及制备所公开的化合物及其药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途的方法。

9. 发明授权

US10427125B2 Methods for performing patterned chemistry 有权
公开(公告)号：US10427125B2
公开(公告)日：2019-10-01
申请号：US14116749
申请日：2012-05-04
申请人： Neal Woodbury , Nidhi Gupta
发明人： Neal Woodbury , John Rajasekaran , Nidhi Gupta
IPC分类号： B82Y30/00 , B01J19/00 , C40B50/14 , G03F7/16
摘要： Provided are methods for performing patterned chemistry and arrays prepared thereby.

10. 发明申请

US20190194358A1 Synthetic Antibodies 审中-公开
公开(公告)号：US20190194358A1
公开(公告)日：2019-06-27
申请号：US16198288
申请日：2018-11-21
申请人： Stephen A Johnston , Neal Woodbury , Christopher W. Diehnelt , Paul Belcher , Nidhi Gupta , Zhan-Gong Zhoa , Matthew Greving , Jack Emery
发明人： Stephen A Johnston , Neal Woodbury , Christopher W. Diehnelt , Paul Belcher , Nidhi Gupta , Zhan-Gong Zhoa , Matthew Greving , Jack Emery
IPC分类号： C07K17/10 , G01N33/68 , C07K17/06
CPC分类号： C07K17/10 , C07K17/06 , G01N33/6845
摘要： The present invention provides methods for synthetic antibodies, methods for making synthetic antibodies, methods for identifying ligands, and related methods and reagents.

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