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    • 4. 发明授权
    • Recombinant polypeptide useful for neurotrophin receptor mediated gene delivery and as neurotrophin agonist
    • 可用于神经营养因子受体介导的基因递送的重组多肽和神经营养因子激动剂
    • US07205387B2
    • 2007-04-17
    • US10652295
    • 2003-08-28
    • Shu WangShan Shan WuJieming ZengNan Ma
    • Shu WangShan Shan WuJieming ZengNan Ma
    • C07K14/00C07K5/00
    • C07K16/40C07H21/04C07K14/475
    • The invention provides a novel recombinant polypeptide that comprises a nucleic acid binding element and a hairpin motif that selectively binds to a neurotrophin receptor. The recombinant polypeptide may be used for neurotrophin receptor mediated delivery of nucleic acid, including therapeutic DNA, bound to the recombinant polypeptide. In one embodiment, the hairpin motif is a hairpin motif of a neurotrophin, such as nerve growth factor, brain derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5. The hairpin motif is also a neurotrophin agonist and therefore may be used to treat any disorder responsive to neurotrophin treatment, such as neurological disorders and tumour. In one embodiment the agonist comprises a hairpin motif that selectively binds to a neurotrophin receptor and a positively charged binding domain which is believed to enhance receptor binding by binding to negatively charged cell membrane.
    • 本发明提供了一种新型重组多肽,其包含选择性结合神经营养因子受体的核酸结合元件和发夹基序。 重组多肽可用于神经营养因子受体介导的与重组多肽结合的核酸包括治疗性DNA的递送。 在一个实施方案中,发夹基序是神经营养蛋白的发夹基序,例如神经生长因子,脑源性神经营养因子,神经营养因子3和神经营养蛋白4/5。 发夹基序也是神经营养因子激动剂,因此可用于治疗任何对神经营养因子治疗反应的病症,例如神经障碍和肿瘤。 在一个实施方案中,激动剂包含选择性结合神经营养因子受体和带正电荷的结合结构域的发夹基序,其被认为通过结合带负电荷的细胞膜增强受体结合。
    • 10. 发明授权
    • I/O impedance controller
    • I / O阻抗控制器
    • US06703908B1
    • 2004-03-09
    • US09619724
    • 2000-07-20
    • Rodney RueschPhilip N. JenkinsNan Ma
    • Rodney RueschPhilip N. JenkinsNan Ma
    • H03H740
    • H03H17/0054
    • There is disclosed apparatus and apparatus for impedance control to provide for controlling the impedance of a communication circuit using an all-digital impedance control circuit wherein one or more control bits are used to tune the output impedance. In one example embodiment, the impedance control circuit is fabricated using circuit components found in a standard macro library of a computer aided design system. According to another example embodiment, there is provided a control for an output driver on an integrated circuit (“IC”) device to provide for forming a resistor divider network with the output driver and a resistor off the IC device so that the divider network produces an output voltage, comparing the output voltage of the divider network with a reference voltage, and adjusting the output impedance of the output driver to attempt to match the output voltage of the divider network and the reference voltage. Also disclosed is over-sampling the divider network voltage, storing the results of the over sampling, repeating the over-sampling and storing, averaging the results of multiple over sampling operations, controlling the impedance with a plurality of bits forming a word, and updating the value of the word by only one least significant bit at a time.
    • 公开了用于阻抗控制的装置和装置,用于使用全数字阻抗控制电路来控制通信电路的阻抗,其中使用一个或多个控制位来调谐输出阻抗。 在一个示例性实施例中,使用在计算机辅助设计系统的标准宏库中发现的电路元件制造阻抗控制电路。 根据另一示例性实施例,提供了一种用于集成电路(“IC”)设备上的输出驱动器的控制,以提供与输出驱动器形成电阻分压器网络和从IC器件断开电阻器,使得分压器网络产生 输出电压,将分压网络的输出电压与参考电压进行比较,以及调整输出驱动器的输出阻抗以尝试匹配分压网络的输出电压和参考电压。 还公开了对分压网络电压进行过采样,存储过采样的结果,重复过采样和存储多个过采样操作的结果的平均值,以形成字的多个位来控制阻抗,以及更新 单词的值一次只有一个最低有效位。