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1. 发明授权

US10995112B2 Crystalline solvate forms of a pharmaceutical 有权
公开(公告)号：US10995112B2
公开(公告)日：2021-05-04
申请号：US16598694
申请日：2019-10-10
申请人： NeurMedix, Inc.
发明人： Steven K. White , Igor Ivanisevic , Kyle Stephens , Mark Andres , Brenton Skylar Wolfe
IPC分类号： C07J1/00 , C07J5/00 , C07J7/00 , A61K31/57
摘要： Described herein are solid state 17α-ethynylandrost-5-ene-3β,7β,17β-triol including amorphous and crystalline forms and specific polymorphic forms thereof, and use of solid state 17α-ethynylandrost-5-ene-3β,7β,17β-triol in treating numerous diseases and disorders, including hyperglycemic conditions, such as type 2 diabetes and metabolic syndrome, autoimmune conditions, such as rheumatoid arthritis, ulcerative colitis and type 1 diabetes, among other inflammation related conditions, and neurodegenerative conditions in subjects or human patients.

2. 发明申请

US20220002338A1 CRYSTALLINE SOLVATE FORMS OF A PHARMACEUTICAL 有权
公开(公告)号：US20220002338A1
公开(公告)日：2022-01-06
申请号：US17240728
申请日：2021-04-26
申请人： NeurMedix, Inc.
发明人： Steven K. White , Igor Ivanisevic , Kyle Stephens , Mark Andres , Brenton Skylar Wolfe
IPC分类号： C07J1/00 , C07J5/00 , C07J7/00 , A61K31/57
摘要： Described herein are solid state 17α-ethynylandrost-5-ene-3β,7β,17β-triol including amorphous and crystalline forms and specific polymorphic forms thereof, and use of solid state 17α-ethynylandrost-5-ene-3β,7β,17β-triol in treating numerous diseases and disorders, including hyperglycemic conditions, such as type 2 diabetes and metabolic syndrome, autoimmune conditions, such as rheumatoid arthritis, ulcerative colitis and type 1 diabetes, among other inflammation related conditions, and neurodegenerative conditions in subjects or human patients.

3. 发明申请

US20180208623A1 CRYSTALLINE SOLVATE FORMS OF A PHARMACEUTICAL 审中-公开
公开(公告)号：US20180208623A1
公开(公告)日：2018-07-26
申请号：US15851523
申请日：2017-12-21
申请人： NeurMedix, Inc.
发明人： Steven K. White , Igor Ivanisevic , Kyle Stephens , Mark Andres , Brenton Skylar Wolfe
IPC分类号： C07J1/00
CPC分类号： C07J1/00 , A61K31/57 , C07B2200/13 , C07J5/00 , C07J7/0005
摘要： Described herein are solid state 17α-ethynylandrost-5-ene-3β,7β,17β-triol including amorphous and crystalline forms and specific polymorphic forms thereof, and use of solid state 17α-ethynylandrost-5-ene-3β,7β,17β-triol in treating numerous diseases and disorders, including hyperglycemic conditions, such as type 2 diabetes and metabolic syndrome, autoimmune conditions, such as rheumatoid arthritis, ulcerative colitis and type 1 diabetes, among other inflammation related conditions, and neurodegenerative conditions in subjects or human patients.

4. 发明授权

US09877972B2 Treatment methods using pharmaceutical solid state forms 有权
公开(公告)号：US09877972B2
公开(公告)日：2018-01-30
申请号：US14459493
申请日：2014-08-14
申请人： NEURMEDIX, INC.
发明人： Steven K White , Igor Ivanisevic , Kyle Stephens , Mark Andres , Brenton Skylar Wolfe
IPC分类号： A61K31/57 , C07J5/00 , C07J7/00
CPC分类号： C07J1/00 , A61K31/57 , C07B2200/13 , C07J5/00 , C07J7/0005
摘要： The invention provides and describes solid state 17α-ethynyl-androst-5-ene-3β, 7β,17β-triol including amorphous and crystalline forms and specific polymorphic forms thereof. Anhydrates and solvates of 17α-ethynyl-androst-5-ene-3β, 7β,17β-triol include Form I anhydrate and Form IV and Form V solvates. The invention further relates to solid and suspension formulations containing 17α-ethynyl-androst-5-ene-3β,7β,17β-triol in a described solid state form and use of the formulations to treat hyperglycemic conditions, such as type 2 diabetes and metabolic syndrome, and autoimmune conditions, such as rheumatoid arthritis, ulcerative colitis and type 1 diabetes, among other inflammation related conditions in subjects or human patients. The invention also relates to methods to make liquid formulations from solid state forms of 17α-ethynyl-androst-5-ene-3β, 7β,17β-triol and uses of such formulations in treating the described conditions.

5. 发明授权

US09850271B2 Crystalline solvate forms of a pharmaceutical 有权
公开(公告)号：US09850271B2
公开(公告)日：2017-12-26
申请号：US15348107
申请日：2016-11-10
申请人： NeurMedix, Inc.
发明人： Steven K White , Igor Ivanisevic , Kyle Stephens , Mark Andres , Brenton Skylar Wolfe
IPC分类号： C07J1/00
CPC分类号： C07J1/00 , A61K31/57 , C07B2200/13 , C07J5/00 , C07J7/0005
摘要： The invention provides and describes solid state 17α-ethynyl-androst-5-ene-3β,7β,17β-triol including amorphous and crystalline forms and specific polymorphic forms thereof. Anhydrates and solvates of 17α-ethynyl-androst-5-ene-3β,7β,17β-triol include Form I anhydrate and Form IV and Form V solvates. The invention further relates to solid and suspension formulations containing 17α-ethynyl-androst-5-ene-3β,7β,17β-triol in a described solid state form and use of the formulations to treat hyperglycemic conditions, such as type 2 diabetes and metabolic syndrome, and autoimmune conditions, such as rheumatoid arthritis, ulcerative colitis and type 1 diabetes, among other inflammation related conditions in subjects or human patients. The invention also relates to methods to make liquid formulations from solid state forms of 17α-ethynyl-androst-5-ene-3β,7β,17β-triol and uses of such formulations in treating the described conditions.

6. 发明申请

US20170152281A1 Crystalline solvate forms of a pharmaceutical 有权
公开(公告)号：US20170152281A1
公开(公告)日：2017-06-01
申请号：US15348107
申请日：2016-11-10
申请人： NeurMedix, Inc.
发明人： Steven K. White , Igor Ivanisevic , Kyle Stephens , Mark Andres , Brenton Skylar Wolfe
IPC分类号： C07J1/00
CPC分类号： C07J1/00 , A61K31/57 , C07B2200/13 , C07J5/00 , C07J7/0005
摘要： The invention provides and describes solid state 17α-ethynyl-androst-5-ene-3β,7β,17β-triol including amorphous and crystalline forms and specific polymorphic forms thereof. Anhydrates and solvates of 17α-ethynyl-androst-5-ene-3β,7β,17β-triol include Form I anhydrate and Form IV and Form V solvates. The invention further relates to solid and suspension formulations containing 17α-ethynyl-androst-5-ene-3β,7β,17β-triol in a described solid state form and use of the formulations to treat hyperglycemic conditions, such as type 2 diabetes and metabolic syndrome, and autoimmune conditions, such as rheumatoid arthritis, ulcerative colitis and type 1 diabetes, among other inflammation related conditions in subjects or human patients. The invention also relates to methods to make liquid formulations from solid state forms of 17α-ethynyl-androst-5-ene-3β,7β,17β-triol and uses of such formulations in treating the described conditions.

7. 发明授权

US09555046B2 Crystalline anhydrate forms of a pharmaceutical 有权
标题翻译：晶体无水物形式的药物
公开(公告)号：US09555046B2
公开(公告)日：2017-01-31
申请号：US14459528
申请日：2014-08-14
申请人： NeurMedix, Inc.
发明人： Steven K White , Igor Ivanisevic , Kyle Stephens , Mark Andres , Brenton Skylar Wolfe
IPC分类号： C07J5/00 , C07J7/00 , A61K31/57
CPC分类号： C07J1/00 , A61K31/57 , C07B2200/13 , C07J5/00 , C07J7/0005
摘要： The invention provides and describes solid state 17α-ethynyl-androst-5-ene-3β,7β,17β-triol including amorphous and crystalline forms and specific polymorphic forms thereof. Anhydrates and solvates of 17α-ethynyl-androst-5-ene-3β,7β,17β-triol include Form I anhydrate and Form IV and Form V solvates. The invention further relates to solid and suspension formulations containing 17α-ethynyl-androst-5-ene-3β,7β,17β-triol in a described solid state form and use of the formulations to treat hyperglycemic conditions, such as type 2 diabetes and metabolic syndrome, and autoimmune conditions, such as rheumatoid arthritis, ulcerative colitis and type 1 diabetes, among other inflammation related conditions in subjects or human patients. The invention also relates to methods to make liquid formulations from solid state forms of 17α-ethynyl-androst-5-ene-3β,7β,17β-triol and uses of such formulations in treating the described conditions.
摘要翻译：本发明提供并描述了包括无定形和结晶形式及其特定多态形式的固态17α-乙炔基 - 雄甾-5-烯-3β，7β，17β-三醇。 17α-乙炔基 - 雄甾-5-烯-3β，7β，17β-三醇的水合物和溶剂合物包括I型无水物和IV型和V型溶剂合物。本发明还涉及含有所述固态形式的17α-乙炔基 - 雄甾-5-烯-3β，7β，17β-三醇的固体和悬浮液制剂，并且该制剂用于治疗高血糖病症如2型糖尿病和代谢综合征和自身免疫病症，例如类风湿性关节炎，溃疡性结肠炎和1型糖尿病以及受试者或人类患者的其它炎症相关病症。本发明还涉及从17α-乙炔基 - 雄甾-5-烯-3β，7β，17β-三醇的固体形式制备液体制剂的方法以及这些制剂在治疗所述病症中的用途。

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