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1. 发明授权

US08906914B2 Ethylene diamine modulators of fatty acid hydrolase 有权
标题翻译：脂肪酸水解酶的乙二胺调节剂
公开(公告)号：US08906914B2
公开(公告)日：2014-12-09
申请号：US13390984
申请日：2010-08-17
申请人： Natalie A. Hawryluk , J. Guy Breitenbucher , William M. Jones , Alison L. Chambers , John M. Keith , Mark Seierstad
发明人： Natalie A. Hawryluk , J. Guy Breitenbucher , William M. Jones , Alison L. Chambers , John M. Keith , Mark Seierstad
IPC分类号： C07D239/42 , C07D403/12 , A61K31/506 , C07D417/12 , C07D413/04 , C07D409/12 , C07D409/04 , C07D401/04 , C07D413/12 , C07D405/12 , C07D405/04
CPC分类号： C07D239/42 , C07D401/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12
摘要： Certain ethylene diamine compounds of Formula (I) are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). Methods of synthesizing such compounds are also disclosed.
摘要翻译：描述了某些式（I）的乙二胺化合物，其可用作FAAH抑制剂。这些化合物可用于治疗由脂肪酰胺水解酶（FAAH）活性介导的疾病状态，病症和病症的药物组合物和方法，例如焦虑症，疼痛，炎症，睡眠障碍，进食障碍，能量代谢紊乱，和运动障碍（例如多发性硬化）。还公开了合成这些化合物的方法。

2. 发明申请

US20110237596A1 HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE 有权
标题翻译：脂肪酸酰胺水解物的替代尿素调节剂
公开(公告)号：US20110237596A1
公开(公告)日：2011-09-29
申请号：US13131067
申请日：2009-11-24
申请人： J. Guy Breitenbucher , John M. Keith , Mark S. Tichenor , Alison L. Chambers , William M. Jones , Natalie A. Hawryluk , Amy K. Timmons , Jeffrey E. Merit , Mark J. Seierstad
发明人： J. Guy Breitenbucher , John M. Keith , Mark S. Tichenor , Alison L. Chambers , William M. Jones , Natalie A. Hawryluk , Amy K. Timmons , Jeffrey E. Merit , Mark J. Seierstad
IPC分类号： A61K31/5025 , C07D413/14 , A61K31/497 , A61K31/4709 , A61P25/24 , C07D471/04 , A61K31/4353 , C07D487/04 , A61P25/22 , A61P29/00 , A61P3/00 , A61P31/18 , A61K31/501 , A61P25/00 , A61P25/28 , A61P25/16 , A61P25/30 , A61P27/02 , A61P37/00 , A61P15/00 , A61P1/00 , A61P1/12 , A61P1/04 , A61P19/02 , A61P9/12 , A61P35/00 , A61P37/08 , A61P3/10
CPC分类号： C07D498/04 , C07D231/56 , C07D295/195 , C07D403/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07D471/12 , C07D487/04
摘要： Certain heteroaryl-substituted piperidinyl and piperazinyl urea compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, insulin resistance, diabetes, osteoporosis, and movement disorders (e.g., multiple sclerosis).
摘要翻译：描述了某些杂芳基取代的哌啶基和哌嗪基脲化合物，其可用作FAAH抑制剂。这些化合物可用于治疗由脂肪酸酰胺水解酶（FAAH）活性介导的疾病状态，病症和病症的药物组合物和方法，例如焦虑症，疼痛，炎症，睡眠障碍，进食障碍，胰岛素抵抗，糖尿病，骨质疏松症和运动障碍（例如，多发性硬化症）。

3. 发明申请

US20110230490A1 HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE 有权
公开(公告)号：US20110230490A1
公开(公告)日：2011-09-22
申请号：US13131061
申请日：2009-11-24
申请人： J. Guy Breitenbucher , John M. Keith , Mark S. Tichenor , Alison L. Chambers , William M. Jones , Natalie A. Hawryluk , Amy K Timmons , Jeffrey E. Merit , Mark J. Seierstad
发明人： J. Guy Breitenbucher , John M. Keith , Mark S. Tichenor , Alison L. Chambers , William M. Jones , Natalie A. Hawryluk , Amy K Timmons , Jeffrey E. Merit , Mark J. Seierstad
IPC分类号： A61K31/5025 , C07D405/14 , A61K31/4545 , A61P29/00 , A61P25/04 , A61P25/22 , A61P25/24 , A61P9/10 , A61P25/08 , A61P25/30 , A61P1/08 , A61P15/00 , A61P37/06 , A61P19/02 , C07D401/12 , A61K31/506 , C07D413/12 , A61K31/454 , C07D487/04 , A61K31/4709 , C07D401/14 , C07D471/04 , A61K31/437
CPC分类号： C07D498/04 , A61K31/437 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/5025 , A61K31/506 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D471/04 , C07D487/04
摘要： Certain heteroaryl-substituted piperidinyl and piperazinyl urea compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, insulin resistance, diabetes, osteoporosis, and movement disorders (e.g., multiple sclerosis).

4. 发明授权

US08598356B2 Heteroaryl-substituted urea modulators of fatty acid amide hydrolase 有权
公开(公告)号：US08598356B2
公开(公告)日：2013-12-03
申请号：US13131061
申请日：2009-11-24
申请人： J. Guy Breitenbucher , John M. Keith , Mark S. Tichenor , Alison L. Chambers , William M. Jones , Natalie A. Hawryluk , Amy K. Timmons , Jeffrey E. Merit , Mark J. Seierstad
发明人： J. Guy Breitenbucher , John M. Keith , Mark S. Tichenor , Alison L. Chambers , William M. Jones , Natalie A. Hawryluk , Amy K. Timmons , Jeffrey E. Merit , Mark J. Seierstad
IPC分类号： C07D211/68 , A61K31/445
CPC分类号： C07D498/04 , A61K31/437 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/5025 , A61K31/506 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D471/04 , C07D487/04
摘要： Certain heteroaryl-substituted piperidinyl and piperazinyl urea compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, insulin resistance, diabetes, osteoporosis, and movement disorders (e.g., multiple sclerosis).

5. 发明授权

US08461159B2 Heteroaryl-substituted urea modulators of fatty acid amide hydrolase 有权
标题翻译：脂肪酰胺水解酶的杂芳基取代的脲调节剂
公开(公告)号：US08461159B2
公开(公告)日：2013-06-11
申请号：US13131067
申请日：2009-11-24
申请人： J. Guy Breitenbucher , John M. Keith , Mark S. Tichenor , Alison L. Chambers , William M. Jones , Natalie A. Hawryluk , Amy K. Timmons , Jeffrey E. Merit , Mark J. Seierstad
发明人： J. Guy Breitenbucher , John M. Keith , Mark S. Tichenor , Alison L. Chambers , William M. Jones , Natalie A. Hawryluk , Amy K. Timmons , Jeffrey E. Merit , Mark J. Seierstad
IPC分类号： A61K31/495 , C07D419/00
CPC分类号： C07D498/04 , C07D231/56 , C07D295/195 , C07D403/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07D471/12 , C07D487/04
摘要： Certain heteroaryl-substituted piperidinyl and piperazinyl urea compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, insulin resistance, diabetes, osteoporosis, and movement disorders (e.g., multiple sclerosis).
摘要翻译：描述了某些杂芳基取代的哌啶基和哌嗪基脲化合物，其可用作FAAH抑制剂。这些化合物可用于治疗由脂肪酸酰胺水解酶（FAAH）活性介导的疾病状态，病症和病症的药物组合物和方法，例如焦虑症，疼痛，炎症，睡眠障碍，进食障碍，胰岛素抵抗，糖尿病，骨质疏松症和运动障碍（例如，多发性硬化症）。

6. 发明申请

US20120149696A1 ETHYLENE DIAMINE MODULATORS OF FATTY ACID HYDROLASE 有权
标题翻译：脂肪酸水解酶的乙烯二胺调节剂
公开(公告)号：US20120149696A1
公开(公告)日：2012-06-14
申请号：US13390984
申请日：2010-08-17
申请人： Natalie A. Hawryluk , J. Guy Breitenbucher , William M. Jones , Alison L. Chambers , John M. Keith , Mark Selerstad
发明人： Natalie A. Hawryluk , J. Guy Breitenbucher , William M. Jones , Alison L. Chambers , John M. Keith , Mark Selerstad
IPC分类号： A61K31/505 , C07D409/04 , C07D417/12 , A61K31/506 , A61P25/22 , A61P25/24 , A61P25/00 , A61P3/04 , A61P29/00 , A61P25/14 , A61P25/28 , A61P25/08 , A61P25/16 , A61P27/02 , A61P25/30 , A61P1/08 , A61P15/00 , A61P27/06 , A61P1/00 , A61P37/06 , A61P1/04 , A61P1/12 , A61P15/04 , A61P9/12 , A61P35/00 , A61P31/14 , A61P37/08 , A61P37/00 , A61P17/04 , A61P3/10 , A61P3/00 , A61P19/10 , A61P19/00 , C07D239/42
CPC分类号： C07D239/42 , C07D401/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12
摘要： Certain ethylene diamine compounds of Formula (I) are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). Methods of synthesizing such compounds are also disclosed.
摘要翻译：描述了某些式（I）的乙二胺化合物，其可用作FAAH抑制剂。这些化合物可用于治疗由脂肪酰胺水解酶（FAAH）活性介导的疾病状态，病症和病症的药物组合物和方法，例如焦虑症，疼痛，炎症，睡眠障碍，进食障碍，能量代谢紊乱，和运动障碍（例如多发性硬化）。还公开了合成这些化合物的方法。

7. 发明申请

US20090062294A1 HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE 审中-公开
标题翻译：脂肪酸酰胺水解物的替代尿素调节剂
公开(公告)号：US20090062294A1
公开(公告)日：2009-03-05
申请号：US12126389
申请日：2008-05-23
申请人： Richard Apodaca , J. Guy Breitenbucher , Natalie A. Hawryluk , William M. Jones , John M. Keith , Jeffrey E. Merit , Mark S. Tichenor , Amy K. Timmons
发明人： Richard Apodaca , J. Guy Breitenbucher , Natalie A. Hawryluk , William M. Jones , John M. Keith , Jeffrey E. Merit , Mark S. Tichenor , Amy K. Timmons
IPC分类号： A61K31/501 , C07D401/00 , C07D403/00 , C07D403/14 , A61P35/00 , A61P25/00 , A61P1/04 , A61P9/00 , A61P37/00 , A61P31/12 , A61P1/00 , A61K31/445 , A61K31/496
CPC分类号： C07D231/40 , C07D237/20 , C07D241/20 , C07D257/06 , C07D261/14 , C07D261/20 , C07D271/12 , C07D285/14 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： Certain heteroaryl-substituted piperidinyl and piperazinyl urea compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, insulin resistance, diabetes, osteoporosis, and movement disorders (e.g., multiple sclerosis).
摘要翻译：描述了某些杂芳基取代的哌啶基和哌嗪基脲化合物，其可用作FAAH抑制剂。这些化合物可用于治疗由脂肪酸酰胺水解酶（FAAH）活性介导的疾病状态，病症和病症的药物组合物和方法，例如焦虑症，疼痛，炎症，睡眠障碍，进食障碍，胰岛素抵抗，糖尿病，骨质疏松症和运动障碍（例如，多发性硬化症）。

8. 发明申请

US20120212166A1 HVAC ADJUSTMENT MODULE 失效
标题翻译： HVAC调整模块
公开(公告)号：US20120212166A1
公开(公告)日：2012-08-23
申请号：US13352515
申请日：2012-01-18
申请人： William F. Merkel , William M. Jones , Robert G. Klimo
发明人： William F. Merkel , William M. Jones , Robert G. Klimo
IPC分类号： H02P6/08
CPC分类号： H02P6/08 , F04D27/004 , F24F11/65 , F24F11/77 , G06F17/5086 , Y02B30/746 , Y02T10/82
摘要： A heating, ventilation and air conditioning (HVAC) system is provided. The system includes an integrated motor including a plurality of operating speeds and an input for selecting one of the plurality of operating speeds. The system further includes a system controller and an adjustment module. The adjustment module includes a plurality of operating modes each associated with one of the plurality of operating speeds and the ability to manually vary associations between the plurality of operating modes and the plurality of operating speeds. The adjustment module selects one of the plurality of operating modes on the basis of control commands received from the system controller and setting programmed or manually entered into and stored in the adjustment module and controls the integrated motor according to the operating speed associated with the selected operating mode.
摘要翻译：提供加热，通风和空调（HVAC）系统。该系统包括包括多个操作速度的集成电动机和用于选择多个操作速度之一的输入。该系统还包括系统控制器和调整模块。调节模块包括多个操作模式，每个操作模式与多个操作速度中的一个相关联，并且能够手动地改变多个操作模式与多个操作速度之间的关联。调整模块基于从系统控制器接收到的控制命令和编程或手动输入并存储在调节模块中的控制命令来选择多个操作模式中的一个，并根据与所选择的操作相关联的操作速度控制集成电动机模式。

9. 发明授权

US07375488B2 Brushless repulsion motor speed control system 失效
标题翻译：无刷斥力电机调速系统
公开(公告)号：US07375488B2
公开(公告)日：2008-05-20
申请号：US11442211
申请日：2006-05-26
申请人： William M. Jones
发明人： William M. Jones
IPC分类号： H02P1/24
CPC分类号： H02P25/102
摘要： A system for controlling the speed of a brushless repulsion motor having a series of switches mounted on a rotating armature for shorting circumferentially spaced armature coils comprising first stationary signaling means and a plurality of rotating detectors for activating said switches; second stationary signaling means for speed control; a plurality of markers on the rotating armature; a speed detector for detecting the speed of the rotating markers and generating a speed feedback signal; means for generating a speed command signal; an error calculator for comparing the speed feedback and speed command signals and generating an error signal; and a controller for controlling the signaling means based on the error signal.
摘要翻译：一种用于控制无刷排斥电动机的速度的系统，其具有安装在旋转电枢上的一系列开关，用于短路周向间隔的电枢线圈，其包括第一固定信号装置和用于启动所述开关的多个旋转检测器; 用于速度控制的第二固定信号装置; 旋转电枢上的多个标记; 速度检测器，用于检测旋转标记的速度并产生速度反馈信号; 用于产生速度指令信号的装置; 误差计算器，用于比较速度反馈和速度指令信号并产生误差信号; 以及控制器，用于基于所述误差信号来控制所述信令装置。

10. 发明授权

US07053586B2 Brushless repulsion motor speed control system 有权
标题翻译：无刷斥力电机调速系统
公开(公告)号：US07053586B2
公开(公告)日：2006-05-30
申请号：US10977268
申请日：2004-10-29
申请人： William M. Jones
发明人： William M. Jones
IPC分类号： H02P5/28
CPC分类号： H02P25/102
摘要： A system for controlling the speed of a brushless repulsion motor having a series of switches mounted on a rotating armature for shorting circumferentially spaced armature coils comprising first stationary signaling means and a plurality of rotating detectors for activating said switches; second stationary signaling means for speed control; a plurality of markers on the rotating armature; a speed detector for detecting the speed of the rotating markers and generating a speed feedback signal; means for generating a speed command signal; an error calculator for comparing the speed feedback and speed command signals and generating an error signal; and a controller for controlling the signaling means based on the error signal.
摘要翻译：一种用于控制无刷排斥电动机的速度的系统，其具有安装在旋转电枢上的一系列开关，用于短路周向间隔的电枢线圈，其包括第一固定信号装置和用于启动所述开关的多个旋转检测器; 用于速度控制的第二固定信号装置; 旋转电枢上的多个标记; 速度检测器，用于检测旋转标记的速度并产生速度反馈信号; 用于产生速度指令信号的装置; 误差计算器，用于比较速度反馈和速度指令信号并产生误差信号; 以及控制器，用于基于所述误差信号来控制所述信令装置。

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