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1. 发明申请

US20070105796A1 Method for inhibiting telomerase activity and inhibitor thereof 审中-公开
标题翻译：抑制端粒酶活性的方法及其抑制剂
公开(公告)号：US20070105796A1
公开(公告)日：2007-05-10
申请号：US10563074
申请日：2005-04-28
申请人： Naoya Wada , Takashi Okamoto , Keiji Tanigaki , Hirofumi Doi , Yasuhiro Kikuchi , Kensaku Imai
发明人： Naoya Wada , Takashi Okamoto , Keiji Tanigaki , Hirofumi Doi , Yasuhiro Kikuchi , Kensaku Imai
IPC分类号： A61K48/00
CPC分类号： C12N9/1205
摘要： The present invention provides a method for inhibiting the activation of telomerase and an agent for inhibiting the activation of telomerase, a method for inhibiting telomerase activity and an agent for inhibiting telomerase activity, a method for preventing and/or a method for treating a cancer disease, an agent for preventing and/or an agent for treating a cancer disease, all of which comprises inhibiting the binding of MAPKAPK3 to TERT that is a catalytic subunit of telomerase or inhibiting the phosphorylation of TERT by active MAPKAPK3; a method of identifying a compound that inhibits the binding of MAPKAPK3 to TERT or a compound that inhibits the phosphorylation of TERT by active MAPKAPK3; and a reagent kit.
摘要翻译：本发明提供抑制端粒酶活化的方法和抑制端粒酶活化的试剂，抑制端粒酶活性的方法和抑制端粒酶活性的方法，预防和/或治疗癌症的方法，用于预防和/或治疗癌症疾病的药物，所有这些都包括抑制MAPKAPK3与作为端粒酶催化亚基的TERT的结合或抑制活性MAPKAPK3的TERT磷酸化; 鉴定抑制MAPKAPK3与TERT结合的化合物或抑制活性MAPKAPK3磷酸化TERT的化合物的方法; 和试剂盒。

2. 发明授权

US06182057B2 Device, method, and program storage medium for executing genetic algorithm 失效
标题翻译：用于执行遗传算法的设备，方法和程序存储介质
公开(公告)号：US06182057B2
公开(公告)日：2001-01-30
申请号：US08990050
申请日：1997-12-12
申请人： Yasuhiro Kikuchi , Hirofumi Doi
发明人： Yasuhiro Kikuchi , Hirofumi Doi
IPC分类号： G06F1518
CPC分类号： G06N3/126
摘要： A genetic algorithm executing device, in which search of a genetic algorithm is improved, sets a distribution of characters at each position of character strings represent candidates of solution, obtain the degree of disorder at each position by the distributions of characters, set a larger mutation rate at the position of which degree of disorder is higher. This device performs a mutation operation on the character strings according to the mutation rates. This device generates the new character strings by selecting positions of which degrees of disorder are higher than a predetermined value, and changing the character at the selected positions.
摘要翻译：遗传算法执行装置，其中改进了遗传算法的搜索，设置了字符串每个位置处的字符分布表示解的候选，通过字符分布获得每个位置的无序程度，设置较大的突变在无序程度较高的位置的比率。该装置根据突变率对字符串进行突变操作。该装置通过选择无序程度高于预定值的位置并改变所选位置的字符来生成新的字符串。

3. 发明申请

US20050154690A1 Document knowledge management apparatus and method 审中-公开
标题翻译：文件知识管理手段和方法
公开(公告)号：US20050154690A1
公开(公告)日：2005-07-14
申请号：US10503387
申请日：2003-02-04
申请人： Kiyoshi Nitta , Hirofumi Doi , Yasuhiro Kikuchi , Hisayuki Horai
发明人： Kiyoshi Nitta , Hirofumi Doi , Yasuhiro Kikuchi , Hisayuki Horai
IPC分类号： G06F17/22 , G06F17/30 , G06F17/24 , G06F17/21 , G06F15/00 , G06F17/00 , G06N5/02 , G06F17/27
CPC分类号： G06F17/2217 , G06F16/30
摘要： In the present invention, a textual document is syntactically analyzed and knowledge is constructed from a single word or plural words. The knowledge is then marked, from the broken down knowledge (represented by the underscores in FIG. 1) or from a part-of-speech, as a related object (node) or a relation (edge) (represented by ‘n’ or ‘e’ shown in FIG. 1). In other words, in the present invention a textual document is treated as knowledge constructed from a single word or plural words. The knowledge extracted from the textual document is structured to form a knowledge structure (such as a graph structure constituted from nodes and edges). At least one link can be established between each of the knowledge structure elements and a semantically closest concept entry in a hierarchical concept dictionary.
摘要翻译：在本发明中，文本文档被语法分析，并从单个单词或多个单词构成知识。然后将知识从分解的知识（由图1中的下划线表示）或从词性部分标记为相关对象（节点）或关系（边缘）（由“n”或 'e'）。换句话说，在本发明中，文本文档被视为从单个单词或多个单词构成的知识。从文本文档中提取的知识被构造成形成知识结构（例如由节点和边缘构成的图形结构）。可以在每个知识结构元素和分层概念词典中的语义上最接近的概念条目之间建立至少一个链接。

4. 发明申请

US20120264201A1 CULTURE APPARATUS 有权
标题翻译：文化装置
公开(公告)号：US20120264201A1
公开(公告)日：2012-10-18
申请号：US13527027
申请日：2012-06-19
申请人： Kuniyoshi Kobayashi , Hiroki Busujima , Yasuhiro Kikuchi , Yuichi Tamaoki , Shinji Sugimoto , Tetsuo Sakurai
发明人： Kuniyoshi Kobayashi , Hiroki Busujima , Yasuhiro Kikuchi , Yuichi Tamaoki , Shinji Sugimoto , Tetsuo Sakurai
IPC分类号： C12M1/34
CPC分类号： C12M41/14 , C12M23/48 , C12M37/00 , Y10S435/809
摘要： A culture apparatus comprising: an inner box configured to form a culture chamber; an outer box configured to cover the inner box; a fan configured to circulate gas inside the culture chamber through an air passage provided in the inner box within the culture chamber; a first through hole configured to penetrate a wall configuring a part of the air passage in the inner box; a second through hole configured to penetrate the wall and disposed at a position at which a flow velocity of the gas circulated through the air passage by the fan is lower than a flow velocity of the gas around the first through hole; a connecting pipe configured to connect the first through hole and the second through hole outside of the inner box; and a sensor configured to detect a concentration of the gas flowing in the culture chamber.
摘要翻译：一种培养装置，包括：内箱，其构造成形成培养室; 外箱，其构造成覆盖所述内箱; 风扇，其构造成通过设置在所述培养室内的内箱内的空气通路使所述培养室内的气体循环; 第一通孔，其构造成穿过构成所述内箱中的所述空气通道的一部分的壁; 第二通孔，被构造成穿透壁并且设置在通过风扇在空气通道中循环的气体的流速低于围绕第一通孔的气体的流速的位置; 连接管，其构造成将所述第一通孔与所述第二通孔连接在所述内箱的外部; 以及传感器，被配置为检测在所述培养室中流动的气体的浓度。

5. 发明申请

US20050084420A1 Incubator 有权
标题翻译：孵化器
公开(公告)号：US20050084420A1
公开(公告)日：2005-04-21
申请号：US10965887
申请日：2004-10-18
申请人： Shinji Osawa , Yasuhiro Kikuchi
发明人： Shinji Osawa , Yasuhiro Kikuchi
IPC分类号： C12M1/38 , B01L1/00 , B01L7/00 , C12M1/00 , C12M1/12 , C12M1/14 , C12M1/36 , C12M3/00
CPC分类号： C12M41/14 , C12M23/48 , Y10S435/809
摘要： An object of the invention is to provide a multigas incubator capable of shortening humidity-returning time after closing its door. The incubator comprises an adiabatic box main body having an opening on a front face thereof, an adiabatic door mounted on the adiabatic box main body in an openable and closable manner, a transparent inner door for openably closing the opening, and an incubation room surrounded by the inner door and the adiabatic box main body for incubating samples such as cells, microbes and the like. The adiabatic box main body comprises an outer box made of a metal, an inner box made of a metal, a heat insulating material arranged inside the outer box between the outer and inner boxes, and an air layer arranged more inside than the heat insulating material. Gases supplied for controlling concentrations of gases in the incubation room are jetted into humidification water.
摘要翻译：本发明的一个目的是提供一种能够在关闭门之后缩短湿度返回时间的多糖培养箱。所述培养箱包括：绝热箱主体，其前表面具有开口;绝热门以可开闭的方式安装在所述绝热箱主体上;透明内门，用于可打开地封闭所述开口;以及孵化室，内门和用于孵育细胞，微生物等样品的绝热箱主体。绝热箱主体包括由金属构成的外箱，由金属制成的内箱，布置在外箱和内箱之间的绝热材料，以及布置在隔热材料内侧的空气层。用于控制孵育室中气体浓度的气体被喷射到加湿水中。

6. 发明申请

US20130092652A1 METHOD FOR MANUFACTURING GRAIN-ORIENTED ELECTRICAL STEEL SHEET 有权
标题翻译：制造面向导电电工钢板的方法
公开(公告)号：US20130092652A1
公开(公告)日：2013-04-18
申请号：US13805520
申请日：2011-06-06
申请人： Keiji Iwata , Yasuhiro Kikuchi
发明人： Keiji Iwata , Yasuhiro Kikuchi
IPC分类号： C23F1/00
CPC分类号： C21D8/1294 , C21D6/008 , C21D8/12 , C21D8/1255 , C21D9/46 , C21D2201/05 , C21D2221/00 , C22C1/02 , C22C38/00 , C22C38/001 , C22C38/02 , C22C38/04 , C22C38/06 , C23F1/00 , C23F1/02 , C23F1/14 , C25F3/06 , H01F1/14783 , H01F1/16
摘要： A resist film is formed on a cold-rolled steel sheet so as to fabricate a groove by etching. At this point, a steel sheet exposed portion where a portion of the steel sheet is exposed is formed in the resist film, and the steel sheet exposed portion has a first region oriented in a sheet width direction, and a plurality of second regions starting from the first region, widths of the first region and the second regions being 20 μm to 100 μm, and a distance from an end portion of one of the second regions to an end portion of another of the second regions adjacent thereto being 60 μm to 570 μm.
摘要翻译：在冷轧钢板上形成抗蚀剂膜，以通过蚀刻制造凹槽。此时，在抗蚀剂膜上形成钢板暴露部分，钢板露出部分具有沿纸张宽度方向取向的第一区域和从第一区域开始的多个第二区域所述第一区域，所述第一区域和所述第二区域的宽度为20μm至100μm，并且从所述第二区域中的一个的端部到与所述第二区域相邻的所述第二区域中的另一个的端部的距离为60μm至570μm 妈妈

7. 发明申请

US20070061194A1 Device and method for generating commercial-containing music data and commercial-containing music data 审中-公开
标题翻译：用于生成包含商业的音乐数据和包含商业的音乐数据的装置和方法
公开(公告)号：US20070061194A1
公开(公告)日：2007-03-15
申请号：US11223489
申请日：2005-09-12
申请人： Yasuhiro Kikuchi , Masahiko Okuno
发明人： Yasuhiro Kikuchi , Masahiko Okuno
IPC分类号： G06Q30/00
CPC分类号： G06Q30/02 , G06Q30/0241
摘要： Problem to be Solved: The object of the present invention is to enable music distribution implemented over the Internet to provide music less expensively than in the past or free of charge. Solution: The present invention provides commercial-containing music data comprised of inserting commercial data before and/or after music data. Since commercial data is heard by a user as a result of the commercial data being played back whenever music data is played back, a portion of all of the fees for playing back music data can be covered thereby.
摘要翻译：要解决的问题：本发明的目的是使得能够通过互联网实现的音乐分发比过去或免费提供音乐更少的费用。解决方案：本发明提供包括在音乐数据之前和/或之后插入商业数据的包含商业的音乐数据。由于随着播放音乐数据时商业数据被播放的结果，用户听到商业数据，所以可以覆盖所有用于播放音乐数据的费用的一部分。

8. 发明申请

US20050048602A1 Kidney repairing factor 审中-公开
标题翻译：肾脏修复因子
公开(公告)号：US20050048602A1
公开(公告)日：2005-03-03
申请号：US10221807
申请日：2001-03-16
申请人： Kyoko Takeuchi , Yoko Kato , Susumu Sekine , Yasuhiro Kikuchi , Kazuhiro Sakurada
发明人： Kyoko Takeuchi , Yoko Kato , Susumu Sekine , Yasuhiro Kikuchi , Kazuhiro Sakurada
IPC分类号： A61K38/00 , A61P13/12 , C07K14/47 , C12P21/08 , C07H21/04 , C07K14/52 , C12N9/64
CPC分类号： C07K14/47 , A61K38/00
摘要： A protein [kidney regeneration factor (KRGF-1)] whose expression is increased at the time of regeneration of damaged tissues in patients with renal diseases is isolated, and a DNA encoding the protein and an antibody recognizing the protein are produced. These materials can be utilized in screening of therapeutic agents for regenerating damaged renal tissues and in diagnosis of renal damage.
摘要翻译：分离在肾病患者再生受损组织时其表达增加的蛋白质[肾再生因子（KRGF-1）]，产生编码蛋白质的DNA和识别该蛋白质的抗体。这些材料可用于筛选用于再生损伤的肾组织和诊断肾损伤的治疗剂。

9. 发明授权

US06301302B1 Moving picture search system cross reference to related application 失效
标题翻译：运动图像搜索系统交叉参考相关应用
公开(公告)号：US06301302B1
公开(公告)日：2001-10-09
申请号：US09628341
申请日：2000-07-28
申请人： Yasuhiro Kikuchi , Shin Yamada , Akiyoshi Tanaka
发明人： Yasuhiro Kikuchi , Shin Yamada , Akiyoshi Tanaka
IPC分类号： H04N712
CPC分类号： H04N5/147 , G06K9/3266 , G11B27/105 , G11B27/107 , G11B27/11 , G11B27/28 , G11B27/34 , G11B2220/20 , G11B2220/90
摘要： Every frame represented by a moving picture signal is divided into blocks. Calculation is made as to a number of pixels forming portions of a caption in each of the blocks. The calculated number of pixels is compared with a threshold value. When the calculated number of pixels is equal to or greater than the threshold value, it is decided that the related block is a caption-containing block. Detection is made as to a time interval related to the moving picture signal during which every frame represented by the moving picture signal has a caption-containing block. A 1-frame-corresponding segment of the moving picture signal is selected which represents a caption-added frame present in the detected time interval.
摘要翻译：由运动图像信号表示的每个帧被划分成块。对于形成每个块中的标题的部分的多个像素进行计算。将计算出的像素数与阈值进行比较。当计算出的像素数量等于或大于阈值时，判定相关块是含有标题的块。对与运动图像信号相关的时间间隔进行检测，在该时间间隔期间，由运动图像信号表示的每个帧具有含字幕的块。选择运动图像信号的1帧对应的段，其表示检测到的时间间隔中存在的字幕相加帧。

10. 发明授权

US5498532A Process for producing amino acids 失效
标题翻译：生产氨基酸的方法
公开(公告)号：US5498532A
公开(公告)日：1996-03-12
申请号：US633169
申请日：1990-12-28
申请人： Ryoichi Katsumata , Yasuhiro Kikuchi , Keiko Nakanishi
发明人： Ryoichi Katsumata , Yasuhiro Kikuchi , Keiko Nakanishi
IPC分类号： C12P7/04 , C12N1/20 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/52 , C12N15/74 , C12P13/04 , C12R1/13 , C12R1/15 , C12R1/19 , C12N15/77
CPC分类号： C12N15/74 , C12N15/52 , C12P13/04 , C12R1/13 , C12R1/15 , Y10S435/849
摘要： The invention relates to coryneform microorganisms capable of assimilating lactose which carry a recombinant DNA capable of conferring the ability to assimilate lactose on coryneform microorganisms; and to a process for producing L-amino acids which comprises culturing said coryneform microorganism capable of assimilating lactose in a culture medium containing lactose to form an amino acid, and recovering said amino acid accumulated in the culture broth. Further, the invention relates to a method for preparing recombinant plasmids containing a DNA fragment essential to the expression of a gene in coryneform microorganisms.
摘要翻译：本发明涉及能够同化乳糖的棒状细菌，其携带能够赋予棒状微生物乳糖的能力的重组DNA; 以及生产L-氨基酸的方法，其包括在含有乳糖的培养基中培养能够吸收乳糖的所述棒状细菌，以形成氨基酸，并回收在培养液中积累的所述氨基酸。此外，本发明涉及一种制备含有在棒状细菌中表达基因所必需的DNA片段的重组质粒的方法。

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