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1. 发明授权

US5955610A Antiviral compounds 失效
公开(公告)号：US5955610A
公开(公告)日：1999-09-21
申请号：US868706
申请日：1997-06-04
申请人： Nghe Nguyen-Ba , Miguel Quimpere , Laval Chan Chun Kong , William L. Brown , Gervais Dionne
发明人： Nghe Nguyen-Ba , Miguel Quimpere , Laval Chan Chun Kong , William L. Brown , Gervais Dionne
IPC分类号： C07H15/04 , C07H19/04 , C07H19/06 , C07H19/16 , C07F9/6512 , C07F9/6521 , C07F9/6561
CPC分类号： C07H19/06 , C07H15/04 , C07H19/04 , C07H19/16
摘要： Nucleotide analogues having the general formula (I) and pharmaceutically acceptable derivatives: ##STR1## wherein n is 0 or an integer; X is O or S, CH.sub.2, CH-halogen, CH--N.sub.3, or C.dbd.CH.sub.2 ;Q and U are independently selected from: O, S, and CH(R.sub.a) wherein R.sub.a is hydrogen, OH, halogen, N.sub.3, NH.sub.2, SH, carboxyl, C.sub.1-6 alkyl or R.sub.a is CH.sub.2 (R.sub.b) wherein R.sub.b is hydrogen, OH, SH, NH.sub.2, C.sub.1-6 alkyl or carboxyl; or both Q and U are CH when Q and U are linked by a double bond;Z is selected from: O, a C.sub.1-6 alkoxy, a C.sub.1-6 thioalkyl, a C.sub.1-6 aminoalkyl, (CH.sub.2).sub.m wherein m is 0 or an integer, and N(R.sub.c).sub.2 wherein both R.sub.c are independently hydrogen or a C.sub.1-6 alkyl; andR2 is a purine or pyrimidine base or an analogue or derivative thereof. Members of this series of analogues possess anti-viral activity.

2. 发明授权

US6005107A Antiviral compounds 失效
公开(公告)号：US6005107A
公开(公告)日：1999-12-21
申请号：US868782
申请日：1997-06-04
申请人： Nghe Nguyen-Ba , Miguel Quimpere , Laval Chan Chun Kong , William L. Brown , Gervais Dionne
发明人： Nghe Nguyen-Ba , Miguel Quimpere , Laval Chan Chun Kong , William L. Brown , Gervais Dionne
IPC分类号： C07H15/04 , C07H19/04 , C07H19/06 , C07H19/16 , C07F9/6512
CPC分类号： C07H15/04 , C07H19/04 , C07H19/06 , C07H19/16
摘要： Nucleotide analogues having the general formula (I) and pharmaceutically acceptable derivatives: ##STR1## wherein n is 0 or an integer; X is O or S, CH.sub.2, CH-halogen, CH--N.sub.3, or C.dbd.CH.sub.2 ;Q and U are independently selected from: O, S, and CH(R.sub.a) wherein R.sub.a is hydrogen, OH, halogen, N.sub.3, NH.sub.2, SH, carboxyl, C.sub.1-6 alkyl or R.sub.a is CH.sub.2 (R.sub.b) wherein R.sub.b is hydrogen, OH, SH, NH.sub.2, C.sub.1-6 alkyl or carboxyl; or both Q and U are CH when Q and U are linked by a double bond;Z is selected from: O, a C.sub.1-6 alkoxy, a C.sub.1-6 thioalkyl, a C.sub.1-6 aminoalkyl, (CH.sub.2).sub.m wherein m is 0 or an integer, and N(R.sub.c).sub.2 wherein both R.sub.c are independently hydrogen or a C.sub.1-6 alkyl; andR2 is a purine or pyrimidine base or an analogue or derivative thereof. Members of this series of analogues possess anti-viral activity.

3. 发明授权

US06194576B1 Process for preparing antiviral 2-phosponate nucleotide analogs 失效
标题翻译：制备抗病毒2-磷酸核苷酸类似物的方法
公开(公告)号：US06194576B1
公开(公告)日：2001-02-27
申请号：US09411980
申请日：1999-10-04
申请人： Nghe Nguyen-Ba , Miguel Quimpere , Laval Chan Chun Kong , William L. Brown , Gervais Dionne
发明人： Nghe Nguyen-Ba , Miguel Quimpere , Laval Chan Chun Kong , William L. Brown , Gervais Dionne
IPC分类号： C07D40704
CPC分类号： C07H15/04 , C07H19/04 , C07H19/06 , C07H19/16
摘要： Nucleotide analogues having the general formula (I) and pharmaceutically acceptable derivatives: wherein n is 0 or an integer; X is O or S, CH2, CH-halogen, CH—N3, or C═CH2; Q and U are independently selected from: O, S, and CH(Ra) wherein Ra is hydrogen, OH, halogen, N3 ,NH2, SH, carboxyl, C1-6 alkyl or Ra is CH2(Rb) wherein Rb is hydrogen, OH, SH, NH2, C1-6 alkyl or carboxyl; or both Q and U are CH when Q and U are linked by a double bond; Z is selected from: O, a C1-6 alkoxy, a C1-6 thioalkyl, a C1-6 aminoalkyl, (CH2)m wherein m is 0 or an integer, and N(Rc)2 wherein both Rc are independently hydrogen or a C1-6 alkyl; and R2 is a purine or pyrimidine base or an analogue or derivative thereof. Members of this series of analogues possess anti-viral activity.
摘要翻译：具有通式（I）的核苷酸类似物和药学上可接受的衍生物：其中n为0或整数; X为O或S，CH 2，CH-卤素，CH-N 3或C = CH 2; Q和U独立地选自：O，S和CH（Ra）其中R a是氢，OH，卤素，N 3，NH 2，SH，羧基，C 1-6烷基或R a是其中R b是氢，OH，SH，NH 2，C 1 -6烷基或羧基; 或者当Q和U通过双键连接时，Q和U都是CH; Z选自：O，C1-6烷氧基，C1-6硫代烷基，C1-6氨基烷基，（CH2）m，其中m是 0或整数，和N（Rc）2，其中两个R c独立地是氢或C 1-6烷基; 并且R 2是嘌呤或嘧啶碱基或其类似物或衍生物。这一系列类似物的成员具有抗病毒活性。

4. 发明授权

US6127540A Antiviral compounds 失效
标题翻译：抗病毒化合物
公开(公告)号：US6127540A
公开(公告)日：2000-10-03
申请号：US411979
申请日：1999-10-04
申请人： Nghe Nguyen-Ba , Miguel Quimpere , Laval Chan Chun Kong , William L. Brown , Gervais Dionne
发明人： Nghe Nguyen-Ba , Miguel Quimpere , Laval Chan Chun Kong , William L. Brown , Gervais Dionne
IPC分类号： C07H15/04 , C07H19/04 , C07H19/06 , C07H19/16 , C07D473/18
CPC分类号： C07H15/04 , C07H19/04 , C07H19/06 , C07H19/16
摘要： Nucleotide analogues having the general formula (I) and pharmaceutically acceptable derivatives: ##STR1## wherein n is 0 or an integer; X is O or S, CH.sub.2, CH--halogen, CH--N.sub.3, or C.dbd.CH.sub.2 ;Q and U are independently selected from: O, S, and CH(R.sub.a) wherein R.sub.a is hydrogen, OH, halogen, N.sub.3, NH.sub.2, SH, carboxyl, C.sub.1-6 alkyl or R.sub.a is CH.sub.2 (R.sub.b) wherein R.sub.b is hydrogen, OH, SH, NH.sub.2, C.sub.1-6 alkyl or carboxyl; or both Q and U are CH when Q and U are linked by a double bond;Z is selected from: O, a C.sub.1-6 alkoxy, a C.sub.1-6 thioalkyl, a C.sub.1-6 aminoalkyl, (CH.sub.2).sub.m wherein m is 0 or an integer, and N(R.sub.c).sub.2 wherein both R.sub.c are independently hydrogen or a C.sub.1-6 alkyl; andR2 is a purine or pyrimidine base or an analogue or derivative thereof. Members of this series of analogues possess anti-viral activity.
摘要翻译：具有通式（I）的核苷酸类似物和药学上可接受的衍生物：其中n为0或整数; X是O或S，CH 2，CH-卤素，CH-N 3或C = CH 2; Q和U独立地选自：O，S和CH（Ra）其中R a是氢，OH，卤素，N 3，NH 2，SH，羧基，C 1-6烷基或R a是CH 2（R b） OH，SH，NH 2，C 1-6烷基或羧基; 或者当Q和U通过双键连接时，Q和U都是CH; Z选自：O，C 1-6烷氧基，C 1-6硫烷基，C 1-6氨基烷基，（CH 2）m，其中m是0或整数，和N（R c）2，其中两个R c独立地是氢或 C 1-6烷基; R2是嘌呤或嘧啶碱基或其类似物或衍生物。这一系列类似物的成员具有抗病毒活性。

5. 发明授权

US5789394A Anti-viral compounds 失效
标题翻译：抗病毒化合物
公开(公告)号：US5789394A
公开(公告)日：1998-08-04
申请号：US639685
申请日：1996-04-29
申请人： Nghe Nguyen-Ba , Miguel Quimpere , Laval Chan Chung Kong , William L. Brown , Gervais Dionne
发明人： Nghe Nguyen-Ba , Miguel Quimpere , Laval Chan Chung Kong , William L. Brown , Gervais Dionne
IPC分类号： C07H15/04 , C07H19/04 , C07H19/06 , C07H19/16 , A61K31/675 , C07F9/6512
CPC分类号： C07H19/06 , C07H15/04 , C07H19/04 , C07H19/16
摘要： Nucleotide analogues having the general formula (I) and pharmaceutically acceptable derivatives: ##STR1## wherein n is 0 or an integer; X is O or S, CH.sub.2, CH-halogen, CH--N.sub.3, or C.dbd.CH.sub.2 ; Q and U are independently selected from: O, S, and CH(R.sub.a) wherein R.sub.a is hydrogen, OH, halogen, N.sub.3, NH.sub.2, SH, carboxyl, C.sub.1-6 alkyl or R.sub.a is CH.sub.2 (R.sub.b) wherein R.sub.b is hydrogen, OH, SH, NH.sub.2, C.sub.1-6 alkyl or carboxyl; or both Q and U are CH when Q and U are linked by a double bond; Z is selected from: O, a C.sub.1-6 alkoxy, a C.sub.1-6 thioalkyl, a C.sub.1-6 aminoalkyl, (CH.sub.2).sub.m wherein m is 0 or an integer, and N(R.sub.c).sub.2 wherein both R.sub.c are independently hydrogen or a C.sub.1-6, alkyl; and R2 is a purine or pyrimidine base or an analogue or derivative thereof are disclosed. Members of this series of analogues possess anti-viral activity.
摘要翻译：具有通式（I）的核苷酸类似物和药学上可接受的衍生物：其中n为0或整数; X是O或S，CH 2，CH-卤素，CH-N 3或C = CH 2; Q和U独立地选自：O，S和CH（Ra）其中R a是氢，OH，卤素，N 3，NH 2，SH，羧基，C 1-6烷基或R a是CH 2（R b） OH，SH，NH 2，C 1-6烷基或羧基; 或者当Q和U通过双键连接时，Q和U都是CH; Z选自：O，C 1-6烷氧基，C 1-6硫烷基，C 1-6氨基烷基，（CH 2）m，其中m是0或整数，和N（R c）2，其中两个R c独立地是氢或 C 1-6烷基; 并且R 2是嘌呤或嘧啶碱基或其类似物或衍生物。这一系列类似物的成员具有抗病毒活性。

6. 发明申请

US20140031467A1 ANTIDRIFT COMPOSITION 有权
标题翻译：防腐剂组合物
公开(公告)号：US20140031467A1
公开(公告)日：2014-01-30
申请号：US13558513
申请日：2012-07-26
申请人： William L. Brown , George A. Policello
发明人： William L. Brown , George A. Policello
IPC分类号： C08K5/544 , C08L33/26
CPC分类号： A01N57/20 , C08K5/544 , C08L33/26 , A01N25/00 , A01N25/24 , A01N25/30 , A01N2300/00
摘要： A solid, water-soluble fast-dissolving antidrift composition includes a urea-based complex-forming component (i) complexed with an antidrift component (ii), the antidrift composition optionally further including an adjuvant component (iii).
摘要翻译：固体，水溶性快速溶解抗蚀剂组合物包括与抗蚀剂组分（ii）络合的脲基络合物形成组分（i），抗蚀组合物任选地还包含佐剂组分（iii）。

7. 发明授权

US5370812A Lubricant compositions for refrigerators comprising polyalkylene glycol and a hydrocarbon solvent 失效
标题翻译：用于包含聚亚烷基二醇和烃溶剂的冰箱的润滑剂组合物
公开(公告)号：US5370812A
公开(公告)日：1994-12-06
申请号：US83820
申请日：1993-06-28
申请人： William L. Brown
发明人： William L. Brown
IPC分类号： C09K5/04 , C10M111/04 , C10M169/04 , C10M171/00 , C09K5/00
CPC分类号： C09K5/045 , C10M111/04 , C10M169/04 , C10M171/008 , C09K2205/24 , C10M2203/02 , C10M2203/022 , C10M2203/024 , C10M2203/04 , C10M2203/045 , C10M2209/1033 , C10M2209/1045 , C10M2209/105 , C10M2209/1055 , C10M2209/1065 , C10M2209/107 , C10M2209/1075 , C10M2209/1085 , C10M2209/1095 , C10M2211/022 , C10M2211/06 , C10N2240/00 , C10N2240/22 , C10N2240/30 , C10N2240/50 , C10N2240/52 , C10N2240/54 , C10N2240/56 , C10N2240/58 , C10N2240/60 , C10N2240/66
摘要： Lubricant compositions are disclosed which comprise polyalkylene glycols and hydrocarbon solvents having 15 or less carbon atoms per molecule. The polyalkylene glycols are soluble in fluorocarbon-based refrigerants, such as for example, HFC-134a, and the hydrocarbon solvents are soluble in the polyalkylene glycols. Thus, the lubricant compositions are particularly well suited as lubricants in refrigeration systems, such as for example, automobile air conditioners, which contain fluorocarbon-based refrigerants. Refrigerant/lubricant compositions comprising refrigerants and the lubricant compositions are also disclosed.
摘要翻译：公开了包含每分子具有15个或更少碳原子的聚亚烷基二醇和烃溶剂的润滑剂组合物。聚亚烷基二醇可溶于氟碳基制冷剂，例如HFC-134a，烃溶剂可溶于聚亚烷基二醇。因此，润滑剂组合物特别适用于制冷系统中的润滑剂，例如含有氟碳基制冷剂的汽车空调。还公开了包含制冷剂和润滑剂组合物的制冷剂/润滑剂组合物。

8. 发明授权

US5152926A Refrigerant lubricant compositions 失效
标题翻译：制冷剂润滑剂组合物
公开(公告)号：US5152926A
公开(公告)日：1992-10-06
申请号：US579720
申请日：1990-09-10
申请人： William L. Brown
发明人： William L. Brown
IPC分类号： C09K5/00 , C09K5/04 , C09K5/08 , C10M105/18 , C10M107/34 , C10M171/00 , C10N20/00 , C10N20/02 , C10N40/30
CPC分类号： C10M171/008 , C09K5/045 , C09K2205/24
摘要： Antiwear additives for refrigerant lubricant compositions and refrigerant lubricant compositions containing said antiwear additives are disclosed for use in compression refrigeration applications.
摘要翻译：公开了用于制冷剂润滑剂组合物和含有所述抗磨添加剂的制冷剂润滑剂组合物的抗磨添加剂用于压缩制冷应用中。

9. 发明授权

US4439650A Switch assembly for automotive pedal construction 失效
标题翻译：用于汽车踏板结构的开关总成
公开(公告)号：US4439650A
公开(公告)日：1984-03-27
申请号：US311191
申请日：1981-10-14
申请人： William L. Brown
发明人： William L. Brown
IPC分类号： G05G1/487 , H01H13/16 , H01H3/14
CPC分类号： G05G1/487 , H01H13/16 , Y10T74/20888
摘要： An improved brake light switch that is integrated into the brake pedal and actuated by the application of pressure to the pedal. The pedal pad is movable relative to the pedal and this relative movement effects closure of the switch.
摘要翻译：一种改进的制动灯开关，其集成到制动踏板中并通过向踏板施加压力而致动。脚踏板相对于踏板是可移动的，并且该相对运动会影响开关的闭合。

10. 发明授权

US4349126A Substrate dispensing apparatus 失效
标题翻译：基板分配装置
公开(公告)号：US4349126A
公开(公告)日：1982-09-14
申请号：US209244
申请日：1980-11-21
申请人： William L. Brown
发明人： William L. Brown
IPC分类号： B65G59/08 , B65H29/36 , B65G59/00
CPC分类号： B65H29/36 , B65G59/08
摘要： Dispensing apparatus for dispensing articles such as thin substrates includes horizontally disposed shelves one above the other. Each shelf is divided into a plurality of lanes. Each lane includes at least one endless belt for moving a stack of upright substrates toward a front edge of the shelf. A drive mechanism is connected to each belt for driving each belt. A transfer member is provided for each lane adjacent the front end portion of the shelf. Each transfer member projects beyond the effective reach of its associated belt so that the leading substrate to be dispensed is supported by the transfer member prior to dropping downwardly off the free end of the transfer member.
摘要翻译：用于分配诸如薄基板的物品的分配装置包括一个在另一个之上的水平布置的搁架。每个货架分为多个车道。每个通道包括至少一个环形带，用于将一堆直立基板朝着货架的前边缘移动。驱动机构连接到每个皮带上，用于驱动每个皮带。为与架子的前端部分相邻的每个通道设置传送部件。每个传送构件突出超出其相关带的有效接触，使得待分配的前导基板在从转印构件的自由端向下掉下之前由转印构件支撑。

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