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1. 发明授权

US09612197B2 Reflection-based tubular waveguide particle plasmon resonance sensing system and sensing device thereof 有权
公开(公告)号：US09612197B2
公开(公告)日：2017-04-04
申请号：US14806321
申请日：2015-07-22
申请人： National Chung Cheng University
发明人： Lai-Kwan Chau , Yu-Chung Huang , Chih-To Wang , Chien-Hsing Chen , Chang-Yue Chiang
IPC分类号： G01N21/552
CPC分类号： G01N21/554 , G01N2201/08
摘要： A reflection-based tubular waveguide particle plasmon resonance sensing system and a sensing device thereof are provided. The sensing device includes a hollow tubular waveguide element having wall, a reflection layer disposed on one end of the wall (distal end), and a noble metal nanoparticle layer distributed on the surface of the wall. An incident light enters the wall through another end of the tubular waveguide element (proximal end) and being total internal reflected many times along the wall, then is reflected by the reflection layer and being total internal reflected many times along the wall again, and finally, the incident light exits the proximal end. Wherein, when the sample contacts the noble metal nanoparticle layer of the tubular waveguide element, the particle plasmon resonance condition is altered and hence the signal intensity of the light exiting the tubular waveguide element changes.

2. 发明申请

US20200072828A1 METHOD AND KIT OF MEASURING CONCENTRATION OF ANALYTE 审中-公开
公开(公告)号：US20200072828A1
公开(公告)日：2020-03-05
申请号：US16507824
申请日：2019-07-10
申请人： NATIONAL CHUNG CHENG UNIVERSITY
发明人： Lai-Kwan Chau , Chang-Yue Chiang , Zong-Yu Yang , Po-Ya Chang
IPC分类号： G01N33/543 , G01N21/55 , G01N21/47
摘要： A method of measuring a concentration of an analyte is provided, including: reacting a test solution including an analyte with a nanoparticle solution including a plurality of nanoparticles and an optical waveguide element to form a sandwich-like structure; and measuring evanescent wave energy of the optical waveguide element absorbed and/or scattered by the plurality of nanoparticles after the plurality of nanoparticles forming the sandwich-like structure by using a photodetector to obtain a first signal, and calculating the concentration of the analyte based on the first signal. Wherein, a detection recognition element is conjugated on a surface of each of the plurality of nanoparticles, and a capture recognition element is conjugated on a waveguide surface of the optical waveguide element.

3. 发明申请

US20160216205A1 Reflection-Based Tubular Waveguide Particle Plasmon Resonance Sensing System and Sensing Device Thereof 有权
标题翻译：基于反射的管状波导粒子等离子体共振传感系统及其感测装置
公开(公告)号：US20160216205A1
公开(公告)日：2016-07-28
申请号：US14806321
申请日：2015-07-22
申请人： National Chung Cheng University
发明人： Lai-Kwan Chau , Yu-Chung Huang , Chih-To Wang , Chien-Hsing Chen , Chang-Yue Chiang
IPC分类号： G01N21/552
CPC分类号： G01N21/554 , G01N2201/08
摘要： A reflection-based tubular waveguide particle plasmon resonance sensing system and a sensing device thereof are provided. The sensing device includes a hollow tubular waveguide element having wall, a reflection layer disposed on one end of the wall (distal end), and a noble metal nanoparticle layer distributed on the surface of the wall. An incident light enters the wall through another end of the tubular waveguide element (proximal end) and being total internal reflected many times along the wall, then is reflected by the reflection layer and being total internal reflected many times along the wall again, and finally, the incident light exits the proximal end. Wherein, when the sample contacts the noble metal nanoparticle layer of the tubular waveguide element, the particle plasmon resonance condition is altered and hence the signal intensity of the light exiting the tubular waveguide element changes.
摘要翻译：提供了一种基于反射的管状波导粒子等离子体共振传感系统及其感测装置。感测装置包括具有壁的中空管状波导元件，设置在壁（远端）的一端上的反射层和分布在壁表面上的贵金属纳米颗粒层。入射光通过管状波导元件（近端）的另一端进入壁，并沿着壁多次被内部反射，然后被反射层反射，并再次沿着壁多次反射多次，最后入射光离开近端。其中，当样品与管状波导元件的贵金属纳米颗粒层接触时，粒子等离子体共振条件发生变化，因此离开管状波导管的光的信号强度发生变化。

4. 发明授权

US10324034B2 Self-referencing localized plasmon resonance sensing device and system thereof 有权
公开(公告)号：US10324034B2
公开(公告)日：2019-06-18
申请号：US15048828
申请日：2016-02-19
申请人： National Chung Cheng University
发明人： Lai-Kwan Chau , Chin-Wei Wu , Chang-Yue Chiang , Chien-Hsing Chen
IPC分类号： G01N21/552
摘要： A self-referencing localized plasmon resonance sensing device and a system thereof are disclosed. The reference optical waveguide element is modified with a noble metal nanoparticle layer. The sensing optical waveguide element is modified with a noble metal nanoparticle layer, which is further modified with a recognition unit. The incident light is guided into the reference and the sensing optical waveguide elements to respectively generate localized plasmon resonance sensor signals. The reference and the sensing optical waveguide elements respectively have a calibration slope. The processor utilizes the calibration slopes to regulate the second difference generated by detecting with the sensing optical waveguide element. The processor utilizes a difference between the first difference, which is generated by detecting with the reference optical waveguide element, and the regulated second difference to obtain a sensor response.

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