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1. 发明申请

US20100292229A1 TRYPHOSTIN-ANALOGS FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES 审中-公开
标题翻译：用于治疗细胞增殖性疾病的TRYPHOSTIN-ANALOGS
公开(公告)号：US20100292229A1
公开(公告)日：2010-11-18
申请号：US12307088
申请日：2007-07-02
申请人： Nicholas J Donato , David Maxwell , Moshe Talpaz , William Bornmann , Zhenghong PENG , Ashutosh Pal , Dongmei Han , Shimei Wang , Geoffrey Bartholomeusz , Vaibhav Kapuria
发明人： Nicholas J Donato , David Maxwell , Moshe Talpaz , William Bornmann , Zhenghong PENG , Ashutosh Pal , Dongmei Han , Shimei Wang , Geoffrey Bartholomeusz , Vaibhav Kapuria
IPC分类号： A61K31/538 , C07D213/46 , A61K31/44 , C07C255/44 , A61K31/275 , C07D233/64 , A61K31/4174 , C07D215/14 , A61K31/47 , C07D211/06 , A61K31/451 , C07D209/20 , A61K31/4045 , C07D333/24 , A61K31/381 , C07D265/36 , A61P35/00 , A61P19/02 , A61P9/10 , A61P17/06
CPC分类号： C07D295/155 , C07C255/41 , C07C2601/02 , C07D209/08 , C07D209/18 , C07D213/61 , C07D233/24 , C07D233/26 , C07D265/36 , C07D307/52 , C07D307/54 , C07D311/76 , C07D317/60 , C07D405/12 , C07D409/12 , C07D495/04
摘要： The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. In general aspects, compounds of the present invention are tyrphostin-like in structure. Compounds of the present invention, in certain embodiments, display significant potency by causing, for example, inhibition of Stat3 activation, reduction in c-myc protein levels and/or induction of apoptosis in tumor cells. In general aspects, compounds of the present invention induce one or more of these activities at nanomolar concentrations and typically function through a unique mechanism involving the induction of stress granules that bind specific signaling molecules and prevent them from participating in signal transduction and oncogenesis.
摘要翻译：本发明涉及化合物及其用于治疗细胞增殖性疾病如癌症的用途。在一般方面，本发明的化合物在结构上是酪氨酸激酶样的。在某些实施方案中，本发明的化合物通过引起例如抑制Stat3激活，c-myc蛋白水平的降低和/或肿瘤细胞中凋亡的诱导来显示出显着的效力。在一般方面，本发明的化合物以纳摩尔浓度诱导这些活性中的一种或多种，并且通常通过涉及诱导结合特异性信号分子并阻止其参与信号转导和肿瘤发生的应激颗粒的独特机制起作用。

2. 发明申请

US20090281115A1 INHIBITORS OF C-KIT AND USES THEREOF 审中-公开
标题翻译： C-kit及其用途的抑制剂
公开(公告)号：US20090281115A1
公开(公告)日：2009-11-12
申请号：US12307001
申请日：2007-06-29
申请人： William Bornmann , David Maxwell , Ashutosh Pal , Zhenghong Peng , Zeev Estrov
发明人： William Bornmann , David Maxwell , Ashutosh Pal , Zhenghong Peng , Zeev Estrov
IPC分类号： A61K31/496 , C07D471/04 , A61K31/437 , A61P35/00 , C12N9/99
CPC分类号： C07D471/04
摘要： Compounds and methods useful as inhibitors of c-Kit are presented. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of c-Kit and processes for synthesizing these compounds are also described herein.
摘要翻译：提出了可用作c-Kit抑制剂的化合物和方法。含有这些化合物的药物组合物，使用这些化合物作为c-Kit抑制剂的方法以及合成这些化合物的方法也在本文中描述。

3. 发明申请

US20110312992A1 Inhibitors of C-Kit and Uses Thereof 审中-公开
标题翻译： C-Kit的抑制剂及其用途
公开(公告)号：US20110312992A1
公开(公告)日：2011-12-22
申请号：US13195825
申请日：2011-08-01
申请人： William Bornmann , David Maxwell , Ashutosh Pal , Zhenghong Peng , Zeev Estrov
发明人： William Bornmann , David Maxwell , Ashutosh Pal , Zhenghong Peng , Zeev Estrov
IPC分类号： A61K31/437 , A61P35/02 , A61P35/00 , C07D471/04 , C12N9/99
CPC分类号： C07D471/04
摘要： Compounds and methods useful as inhibitors of c-Kit are presented. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of c-Kit and processes for synthesizing these compounds are also described herein.
摘要翻译：提出了可用作c-Kit抑制剂的化合物和方法。含有这些化合物的药物组合物，使用这些化合物作为c-Kit抑制剂的方法以及合成这些化合物的方法也在本文中描述。

4. 发明申请

US20100144738A1 INHIBITORS OF C-MET AND USES THEREOF 审中-公开
标题翻译： C-MET的抑制剂及其用途
公开(公告)号：US20100144738A1
公开(公告)日：2010-06-10
申请号：US12439491
申请日：2007-08-29
申请人： William Bornmann , David Maxwell , Yunming Ying , Dongmei Han , Zhenghong Peng , Varsha Gandhi , Christine Stellrecht
发明人： William Bornmann , David Maxwell , Yunming Ying , Dongmei Han , Zhenghong Peng , Varsha Gandhi , Christine Stellrecht
IPC分类号： A61K31/522 , C07D473/00 , C07D487/04 , A61K31/5025 , A61P25/00
CPC分类号： C07D473/00 , C07D487/04
摘要： The present invention relates to compounds and methods use as inhibitors of c-Met. Certain compounds of the subject invention have the following structural formula (I). Other compounds of the subject invention have structural formulas as defined herein. Also disclosed herein are pharmaceutical compositions comprising the compounds of the subject invention.
摘要翻译：本发明涉及用作c-Met抑制剂的化合物和方法。本发明的某些化合物具有以下结构式（I）。本发明的其它化合物具有本文定义的结构式。本文还公开了包含本发明化合物的药物组合物。

5. 发明申请

US20110097268A1 RADIOHALOIMATINIBS AND METHODS OF THEIR SYNTHESIS AND USE IN PET IMAGING OF CANCERS 审中-公开
标题翻译：放射性蛋白酶及其合成及其在PET成像中的应用
公开(公告)号：US20110097268A1
公开(公告)日：2011-04-28
申请号：US12310333
申请日：2007-08-22
申请人： William Bornmann , Mian Alauddin , Juri Gelovani , Pradip Ghosh , Liwei Guo , Dongmei Han , David Maxwell , Uday Mukhopadhyay , Zhenghong Peng , Aleksandr Shavrin , Yunming Ying
发明人： William Bornmann , Mian Alauddin , Juri Gelovani , Pradip Ghosh , Liwei Guo , Dongmei Han , David Maxwell , Uday Mukhopadhyay , Zhenghong Peng , Aleksandr Shavrin , Yunming Ying
IPC分类号： A61K51/04 , C07D403/14 , A61P35/00
CPC分类号： A61K51/0491
摘要： We disclose methods of synthesizing radiohalidated organic compounds and their use in positron emission tomography (PET) imaging of cancer cells.
摘要翻译：我们公开了合成放射性有机化合物的方法及其在癌细胞正电子发射断层扫描（PET）成像中的应用。

6. 发明申请

US20100322858A1 Radiohaloimatinibs and Methods of Their Synthesis and Use in PET Imaging of Cancers 审中-公开
标题翻译：他们合成和应用于PET成像的放射性卤代西他滨及其方法
公开(公告)号：US20100322858A1
公开(公告)日：2010-12-23
申请号：US12438045
申请日：2007-08-22
申请人： William Bornmann , Mian Alauddin , Juri Gelovani , Pradip Ghosh , Liwei Guo , Dongmei Han , David Maxwell , Uday Mukhopadhyay , Zhenghong Peng , Aleksandr Shavrin , Yunming Ying
发明人： William Bornmann , Mian Alauddin , Juri Gelovani , Pradip Ghosh , Liwei Guo , Dongmei Han , David Maxwell , Uday Mukhopadhyay , Zhenghong Peng , Aleksandr Shavrin , Yunming Ying
IPC分类号： A61K49/04 , C07H5/02
CPC分类号： A61K51/0491
摘要： We disclose methods of synthesizing radiohalidated organic compounds and their use in positron emission tomography (PET) imaging of cancer cells.
摘要翻译：我们公开了合成放射性有机化合物的方法及其在癌细胞正电子发射断层扫描（PET）成像中的应用。

7. 发明申请

US20100144743A1 COMPOSITIONS AND METHODS FOR INHIBITION OF TYROSINE KINASES 审中-公开
标题翻译：用于抑制酪氨酸激酶的组合物和方法
公开(公告)号：US20100144743A1
公开(公告)日：2010-06-10
申请号：US12439402
申请日：2007-09-04
申请人： William Bornmann , David Maxwell , Zhenghong Peng , Liwei Guo
发明人： William Bornmann , David Maxwell , Zhenghong Peng , Liwei Guo
IPC分类号： A61K31/506 , C07D239/42 , C07D403/10 , C07D471/04 , A61K31/4985 , A61P35/00
CPC分类号： A61K31/506
摘要： Compositions for inhibiting the catalytic activity of tyrosine kinases comprising compounds represented by Formulas (I), (II), and (III). Methods for treating proliferative diseases comprising administering a therapeutically effective amount of the above compositions.
摘要翻译：用于抑制酪氨酸激酶的催化活性的组合物，其包含由式（I），（II）和（III）表示的化合物。治疗增殖性疾病的方法包括施用治疗有效量的上述组合物。

8. 发明申请

US20100152140A1 Method of Cancer Treatment with Naphthol Analogs 审中-公开
标题翻译：萘酚类似物治疗癌症的方法
公开(公告)号：US20100152140A1
公开(公告)日：2010-06-17
申请号：US12529252
申请日：2008-01-18
申请人： Ja Seok Koo , William Bornmann , David Maxwell
发明人： Ja Seok Koo , William Bornmann , David Maxwell
IPC分类号： A61K31/66
CPC分类号： A61K31/661
摘要： In one embodiment, the present invention relates to a method of treating a cancer characterized by overexpression of cyclic adenosine monophosphate response element-binding protein (CREB) or phosphorylated CREB (p-CREB) by administering to a patient suffering from the cancer a pharmaceutically-effective amount of a composition comprising a compound selected from the group consisting of 2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methylindol-3-yl)maleimide, naphthol analogs having the structure (I), wherein R1 is selected from the group consisting of —H, —F, —Cl, —Br, and —I; R2 is selected from the group consisting of —H, —F, —Cl, —Br, —I, —C1-6 alkyl, —C1-6alkenyl, and —C1-6 alkynyl; R3 is selected from the group consisting of —H and —NO2; and R4 is selected from the group consisting of —H, —C1-6 alkyl, —C1-6 alkenyl, —C1-6 alkynyl, —OC1-6 alkyl, —OC1-6 alkenyl, and —OC1-6 alkynyl; and salts and esters thereof.
摘要翻译：在一个实施方案中，本发明涉及一种治疗癌症的方法，其特征在于通过向患有癌症的患者施用药学上可接受的方法来过表达环腺苷一磷酸应答元件结合蛋白（CREB）或磷酸化CREB（p-CREB）有效量的包含选自2- {1- [3-（脒基硫代）丙基] -1H-吲哚-3-基} -3-（1-甲基吲哚-3-基）马来酰亚胺的化合物的组合物，具有结构（I）的萘酚类似物，其中R 1选自-H，-F，-Cl，-Br和-I; R 2选自-H，-F，-Cl，-Br，-I，-C 1-6烷基，-C 1-6烯基和-C 1-6炔基; R3选自-H和-NO 2; 并且R 4选自-H，-C 1-6烷基，-C 1-6烯基，-C 1-6炔基，-OC 1-6烷基，-OC 1-6链烯基和-OC 1-6苯基; 及其盐和酯。

9. 发明授权

US5639074A Interlaced wave spring 失效
标题翻译：隔行波的春天
公开(公告)号：US5639074A
公开(公告)日：1997-06-17
申请号：US611055
申请日：1996-03-05
申请人： Michael Greenhill , David Maxwell
发明人： Michael Greenhill , David Maxwell
IPC分类号： F16F1/32 , F16F1/06
CPC分类号： F16F1/328
摘要： An interlaced wave spring is formed from two constituent wave springs of similar thickness, amplitude and frequency. The two constituent wave springs are combined together by interlacing them so that the spring turns of each spring abut each other for substantially the entire length of the interlaced spring. This interlacing effectively increases the thickness of the spring turns of the interlaced spring to thereby provide increased loading and greater fatigue resistance characteristics.
摘要翻译：由两个相似厚度，幅度和频率的组成波形弹簧形成隔行波形弹簧。两个组成的波形弹簧通过交织它们组合在一起，使得每个弹簧的弹簧圈在隔行弹簧的大致整个长度上彼此抵接。这种交织有效地增加了交错弹簧的弹簧圈的厚度，从而提供了增加的负载和更大的抗疲劳特性。

10. 发明授权

US07899237B2 Method, apparatus and system for detecting anomalies in mixed signal devices 有权
标题翻译：用于检测混合信号装置异常的方法，装置和系统
公开(公告)号：US07899237B2
公开(公告)日：2011-03-01
申请号：US11683548
申请日：2007-03-08
申请人： Dat T. Nguyen , Thao To , David Maxwell , Naweed Anjum
发明人： Dat T. Nguyen , Thao To , David Maxwell , Naweed Anjum
IPC分类号： G06K9/00
CPC分类号： G01R31/3167 , G01R31/311
摘要： An embodiment relates generally to a method of testing a mixed signal device. The method includes monitoring multiple parameters of the mixed signal device and scanning the mixed signal device with an optical source. The method also includes forming multiple windows, where each window is assigned to a respective parameter. The method further includes comparing an image from a respective image to a reference image to determine an existence of an anomaly.
摘要翻译：实施例一般涉及测试混合信号装置的方法。该方法包括监视混合信号装置的多个参数并用光源扫描混合信号装置。该方法还包括形成多个窗口，其中每个窗口被分配给相应的参数。该方法还包括将来自相应图像的图像与参考图像进行比较，以确定异常的存在。

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