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    • 2. 发明授权
    • Antibodies to c-Met
    • c-Met的抗体
    • US08163280B2
    • 2012-04-24
    • US12321963
    • 2009-01-26
    • Neil R. MichaudShama KajijiGary BorzilloVahe BedianKevin ColemanLarry L. GreenXiao-Chi Jia
    • Neil R. MichaudShama KajijiGary BorzilloVahe BedianKevin ColemanLarry L. GreenXiao-Chi Jia
    • A61K39/395
    • A61K39/39558A61K2039/505C07K16/2863C07K16/3076C07K2317/21C07K2317/73C07K2317/74C07K2317/75C07K2317/76C07K2317/92
    • The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-c-Met antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-c-Met antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-c-Met antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
    • 本发明涉及特异性结合c-Met,优选人c-Met的人抗体及其抗原结合部分的抗体,其功能是抑制c-Met。 本发明还涉及人抗c-Met抗体及其抗原结合部分。 本发明还涉及嵌合,双特异性,衍生的单链抗体或融合蛋白的部分的抗体。 本发明还涉及衍生自人抗c-Met抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗c-Met抗体的方法,包含这些抗体的组合物和使用该抗体和组合物进行诊断和治疗的方法。 本发明还提供使用编码包含人抗c-Met抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
    • 3. 发明申请
    • Antibodies to c-Met
    • c-Met的抗体
    • US20100040629A1
    • 2010-02-18
    • US12321963
    • 2009-01-26
    • Neil R. MichaudShama KajijiGary BorzilloVahe BedianKevin ColemanLarry L. GreenXiao-Chi Jia
    • Neil R. MichaudShama KajijiGary BorzilloVahe BedianKevin ColemanLarry L. GreenXiao-Chi Jia
    • A61K39/395
    • A61K39/39558A61K2039/505C07K16/2863C07K16/3076C07K2317/21C07K2317/73C07K2317/74C07K2317/75C07K2317/76C07K2317/92
    • The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-c-Met antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-c-Met antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-c-Met antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
    • 本发明涉及特异性结合c-Met,优选人c-Met的人抗体及其抗原结合部分的抗体,其功能是抑制c-Met。 本发明还涉及人抗c-Met抗体及其抗原结合部分。 本发明还涉及嵌合,双特异性,衍生的单链抗体或融合蛋白的部分的抗体。 本发明还涉及衍生自人抗c-Met抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗c-Met抗体的方法,包含这些抗体的组合物和使用该抗体和组合物进行诊断和治疗的方法。 本发明还提供使用编码包含人抗c-Met抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
    • 6. 发明授权
    • Antibodies to c-Met
    • c-Met的抗体
    • US07498420B2
    • 2009-03-03
    • US10910901
    • 2004-08-03
    • Neil R. MichaudShama KajijiGary BorzilloVahe BedianKevin ColemanLarry L. GreenXiao-Chi Jia
    • Neil R. MichaudShama KajijiGary BorzilloVahe BedianKevin ColemanLarry L. GreenXiao-Chi Jia
    • C07K16/00
    • A61K39/39558A61K2039/505C07K16/2863C07K16/3076C07K2317/21C07K2317/73C07K2317/74C07K2317/75C07K2317/76C07K2317/92
    • The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-c-Met antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-c-Met antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-c-Met antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
    • 本发明涉及特异性结合c-Met,优选人c-Met的人抗体及其抗原结合部分的抗体,其功能是抑制c-Met。 本发明还涉及人抗c-Met抗体及其抗原结合部分。 本发明还涉及嵌合,双特异性,衍生的单链抗体或融合蛋白的部分的抗体。 本发明还涉及衍生自人抗c-Met抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗c-Met抗体的方法,包含这些抗体的组合物和使用该抗体和组合物进行诊断和治疗的方法。 本发明还提供使用编码包含人抗c-Met抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。