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1. 发明申请

US20060039891A1 Antineoplastic-dendritic polymer drug delivery system 审中-公开
标题翻译：抗肿瘤树突状聚合物药物递送系统
公开(公告)号：US20060039891A1
公开(公告)日：2006-02-23
申请号：US10493354
申请日：2001-10-29
申请人： Navid Malik , Ruth Duncan , Donald Tomalia , Roseita Esfand
发明人： Navid Malik , Ruth Duncan , Donald Tomalia , Roseita Esfand
IPC分类号： A61K31/765
CPC分类号： A61K31/765
摘要： Antineoplastic dendritic polymer conjugates which are useful drug delivery systems for carrying antineoplastic agents to malignant tumors are prepared. The antineoplastic agent is encapsulated within the dendritic polymer using an ionic charge shunt mechanism, whereby, the antineoplastic agent interacts with the anionic functional groups on the surface of the dendritic polymer allowing the antineoplastic agent to be uptaken by the dendritic polymer through an association with the functional groups of the interior of the dendritic polymer. The antineoplastic dendritic polymer conjugates may be administered intravenously, orally, parentally, subcutaneously, intraarterially or topically to an animal having a malignant tumor in an amount which is effective to inhibit growth of the malignant tumor. The antineoplastic dendritic polymer conjugates exhibit high drug efficiency, high drug carrying capacity, good water solubility, good stability on storage, and reduced toxicity.
摘要翻译：制备用于将抗肿瘤药物携带到恶性肿瘤中的有用的药物递送系统的抗肿瘤树突状聚合物缀合物。使用离子电荷分流机制将抗肿瘤剂包封在树突状聚合物内，由此，抗肿瘤剂与树突状聚合物表面上的阴离子官能团相互作用，允许抗肿瘤剂被树状聚合物吸收，通过与树枝状聚合物内部的官能团。抗肿瘤性树突状聚合物缀合物可以以有效抑制恶性肿瘤生长的量静脉内，口服，亲本，皮下，动脉内或局部给予具有恶性肿瘤的动物。抗肿瘤树突状聚合物缀合物具有药效高，药物携带能力强，水溶性好，储存稳定性好，毒性降低。

2. 发明授权

US06790437B2 Method of treating cancerous tumors with a dendritic-platinate drug delivery system 有权
标题翻译：用树突状药物递送系统治疗癌性肿瘤的方法
公开(公告)号：US06790437B2
公开(公告)日：2004-09-14
申请号：US09881126
申请日：2001-06-14
申请人： Navid Malik , Ruth Duncan
发明人： Navid Malik , Ruth Duncan
IPC分类号： A61P3500
CPC分类号： B82Y5/00 , A61K47/6949 , C08G69/00 , C08G69/02 , C08G83/003 , Y10S424/16
摘要： Dendritic polymer conjugates which are useful drug delivery systems for carrying platinum containing anti-tumor agents to malignant tumors are prepared by obtaining a dendritic polymer having functional groups which are accessible to a platinum containing compound capable of interacting with the functional groups, contacting the dendritic polymer with the platinum containing compound, and reacting the dendritic polymer with the platinum containing compound. The dendritic polymer platinates may be administered intravenously, orally, parentally, subcutaneously or topically to an animal having a malignant tumor in an amount which is effective to inhibit growth of the malignant tumor. The dendritic polymer platinates exhibit high drug efficiency, high drug carrying capacity, good water solubility, good stability on storage, reduced toxicity, and improved anti-tumor activity in vivo.
摘要翻译：作为携带含有抗肿瘤剂的含铂药物的有用的药物递送系统的树突状聚合物缀合物通过获得具有官能团的树枝状聚合物来制备，所述树枝状聚合物具有能够与所述官能团相互作用的含铂化合物，所述树枝状聚合物接触所述树枝状聚合物与含铂化合物反应，并使树枝状聚合物与含铂化合物反应。树突状聚合物平板可以静脉内，口服，亲本，皮下或局部给予具有有效抑制恶性肿瘤生长的恶性肿瘤的动物。树状聚合物平板显示出高的药物效率，高的药物携带能力，良好的水溶性，良好的储存稳定性，降低的毒性和改善的体内抗肿瘤活性。

3. 发明授权

US07005124B2 Dendritic-antineoplastic drug delivery system 失效
公开(公告)号：US07005124B2
公开(公告)日：2006-02-28
申请号：US10016733
申请日：2001-10-29
申请人： Navid Malik , Ruth Duncan , Donald A. Tomalia , Roseita Esfand
发明人： Navid Malik , Ruth Duncan , Donald A. Tomalia , Roseita Esfand
IPC分类号： A61K47/48 , A61K33/24 , A61K31/80
CPC分类号： B82Y5/00 , A61K47/6949 , C08G69/00 , C08G69/02 , C08G83/003 , Y10S424/16
摘要： Antineoplastic dendritic polymer conjugates which are useful drug delivery systems for carrying antineoplastic agents to malignant tumors are prepared by obtaining a dendritic polymer having functional groups which are accessible to an antineoplastic agent capable of interacting with the functional groups, and contacting the dendritic polymer with the antineoplastic agent. The preferred platin-based analogues of the antineoplastic agents conjugated to the dendritic polymer may be administered intravenously, orally, parentally, subcutaneously, intramuscularly, intraarterially or topically to an animal having a malignant tumor in an amount which is effective to inhibit growth of the malignant tumor. The antineoplastic dendritic polymer conjugates exhibit high drug efficiency, high drug carrying capacity, good water solubility, good stability on storage, reduced toxicity, and improved anti-tumor activity in vivo.

4. 发明授权

US06585956B2 Dendritic-platinate drug delivery system 失效
标题翻译：树枝状药物递送系统
公开(公告)号：US06585956B2
公开(公告)日：2003-07-01
申请号：US09111232
申请日：1998-07-07
申请人： Navid Malik , Ruth Duncan
发明人： Navid Malik , Ruth Duncan
IPC分类号： A61K4748
CPC分类号： B82Y5/00 , A61K47/6949 , C08G69/00 , C08G69/02 , C08G83/003 , Y10S424/16
摘要： Dendritic polymer conjugates which are useful drug delivery systems for carrying platinum containing anti-tumor agents to malignant tumors are prepared by obtaining a dendritic polymer having functional groups which are accessible to a platinum containing compound capable of interacting with the functional groups, contacting the dendritic polymer with the platinum containing compound, and reacting the dendritic polymer with the platinum containing compound. The dendritic polymer platinates may be administered intravenously, orally, parentally, subcutaneously or topically to an animal having a malignant tumor in an amount which is effective to inhibit growth of the malignant tumor. The dendritic polymer platinates exhibit high drug efficiency, high drug carrying capacity, good water solubility, good stability on storage, reduced toxicity, and improved anti-tumor activity in vivo.
摘要翻译：作为携带含有抗肿瘤剂的含铂药物的有用的药物递送系统的树突状聚合物缀合物通过获得具有官能团的树枝状聚合物来制备，所述树枝状聚合物具有能够与所述官能团相互作用的含铂化合物，所述树枝状聚合物接触所述树枝状聚合物与含铂化合物反应，并使树枝状聚合物与含铂化合物反应。树突状聚合物平板可以静脉内，口服，亲本，皮下或局部给予具有有效抑制恶性肿瘤生长的恶性肿瘤的动物。树状聚合物平板显示出高的药物效率，高的药物携带能力，良好的水溶性，良好的储存稳定性，降低的毒性和改善的体内抗肿瘤活性。

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