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1. 发明授权

US08992964B2 Process for demineralization of bone matrix with preservation of natural growth factors 有权
标题翻译：骨质疏松矿物质保存自然生长因子的方法
公开(公告)号：US08992964B2
公开(公告)日：2015-03-31
申请号：US13453818
申请日：2012-04-23
申请人： Nancy J. Shelby , Steven M. Scott , Benjamin P. Luchsinger , Gregory A. Juda , Kelly R. Kirker , Jesus Hernandez , Darrel L. Holmes
发明人： Nancy J. Shelby , Steven M. Scott , Benjamin P. Luchsinger , Gregory A. Juda , Kelly R. Kirker , Jesus Hernandez , Darrel L. Holmes
IPC分类号： A61F2/02 , A61L27/36 , A61F2/46 , A61L27/38 , A61L27/54 , A61L27/56 , C12N5/00
CPC分类号： A61L27/3608 , A61F2/4644 , A61L27/227 , A61L27/28 , A61L27/3683 , A61L27/3691 , A61L27/38 , A61L27/3804 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2420/00 , A61L2430/02 , A61L2430/06 , C12N5/0062 , C12N5/0068 , C12N2503/02 , C12N2533/90 , C12N2537/00
摘要： A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.
摘要翻译：通过将骨体放置在包含酸的第一处理溶液中以使骨体软化矿石的方法来生产脱矿质骨基质。以特定的时间间隔周期性地从第一溶液中除去骨体，以对骨骼的机械性质进行至少一个测试，例如压缩试验。当测试产生期望的结果时，骨体暴露于比第一处理溶液酸性低的第二处理溶液，从而最小化骨体暴露于该过程的脱盐阶段的恶劣酸性条件。

2. 发明申请

US20080305145A1 PROCESS FOR DEMINERALIZATION OF BONE MATRIX WITH PRESERVATION OF NATURAL GROWTH FACTORS 有权
标题翻译：骨骼基质与自然生长因子的保存过程
公开(公告)号：US20080305145A1
公开(公告)日：2008-12-11
申请号：US12130384
申请日：2008-05-30
申请人： Nancy J. Shelby , Steven M. Scott , Benjamin P. Luchsinger , Gregory A. Juda , Kelly R. Kirker , Jesus Hernandez , Darrel L. Holmes
发明人： Nancy J. Shelby , Steven M. Scott , Benjamin P. Luchsinger , Gregory A. Juda , Kelly R. Kirker , Jesus Hernandez , Darrel L. Holmes
IPC分类号： A61K9/00 , C12N5/00 , A61K35/12 , C12Q1/02 , A61P43/00
CPC分类号： A61L27/3608 , A61F2/4644 , A61L27/227 , A61L27/28 , A61L27/3683 , A61L27/3691 , A61L27/38 , A61L27/3804 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2420/00 , A61L2430/02 , A61L2430/06 , C12N5/0062 , C12N5/0068 , C12N2503/02 , C12N2533/90 , C12N2537/00
摘要： A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.
摘要翻译：通过将骨体放置在包含酸的第一处理溶液中以使骨体软化矿石的方法来生产脱矿质骨基质。以特定的时间间隔周期性地从第一溶液中除去骨体，以对骨骼的机械性质进行至少一个测试，例如压缩试验。当测试产生期望的结果时，骨体暴露于比第一处理溶液酸性低的第二处理溶液，从而最小化骨体暴露于该过程的脱盐阶段的恶劣酸性条件。

3. 发明申请

US20150202346A1 DEMINERALIZED BONE MATRIX 审中-公开
标题翻译：骨化矩阵
公开(公告)号：US20150202346A1
公开(公告)日：2015-07-23
申请号：US14672763
申请日：2015-03-30
申请人： Nancy J. Shelby , Steven M. Scott , Benjamin P. Luchsinger , Gregory A. Juda , Kelly R. Kirker , Jesus Hernandez , Darrel L. Holmes
发明人： Nancy J. Shelby , Steven M. Scott , Benjamin P. Luchsinger , Gregory A. Juda , Kelly R. Kirker , Jesus Hernandez , Darrel L. Holmes
IPC分类号： A61L27/36 , A61L27/56 , A61L27/22
CPC分类号： A61L27/3608 , A61F2/4644 , A61L27/227 , A61L27/28 , A61L27/3683 , A61L27/3691 , A61L27/38 , A61L27/3804 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2420/00 , A61L2430/02 , A61L2430/06 , C12N5/0062 , C12N5/0068 , C12N2503/02 , C12N2533/90 , C12N2537/00
摘要： A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.
摘要翻译：通过将骨体放置在包含酸的第一处理溶液中以使骨体软化矿石的方法来生产脱矿质骨基质。以特定的时间间隔周期性地从第一溶液中除去骨体，以对骨骼的机械性质进行至少一个测试，例如压缩试验。当测试产生期望的结果时，骨体暴露于比第一处理溶液酸性低的第二处理溶液，从而最小化骨体暴露于该过程的脱盐阶段的恶劣酸性条件。

4. 发明申请

US20150258244A1 Demineralized Bone Matrix 审中-公开
公开(公告)号：US20150258244A1
公开(公告)日：2015-09-17
申请号：US14672727
申请日：2015-03-30
申请人： Nancy J. Shelby , Steven M. Scott , Benjamin P. Luchsinger , Gregory A. Juda , Kelly R. Kirker , Jesus Hernandez , Darrel L. Holmes
发明人： Nancy J. Shelby , Steven M. Scott , Benjamin P. Luchsinger , Gregory A. Juda , Kelly R. Kirker , Jesus Hernandez , Darrel L. Holmes
IPC分类号： A61L27/36 , A61L27/38 , A61L27/28 , A61L27/54
CPC分类号： A61L27/3608 , A61F2/4644 , A61L27/227 , A61L27/28 , A61L27/3683 , A61L27/3691 , A61L27/38 , A61L27/3804 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2420/00 , A61L2430/02 , A61L2430/06 , C12N5/0062 , C12N5/0068 , C12N2503/02 , C12N2533/90 , C12N2537/00
摘要： A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.

5. 发明申请

US20120213859A1 PROCESS FOR DEMINERALIZATION OF BONE MATRIX WITH PRESERVATION OF NATURAL GROWTH FACTORS 有权
标题翻译：骨骼基质与自然生长因子的保存过程
公开(公告)号：US20120213859A1
公开(公告)日：2012-08-23
申请号：US13453818
申请日：2012-04-23
申请人： Nancy J. Shelby , Steven M. Scott , Benjamin P. Luchsinger , Gregory A. Juda , Kelly R. Kirker , Jesus Hernandez , Darrel L. Holmes
发明人： Nancy J. Shelby , Steven M. Scott , Benjamin P. Luchsinger , Gregory A. Juda , Kelly R. Kirker , Jesus Hernandez , Darrel L. Holmes
IPC分类号： A61K35/32 , A61P19/00
CPC分类号： A61L27/3608 , A61F2/4644 , A61L27/227 , A61L27/28 , A61L27/3683 , A61L27/3691 , A61L27/38 , A61L27/3804 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2420/00 , A61L2430/02 , A61L2430/06 , C12N5/0062 , C12N5/0068 , C12N2503/02 , C12N2533/90 , C12N2537/00
摘要： A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.
摘要翻译：通过将骨体放置在包含酸的第一处理溶液中以使骨体软化矿石的方法来生产脱矿质骨基质。以特定的时间间隔周期性地从第一溶液中除去骨体，以对骨骼的机械性质进行至少一个测试，例如压缩试验。当测试产生期望的结果时，骨体暴露于比第一处理溶液酸性低的第二处理溶液，从而最小化骨体暴露于该过程的脱盐阶段的恶劣酸性条件。

6. 发明授权

US08574825B2 Process for demineralization of bone matrix with preservation of natural growth factors 有权
公开(公告)号：US08574825B2
公开(公告)日：2013-11-05
申请号：US12130384
申请日：2008-05-30
申请人： Nancy J. Shelby , Steven M. Scott , Benjamin P. Luchsinger , Gregory A. Juda , Kelly R. Kirker , Jesus Hernandez , Darrel L. Holmes
发明人： Nancy J. Shelby , Steven M. Scott , Benjamin P. Luchsinger , Gregory A. Juda , Kelly R. Kirker , Jesus Hernandez , Darrel L. Holmes
IPC分类号： A01N1/00
CPC分类号： A61L27/3608 , A61F2/4644 , A61L27/227 , A61L27/28 , A61L27/3683 , A61L27/3691 , A61L27/38 , A61L27/3804 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2420/00 , A61L2430/02 , A61L2430/06 , C12N5/0062 , C12N5/0068 , C12N2503/02 , C12N2533/90 , C12N2537/00
摘要： A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.

7. 发明申请

US20140170232A1 PROCESS FOR DEMINERALIZATION OF BONE MATRIX WITH PRESERVATION OF NATURAL GROWTH FACTORS 有权
标题翻译：骨骼基质与自然生长因子的保存过程
公开(公告)号：US20140170232A1
公开(公告)日：2014-06-19
申请号：US14186993
申请日：2014-02-21
申请人： Nancy J. Shelby , Steven M. Scott , Benjamin P. Luchsinger , Gregory A. Juda , Kelly R. Kirker , Darrel L. Holmes , Michael Mansfield
发明人： Nancy J. Shelby , Steven M. Scott , Benjamin P. Luchsinger , Gregory A. Juda , Kelly R. Kirker , Darrel L. Holmes , Michael Mansfield
IPC分类号： A61L27/36 , A61L27/54
CPC分类号： A61L27/3608 , A61F2/4644 , A61L27/227 , A61L27/28 , A61L27/3683 , A61L27/3691 , A61L27/38 , A61L27/3804 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2420/00 , A61L2430/02 , A61L2430/06 , C12N5/0062 , C12N5/0068 , C12N2503/02 , C12N2533/90 , C12N2537/00
摘要： A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.
摘要翻译：通过将骨体放置在包含酸的第一处理溶液中以使骨体软化矿石的方法来生产脱矿质骨基质。以特定的时间间隔周期性地从第一溶液中除去骨体，以对骨骼的机械性质进行至少一个测试，例如压缩试验。当测试产生期望的结果时，骨体暴露于比第一处理溶液酸性低的第二处理溶液，从而最小化骨体暴露于该过程的脱盐阶段的恶劣酸性条件。

8. 发明授权

US5563987A Pagemap memory representation in RISC processor printers 失效
标题翻译： RISC处理器打印机中的页面映射存储器表示
公开(公告)号：US5563987A
公开(公告)日：1996-10-08
申请号：US330943
申请日：1994-10-28
申请人： Steven M. Scott
发明人： Steven M. Scott
IPC分类号： G06K15/00
CPC分类号： G06F12/10 , G06K15/00 , G06F12/1027 , G06K2215/0065
摘要： Disclosed is a process and apparatus for pagemap memory representation in RISC controlled printers. The technique disclosed optimizes pagemaps in memory to minimize losses in processor efficiency of processors having data caches, TLB's and virtual memory, due to unavailability of desired data in first the data cache, then the random access memory. The technique is particularly applicable to RISC processors having a plurality of table lookaside buffers, each containing the address of a frame or page of memory, each frame comprising a finite number of bytes of data. This is accomplished by dividing the pagemap into one dimensional array of swaths of scans, each swath containing a two dimensional array of words in column major order. Each of said swaths having a height measured in scans which is a function of frame size, data cache line size and set associativity of the data cache, but which is an integral multiple of the number of words in a data cache line. The optimization of set associativity of data cache line utilization is accomplished by determining that the swath height divided by the number of words in a data cache line are not evenly divided by two.
摘要翻译：公开了用于RISC控制的打印机中的页面映射存储器表示的过程和装置。所公开的技术优化了存储器中的页面映像，以便由于在第一数据高速缓存中不可用的期望数据，随机存取存储器，使具有数据高速缓存，TLB和虚拟存储器的处理器的处理器效率的损失最小化。该技术特别适用于具有多个表后备缓冲器的RISC处理器，每个缓冲器包含一个或多个存储器的地址，每个帧包括有限数量的数据字节。这是通过将页面映射划分为扫描行扫描的一维阵列来实现的，每个条带以列主要顺序包含二维数组的单词。每个所述条具有在扫描中测量的高度，其是数据高速缓存的帧大小，数据高速缓存行大小和设置的关联性的函数，但它是数据高速缓存行中字数的整数倍。数据高速缓存行利用率的集合关联性的优化是通过确定数据高速缓存行中的字数除以2之外的字数除以高度来实现的。

9. 发明授权

US5563625A Fast 180 degree image rotation and reversal 失效
标题翻译：快速180度图像旋转和反转
公开(公告)号：US5563625A
公开(公告)日：1996-10-08
申请号：US302307
申请日：1994-09-08
申请人： Steven M. Scott
发明人： Steven M. Scott
IPC分类号： G06T3/60 , G09G5/34
CPC分类号： G06T3/60
摘要： A method of reversing all of the pixels in an image word uses recursive steps of shifting the image word a varying, predetermined number of spaces, followed by filtering the shifted and unshifted words through a varying, predetermined mask. The number of cycles necessary to reverse an image word having 2.sup.n pixels is n cycles, plus one additional shifting step. This method of reversing a single image word is used to generate the mirror image of an input image. This image word reversal method is also useful for rotating an image word 180 degrees about an axis through its center.
摘要翻译：反转图像字中的所有像素的方法使用将图像字移动到变化的预定数量的空间的递归步骤，然后通过变化的预定掩码来对移位和未移位的字进行滤波。反转具有2n个像素的图像字所需的周期数是n个周期，加上一个附加的移位步骤。使用这种反转单个图像字的方法来生成输入图像的镜像。该图像字反转方法也可用于使图像字绕其中心旋转180度。

10. 发明授权

US5727220A Method and system for caching and referencing cached document pages utilizing a presentation data stream 失效
标题翻译：用于使用演示数据流来缓存和引用缓存的文档页面的方法和系统
公开(公告)号：US5727220A
公开(公告)日：1998-03-10
申请号：US564756
申请日：1995-11-29
申请人： Reinhard H. Hohensee , David E. Stone , Ronald D. Parrish , Dwight R. Palmer , Steven M. Scott , Brian G. Platte
发明人： Reinhard H. Hohensee , David E. Stone , Ronald D. Parrish , Dwight R. Palmer , Steven M. Scott , Brian G. Platte
IPC分类号： G06T1/60 , G06F9/00
CPC分类号： G06T1/60
摘要： A method and system for presenting a document at a presentation device utilizing a presentation data stream having a continuous ordered stream of uniquely identified data objects and associated elements which specify format and presentation parameters for each of those data objects. The data stream contains a plurality of documents, including a resource document and a presentation document, which each comprise a collection of the uniquely identified data objects and associated elements. A save object command structure is defined within a resource document within the presentation data stream. Within the save object command structure, a particular data object is identified. In response to receipt of the save object command structure at the presentation device, the particular data object is stored within storage media. Thereafter, an include saved object command structure is defined within a diverse presentation document within a presentation data stream. The particular data object is identified within the include saved object command structure. In response to receipt of the include saved object command structure at the presentation device, the particular data object is presented within the presentation document, thereby enabling a portion of the resource document stored at the presentation device to be utilized within the presentation document such that presentation efficiency is enhanced.
摘要翻译：一种用于在呈现设备处呈现文档的方法和系统，该呈现设备利用具有唯一标识的数据对象的连续有序流的表示数据流以及为每个这些数据对象指定格式和呈现参数的相关元素。数据流包含多个文档，包括资源文档和呈现文档，每个文档包括唯一标识的数据对象和相关元素的集合。在呈现数据流内的资源文档内定义保存对象命令结构。在保存对象命令结构中，识别特定的数据对象。响应于在呈现设备处接收到保存对象命令结构，特定数据对象被存储在存储介质中。此后，在呈现数据流内的不同的呈现文档内定义包括保存的对象命令结构。特定数据对象在包含保存的对象命令结构中被识别。响应于在呈现设备处接收到包括保存的对象命令结构，特定数据对象被呈现在呈现文档内，从而使存储在呈现设备处的资源文档的一部分能够在演示文档内被利用，使得呈现效率提高。

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