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    • 10. 发明授权
    • Cyclic amine compound
    • 环胺化合物
    • US08158790B2
    • 2012-04-17
    • US12306281
    • 2007-06-22
    • Shojiro MiyazakiYuji NakamuraTakahiro NagayamaTaro TokuiYasuyuki Ogawa
    • Shojiro MiyazakiYuji NakamuraTakahiro NagayamaTaro TokuiYasuyuki Ogawa
    • C07D241/06C07D241/08C07D401/04C07D403/04A61K31/495A61K31/496A61P9/04A61P9/10A61P9/12
    • C07D401/04C07D211/18C07D211/22C07D211/70C07D241/04C07D241/08
    • The present invention provides an excellent antihypertensive medicament. The medicament of the present invention comprises a compound having the general formula (I) and the like: [wherein R1: H, substitutable alkyl, substitutable alkenyl, substitutable cyclic hydrocarbon, substitutable heterocyclyl or the like; R2: H, substitutable alkyl, substitutable alkenyl, substitutable cycloalkyl or the like; R3, R4; H, substitutable alkyl, substitutable alkenyl, substitutable cycloalkyl or the like; R5, R6: H, substitutable alkyl, substitutable cycloalkyl, substitutable alkoxy or the like; R7, R8: H, substitutable alkyl, substitutable cycloalkyl or the like; X: the formula (II) or the like; A: substitutable cyclic hydrocarbon, substitutable heterocyclyl or the like; Y: a single bond, substitutable alkylene, substitutable alkenylene, —(CH2)a—X1—(CH2)b—(X1: the formula —NH—, —O— or the like; a, b: 0-5) or the like; B: substitutable cyclic hydrocarbon, substitutable heterocyclyl or the like].
    • 本发明提供了优异的抗高血压药物。 本发明的药物包含具有通式(I)等的化合物:其中R 1:H,可取代的烷基,可取代的链烯基,可取代的环状烃,可取代的杂环基等; R2:H,可取代的烷基,可取代的烯基,可取代的环烷基等; R3,R4; H,可取代的烷基,可取代的烯基,可取代的环烷基等; R5,R6:H,可取代的烷基,可取代的环烷基,可取代的烷氧基等; R7,R8:H,可取代的烷基,可取代的环烷基等; X:式(II)等; A:可取代的环烃,可取代的杂环基等; Y:单键,可取代亚烷基,可取代亚烯基, - (CH 2)a -X 1 - (CH 2)b - (X 1:式-NH-,-O-等; a,b:0-5)或 类似; B:可取代的环状烃,可取代的杂环基等]。