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1. 发明申请

US20130295096A1 DEGRADED AGONIST ANTIBODY 审中-公开
标题翻译：降解激素抗体
公开(公告)号：US20130295096A1
公开(公告)日：2013-11-07
申请号：US13856119
申请日：2013-04-03
申请人： Naoshi Fukushima , Masayuki Tsuchiya , Shinsuke Uno , Toshihiko Ohtomo , Naohiro Yabuta , Hiroyuki Tsunoda
发明人： Naoshi Fukushima , Masayuki Tsuchiya , Shinsuke Uno , Toshihiko Ohtomo , Naohiro Yabuta , Hiroyuki Tsunoda
IPC分类号： C07K16/28
CPC分类号： C07K16/2869 , A61K38/00 , A61K2039/505 , C07K16/24 , C07K16/28 , C07K16/2866 , C07K16/3061 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2319/00
摘要： The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking a cell surface molecule(s) to thereby serve as an agonist.
摘要翻译：本发明涉及含有两个或更多个H链V区和两个或多个单克隆抗体的L链V区的修饰抗体，并且可以通过交联细胞表面分子从而将信号转导入细胞，从而用作激动剂。

2. 发明申请

US20090311718A1 DEGRADED AGONIST ANTIBODY 审中-公开
标题翻译：降解激素抗体
公开(公告)号：US20090311718A1
公开(公告)日：2009-12-17
申请号：US12497131
申请日：2009-07-02
申请人： Naoshi Fukushima , Masayuki Tsuchiya , Shinsuke Uno , Toshihiko Ohtomo , Naohiro Yabuta , Hiroyuki Tsunod
发明人： Naoshi Fukushima , Masayuki Tsuchiya , Shinsuke Uno , Toshihiko Ohtomo , Naohiro Yabuta , Hiroyuki Tsunod
IPC分类号： G01N33/53 , C12P21/08 , C12N5/10 , C12N5/06 , C12N1/00 , C07K16/18 , C07H21/04
CPC分类号： C07K16/2869 , A61K38/00 , A61K2039/505 , C07K16/24 , C07K16/28 , C07K16/2866 , C07K16/3061 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2319/00
摘要： The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking a cell surface molecule(s) to thereby serve as an agonist. The modified antibody can be used as a signal transduction agonist and, therefore, useful as a preventive and/or remedy for various diseases such as cancer, inflammation, hormone disorders and blood diseases.
摘要翻译：本发明涉及含有两个或更多个H链V区和两个或多个单克隆抗体的L链V区的修饰抗体，并且可以通过交联细胞表面分子从而将信号转导入细胞，从而用作激动剂。修饰的抗体可以用作信号转导激动剂，因此可用作各种疾病如癌症，炎症，激素失调和血液疾病的预防和/或补救。

3. 发明申请

US20080009038A1 Methods for Enhancing Antibody Activity 审中-公开
标题翻译：增强抗体活性的方法
公开(公告)号：US20080009038A1
公开(公告)日：2008-01-10
申请号：US10582413
申请日：2004-12-10
申请人： Toshihiko Ohtomo , Naohiro Yabuta , Hiroyuki Tsunoda , Masayuki Tsuchiya
发明人： Toshihiko Ohtomo , Naohiro Yabuta , Hiroyuki Tsunoda , Masayuki Tsuchiya
IPC分类号： C12P21/00 , C07K16/00
CPC分类号： C07K16/00 , C07K16/18 , C07K2317/622 , C07K2317/75
摘要： Anti-human Mp1 antibodies were isolated and purified, and then single-chain anti-human Mp1 antibodies were prepared using genetic engineering techniques. The antibodies were found to exhibit a high agonistic activity. This shows that the activity of an antibody can be enhanced by making the antibody into a single-chain polypeptide that comprises two or more heavy chain variable regions and two or more light chain variable regions linked via linkers.
摘要翻译：分离和纯化抗人Mp1抗体，然后使用遗传工程技术制备单链抗人Mp1抗体。发现抗体表现出高的激动作用。这表明通过将抗体制成包含两个或多个重链可变区和通过接头连接的两个或更多个轻链可变区的单链多肽，可以增强抗体的活性。

4. 发明授权

US08586039B2 Degraded TPO agonist antibody 失效
标题翻译：降解的TPO激动剂抗体
公开(公告)号：US08586039B2
公开(公告)日：2013-11-19
申请号：US13225999
申请日：2011-09-06
申请人： Masayuki Tsuchiya , Toshihiko Ohtomo , Naohiro Yabuta , Hiroyuki Tsunoda , Tetsuro Orita
发明人： Masayuki Tsuchiya , Toshihiko Ohtomo , Naohiro Yabuta , Hiroyuki Tsunoda , Tetsuro Orita
IPC分类号： A61K38/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/24 , C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2319/00
摘要： The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking TPO receptor to thereby exert TPO agonist action. The modified antibody can be used as a TPO signal transduction agonist and, therefore, useful as a remedy for various diseases such as platelet-reduction-related blood diseases, thrombopenia following chemotherapy for cancer or leukemia, etc.
摘要翻译：本发明涉及含有两个或多个H链V区和两个或更多个单克隆抗体的L链V区的修饰抗体，并且可通过交联TPO受体将信号转导进入细胞从而发挥TPO激动剂作用。修饰的抗体可用作TPO信号转导激动剂，因此可用作各种疾病如血小板减少相关血液疾病，癌症或白血病化疗后的血小板减少症等的补救。

5. 发明授权

US08034903B2 Degraded TPO agonist antibody 失效
标题翻译：降解的TPO激动剂抗体
公开(公告)号：US08034903B2
公开(公告)日：2011-10-11
申请号：US10399518
申请日：2001-10-22
申请人： Masayuki Tsuchiya , Toshihiko Ohtomo , Naohiro Yabuta , Hiroyuki Tsunoda , Tetsuro Orita
发明人： Masayuki Tsuchiya , Toshihiko Ohtomo , Naohiro Yabuta , Hiroyuki Tsunoda , Tetsuro Orita
IPC分类号： C12P21/08 , A61K39/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/24 , C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2319/00
摘要： The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking TPO receptor to thereby exert TPO agonist action. The modified antibody can be used as a TPO signal transduction agonist and, therefore, useful as a remedy for various diseases such as platelet-reduction-related blood diseases, thrombopenia following chemotherapy for cancer or leukemia, etc.
摘要翻译：本发明涉及含有两个或多个H链V区和两个或更多个单克隆抗体的L链V区的修饰抗体，并且可通过交联TPO受体将信号转导进入细胞从而发挥TPO激动剂作用。修饰的抗体可用作TPO信号转导激动剂，因此可用作各种疾病如血小板减少相关血液疾病，癌症或白血病化疗后的血小板减少症等的补救。

6. 发明申请

US20120015436A1 DEGRADED TPO AGONIST ANTIBODY 失效
标题翻译：降解的TPO激动剂抗体
公开(公告)号：US20120015436A1
公开(公告)日：2012-01-19
申请号：US13225999
申请日：2011-09-06
申请人： Masayuki Tsuchiya , Toshihiko Ohtomo , Naohiro Yabuta , Hiroyuki Tsunoda , Tetsuro Orita
发明人： Masayuki Tsuchiya , Toshihiko Ohtomo , Naohiro Yabuta , Hiroyuki Tsunoda , Tetsuro Orita
IPC分类号： C12N5/10 , C12N1/21 , C12N1/19 , C12N15/13 , C12N1/15
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/24 , C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2319/00
摘要： The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking TPO receptor to thereby exert TPO agonist action. The modified antibody can be used as a TPO signal transduction agonist and, therefore, useful as a remedy for various diseases such as platelet-reduction-related blood diseases, thrombopenia following chemotherapy for cancer or leukemia, etc.
摘要翻译：本发明涉及含有两个或多个H链V区和两个或更多个单克隆抗体的L链V区的修饰抗体，并且可通过交联TPO受体将信号转导进入细胞从而发挥TPO激动剂作用。修饰的抗体可用作TPO信号转导激动剂，因此可用作各种疾病如血小板减少相关血液疾病，癌症或白血病化疗后的血小板减少症等的补救。

7. 发明授权

US06903194B1 Antibody against human parathormone related peptides 失效
标题翻译：抗人类parathormone相关肽的抗体
公开(公告)号：US06903194B1
公开(公告)日：2005-06-07
申请号：US09269332
申请日：1997-09-24
申请人： Koh Sato , Yuji Wakahara , Naohiro Yabuta
发明人： Koh Sato , Yuji Wakahara , Naohiro Yabuta
IPC分类号： C12P21/02 , A61K38/00 , A61K39/395 , C07K16/26 , C12N15/13 , C12N15/62 , C12P21/08 , C07K1/10
CPC分类号： C07K16/26 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2319/00
摘要： Disclosed are an antibody against human para-thyroid-hormone-related protein, a DNA coding for the antibody, a recombinant vector containing the DNA, a transformant transformed with the recombinant vector, a method for preparation of the antibody, and uses of the antibody.
摘要翻译：公开了针对人甲状腺激素相关蛋白的抗体，编码抗体的DNA，含有DNA的重组载体，用重组载体转化的转化体，抗体的制备方法和抗体的用途。

8. 发明申请

US20050136057A1 Antibodies against human parathyroid hormone related protein 失效
标题翻译：抗甲状旁腺激素相关蛋白的抗体
公开(公告)号：US20050136057A1
公开(公告)日：2005-06-23
申请号：US11047996
申请日：2005-02-02
申请人： Koh Sato , Yuji Wakahara , Naohiro Yabuta
发明人： Koh Sato , Yuji Wakahara , Naohiro Yabuta
IPC分类号： C12P21/02 , A61K38/00 , A61K39/395 , C07K16/26 , C12N15/13 , C12N15/62 , C12P21/08
CPC分类号： C07K16/26 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2319/00
摘要： Disclosed are an antibody against human para-thyroid-hormone-related protein, a DNA coding for the antibody, a recombinant vector containing the DNA, a transformant transformed with the recombinant vector, a method for preparation of the antibody, and uses of the antibody.
摘要翻译：公开了针对人甲状腺激素相关蛋白的抗体，编码抗体的DNA，含有DNA的重组载体，用重组载体转化的转化体，抗体的制备方法和抗体的用途。

9. 发明授权

US07842790B2 Antibodies against human parathyroid hormone related protein 失效
标题翻译：抗甲状旁腺激素相关蛋白的抗体
公开(公告)号：US07842790B2
公开(公告)日：2010-11-30
申请号：US11931429
申请日：2007-10-31
申请人： Koh Sato , Yuji Wakahara , Naohiro Yabuta
发明人： Koh Sato , Yuji Wakahara , Naohiro Yabuta
IPC分类号： C07K16/26
CPC分类号： C07K16/26 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2319/00
摘要： Disclosed are an antibody against human para-thyroid-hormone-related protein, a DNA coding for the antibody, a recombinant vector containing the DNA, a transformant transformed with the recombinant vector, a method for preparation of the antibody, and uses of the antibody.
摘要翻译：公开了针对人甲状腺激素相关蛋白的抗体，编码抗体的DNA，含有DNA的重组载体，用重组载体转化的转化体，抗体的制备方法和抗体的用途。

10. 发明授权

US07494647B2 Humanized antibody against human tissue factor (TF) and process of production of the humanized antibody 有权
标题翻译：针对人组织因子（TF）的人源化抗体和人源化抗体的生产过程
公开(公告)号：US07494647B2
公开(公告)日：2009-02-24
申请号：US10462062
申请日：2003-06-16
申请人： Koh Sato , Hideki Adachi , Naohiro Yabuta
发明人： Koh Sato , Hideki Adachi , Naohiro Yabuta
IPC分类号： A61K39/395
CPC分类号： C07K16/36 , A61K2039/505 , C07K2317/24 , C07K2319/00
摘要： A humanized antibody against tissue factor (TF), comprising:A: a humanized H chain comprising (1) a H chain V region comprising the H chain CDRs of a mouse monoclonal antibody against TF and the H chain FRs of a human antibody, and (2) the H chain C region of a human antibody; andB: a humanized L chain comprising (1) an L chain V region comprising the L chain CDRs of a mouse monoclonal antibody against TF and the L chain FRs of a human antibody, and (2) the L chain C region of a human antibody.After generating a humanized V region by grafting the CDRs of a mouse monoclonal antibody onto a human antibody, a humanized antibody having a higher activity is searched by replacing the FR of the above region with the corresponding FR of the human antibody having a high homology.
摘要翻译：一种抗组织因子（TF）的人源化抗体，包括：A：人源化H链，其包含（1）H链V区，其包含针对TF的小鼠单克隆抗体的H链CDR和人抗体的H链FR，以及（2）人抗体的H链C区; 和B：人源化L链，其包含（1）包含针对TF的小鼠单克隆抗体的L链CDR和人抗体的L链FR的L链V区，和（2）人的L链C区抗体。通过将小鼠单克隆抗体的CDR移植到人抗体上产生人源化V区后，通过用具有高同源性的人抗体的相应FR代替上述区域的FR来搜索具有较高活性的人源化抗体。

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