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2. 发明申请

US20140154184A1 TIME-GATED FLUORESCENCE IMAGING WITH SI-CONTAINING PARTICLES 审中-公开
标题翻译：具有含SI颗粒的时域荧光成像
公开(公告)号：US20140154184A1
公开(公告)日：2014-06-05
申请号：US14113960
申请日：2012-04-27
申请人： Michael J. Sailor , Luo Gao , David J. Hall , Robert Mattrey
发明人： Michael J. Sailor , Luo Gao , David J. Hall , Robert Mattrey
IPC分类号： A61K49/00
CPC分类号： A61K49/0021 , A61B5/0071 , G01N21/6408 , G01N21/6456 , G01N21/6489 , G01N33/54346 , G01N2021/6432
摘要： A method for imaging leverages the fluorescence lifetime of a fluorescent Si-containing particle to distinguish from background fluorescence. A particle is introduced into tissue. An excitation light pulse is applied to excite luminescence from the fluorescent Si-containing particle. Time-gated measuring of a responsive luminescence signal identifies the particle. In preferred embodiments the particle is coated or encapsulated with an organic material. The fluorescence lifetime of particles can be controlled during manufacture, such as by oxidation levels, quenching treatments, or by aging. This permits introducing and using groups of particles in imaging that have unique lifetimes and multiple time gating can be used to identify different particles or to monitor the change in lifetime of a single set of particles as they respond to a biochemical stimulus. The particles can also be functionalized for affinity to particular tissues and can be loaded with treatment molecules.
摘要翻译：用于成像的方法利用荧光含Si颗粒的荧光寿命来区分背景荧光。将颗粒引入组织。施加激发光脉冲以激发来自荧光含Si颗粒的发光。响应发光信号的时间门控测量识别粒子。在优选的实施方案中，颗粒被涂覆或用有机材料包封。颗粒的荧光寿命可以在制造过程中进行控制，例如通过氧化水平，淬火处理或老化来控制。这允许在成像中引入和使用具有独特寿命的颗粒群，并且可以使用多次浇注来识别不同的颗粒或者在响应于生化刺激时监测单组颗粒的寿命的变化。颗粒也可以被功能化以对特定组织的亲和力并且可以加载治疗分子。

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