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1. 发明申请

US20100016400A1 AZABICYCLIC MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：亚型脂蛋白受体拮抗剂
公开(公告)号：US20100016400A1
公开(公告)日：2010-01-21
申请号：US11719687
申请日：2005-11-18
申请人： Naresh Kumar , Mohammad Salman , Kirandeep Kaur , Anita Mehta , Sudershan K. Arora , Anita Chugh
发明人： Naresh Kumar , Mohammad Salman , Kirandeep Kaur , Anita Mehta , Sudershan K. Arora , Anita Chugh
IPC分类号： A61K31/403 , C07D209/52 , C07D409/06 , A61P11/00
CPC分类号： C07D209/52 , C07D409/06
摘要： The present invention generally relates to muscarinic receptor antagonists, which are useful for treating various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to processes for preparing compounds described herein, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.
摘要翻译：本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。本发明还涉及制备本文所述化合物的方法，含有所公开化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

2. 发明授权

US06956040B2 Oxazolidinone piperazinyl derivatives as potential antimicrobials 失效
标题翻译：恶唑烷酮哌嗪衍生物作为潜在的抗菌药物
公开(公告)号：US06956040B2
公开(公告)日：2005-10-18
申请号：US10051784
申请日：2002-01-17
申请人： Anita Mehta , Sudershan K. Arora , Bis{umlaut over (w)}ajit Das , Abhijit Ray , Sonali Rudra , Ashok Rattan
发明人： Anita Mehta , Sudershan K. Arora , Bis{umlaut over (w)}ajit Das , Abhijit Ray , Sonali Rudra , Ashok Rattan
IPC分类号： C07D413/12 , C07D413/14 , A61K31/496 , A61P31/04
CPC分类号： C07D413/12
摘要： The present invention relates to certain substituted phenyl piperazinyl oxazolidinones, for example, to those having the structure of Formula I with the variables as defined within, and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
摘要翻译：本发明涉及某些取代的苯基哌嗪基恶唑烷酮，例如具有式I结构的具有变量的定义的那些，以及其合成方法。本发明还涉及含有作为抗微生物剂的本发明化合物的药物组合物。这些化合物是有用的抗微生物剂，对许多人类和兽医病原体有效，包括革兰氏阳性好氧细菌如多重耐药性葡萄球菌，链球菌和肠球菌以及厌氧生物如细菌属。和梭菌属（Clostridia spp。）物种和酸性快速生物如结核分枝杆菌，鸟分枝杆菌和分枝杆菌属。

3. 发明申请

US20100113371A9 Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds 审中-公开
标题翻译：戊糖单糖衍生物作为抗炎化合物
公开(公告)号：US20100113371A9
公开(公告)日：2010-05-06
申请号：US11722573
申请日：2005-12-22
申请人： Viswajanani Jitendra Sattigeri , Sudershan K. Arora , Mohammad Salman , Venkata P. Palle , Muthukaman Nagarajan , Rajkumar Shirumalla , Gurpreet Kaur Aulakh , Abhijit Ray
发明人： Viswajanani Jitendra Sattigeri , Sudershan K. Arora , Mohammad Salman , Venkata P. Palle , Muthukaman Nagarajan , Rajkumar Shirumalla , Gurpreet Kaur Aulakh , Abhijit Ray
IPC分类号： A61K31/7008 , C07H15/04 , A61P29/00 , C07H15/12
CPC分类号： C07H3/02 , C07H15/02 , C07H15/18 , C07H15/26
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds of this invention can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases, for example, bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection or psoriasis. The present invention also relates to pharmacological compositions containing these monosaccharide derivatives, as well as methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or auto immune disorders.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本发明的化合物可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植物排斥或银屑病。本发明还涉及含有这些单糖衍生物的药物组合物，以及治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥和其它炎症和/或自身免疫的方法疾病

4. 发明申请

US20090221515A1 MONOSACCHARIDE DERIVATIVES 审中-公开
标题翻译：单糖衍生物
公开(公告)号：US20090221515A1
公开(公告)日：2009-09-03
申请号：US11574465
申请日：2005-08-31
申请人： Viswajanani Jitendra Sattigeri , Sudershan K. Arora , Venkata P. Palle , Mohammad Salman , Abhijit Ray , Raj Kumar Shirumalla , Abdul Rehaman Abdul Rauf
发明人： Viswajanani Jitendra Sattigeri , Sudershan K. Arora , Venkata P. Palle , Mohammad Salman , Abhijit Ray , Raj Kumar Shirumalla , Abdul Rehaman Abdul Rauf
IPC分类号： A61K31/7008 , C07H5/04
CPC分类号： C07H15/18
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis or allergic rhinitis. Pharmacological compositions containing the compounds of the present invention and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文公开的化合物可用于抑制和预防炎症和相关病理学，包括炎症和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒症或过敏性鼻炎。包含本发明化合物的药物组合物，治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，还提供了使用该化合物的瘙痒症，过敏性鼻炎和其它炎性和/或自身免疫性疾病。

5. 发明申请

US20090075909A1 Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds 审中-公开
标题翻译：戊糖单糖衍生物作为抗炎化合物
公开(公告)号：US20090075909A1
公开(公告)日：2009-03-19
申请号：US11722573
申请日：2005-12-22
申请人： Viswajanani Jitendra Sattigeri , Sudershan K. Arora , Mohammad Salman , Venkata P. Palle , Muthukaman Nagarajan , Rajkumar Shirumalla , Gurpreet Kaur Aulakh , Abhijit Ray
发明人： Viswajanani Jitendra Sattigeri , Sudershan K. Arora , Mohammad Salman , Venkata P. Palle , Muthukaman Nagarajan , Rajkumar Shirumalla , Gurpreet Kaur Aulakh , Abhijit Ray
IPC分类号： A61K31/7008 , C07H15/04 , A61P29/00 , C07H15/12
CPC分类号： C07H3/02 , C07H15/02 , C07H15/18 , C07H15/26
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds of this invention can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases, for example, bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection or psoriasis. The present invention also relates to pharmacological compositions containing these monosaccharide derivatives, as well as methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or auto immune disorders.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本发明的化合物可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥或银屑病。本发明还涉及含有这些单糖衍生物的药物组合物，以及治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥和其它炎症和/或自身免疫的方法疾病

6. 发明申请

US20090048186A1 Monosaccharide Derivatives as Anti-Inflammatory and/or Anti-Cancer Agents 审中-公开
标题翻译：单糖衍生物作为抗炎和/或抗癌剂
公开(公告)号：US20090048186A1
公开(公告)日：2009-02-19
申请号：US11912064
申请日：2005-04-19
申请人： Vishwajanani Jitendra Sattigeri , Sudershan K. Arora , Mohammad Salman , Venkata P. Palle , Ashis Mukherjee , Abhijit Ray , Raj Kumar Shirumalla
发明人： Vishwajanani Jitendra Sattigeri , Sudershan K. Arora , Mohammad Salman , Venkata P. Palle , Ashis Mukherjee , Abhijit Ray , Raj Kumar Shirumalla
IPC分类号： A61K31/7052 , C07H15/18 , A61K31/7034 , C07D493/04 , C07H17/02
CPC分类号： C07H9/04 , C07H3/02 , C07H15/00
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文中的化合物障碍可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。含有本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏性还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

7. 发明授权

US5367062A Disubstituted and deoxydisubstituted derivatives of .alpha.-d-lyxofuranosides having anti-inflammatory and anti-proliferative activity 失效
标题翻译：具有抗炎和抗增殖活性的α-脱氢呋喃糖苷的二取代和脱氧二取代衍生物
公开(公告)号：US5367062A
公开(公告)日：1994-11-22
申请号：US933312
申请日：1992-08-21
申请人： Sudershan K. Arora , Peter J. Schied
发明人： Sudershan K. Arora , Peter J. Schied
IPC分类号： C07H9/04 , C07H15/04 , C07H15/18 , C07H15/26 , C07H19/04 , C07H19/24 , C07H17/02
CPC分类号： C07H9/04 , C07H15/04 , C07H15/18 , C07H15/26 , C07H19/04 , C07H19/24
摘要： Derivatives of disubstituted and deoxydisubstituted .alpha.-D-lyxofuranosides and intermediates for preparing these derivatives are described. These compounds exhibit significant antiinflammatory and anti-proliferative activity and are useful for treating inflammatory and/or autoimmune disorders such as psoriasis, asthma, atopic dermatitis, rheumatoid arthritis, osteoarthritis, scleroderma, systemic lupus erythematosus, and cancer (particularly melanoma and colon cancer).
摘要翻译：描述了用于制备这些衍生物的二取代和脱氧双取代的α-脱氢呋喃糖苷的衍生物和中间体。这些化合物显示出显着的抗炎和抗增殖活性，并且可用于治疗牛皮癣，哮喘，特应性皮炎，类风湿性关节炎，骨关节炎，硬皮病，系统性红斑狼疮和癌症（特别是黑素瘤和结肠癌）的炎性和/或自身免疫疾病。。

8. 发明授权

US5344924A Solvent-free synthesis of ethereally substituted blocked monosaccharides and the selective hydrolysis thereof 失效
标题翻译：无溶剂合成醚基取代的封闭单糖及其选择性水解
公开(公告)号：US5344924A
公开(公告)日：1994-09-06
申请号：US044085
申请日：1993-04-06
申请人： Sudershan K. Arora
发明人： Sudershan K. Arora
IPC分类号： C07H1/00 , C07H9/04 , C07H15/04
CPC分类号： C07H15/04
摘要： A solvent-free method for synthesizing an ethereally-substituted, blocked monosaccharide comprising the steps of:1) mixing, in the absence of solvent, a partially blocked monosaccharide unblocked at one position, an alkyl halide or a substituted alkyl halide, and an anhydrous alkali base;2) heating the mixture to a temperature sufficient to allow the mixture to react;3) maintaining the mixture at a suitable temperature for a time sufficient to form an ethereally-substituted blocked monosaccharide and drive off any water produced;4) removing any unreacted alkyl halide or substituted alkyl halide from the mixture;5) recovering the ethereally-substituted blocked monosaccharide product from the mixture; and, optionally,6) selectively hydrolyzing the ethereally-substituted blocked monosaccharide product to remove one or more of the acetal blocking groups.
摘要翻译：用于合成醚取代的封端单糖的无溶剂方法，包括以下步骤：1）在不存在溶剂的情况下，将在一个位置上未封端的部分封闭的单糖，烷基卤或取代的烷基卤和无水物混合碱碱 2）将混合物加热到足以使混合物反应的温度; 3）将混合物保持在合适的温度下足以形成醚取代的封闭单糖并驱除所产生的水; 4）从混合物中除去任何未反应的烷基卤或取代的烷基卤; 5）从混合物中回收醚取代的封闭单糖产物; 和任选地，6）选择性地水解醚取代的封闭单糖产物以除去一个或多个缩醛封闭基团。

9. 发明授权

US5010058A 3,5,6-substituted derivatives of 1,2-O-isopropylidene-.alpha.,D-glucofuranose and intermediates for preparing these derivatives 失效
标题翻译： 1,2-O-异亚丙基-α，D-葡萄糖呋喃糖的3,5,6-取代衍生物和制备这些衍生物的中间体
公开(公告)号：US5010058A
公开(公告)日：1991-04-23
申请号：US369932
申请日：1989-06-22
申请人： Bruce Ronsen , Sudershan K. Arora , Albert V. Thomas
发明人： Bruce Ronsen , Sudershan K. Arora , Albert V. Thomas
IPC分类号： A61K31/70 , A61P29/00 , A61P37/00 , A61P37/08 , C07H9/00 , C07H9/04 , C07H15/12 , C07H15/14
CPC分类号： C07H9/04 , C07H15/12 , C07H15/14 , Y10S514/825 , Y10S514/861
摘要： Derivatives of 1,2-O-isopropylidene-.alpha.,D-glucofuranose and intermediates for preparing these derivatives are described. These derivatives are useful for treating animals and mammals with inflammatory and/or autoimmune disorders such as autoimmune deficiency syndrome, psoriasis, atopic dermatitus, rheumatoid arthritis, osteoarthritis, scleroderma and systemic lupus erythematosus.

10. 发明授权

US5360794A Disubstituted and deoxy disubstituted derivatives of .alpha.-D-mannofuranosides and .beta.-L-gulofuranosides having anti-inflammatory and anti-proliferative activity 失效
标题翻译：具有抗炎和抗增殖活性的α-D-甘露聚糖苷和β-L-呋喃核糖苷的二取代和脱氧双取代衍生物
公开(公告)号：US5360794A
公开(公告)日：1994-11-01
申请号：US923452
申请日：1992-08-03
申请人： Sudershan K. Arora
发明人： Sudershan K. Arora
IPC分类号： C07H15/04 , C07H15/08 , C07H15/12 , C07H15/203 , C07H15/26 , C07H19/04 , C07H19/044 , C07H19/24 , A61K31/70
CPC分类号： C07H15/08 , C07H15/04 , C07H15/12 , C07H15/203 , C07H15/26 , C07H19/04 , C07H19/044 , C07H19/24
摘要： The compounds of the present invention are deoxy disubstituted or dideoxy disubstituted derivatives of .alpha.-D-mannofuranoside and .beta.-L-gulofuranoside hexoses which exhibit anti-inflammatory and anti-proliferative activity. Pharmaceutical compositions containing the compounds and methods of treating inflammatory and/or autoimmune disorders employing the compounds are disclosed.
摘要翻译：本发明的化合物是具有抗炎和抗增殖活性的α-D-甘露聚糖苷和β-L-呋喃核糖苷己糖的脱氧双取代或双脱氧双取代衍生物。公开了含有化合物的药物组合物和使用该化合物治疗炎性和/或自身免疫性疾病的方法。

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