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1. 发明申请

US20120053071A1 METHOD FOR THE DETECTION OF DNA METHYLATION PATTERNS 审中-公开
标题翻译：检测DNA甲基化模式的方法
公开(公告)号：US20120053071A1
公开(公告)日：2012-03-01
申请号：US13140972
申请日：2009-12-14
申请人： Nevenka Dimitrova , Chetan Mittal , Sitharthan Kamalakaran
发明人： Nevenka Dimitrova , Chetan Mittal , Sitharthan Kamalakaran
IPC分类号： C40B30/04 , C40B30/00 , G06F19/00 , C12Q1/68
CPC分类号： C12Q1/6827 , C12Q2523/125
摘要： The present invention relates to a method for the detection of a DNA methylation signature associated with the presence of or the predisposition to develop a disorder, the method comprising the identification of one or more candidate genes exhibiting differential DNA methylation in target and reference samples as well as the respective determination of the nucleic acid sites in said candidate genes that are differentially methylated and the recognition sites for DNA binding factors, said DNA binding factors each recognizing such a differentially methylated nucleic acid site, wherein the patterns of differentially methylated nucleic acid sites and of DNA binding factor recognition sites obtained together represent a DNA methylation signature that is indicative for the presence of or the predisposition to develop a disorder in a target sample.
摘要翻译：本发明涉及一种用于检测与发生病症的存在或倾向相关的DNA甲基化特征的方法，所述方法包括鉴定靶和参照样品中显示差异DNA甲基化的一个或多个候选基因作为差异甲基化的所述候选基因中的核酸位点和DNA结合因子的识别位点的各自测定，所述DNA结合因子各自识别这样的差异甲基化核酸位点，其中差异甲基化的核酸位点和一起获得的DNA结合因子识别位点代表一种DNA甲基化特征，其指示在目标样品中存在发生障碍的倾向或倾向。

2. 发明授权

US09528113B2 Therapy delivery and monitoring using a gene of interest-reporter fusion protein and optical imaging 有权
标题翻译：使用感兴趣的基因 - 报告融合蛋白和光学成像的治疗传播和监测
公开(公告)号：US09528113B2
公开(公告)日：2016-12-27
申请号：US12993109
申请日：2009-05-14
申请人： Nevenka Dimitrova , Chetan Mittal
发明人： Nevenka Dimitrova , Chetan Mittal
IPC分类号： G01N33/00 , C12N15/62 , C07K14/435 , C07K14/71 , C12Q1/68
CPC分类号： C12N15/62 , C07K14/43595 , C07K14/71 , C07K2319/60 , C12Q1/6897 , C12Q2537/164 , C12Q2525/207 , C12Q2525/143
摘要： The present invention relates to a method of non-invasively monitoring the expression of a gene of interest in a cell when contacting said cell with a compound influencing the expression of said gene of interest. The present invention is also concerned with different isolated nucleic acid molecules comprising a coding sequence. Said coding sequence comprises a gene of interest-sequence encoding a gene of interest-polypeptide fused to a reporter sequence encoding a fluorescent reporter polypeptide and is operatively coupled to a promoter sequence. The present invention is also concerned with the use of a method and a nucleic acid molecule of the invention for delivering a compound influencing the expression of a gene of interest in a cell, monitoring the delivery of said compound as well as monitoring the influence on the expression of said gene of interest induced by said compound at the same time.
摘要翻译：本发明涉及当使所述细胞与影响目标基因表达的化合物接触时非侵入性地监测细胞中目的基因的表达的方法。本发明还涉及包含编码序列的不同分离的核酸分子。所述编码序列包含编码与编码荧光报道多肽的报告基因融合的感兴趣基因多肽的目标基因序列，并且可操作地偶联至启动子序列。本发明还涉及本发明的方法和核酸分子用于递送影响细胞中目的基因表达的化合物，监测所述化合物的递送以及监测对所述化合物的影响所述化合物同时诱导的所述感兴趣的基因的表达。

3. 发明申请

US20110246082A1 METHOD FOR SPECTRAL DNA ANALYSIS 审中-公开
标题翻译：光谱DNA分析方法
公开(公告)号：US20110246082A1
公开(公告)日：2011-10-06
申请号：US12995678
申请日：2009-06-12
申请人： Anca Ioana Daniela Bucur , Jasper Johannes Adrianus Van Leeuwen , Nevenka Dimitrova , Chetan Mittal
发明人： Anca Ioana Daniela Bucur , Jasper Johannes Adrianus Van Leeuwen , Nevenka Dimitrova , Chetan Mittal
IPC分类号： G06F19/00
CPC分类号： G16B30/00 , G16B40/00 , G16B45/00
摘要： The present invention relates a method for analyzing a DNA sequence. The DNA sequence by converting the DNA sequence into a plurality of binary indicator sequences (BIS), and applying short term Fourier transform (STFT) on the binary indicator sequences. A binning function (BF) is applied to the Fourier coefficients (Usk_X(k)) and thereby modifying the corresponding Fourier coefficients (Usk_X(k)). Finally, substantially equal modified Fourier coefficients (Usk_X(k)) is found. The invention provides the user with a much improved ability to see unique strong patterns in vast amount of DNA sequence data.
摘要翻译：本发明涉及DNA序列分析方法。 DNA序列通过将DNA序列转化为多个二进制指示符序列（BIS），并在二进制指示符序列上应用短期傅里叶变换（STFT）。分数函数（BF）被应用于傅里叶系数（Usk_X（k）），从而修改对应的傅里叶系数（Usk_X（k））。最后，找到基本相等的修正傅里叶系数（Usk_X（k））。本发明为用户提供了大量改进的在大量DNA序列数据中看到独特强大模式的能力。

4. 发明授权

US10292679B2 Doppler ultrasound based fetal monitoring 有权
公开(公告)号：US10292679B2
公开(公告)日：2019-05-21
申请号：US13879045
申请日：2011-10-17
申请人： Chetan Mittal , Balasundar Iyyavu Raju
发明人： Chetan Mittal , Balasundar Iyyavu Raju
IPC分类号： A61B5/00 , A61B8/08 , A61B8/00
摘要： A fetal movement monitoring method that limits the ultrasound radiation to safe levels and conforms to the ALARA principle is disclosed. The disclosed method of monitoring fetal movements by Doppler ultrasound comprises accumulating the time for which ultrasound is radiated into a subject, comparing the accumulated time with a first reference total time, counting the number of fetal movements in the subject, comparing the number of movements with a reference number, deciding at least one of a further action of the device and an action to be recommended to the subject and conveying at least one of a further action of the device, an information to the subject about the counted fetal movements and an action recommended to the subject. A Doppler ultrasound device for monitoring fetal movements in a subject is also disclosed.

5. 发明申请

US20130197362A1 DOPPLER ULTRASOUND BASED FETAL MONITORING 审中-公开
标题翻译：多普勒超声波基极化监测
公开(公告)号：US20130197362A1
公开(公告)日：2013-08-01
申请号：US13879045
申请日：2011-10-17
申请人： Chetan Mittal , Balasundar Iyyavu Raju
发明人： Chetan Mittal , Balasundar Iyyavu Raju
IPC分类号： A61B8/08 , A61B8/00
CPC分类号： A61B8/0866 , A61B8/08 , A61B8/4427 , A61B8/46 , A61B8/488 , A61B8/54
摘要： A fetal movement monitoring method that limits the ultrasound radiation to safe levels and conforms to the ALARA principle is disclosed. The disclosed method of monitoring fetal movements by Doppler ultrasound comprises accumulating the time for which ultrasound is radiated into a subject, comparing the accumulated time with a first reference total time, counting the number of fetal movements in the subject, comparing the number of movements with a reference number, deciding at least one of a further action of the device and an action to be recommended to the subject and conveying at least one of a further action of the device, an information to the subject about the counted fetal movements and an action recommended to the subject. A Doppler ultrasound device for monitoring fetal movements in a subject is also disclosed.
摘要翻译：公开了一种将超声辐射限制在安全水平并符合ALARA原理的胎动监测方法。所公开的通过多普勒超声检测胎儿运动的方法包括将超声辐射到受试者的时间累积，将累积时间与第一参考总时间进行比较，对受试者的胎动数进行计数，将运动次数与参考号码，决定该设备的进一步动作中的至少一个以及要向该对象推荐的动作中的至少一个，并且传达该设备的进一步动作中的至少一个，关于该计数的胎儿动作的信息，以及动作推荐给主题。还公开了一种用于监测受试者中胎儿运动的多普勒超声装置。

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