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1. 发明申请

US20080064856A1 Methods for reducing protein aggregation 审中-公开
标题翻译：降低蛋白质聚集的方法
公开(公告)号：US20080064856A1
公开(公告)日：2008-03-13
申请号：US11725534
申请日：2007-03-19
申请人： Nicholas Warne , Angela Kantor , Thomas Crowley , Erin Soley , Li Li , Nicholas Luksha , Edie Neidhardt
发明人： Nicholas Warne , Angela Kantor , Thomas Crowley , Erin Soley , Li Li , Nicholas Luksha , Edie Neidhardt
IPC分类号： C07K14/755 , C07K1/14 , C07K14/00
CPC分类号： A61K39/39591 , A61K9/0019 , A61K9/19 , A61K38/00 , A61K47/183 , A61K47/26 , C07K2319/30
摘要： Methods of reducing aggregation of a protein or proteins in a formulation, and protein formulations having reduced aggregation properties are provided. The methods and formulations described herein maintain the biological activity of a protein and increase the shelf life of protein formulations.
摘要翻译：提供了减少制剂中蛋白质或蛋白质聚集的方法，以及具有降低的聚集性质的蛋白质制剂。本文描述的方法和制剂维持蛋白质的生物活性并增加蛋白质制剂的保质期。

2. 发明申请

US20070237758A1 IMMUNOGLOBULIN FUSION PROTEIN FORMULATIONS 审中-公开
标题翻译：免疫球蛋白融合蛋白制剂
公开(公告)号：US20070237758A1
公开(公告)日：2007-10-11
申请号：US11562299
申请日：2006-11-21
申请人： Anthony Barry , Thomas Crowley , Daniel Dixon , Jennifer Juneau , Ajay Kumar , Li Li , Nicholas Luksha , Michael Shamashkin , Erin Soley , Nicholas Warne , Chandra Webb
发明人： Anthony Barry , Thomas Crowley , Daniel Dixon , Jennifer Juneau , Ajay Kumar , Li Li , Nicholas Luksha , Michael Shamashkin , Erin Soley , Nicholas Warne , Chandra Webb
IPC分类号： A61K39/395
CPC分类号： C07K14/7155 , A61K38/1774 , C07K14/705 , C07K2319/30 , C07K2319/31
摘要： The present invention provides compositions of Ig fusion proteins, especially compositions including an Ig fusion protein, a bulking agent, a disaccharide, a surfactant, and a buffer. In one aspect, these compositions are stable under long-term storage or at least one freeze/thaw cycle. The invention also provides methods of preparation of the Ig fusion protein compositions. In one aspect, compositions of the invention are lyophilized. In a further aspect, the compositions are lyophilized by a process that includes an annealing step.
摘要翻译：本发明提供Ig融合蛋白的组合物，特别是包含Ig融合蛋白，填充剂，二糖，表面活性剂和缓冲液的组合物。在一个方面，这些组合物在长期储存或至少一个冷冻/融化循环下是稳定的。本发明还提供了Ig融合蛋白组合物的制备方法。在一个方面，本发明的组合物被冻干。在另一方面，组合物通过包括退火步骤的方法冻干。

3. 发明申请

US20110033464A1 IMMUNOGLOBULIN FUSION PROTEIN FORMULATIONS 审中-公开
标题翻译：免疫球蛋白融合蛋白制剂
公开(公告)号：US20110033464A1
公开(公告)日：2011-02-10
申请号：US12910146
申请日：2010-10-22
申请人： Anthony BARRY , Thomas Crowley , Daniel Dixon , Jennifer Juneau , Ajay Kumar , Li Li , Nicholas Luksha , Michael Shamashkin , Erin Soley , Nicholas Warne , Chandra Webb
发明人： Anthony BARRY , Thomas Crowley , Daniel Dixon , Jennifer Juneau , Ajay Kumar , Li Li , Nicholas Luksha , Michael Shamashkin , Erin Soley , Nicholas Warne , Chandra Webb
IPC分类号： A61K39/395
CPC分类号： C07K14/7155 , A61K38/1774 , C07K14/705 , C07K2319/30 , C07K2319/31
摘要： The present invention provides compositions of Ig fusion proteins, especially compositions including an Ig fusion protein, a bulking agent, a disaccharide, a surfactant, and a buffer. In one aspect, these compositions are stable under long-term storage or at least one freeze/thaw cycle. The invention also provides methods of preparation of the Ig fusion protein compositions. In one aspect, compositions of the invention are lyophilized. In a further aspect, the compositions are lyophilized by a process that includes an annealing step.
摘要翻译：本发明提供Ig融合蛋白的组合物，特别是包含Ig融合蛋白，填充剂，二糖，表面活性剂和缓冲液的组合物。在一个方面，这些组合物在长期储存或至少一个冷冻/融化循环下是稳定的。本发明还提供了Ig融合蛋白组合物的制备方法。在一个方面，本发明的组合物被冻干。在另一方面，组合物通过包括退火步骤的方法冻干。

4. 发明申请

US20050050286A1 Apparatus and method for asynchronous logical mirroring 审中-公开
标题翻译：异步逻辑镜像的装置和方法
公开(公告)号：US20050050286A1
公开(公告)日：2005-03-03
申请号：US10651149
申请日：2003-08-28
申请人： Thomas Crowley , Robert Gintowt , Kevin Griffin , Scott Helt , Glen Nelson , Mark Piazza
发明人： Thomas Crowley , Robert Gintowt , Kevin Griffin , Scott Helt , Glen Nelson , Mark Piazza
IPC分类号： G06F11/20 , G06F12/16
CPC分类号： G06F11/2064 , G06F11/2074
摘要： An apparatus and method provides the capability of mirroring storage between geographically remote locations in an asynchronous manner that does not require all writes on primary storage to be performed in the same order on the mirrored storage. The mirroring of the present invention is “logical mirroring”, which does not require identical disk drives, and which supports mirroring between geographically remote locations to protect against catastrophic site failure. A sequence number is assigned to data written to primary storage before the data is transferred to the mirrored storage. The mirrored storage can write data asynchronously, which may result in some data being written before previous data on the mirrored storage. When a system failure occurs that requires use of the mirrored storage, the mirrored storage is first quiesced to allow all pending writes to occur. If the mirrored storage has no missing data corresponding to a sequence number that is lower than the highest sequence number of data written to the mirrored storage, the mirrored storage may be used. If, however, the mirrored storage has missing data corresponding to a sequence number that is lower than the highest sequence number of data written to the mirrored storage, the mirrored storage cannot be used.
摘要翻译：设备和方法提供以异步方式在地理上远程位置之间镜像存储的能力，其不需要在镜像存储上以相同顺序执行主存储上的所有写入。本发明的镜像是“逻辑镜像”，其不需要相同的磁盘驱动器，并且其支持在地理上偏远的位置之间的镜像，以防止灾难性的站点故障。在将数据传输到镜像存储之前，将序列号分配给写入主存储器的数据。镜像存储器可以异步写入数据，这可能导致一些数据在镜像存储器上的先前数据之前写入。当发生需要使用镜像存储的系统故障时，镜像存储首先被停顿以允许发生所有挂起的写入。如果镜像存储器没有与低于写入到镜像存储器的最高序列数据的序列号相对应的丢失数据，则可以使用镜像存储器。但是，如果镜像存储具有对应于低于写入镜像存储的最高序列数的序列号的数据丢失，则不能使用镜像存储。

5. 外观设计

USD593419S1 Truck shaped package 有权
标题翻译：卡车形包装
公开(公告)号：USD593419S1
公开(公告)日：2009-06-02
申请号：US29305438
申请日：2008-03-20
申请人： Thomas Crowley
设计人： Thomas Crowley

6. 发明申请

US20050198369A1 Multiple connection management system 失效
标题翻译：多连接管理系统
公开(公告)号：US20050198369A1
公开(公告)日：2005-09-08
申请号：US10757789
申请日：2004-01-15
申请人： Troy Armstrong , Thomas Crowley , Kenneth Linn , James Naylor , Joseph Writz
发明人： Troy Armstrong , Thomas Crowley , Kenneth Linn , James Naylor , Joseph Writz
IPC分类号： G06F13/10 , G06F15/173
CPC分类号： G06F13/102
摘要： An apparatus, program product and method for managing a number of physical connections to a peripheral device. A multipath driver provides a logical connection interface to a client. This interface allows the client to efficiently access the peripheral device over one or more of the physical connections. In so doing, the logical connection interface associates connections with a primary connection, deletes inactive connections from memory, as well as updates and uses a list of active connections to seamlessly route data to the peripheral device.
摘要翻译：一种用于管理到外围设备的多个物理连接的装置，程序产品和方法。多路径驱动程序为客户端提供逻辑连接接口。该接口允许客户端通过一个或多个物理连接有效地访问外围设备。这样做，逻辑连接接口将连接与主连接相关联，从内存中删除非活动连接，并更新并使用活动连接列表将数据无缝路由到外围设备。

7. 外观设计

USD583239S1 Display card 有权
标题翻译：显示卡
公开(公告)号：USD583239S1
公开(公告)日：2008-12-23
申请号：US29305439
申请日：2008-03-20
申请人： Thomas Crowley
设计人： Thomas Crowley

8. 发明申请

US20060081345A1 Method for bleaching wood fibers 审中-公开
标题翻译：漂白木纤维的方法
公开(公告)号：US20060081345A1
公开(公告)日：2006-04-20
申请号：US11249880
申请日：2005-10-13
申请人： Qiang Huang , Ranganammar Goda , Thomas Crowley
发明人： Qiang Huang , Ranganammar Goda , Thomas Crowley
IPC分类号： D21C3/00 , D21C3/04 , D21C3/02
CPC分类号： D21C9/163 , D21C9/1084
摘要： A method for bleaching wood fibers with a mixture of sodium borohydride and sodium bisulfite followed by peroxide bleaching in the same vessel.
摘要翻译：用硼氢化钠和亚硫酸氢钠的混合物漂白木纤维，然后在同一容器中漂白过氧化物漂白的方法。

9. 发明授权

US06748260B2 Hand-held surface ECG and RF apparatus incorporated with a medical device 有权
标题翻译：配有医疗设备的手持式表面ECG和RF装置
公开(公告)号：US06748260B2
公开(公告)日：2004-06-08
申请号：US09821201
申请日：2001-03-29
申请人： Nelson Au , Mark Brecht , Marion Buchenau , Thomas Crowley , David Karshmer , Chester G. Nelson , Nick Oakley , Edwin M. Pearce, Jr. , Nancy Perry Pool , Richard M. Powell , Elisha Tal
发明人： Nelson Au , Mark Brecht , Marion Buchenau , Thomas Crowley , David Karshmer , Chester G. Nelson , Nick Oakley , Edwin M. Pearce, Jr. , Nancy Perry Pool , Richard M. Powell , Elisha Tal
IPC分类号： A61B504
CPC分类号： A61B5/0006 , A61B5/0404 , A61B2560/0468 , G06F19/00
摘要： A hand-holdable structure implementing electrodes to enable good skin-electrode contact to acquire ECG readings is disclosed. Specifically, the structure is shaped to enable patients to apply a simple gentle grip to have a reliable skin-electrode contact and to automatically commence ECG tracing transmission to a patient monitoring station. In one embodiment the structure incorporates an RF telemetry head to simultaneously transfer IMD stored data in conjunction with the ECG tracings. The structure independently or in combination with the RF telemetry head is adaptable to a system of data communications with a programmer or equivalent instrument to transfer ECG and IMD data to a remotely located physician station or patient data storage server. The system is also adaptable for use with a web-enabled network such as, without limitation, the Internet, intranet, World Wide Web, extranet or equivalent.
摘要翻译：公开了实现电极以实现良好皮肤电极接触以获取ECG读数的手持式结构。具体地，该结构的形状使得患者能够施加简单的温和握持以具有可靠的皮肤 - 电极接触并且自动地开始向患者监测站进行ECG跟踪传输。在一个实施例中，该结构包括RF遥测头以与ECG跟踪一起同时传送IMD存储的数据。该结构独立地或与RF遥测头组合适用于与编程器或等效仪器的数据通信系统，以将ECG和IMD数据传输到位于远程的医师站或患者数据存储服务器。该系统还适用于具有网络功能的网络，例如但不限于互联网，内联网，万维网，外部网或等同物。

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