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1. 发明授权

US5360740A Assay system for degenerative muscle disease 失效
标题翻译：退行性肌肉疾病的测定系统
公开(公告)号：US5360740A
公开(公告)日：1994-11-01
申请号：US907680
申请日：1992-07-02
申请人： Nancy Y. Ip , Peter S. DiStefano , Neil Stahl
发明人： Nancy Y. Ip , Peter S. DiStefano , Neil Stahl
IPC分类号： G01N33/50 , G01N33/53 , G01N33/561 , G01N33/68 , G01N33/536 , G01N33/543 , G01N33/566
CPC分类号： G01N33/6896 , G01N33/6872 , G01N2800/2878 , G01N2800/52 , Y10S436/811
摘要： An assay system useful for detecting denervated or degenerating muscle by measuring the amount of soluble ciliary neurotrophic factor receptor in body fluids is described.
摘要翻译：描述了通过测量体液中可溶性睫状神经营养因子受体的量来检测去神经支配或退化肌肉的测定系统。

2. 发明申请

US20090137416A1 Isolating Cells Expressing Secreted Proteins 审中-公开
标题翻译：分离表达分泌蛋白的细胞
公开(公告)号：US20090137416A1
公开(公告)日：2009-05-28
申请号：US12240541
申请日：2008-09-29
申请人： James P. Fandl , Gang Chen , Neil Stahl , George D. Yancopoulos
发明人： James P. Fandl , Gang Chen , Neil Stahl , George D. Yancopoulos
IPC分类号： C40B30/04 , G01N33/53
CPC分类号： G01N33/6854 , C12N15/65 , G01N33/566 , G01N33/56966 , G01N2333/7051
摘要： A method of detecting and isolating cells that produce a secreted protein of interest (POI) that has a T cell receptor variable domain, comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule.
摘要翻译：一种检测和分离产生具有T细胞受体可变区的目标分泌蛋白质（POI）的细胞的方法，包括：a）通过以下步骤构建细胞系：瞬时或稳定表达结合POI的细胞表面捕获分子，通过用编码这种细胞表面捕获分子的核酸转染细胞系; b）同时或随后用编码POI的第二核酸同时转染所述细胞，其中所述POI被分泌; c）通过使细胞与结合POI的检测分子接触来检测表面显示的POI; 和d）基于检测分子分离细胞。

3. 发明授权

US07361350B2 Use of an IL-1 antagonist for treating arthritis 有权
标题翻译：使用IL-1拮抗剂治疗关节炎
公开(公告)号：US07361350B2
公开(公告)日：2008-04-22
申请号：US11056730
申请日：2005-02-11
申请人： Scott Mellis , Neil Stahl , Allen Radin , Steven Weinstein , Denise Calaprice , Margaret Karow , Joanne Papadopoulos
发明人： Scott Mellis , Neil Stahl , Allen Radin , Steven Weinstein , Denise Calaprice , Margaret Karow , Joanne Papadopoulos
IPC分类号： A61K39/00 , C07K14/715
CPC分类号： C07H21/04 , A61K38/00 , C07K14/715 , C07K14/7155 , C07K16/244 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32
摘要： Methods of treating, inhibiting, or ameliorating arthritis, including rheumatoid arthritis, osteoarthritis, psoriatic arthritis, ankylosing spondylitis, or juvenile rheumatoid arthritis, in a human subject in need thereof, comprising administering to a subject in need a therapeutic amount of an interleukin 1 (IL-1) antagonist, wherein arthritis inhibited, or ameliorated. The IL-1 antagonist is an IL-1-specific fusion protein comprising an IL-1 binding portion of the extracellular domain of human II-1RAcP, an IL-1 binding portion of the extracellular domain of human IL-1RI, and a multimerizing component antagonist, preferably comprising a sequence selected from the group consisting of SEQ ID NO:4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, or a substantially identical sequence.
摘要翻译：在有需要的人类受试者中治疗，抑制或改善关节炎，包括类风湿性关节炎，骨关节炎，银屑病关节炎，强直性脊柱炎或幼年型类风湿性关节炎的方法，包括向需要治疗的受试者施用治疗量的白介素1（ IL-1）拮抗剂，其中关节炎被抑制或改善。 IL-1拮抗剂是IL-1特异性融合蛋白，其包含人II-1RAcP的细胞外结构域的IL-1结合部分，人IL-1RI细胞外结构域的IL-1结合部分和多聚化优选包含选自SEQ ID NO：4,6,8,10,12,14,16,18,20,22,24,26的序列，或基本相同的序列。

4. 发明申请

US20060210566A1 Methods of treating anemia by inhibition of vascular endothelial growth factor (VEGF) 有权
标题翻译：通过抑制血管内皮生长因子（VEGF）治疗贫血的方法
公开(公告)号：US20060210566A1
公开(公告)日：2006-09-21
申请号：US11373358
申请日：2006-03-10
申请人： Jocelyn Holash , Jesse Cedarbaum , John Rudge , George Yancopoulos , Neil Stahl
发明人： Jocelyn Holash , Jesse Cedarbaum , John Rudge , George Yancopoulos , Neil Stahl
IPC分类号： A61K39/395
CPC分类号： C07K14/71 , A61K38/00 , C07K2319/30
摘要： Methods of treating anemic disorders in human subjects comprising administering a VEGF antagonist comprising a fusion polypeptide having an immunoglobulin-like (Ig) domain 2 of the VEGF receptor Flt1 and Ig domain 3 of the VEGF receptor Flk1 or Flt4, and a multimerizing component. Further included are methods of preventing anemia, increasing hematocrit levels, and increasing or stimulating erythropoietin, particularly in subjects being treated for cancer with chemotherapeutic agents and/or radiation.
摘要翻译：治疗人受试者中贫血障碍的方法包括给予包含融合多肽的VEGF拮抗剂，所述融合多肽具有VEGF受体Flt1的免疫球蛋白样（Ig）结构域2和VEGF受体Flk1或Flt4的Ig结构域3和多聚化成分。还包括预防贫血，增加血细胞比容水平以及增加或刺激促红细胞生成素的方法，特别是在用化学治疗剂和/或辐射治疗癌症的受试者中。

5. 发明授权

US5470952A CNTF and IL-6 antagonists 失效
标题翻译： CNTF和IL-6拮抗剂
公开(公告)号：US5470952A
公开(公告)日：1995-11-28
申请号：US140222
申请日：1993-10-20
申请人： Neil Stahl , Aris N. Economides , George D. Yancopoulos
发明人： Neil Stahl , Aris N. Economides , George D. Yancopoulos
IPC分类号： C12N15/09 , A61K38/00 , A61P3/02 , A61P19/10 , A61P35/02 , A61P43/00 , C07K7/06 , C07K14/475 , C07K14/52 , C07K14/54 , C07K14/715 , C12N15/19 , C12N15/24 , C12P21/02
CPC分类号： C07K14/715 , C07K14/475 , C07K14/5412 , A61K38/00
摘要： Heterodimer proteins comprising a soluble .alpha. specificity determining cytokine receptor component and the extracellular domain of a .beta. receptor component function as CNTF and IL-6 antagonsists.
摘要翻译：包含可溶性α特异性测定细胞因子受体组分的异二聚体蛋白质和β受体组分的胞外结构域作为CNTF和IL-6抗体分子起作用。

6. 发明授权

US07927583B2 Receptor based antagonists and methods of making and using 有权
标题翻译：基于受体的拮抗剂及其制备和使用方法
公开(公告)号：US07927583B2
公开(公告)日：2011-04-19
申请号：US12177185
申请日：2008-07-22
申请人： Neil Stahl , George D. Yancopoulos
发明人： Neil Stahl , George D. Yancopoulos
IPC分类号： A61K38/20 , A61K39/00 , A61K38/16
CPC分类号： C07H21/04 , A61K38/00 , C07K14/715 , C07K14/7155 , C07K16/244 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32
摘要： The present invention provides a fusion polypeptide capable of binding a cytokine to form a nonfunctional complex. It also provides a nucleic acid sequence encoding the fusion polypeptide and methods of making and uses for the fusion polypeptide.
摘要翻译：本发明提供能够结合细胞因子以形成非功能性复合物的融合多肽。它还提供编码融合多肽的核酸序列以及制备和用于融合多肽的方法。

7. 发明授权

US07531172B2 Methods of treating diseases with a VEGF antagonist 有权
标题翻译：用VEGF拮抗剂治疗疾病的方法
公开(公告)号：US07531172B2
公开(公告)日：2009-05-12
申请号：US11502736
申请日：2006-08-11
申请人： Neil Stahl , George D. Yancopoulos , Eric Furfine , Jesse M. Cedarbaum
发明人： Neil Stahl , George D. Yancopoulos , Eric Furfine , Jesse M. Cedarbaum
IPC分类号： A61K38/18 , C07K14/71 , C12N15/62
CPC分类号： A61K38/179
摘要： A method of reducing or preventing hypertension associated with administration of a vascular endothelial growth factor (VEGF) antagonist in a human subjects suffering from a disease or condition treatable with a VEGF antagonist in which is it desirable to reduce or prevent hypertension. The method is particularly useful for treatment of patients unresponsive to treatment with a VEGF inhibitor administered intravenously.
摘要翻译：在患有可用VEGF拮抗剂治疗的疾病或病症的人类受试者中降低或预防与血管内皮生长因子（VEGF）拮抗剂的给药相关的高血压的方法，其中希望减少或预防高血压。该方法对于治疗对用静脉内施用的VEGF抑制剂治疗无反应的患者特别有用。

8. 发明授权

US06811780B2 Methods of using cytokine antagonists to treat HIV infection and AIDS 有权
标题翻译：使用细胞因子拮抗剂治疗艾滋病毒和艾滋病的方法
公开(公告)号：US06811780B2
公开(公告)日：2004-11-02
申请号：US10427863
申请日：2003-05-01
申请人： Eric S. Furfine , Neil Stahl
发明人： Eric S. Furfine , Neil Stahl
IPC分类号： A61K39395
CPC分类号： C07K16/247 , A61K38/1793 , A61K39/39 , A61K2039/505 , A61K2039/55516 , A61K2039/57
摘要： The invention is methods of using cytokine antagonists to treat HIV. In particular, the invention is methods of treating HIV using L-4 and IL-13 cytokine antagonists, including cytokine traps and anti-IL-4 or anti-IL-13 antibodies. The invention also includes augmenting the efficacy of HIV vaccination by co-administration of the vaccine with IL-4 and IL-13 cytokine antagonists.
摘要翻译：本发明是使用细胞因子拮抗剂治疗HIV的方法。特别地，本发明是使用L-4和IL-13细胞因子拮抗剂（包括细胞因子捕获物和抗IL-4或抗IL-13抗体）来治疗HIV的方法。本发明还包括通过将疫苗与IL-4和IL-13细胞因子拮抗剂共同给药来增强HIV疫苗接种的功效。

9. 发明授权

US06660499B1 DCR5, a BMP-binding protein, and applications thereof 有权
标题翻译： DCR5，BMP结合蛋白及其应用
公开(公告)号：US06660499B1
公开(公告)日：2003-12-09
申请号：US09762960
申请日：2001-02-14
申请人： Aris N. Economides , Neil Stahl
发明人： Aris N. Economides , Neil Stahl
IPC分类号： C12P2106
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/02
摘要： DCR5, a protein related to DAN (Differential-screening-selected gene Aberrative in Neuroblastoma) and related nucleic acids are provided. Included are natural DCR5 homologs from several species and proteins comprising a DCR5 domain having specific activity, particularly the ability to antagonize a bone morphogenetic protein. The proteins may be produced recombinantly from transformed host cells with the subject nucleic acids. Also provided are isolated hybridization probes and primers capable of specifically hybridizing with the disclosed genes, specific binding agents and methods of making and using the subject compositions.
摘要翻译：提供了与DAN相关的蛋白质（神经母细胞瘤中的差异筛选选择基因Aberrative）和相关核酸的DCR5。包括来自几种物种的天然DCR5同源物和包含具有比活性的DCR5结构域的蛋白质，特别是拮抗骨形态发生蛋白的能力。蛋白质可以用受试核酸从转化的宿主细胞重组产生。还提供了能够与所公开的基因，特异性结合剂和制备和使用本发明组合物的方法特异性杂交的分离的杂交探针和引物。

10. 发明授权

US07435553B2 Isolating cells expressing secreted proteins 有权
标题翻译：分离表达分泌蛋白的细胞
公开(公告)号：US07435553B2
公开(公告)日：2008-10-14
申请号：US11434403
申请日：2006-05-15
申请人： James P Fandl , Neil Stahl , Gang Chen , George D. Yancopoulos
发明人： James P Fandl , Neil Stahl , Gang Chen , George D. Yancopoulos
IPC分类号： G01N33/53 , C12N15/09
CPC分类号： C40B30/04 , A01K2217/05 , A01K2267/01 , C07K14/315 , C07K14/52 , C07K16/2863 , C07K2317/77 , C07K2319/00 , C12N15/1051 , G01N33/56966 , G01N33/6845 , G01N2500/10
摘要： A method of detecting and isolating cells that produce any secreted protein of interest (POI), comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule.
摘要翻译：一种检测和分离产生任何分泌的感兴趣蛋白质（POI）的细胞的方法，包括：a）通过用核酸转染细胞系来构建瞬时或稳定表达结合POI的细胞表面捕获分子的细胞系编码这种细胞表面捕获分子; b）同时或随后用编码POI的第二核酸同时转染所述细胞，其中所述POI被分泌; c）通过使细胞与结合POI的检测分子接触来检测表面显示的POI; 和d）基于检测分子分离细胞。

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