专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5846540A Immunogenic chimeras comprising nucleic acid sequences encoding endoplasmic reticulum signal sequence peptides and at least one other peptide, and their uses in vaccines and disease treatments 失效
公开(公告)号：US5846540A
公开(公告)日：1998-12-08
申请号：US471341
申请日：1995-06-06
申请人： Nicholas P. Restifo , Steven A. Rosenberg , Jack R. Bennink , Igor Bacik , Jonathan W. Yewdell
发明人： Nicholas P. Restifo , Steven A. Rosenberg , Jack R. Bennink , Igor Bacik , Jonathan W. Yewdell
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/205 , A61K39/39 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/06 , C07H21/04 , C07K14/005 , C07K14/075 , C07K14/145 , C07K14/195 , C07K14/44 , C07K14/47 , C07K14/77 , C07K14/82 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/62 , C12P21/02 , C12R1/91 , C12N15/63
CPC分类号： A61K39/205 , A61K39/0011 , A61K39/12 , A61K39/145 , C07K14/005 , C07K14/47 , C07K14/77 , C12N15/625 , A61K2039/5158 , A61K2039/5256 , A61K39/00 , C07K2319/00 , C07K2319/04 , C07K2319/40 , C12N2710/24143 , C12N2760/16134 , C12N2760/20122 , C12N2760/20134
摘要： Immunogenic chimeric proteins comprising an endoplasmic reticulum signal sequence and at least one other peptide are disclosed. The invention relates to the design of vaccinia virus constructs capable of directing host organism synthesis of immunogenic chimeric proteins which can be used as immunogens, as vaccines, or in methods of treatment for cancer, infectious diseases, or autoimmune diseases.

2. 发明授权

US5733548A Immunogenic chimeras comprising nucleic acid sequences encoding endoplasmic reticulum signal sequence peptides and at least one other peptide, and their uses in vaccines and disease treatments 失效
公开(公告)号：US5733548A
公开(公告)日：1998-03-31
申请号：US464318
申请日：1995-06-05
申请人： Nicholas P. Restifo , Steven A. Rosenberg , Jack R. Bennink , Igor Bacik , Jonathan W. Yewdell
发明人： Nicholas P. Restifo , Steven A. Rosenberg , Jack R. Bennink , Igor Bacik , Jonathan W. Yewdell
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/205 , A61K39/39 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/06 , C07H21/04 , C07K14/005 , C07K14/075 , C07K14/145 , C07K14/195 , C07K14/44 , C07K14/47 , C07K14/77 , C07K14/82 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/62 , C12P21/02 , C12R1/91 , A61K38/02 , C07K2/00
CPC分类号： A61K39/205 , A61K39/0011 , A61K39/12 , A61K39/145 , C07K14/005 , C07K14/47 , C07K14/77 , C12N15/625 , A61K2039/5158 , A61K2039/5256 , A61K39/00 , C07K2319/00 , C07K2319/04 , C07K2319/40 , C12N2710/24143 , C12N2760/16134 , C12N2760/20122 , C12N2760/20134
摘要： Immunogenic chimeric proteins comprising an endoplasmic reticulum signal sequence and at least one other peptide are disclosed. The invention relates to the design of vaccinia virus constructs capable of directing host organism synthesis of immunogenic chimeric proteins which can be used as immunogens, as vaccines, or in methods of treatment for cancer, infectious diseases, or autoimmune diseases.

3. 发明授权

US5856187A Immunogenic chimeras comprising nucleic acid sequences encoding endoplasmic reticulum signal sequence peptides and at least one other peptide, and their uses in vaccines and disease treatments 失效
标题翻译：包含编码内质网信号序列肽和至少一种其他肽的核酸序列的免疫原性嵌合体及其在疫苗和疾病治疗中的用途
公开(公告)号：US5856187A
公开(公告)日：1999-01-05
申请号：US461566
申请日：1995-06-05
申请人： Nicholas P. Restifo , Steven A. Rosenberg , Jack R. Bennick , Igor Bacik , Jonathan W. Yewdell
发明人： Nicholas P. Restifo , Steven A. Rosenberg , Jack R. Bennick , Igor Bacik , Jonathan W. Yewdell
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/205 , A61K39/39 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/06 , C07H21/04 , C07K14/005 , C07K14/075 , C07K14/145 , C07K14/195 , C07K14/44 , C07K14/47 , C07K14/77 , C07K14/82 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/62 , C12P21/02 , C12R1/91 , C12N5/08
CPC分类号： A61K39/205 , A61K39/0011 , A61K39/12 , A61K39/145 , C07K14/005 , C07K14/47 , C07K14/77 , C12N15/625 , A61K2039/5158 , A61K2039/5256 , A61K39/00 , C07K2319/00 , C07K2319/04 , C07K2319/40 , C12N2710/24143 , C12N2760/16134 , C12N2760/20122 , C12N2760/20134
摘要： Immunogenic chimeric proteins comprising an endoplasmic reticulum signal sequence and at least one other peptide are disclosed. The invention relates to the design of vaccinia virus constructs capable of directing host organism synthesis of immunogenic chimeric proteins which can be used as immunogens, as vaccines, or in methods of treatment for cancer, infectious diseases, or autoimmune diseases.
摘要翻译：公开了包含内质网信号序列和至少一种其它肽的免疫原性嵌合蛋白。本发明涉及能够引导宿主生物体合成可用作免疫原的免疫原性嵌合蛋白，疫苗或癌症，感染性疾病或自身免疫性疾病的治疗方法的痘苗病毒构建体的设计。

4. 发明授权

US08556882B2 Inducible interleukin-12 有权
标题翻译：诱导性白细胞介素-12
公开(公告)号：US08556882B2
公开(公告)日：2013-10-15
申请号：US13266280
申请日：2010-04-22
申请人： Richard A. Morgan , Steven A. Rosenberg , Ling Zhang , Nicholas P. Restifo
发明人： Richard A. Morgan , Steven A. Rosenberg , Ling Zhang , Nicholas P. Restifo
IPC分类号： C12N1/15 , C12N1/13 , C12N1/21
CPC分类号： C07K14/5434 , A61K38/00 , C07K14/4702 , Y02A50/411
摘要： The invention provides an isolated or purified nucleic acid comprising a nucleotide sequence encoding a nuclear factor of activated T-cells (NFAT) promoter operatively associated with a nucleotide sequence encoding IL-12. The invention also provides a nucleic acid comprising a nucleotide sequence encoding a nuclear factor of activated T-cells (NFAT) promoter operatively associated with a nucleotide sequence encoding IL-12, wherein the NFAT promoter is located 3′ of the nucleotide sequence encoding IL-12. Also provided are related recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. The invention further provides the use of the inventive nucleic acids or related materials in the treatment or prevention of cancer or an infectious disease in a mammal and in the induction of IL-12 expression in a mammal.
摘要翻译：本发明提供了分离或纯化的核酸，其包含编码与编码IL-12的核苷酸序列可操作地相关的活化T细胞（NFAT）启动子核因子的核苷酸序列。本发明还提供了一种核酸，其包含编码与编码IL-12的核苷酸序列可操作地相关的活化的T细胞（NFAT）启动子的核因子的核苷酸序列，其中所述NFAT启动子位于编码IL-12的核苷酸序列的3' 12。还提供了相关的重组表达载体，宿主细胞，细胞群和药物组合物。本发明进一步提供了本发明的核酸或相关材料在哺乳动物中治疗或预防癌症或感染性疾病以及在哺乳动物中诱导IL-12表达的用途。

5. 发明申请

US20220282208A1 METHODS OF ISOLATING T CELL POPULATIONS 有权
公开(公告)号：US20220282208A1
公开(公告)日：2022-09-08
申请号：US17636206
申请日：2020-09-18
申请人： Douglas C. PALMER , Anna PASETTO , Nicholas P. RESTIFO , Steven A. ROSENBERG , THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Douglas C. Palmer , Anna Pasetto , Nicholas P. Restifo , Steven A. Rosenberg
IPC分类号： C12N5/00 , G01N33/58 , G01N33/50 , C12N5/078 , A61K35/17 , C07K14/725
摘要： Provided are methods of producing an isolated population of cells for adoptive cell therapy comprising use of at least one cell permeable Ca2+ dye. Further embodiments of the invention provide isolated populations of cells produced by the methods, related pharmaceutical compositions, and related methods of treating or preventing cancer in a patient.

6. 发明申请

US20120071859A1 INDUCIBLE INTERLEUKIN-12 有权
标题翻译：可诱导的白细胞介素12
公开(公告)号：US20120071859A1
公开(公告)日：2012-03-22
申请号：US13266280
申请日：2010-04-22
申请人： Richard A. Morgan , Steven A. Rosenberg , Ling Zhang , Nicholas P. Restifo
发明人： Richard A. Morgan , Steven A. Rosenberg , Ling Zhang , Nicholas P. Restifo
IPC分类号： A61M37/00 , A61K31/711 , A61P35/00 , C12N1/11 , C12N5/10 , C12N1/15 , C12N1/13 , C12N1/21 , C12N15/24 , A61P31/00
CPC分类号： C07K14/5434 , A61K38/00 , C07K14/4702 , Y02A50/411
摘要： The invention provides an isolated or purified nucleic acid comprising a nucleotide sequence encoding a nuclear factor of activated T-cells (NFAT) promoter operatively associated with a nucleotide sequence encoding IL-12. The invention also provides a nucleic acid comprising a nucleotide sequence encoding a nuclear factor of activated T-cells (NFAT) promoter operatively associated with a nucleotide sequence encoding IL-12, wherein the NFAT promoter is located 3′ of the nucleotide sequence encoding IL-12. Also provided are related recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. The invention further provides the use of the inventive nucleic acids or related materials in the treatment or prevention of cancer or an infectious disease in a mammal and in the induction of IL-12 expression in a mammal.
摘要翻译：本发明提供了分离或纯化的核酸，其包含编码与编码IL-12的核苷酸序列可操作地相关的活化T细胞（NFAT）启动子核因子的核苷酸序列。本发明还提供了一种核酸，其包含编码与编码IL-12的核苷酸序列可操作地相关的活化的T细胞（NFAT）启动子的核因子的核苷酸序列，其中所述NFAT启动子位于编码IL-12的核苷酸序列的3' 12。还提供了相关的重组表达载体，宿主细胞，细胞群和药物组合物。本发明进一步提供了本发明的核酸或相关材料在哺乳动物中治疗或预防癌症或感染性疾病以及在哺乳动物中诱导IL-12表达的用途。

7. 发明授权

US08613932B2 GP100-specific T cell receptors and related materials and methods of use 有权
标题翻译： GP100特异性T细胞受体及相关材料及使用方法
公开(公告)号：US08613932B2
公开(公告)日：2013-12-24
申请号：US13483286
申请日：2012-05-30
申请人： Nicholas P. Restifo , Lydie Cassard , Zhiya Yu , Steven A. Rosenberg
发明人： Nicholas P. Restifo , Lydie Cassard , Zhiya Yu , Steven A. Rosenberg
IPC分类号： A61K39/00 , C07K2/00 , C12N5/18
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/7051 , C07K16/30 , C12N15/85 , C12N15/86 , G01N33/57492
摘要： The invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino acids 154-162 of gp100 (SEQ ID NO: 1), as well as related polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding fragments thereof, conjugates, and pharmaceutical compositions, are further provided. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host comprising the use of the inventive materials described herein.
摘要翻译：本发明提供了包含对癌抗原gp100具有抗原特异性的鼠T细胞受体（TCR）的人细胞，特别是人T细胞。具有对gp100（SEQ ID NO：1）的氨基酸154-162具有抗原特异性的分离或纯化的TCR，以及相关多肽，蛋白质，核酸，重组表达载体，宿主细胞，细胞群，抗体或抗原结合其片段，缀合物和药物组合物。本发明还提供了检测宿主中癌症存在的方法以及在宿主中治疗或预防癌症的方法，所述方法包括使用本文所述的本发明材料。

8. 发明申请

US20120230962A1 GP100-SPECIFIC T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USE 有权
标题翻译： GP100特异性T细胞受体及相关材料及其使用方法
公开(公告)号：US20120230962A1
公开(公告)日：2012-09-13
申请号：US13483286
申请日：2012-05-30
申请人： Nicholas P. Restifo , Lydie Cassard , Zhiya Yu , Steven A. Rosenberg
发明人： Nicholas P. Restifo , Lydie Cassard , Zhiya Yu , Steven A. Rosenberg
IPC分类号： C07K14/705 , C12N15/12 , A61K35/12 , C12N5/071 , G01N33/574 , A61K38/17 , C07K16/30 , C12N15/85
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/7051 , C07K16/30 , C12N15/85 , C12N15/86 , G01N33/57492
摘要： The invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino acids 154-162 of gp100 (SEQ ID NO: 1), as well as related polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding fragments thereof, conjugates, and pharmaceutical compositions, are further provided. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host comprising the use of the inventive materials described herein.
摘要翻译：本发明提供了包含对癌抗原gp100具有抗原特异性的鼠T细胞受体（TCR）的人细胞，特别是人T细胞。具有对gp100（SEQ ID NO：1）的氨基酸154-162具有抗原特异性的分离或纯化的TCR，以及相关多肽，蛋白质，核酸，重组表达载体，宿主细胞，细胞群，抗体或抗原结合其片段，缀合物和药物组合物。本发明还提供了检测宿主中癌症存在的方法以及在宿主中治疗或预防癌症的方法，所述方法包括使用本文所述的本发明材料。

9. 发明授权

US08216565B2 GP100-specific T cell receptors and related materials and methods of use 有权
标题翻译： GP100特异性T细胞受体及相关材料及使用方法
公开(公告)号：US08216565B2
公开(公告)日：2012-07-10
申请号：US12522321
申请日：2008-01-11
申请人： Nicholas P. Restifo , Lydie Cassard , Zhiya Yu , Steven A. Rosenberg
发明人： Nicholas P. Restifo , Lydie Cassard , Zhiya Yu , Steven A. Rosenberg
IPC分类号： A01N63/00 , A01N43/04 , A61K48/00 , C07H21/02 , C07H21/04
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/7051 , C07K16/30 , C12N15/85 , C12N15/86 , G01N33/57492
摘要： The invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino acids 154-162 of gp100 (SEQ ID NO: 1), as well as related polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding fragments thereof, conjugates, and pharmaceutical compositions, are further provided. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host comprising the use of the inventive materials described herein.
摘要翻译：本发明提供了包含对癌抗原gp100具有抗原特异性的鼠T细胞受体（TCR）的人细胞，特别是人T细胞。具有对gp100（SEQ ID NO：1）的氨基酸154-162具有抗原特异性的分离或纯化的TCR以及相关多肽，蛋白质，核酸，重组表达载体，宿主细胞，细胞群，抗体或抗原结合其片段，缀合物和药物组合物。本发明还提供了检测宿主中癌症存在的方法以及在宿主中治疗或预防癌症的方法，所述方法包括使用本文所述的本发明的材料。

10. 发明申请

US20100015113A1 GP100-SPECIFIC T CELL RECEPTORS AND RELATED MATERIALS AND METHODS OF USE 有权
标题翻译： GP100特异性T细胞受体及相关材料及其使用方法
公开(公告)号：US20100015113A1
公开(公告)日：2010-01-21
申请号：US12522321
申请日：2008-01-11
申请人： Nicholas P. Restifo , Lydie Cassard , Zhiya Yu , Steven A. Rosenberg
发明人： Nicholas P. Restifo , Lydie Cassard , Zhiya Yu , Steven A. Rosenberg
IPC分类号： A61K35/12 , C12N5/08 , C07K14/725 , C07K16/18 , C07H21/04 , C12N15/63 , G01N33/53 , A61P35/04
CPC分类号： C07K14/70503 , A61K38/00 , C07K14/7051 , C07K16/30 , C12N15/85 , C12N15/86 , G01N33/57492
摘要： The invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino acids 154-162 of gp100 (SEQ ID NO: 1), as well as related polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding fragments thereof, conjugates, and pharmaceutical compositions, are further provided. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host comprising the use of the inventive materials described herein.
摘要翻译：本发明提供了包含对癌抗原gp100具有抗原特异性的鼠T细胞受体（TCR）的人细胞，特别是人T细胞。具有对gp100（SEQ ID NO：1）的氨基酸154-162具有抗原特异性的分离或纯化的TCR，以及相关多肽，蛋白质，核酸，重组表达载体，宿主细胞，细胞群，抗体或抗原结合其片段，缀合物和药物组合物。本发明还提供了检测宿主中癌症存在的方法以及在宿主中治疗或预防癌症的方法，所述方法包括使用本文所述的本发明材料。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式