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1. 发明授权

US09528334B2 Well drilling methods with automated response to event detection 有权
标题翻译：钻井方法具有自动响应事件检测功能
公开(公告)号：US09528334B2
公开(公告)日：2016-12-27
申请号：US13491513
申请日：2012-06-07
申请人： Nancy Davis , Cody Butler , Charles M. Pool , Ryan Hourd , Aaron Reynolds , Craig W. Godfrey , Frank Urias , Saad Saeed , Emad Bakri , James R. Lovorn
发明人： Nancy Davis , Cody Butler , Charles M. Pool , Ryan Hourd , Aaron Reynolds , Craig W. Godfrey , Frank Urias , Saad Saeed , Emad Bakri , James R. Lovorn
IPC分类号： E21B44/00 , E21B21/10 , E21B47/00 , E21B21/08 , E21B21/00
CPC分类号： E21B21/10 , E21B21/08 , E21B44/00 , E21B47/00 , E21B2021/006
摘要： A well drilling method can include detecting a drilling event by comparing a parameter signature generated during drilling to an event signature indicative of the drilling event, and automatically controlling a drilling operation in response to at least a partial match resulting from comparing the parameter signature to the event signature. A well drilling system can include a control system which compares a parameter signature for a drilling operation to an event signature indicative of a drilling event, and a controller which controls the drilling operation automatically in response to the drilling event being indicated by at least a partial match between the parameter signature and the event signature.
摘要翻译：钻井方法可以包括通过将在钻井过程中生成的参数签名与指示钻井事件的事件签名进行比较来检测钻井事件，以及响应于至少部分匹配而自动地控制钻井操作，所述至少一部分匹配是将参数签名与事件签名。钻井系统可以包括将钻井操作的参数签名与指示钻井事件的事件签名进行比较的控制系统;以及控制器，其响应于钻井事件自动地控制钻井操作，所述控制系统由至少部分匹配参数签名和事件签名。

2. 发明授权

US08240398B2 Annulus pressure setpoint correction using real time pressure while drilling measurements 有权
标题翻译：环钻压力设定值校正，使用实时压力进行钻孔测量
公开(公告)号：US08240398B2
公开(公告)日：2012-08-14
申请号：US13116082
申请日：2011-05-26
申请人： James R. Lovorn , Saad Saeed , Nancy Davis
发明人： James R. Lovorn , Saad Saeed , Nancy Davis
IPC分类号： E21B21/08
CPC分类号： E21B21/08 , E21B21/106 , E21B2021/006
摘要： A method of controlling pressure in a wellbore can include determining a real time wellbore pressure PwbRT1 at a pressure sensor in the wellbore, calculating hydrostatic pressure Ph1 at the pressure sensor, determining a real time annulus pressure PaRT, calculating friction pressure Pf due at least to circulation of the fluid through the wellbore and depth in the wellbore, calculating a friction pressure correction factor CFPf1 equal to (PwbRT1−Ph1−PaRT)/Pf, and controlling operation of a pressure control device, based on the friction pressure correction factor CFPf1. The method can further include determining a desired wellbore pressure PwbD1 at the pressure sensor, calculating an annulus pressure setpoint PaSP1 equal to PwbD1−Ph1−(Pf*CFPf1), and adjusting the pressure control device as needed to maintain PaRT equal to PaSP1.
摘要翻译：控制井眼中的压力的方法可以包括确定在井眼中的压力传感器处的实时井眼压力PwbRT1，计算压力传感器处的静压力Ph1，确定实时环空压力PaRT，计算摩擦压力Pf至少为流体通过井筒的循环和井眼中的深度，计算等于（PwbRT1-Ph1-PaRT）/ Pf的摩擦压力校正因子CFPf1，并且基于摩擦压力校正因子CFPf1来控制压力控制装置的操作。该方法还可以包括确定压力传感器处的期望的井眼压力PwbD1，计算等于PwbD1-Ph1-（Pf * CFPf1）的环形压力设定点PaSP1，以及根据需要调节压力控制装置以将PaRT保持等于PaSP1。

3. 发明授权

US08397836B2 Pressure and flow control in drilling operations 有权
标题翻译：钻井作业中的压力和流量控制
公开(公告)号：US08397836B2
公开(公告)日：2013-03-19
申请号：US13492688
申请日：2012-06-08
申请人： Charles M. Pool , Nancy Davis , Frank Urias , Neal G. Skinner
发明人： Charles M. Pool , Nancy Davis , Frank Urias , Neal G. Skinner
IPC分类号： E21B10/22
CPC分类号： E21B21/08 , E21B21/10
摘要： A method of maintaining a desired downhole pressure during a drilling operation can include measuring a parameter with a sensor, communicating actual parameter values from the sensor to a predictive device, training the predictive device to output predicted parameter values in response to input of the actual parameter values, and outputting the predicted parameter values from the predictive device when the predictive device ceases receiving the actual parameter values. A well drilling system can include a predictive device which outputs predicted parameter values in response to input of actual parameter values to the predictive device. The predictive device continues to output the predicted parameter values, even when the predictive device fails to receive valid actual parameter values. Another well drilling system includes a data validator which communicates valid actual parameter values to the predictive device, but does not communicate invalid actual parameter values to the predictive device.
摘要翻译：在钻井操作期间维持期望的井下压力的方法可以包括使用传感器测量参数，将来自传感器的实际参数值传达到预测装置，训练预测装置以响应于实际参数的输入来输出预测参数值值，并且当预测装置停止接收实际参数值时，从预测装置输出预测参数值。钻井系统可以包括预测装置，其响应于对预测装置的实际参数值的输入而输出预测参数值。即使预测装置未能接收到有效的实际参数值，预测装置继续输出预测的参数值。另一个钻井系统包括数据验证器，其将有效的实际参数值传达给预测装置，但不向预测装置传送无效的实际参数值。

4. 发明授权

US08286730B2 Pressure and flow control in drilling operations 有权
标题翻译：钻井作业中的压力和流量控制
公开(公告)号：US08286730B2
公开(公告)日：2012-10-16
申请号：US13022964
申请日：2011-02-08
申请人： Charles M. Pool , Nancy Davis , Frank Urias , Neal G. Skinner
发明人： Charles M. Pool , Nancy Davis , Frank Urias , Neal G. Skinner
IPC分类号： E21B10/22
CPC分类号： E21B21/08 , E21B21/10
摘要： A method of maintaining a desired downhole pressure during a drilling operation can include measuring a parameter with a sensor, communicating actual parameter values from the sensor to a predictive device, training the predictive device to output predicted parameter values in response to input of the actual parameter values, and outputting the predicted parameter values from the predictive device when the predictive device ceases receiving the actual parameter values. A well drilling system can include a predictive device which outputs predicted parameter values in response to input of actual parameter values to the predictive device. The predictive device continues to output the predicted parameter values, even when the predictive device fails to receive valid actual parameter values. Another well drilling system includes a data validator which communicates valid actual parameter values to the predictive device, but does not communicate invalid actual parameter values to the predictive device.
摘要翻译：在钻井操作期间维持期望的井下压力的方法可以包括使用传感器测量参数，将来自传感器的实际参数值传达到预测装置，训练预测装置以响应于实际参数的输入来输出预测参数值值，并且当预测装置停止接收实际参数值时，从预测装置输出预测参数值。钻井系统可以包括预测装置，其响应于对预测装置的实际参数值的输入而输出预测参数值。即使预测装置未能接收到有效的实际参数值，预测装置继续输出预测的参数值。另一个钻井系统包括数据验证器，其将有效的实际参数值传达给预测装置，但不向预测装置传送无效的实际参数值。

5. 发明授权

US09328573B2 Integrated geomechanics determinations and wellbore pressure control 有权
标题翻译：综合地质力学测定和井筒压力控制
公开(公告)号：US09328573B2
公开(公告)日：2016-05-03
申请号：US13144321
申请日：2009-10-05
申请人： William Bradley Standifird , Syed AiJaz Rizvi , Xiaomin Hu , James R. Lovorn , Sara Shayegi , Nancy Davis , Jeremy Greenwood
发明人： William Bradley Standifird , Syed AiJaz Rizvi , Xiaomin Hu , James R. Lovorn , Sara Shayegi , Nancy Davis , Jeremy Greenwood
IPC分类号： E21B21/08
CPC分类号： E21B21/08 , E21B44/00 , E21B2021/006
摘要： Well pressure control is integrated in real time with geomechanics determinations made during drilling. A well drilling method includes updating determinations of properties of a formation surrounding a wellbore in real time as the wellbore is being drilled; and controlling wellbore pressure in real time as the wellbore is being drilled, in response to the updated determinations of the formation properties. Another well drilling method includes obtaining sensor measurements in a well drilling system in real time as a wellbore is being drilled; transmitting the sensor measurements to a control system in real time; the control system determining in real time properties of a formation surrounding the wellbore based on the sensor measurements, and the control system transmitting in real time a pressure setpoint to a controller; and the controller controlling operation of at least one flow control device, thereby influencing a well pressure toward the pressure setpoint.
摘要翻译：良好的压力控制与钻井过程中的地质力学测量实时整合。钻井方法包括在钻井时更新实时测量围绕井身的地层的性质; 并且响应于更新的地层性质的确定，在钻井时实时地控制井筒压力。另一种钻井方法包括在钻井时实时地在钻井系统中获得传感器测量值; 将传感器测量实时传输到控制系统; 所述控制系统基于所述传感器测量值确定围绕所述井筒的地层的实时性质，以及所述控制系统实时地将压力设定点传送到控制器; 并且控制器控制至少一个流量控制装置的操作，从而影响朝向压力设定点的井压力。

6. 发明申请

US20110290562A1 INTEGRATED GEOMECHANICS DETERMINATIONS AND WELLBORE PRESSURE CONTROL 有权
标题翻译：综合地球物理学测定和井筒压力控制
公开(公告)号：US20110290562A1
公开(公告)日：2011-12-01
申请号：US13144321
申请日：2009-10-05
申请人： William Bradley Standifird , Syed AiJaz Rizvi , Xiaomin Hu , James R. Lovorn , Sara Shayegi , Nancy Davis , Jeremy Greenwood
发明人： William Bradley Standifird , Syed AiJaz Rizvi , Xiaomin Hu , James R. Lovorn , Sara Shayegi , Nancy Davis , Jeremy Greenwood
IPC分类号： E21B7/00
CPC分类号： E21B21/08 , E21B44/00 , E21B2021/006
摘要： Well pressure control is integrated in real time with geomechanics determinations made during drilling. A well drilling method includes updating determinations of properties of a formation surrounding a wellbore in real time as the wellbore is being drilled; and controlling wellbore pressure in real time as the wellbore is being drilled, in response to the updated determinations of the formation properties. Another well drilling method includes obtaining sensor measurements in a well drilling system in real time as a wellbore is being drilled; transmitting the sensor measurements to a control system in real time; the control system determining in real time properties of a formation surrounding the wellbore based on the sensor measurements, and the control system transmitting in real time a pressure setpoint to a controller; and the controller controlling operation of at least one flow control device, thereby influencing a well pressure toward the pressure setpoint.
摘要翻译：良好的压力控制与钻井过程中的地质力学测量实时整合。钻井方法包括在钻井时更新实时测量围绕井身的地层的性质; 并且响应于更新的地层性质的确定，在钻井时实时地控制井筒压力。另一种钻井方法包括在钻井时实时地在钻井系统中获得传感器测量值; 将传感器测量实时传输到控制系统; 所述控制系统基于所述传感器测量值确定围绕所述井筒的地层的实时性质，以及所述控制系统实时地将压力设定点传送到控制器; 并且控制器控制至少一个流量控制装置的操作，从而影响朝向压力设定点的井压力。

7. 发明授权

US06783939B2 Alphavirus vectors and virosomes with modified HIV genes for use in vaccines 有权
标题翻译：甲病毒载体和具有修饰的HIV基因的病毒体用于疫苗
公开(公告)号：US06783939B2
公开(公告)日：2004-08-31
申请号：US09991258
申请日：2001-11-16
申请人： Robert Olmsted , Paula Keith , Sergey Dryga , Ian Caley , Maureen Maughan , Robert Johnston , Nancy Davis , Ronald Swanstrom
发明人： Robert Olmsted , Paula Keith , Sergey Dryga , Ian Caley , Maureen Maughan , Robert Johnston , Nancy Davis , Ronald Swanstrom
IPC分类号： C12Q168
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/575 , C12N7/00 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2770/36143 , C12N2770/36151
摘要： The present invention provides methods and compositions comprising a population of alphavirus replicon particles comprising two or more isolated nucleic acids selected from 1) an isolated nucleic acid encoding an env gene product or an immunogenic fragment thereof of a human immunodeficiency virus, 2) an isolated nucleic acid encoding a g&agr;g gene product or an immunogenic fragment thereof of a human immunodeficiency virus, wherein the g&agr;g gene product or immunogenic fragment thereof is modified to inhibit formation of virus-like particles containing the g&agr;g gene product or the immunogenic fragment thereof and their release from a cell, and 3) an isolated nucleic acid encoding a pol gene product or an immunogenic fragment thereof of a human immunodeficiency virus, wherein the pol gene product or immunogenic fragment thereof is modified to inhibit protease, integrase, RNase H and/or reverse transcriptase activity, and wherein the nucleic acids are each contained within a separate alphavirus replicon particle.
摘要翻译：本发明提供方法和组合物，其包含包含两种或多种分离的核酸的甲型病毒复制子颗粒群，所述分离的核酸选自1）编码人免疫缺陷病毒的env基因产物或其免疫原性片段的分离的核酸，2）分离的核酸编码人免疫缺陷病毒的galphag基因产物或其免疫原性片段的酸，其中所述galphag基因产物或其免疫原性片段被修饰以抑制含有galphag基因产物或其免疫原性片段的病毒样颗粒的形成及其从细胞，以及3）编码人免疫缺陷病毒的pol基因产物或其免疫原性片段的分离的核酸，其中pol基因产物或其免疫原性片段被修饰以抑制蛋白酶，整合酶，RNA酶H和/或逆转录酶活性，并且其中所述核酸各自包含在分离物内食用甲病毒复制子颗粒。

8. 发明申请

US20090277454A1 Gas Supply System 审中-公开
标题翻译：供气系统
公开(公告)号：US20090277454A1
公开(公告)日：2009-11-12
申请号：US12115842
申请日：2008-05-06
申请人： Tom Davis , Nancy Davis
发明人： Tom Davis , Nancy Davis
IPC分类号： A61M16/00
CPC分类号： B65H75/48 , A61M16/0672 , A61M16/0875 , A61M2202/0208 , A61M2209/082 , B65H75/38 , B65H75/4463 , B65H75/4471 , B65H2701/33 , Y10T137/6851 , Y10T137/6936 , Y10T137/6943 , Y10T137/6954
摘要： A gas supply system is disclosed. The gas supply system includes a housing, a spool, a gas tube, at least one opening, a retract mechanism and a holding member. The spool is configured within the housing. The gas tube is retractably wound on the spool and includes a first end portion and a second end portion capable of being connected to a gas supply and a nasal cannula respectively. The at least one opening is configured on the housing for enabling at least one of the first end portion and the second end portion of the gas tube to extend out of the housing. The retract mechanism is configured in the housing and is capable of retracting a portion of the gas tube extended out of the housing. The holding member extends from the housing and enables the gas supply system to be removably mounted on a supporting member.
摘要翻译：公开了一种供气系统。气体供给系统包括壳体，阀芯，气体管，至少一个开口，缩回机构和保持构件。阀芯配置在外壳内。气体管可收缩地卷绕在线轴上，并且包括能够分别连接到气体供应器和鼻插管的第一端部部分和第二端部部分。所述至少一个开口构造在所述壳体上，以使得所述气体管的所述第一端部部分和所述第二端部中的至少一个能够延伸出所述壳体。缩回机构构造在壳体中并且能够缩回从壳体延伸出的气体管的一部分。保持构件从壳体延伸并且使气体供应系统可拆卸地安装在支撑构件上。

9. 外观设计

USD287745S Doll 失效
公开(公告)号：USD287745S
公开(公告)日：1987-01-13
申请号：US600901
申请日：1984-04-16
申请人： Nancy Davis
设计人： Nancy Davis

10. 发明申请

US20060099587A1 Alphavirus vectors having attentuated virion structural proteins 审中-公开
标题翻译：具有病毒粒子结构蛋白的甲病毒载体
公开(公告)号：US20060099587A1
公开(公告)日：2006-05-11
申请号：US10517083
申请日：2003-06-20
申请人： Robert Johnston , Nancy Davis , Ande West , Jonathan Smith
发明人： Robert Johnston , Nancy Davis , Ande West , Jonathan Smith
IPC分类号： C12Q1/68 , C12N7/00 , C12N7/01
CPC分类号： C07K14/005 , A61K2039/5154 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , C12N15/86 , C12N2740/16222 , C12N2770/36122 , C12N2770/36143
摘要： The present invention provides immunogenic compositions and methods that may be used to administer safer (i.e., attenuated) alphavirus vectors (such as alphavirus vectors comprising a VEE virion shell) that retain improved immunogenicity as compared with other attenuated alphaviruses (e.g., the VEE 3014 mutant, described below). In particular embodiments of the invention, the alphavirus vector comprises VEE structural proteins comprising an attenuating mutation in the E1 glycoprotein. In other particular embodiments, the attenuating mutation is in the fusogenic region of the E1 glycoprotein. The present invention enables administration of lower dosages of a safer (i.e., attenuated) virus and, thus, can further reduce manufacturing costs. The present inventors have found that immunogenicity of alphavirus vectors may be influenced by a number of factors including species, site and route of administration.
摘要翻译：本发明提供免疫原性组合物和方法，其可用于与其他减毒的甲病毒（例如，VEE 3014突变体）相比，其保持更高（即减毒）的甲病毒载体（例如包含VEE病毒粒子的甲病毒载体），其保持改善的免疫原性，如下面所描述的）。在本发明的具体实施方案中，甲病毒载体包含在E1糖蛋白中包含减毒突变的VEE结构蛋白。在其它具体实施方案中，减毒突变位于E1糖蛋白的融合区。本发明使得能够施用较低剂量的更安全（即，减毒）的病毒，因此可以进一步降低制造成本。本发明人已经发现甲病毒载体的免疫原性可能受许多因素的影响，包括物种，部位和给药途径。

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