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    • 6. 发明申请
    • Therapeutic Uses For Aminosterol Compounds
    • 氨基甾醇化合物的治疗用途
    • US20080221075A1
    • 2008-09-11
    • US12041440
    • 2008-03-03
    • Michael ZasloffJon WilliamsWilliam KinneyMark AndersonMichael McLane
    • Michael ZasloffJon WilliamsWilliam KinneyMark AndersonMichael McLane
    • A61K31/56C07J41/00A61P3/04
    • A61K31/575C07J41/0055
    • A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Various pharmaceutical products may be produced including this pharmaceutical composition. Such pharmaceutical products may be used for the treatment of obesity or diabetes. Methods for using the pharmaceutical compositions also are described. In these methods, various diseases are treated or other body functions are activated or inhibited by administering an effective amount of the pharmaceutical composition. For example, diabetes and obesity may be treated by administering an effective amount of the pharmaceutical compositions. Weight gain, and growth factor production can be inhibited by administering an effective amount of these pharmaceutical compositions. Appetite can be suppressed by administering an effective amount of the pharmaceutical compositions, and a diuretic effect can be produced.
    • 药物组合物包含作为活性成分的如图14所示的根据式1436的化合物。 1,或其药学上可接受的盐,和药学上可接受的载体或赋形剂。 可以生产包括该药物组合物的各种药物。 这样的药物可以用于治疗肥胖或糖尿病。 还描述了使用药物组合物的方法。 在这些方法中,通过施用有效量的药物组合物来治疗各种疾病或其他身体功能被激活或抑制。 例如,可以通过施用有效量的药物组合物来治疗糖尿病和肥胖症。 通过施用有效量的这些药物组合物可以抑制体重增加和生长因子产生。 可以通过施用有效量的药物组合物来抑制食欲,并且可以产生利尿作用。
    • 7. 发明申请
    • Therapeutic Uses for an Aminosterol Compound
    • 氨基甾醇化合物的治疗用途
    • US20130281419A1
    • 2013-10-24
    • US13673500
    • 2012-11-09
    • Michael ZasloffJon WilliamsWilliam KinneyMark AndersonMichael McLane
    • Michael ZasloffJon WilliamsWilliam KinneyMark AndersonMichael McLane
    • A61K31/575
    • A61K31/575C07J41/0055
    • A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Various pharmaceutical products may be produced including this pharmaceutical composition. Such pharmaceutical products may be used for the treatment of obesity or diabetes. Methods for using the pharmaceutical compositions also are described. In these methods, various diseases are treated or other body functions are activated or inhibited by administering an effective amount of the pharmaceutical composition. For example, diabetes and obesity may be treated by administering an effective amount of the pharmaceutical compositions. Weight gain and growth factor production can be inhibited by administering an effective amount of these pharmaceutical compositions. Appetite can be suppressed by administering an effective amount of the pharmaceutical compositions, and a diuretic effect can be produced.
    • 药物组合物包含作为活性成分的如图14所示的根据式1436的化合物。 1,或其药学上可接受的盐,和药学上可接受的载体或赋形剂。 可以生产包括该药物组合物的各种药物。 这样的药物可以用于治疗肥胖或糖尿病。 还描述了使用药物组合物的方法。 在这些方法中,通过施用有效量的药物组合物来治疗各种疾病或其他身体功能被激活或抑制。 例如,可以通过施用有效量的药物组合物来治疗糖尿病和肥胖症。 通过施用有效量的这些药物组合物可以抑制体重增加和生长因子产生。 可以通过施用有效量的药物组合物来抑制食欲,并且可以产生利尿作用。
    • 9. 发明申请
    • Distributed Physics Based Training System and Methods
    • 基于分布式物理的训练系统和方法
    • US20090099824A1
    • 2009-04-16
    • US12085541
    • 2006-11-28
    • Mark FalashEytan PollakYushan ChenJon Williams
    • Mark FalashEytan PollakYushan ChenJon Williams
    • G06G7/70
    • G09B9/00H04L67/38
    • A distributed simulation system is composed of simulator stations linked over a network that each renders real-time video imagery for its user from scene data stored in its data storage. The simulation stations are each connected with a physics farm that manages the virtual objects in the shared virtual environment based on their physical attribute data using physics engines, including an engine at each simulation station. The physics engines of the physics farm are assigned virtual objects so as to reduce the effects of latency, to ensure fair fight requirements of the system, and, where the simulation is of a vehicle, to accurately model the ownship of the user at the station. A synchronizer system is also provided that allows for action of simulated entities relying on localized closed loop controls to cause the entities to meet specific goal points at specified system time points.
    • 分布式仿真系统由通过网络链接的模拟器站组成,每个模拟站通过存储在其数据存储器中的场景数据为其用户呈现实时视频图像。 模拟站各自与物理场连接,物理场基于使用物理引擎(包括每个模拟站的引擎)的物理属性数据来管理共享虚拟环境中的虚拟对象。 物理场的物理引擎被分配虚拟对象,以减少延迟的影响,以确保系统的公平对抗要求,并且在模拟车辆的情况下,准确地对车站用户进行建模 。 还提供了同步器系统,其允许依赖于本地化闭环控制的模拟实体的动作使得实体在指定的系统时间点满足特定的目标点。
    • 10. 发明授权
    • Therapeutic uses for aminosterol compounds
    • 氨基甾醇化合物的治疗用途
    • US07410959B1
    • 2008-08-12
    • US09885247
    • 2000-07-13
    • Michael ZasloffJon WilliamsWilliam KinneyMark AndersonMichael McLane
    • Michael ZasloffJon WilliamsWilliam KinneyMark AndersonMichael McLane
    • A61K31/56A61K31/555A01N55/02C07J41/00
    • A61K31/575C07J41/0055
    • A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Various pharmaceutical products may be produced including this pharmaceutical composition. Such pharmaceutical products may be used for the treatment of obesity or diabetes. Methods for using the pharmaceutical compositions also are described. In these methods, various diseases are treated or other body functions are activated or inhibited by administering an effective amount of the pharmaceutical composition. For example, diabetes and obesity may be treated by administering an effective amount of the pharmaceutical compositions. Weight gain, and growth factor production can be inhibited by administering an effective amount of these pharmaceutical compositions. Appetite can be suppressed by administering an effective amount of the pharmaceutical compositions, and a diuretic effect can be produced.
    • 药物组合物包含作为活性成分的如图14所示的根据式1436的化合物。 1,或其药学上可接受的盐,和药学上可接受的载体或赋形剂。 可以生产包括该药物组合物的各种药物。 这样的药物可以用于治疗肥胖或糖尿病。 还描述了使用药物组合物的方法。 在这些方法中,通过施用有效量的药物组合物来治疗各种疾病或其他身体功能被激活或抑制。 例如,可以通过施用有效量的药物组合物来治疗糖尿病和肥胖症。 通过施用有效量的这些药物组合物可以抑制体重增加和生长因子产生。 可以通过施用有效量的药物组合物来抑制食欲,并且可以产生利尿作用。