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1. 发明申请

US20120052289A1 REMOVABLE ANTIFOGGING COATINGS, ARTICLES, COATING COMPOSITIONS, AND METHODS 审中-公开
标题翻译：可拆卸抗菌涂料，制品，涂料组合物和方法
公开(公告)号：US20120052289A1
公开(公告)日：2012-03-01
申请号：US12809388
申请日：2008-12-15
申请人： Naiyong Jing , Xue-Hua Chen , Ruo-Ni Sun , Zhigang Yu , Xiaoling Xie , Jinyu Chen
发明人： Naiyong Jing , Xue-Hua Chen , Ruo-Ni Sun , Zhigang Yu , Xiaoling Xie , Jinyu Chen
IPC分类号： B32B5/16 , B05D5/00 , C09D5/00 , B05D1/00 , B82Y30/00
CPC分类号： C09D163/00 , B82Y30/00 , C01P2004/64 , C03C17/32 , C09C1/00 , C09C1/3081 , C09C1/407 , C09C3/12 , C09D1/00 , C09D5/008 , Y10T428/259
摘要： A coating composition which imparts antifog properties to substrates coated therewith. The coating compositions are removable and utilize nanoparticles funtionalized with epoxy groups. The removable coating compositions are particularly useful on personal protection equipment such as face masks, shields, and protective glasses.
摘要翻译：一种涂料组合物，其赋予其涂布的基材上的防雾性能。涂料组合物是可去除的并且利用用环氧基团赋形的纳米颗粒。可去除的涂料组合物特别适用于个人防护设备，如面罩，护罩和防护眼镜。

2. 发明授权

US07056944B2 Pyrazole compositions useful as inhibitors of erk 失效
标题翻译：用作erk抑制剂的吡唑组合物
公开(公告)号：US07056944B2
公开(公告)日：2006-06-06
申请号：US10688613
申请日：2003-10-17
申请人： Michael Hale , Xiaoling Xie , Jeremy Green , Jingrong Cao , Christopher Baker , Francois Maltais , James Janetka , Guy Bemis , Michael Mullican , Judith Straub , Qing Tang , Robert Mashal
发明人： Michael Hale , Xiaoling Xie , Jeremy Green , Jingrong Cao , Christopher Baker , Francois Maltais , James Janetka , Guy Bemis , Michael Mullican , Judith Straub , Qing Tang , Robert Mashal
IPC分类号： A61K31/40 , C07D207/00
CPC分类号： C07D401/14 , C07D231/38 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
摘要翻译：本文描述了可用作具有下式的蛋白激酶抑制剂的化合物：其中R 1-4，Q和T在说明书中描述。该化合物可用于治疗由蛋白激酶抑制剂，特别是癌症，炎症性疾病，再狭窄和心血管疾病等疾病减轻的哺乳动物的疾病状态。

3. 发明授权

US06528509B1 Pyrazole compositions useful as inhibitors of ERK 有权
标题翻译：吡唑组合物可用作ERK的抑制剂
公开(公告)号：US06528509B1
公开(公告)日：2003-03-04
申请号：US09972437
申请日：2001-10-05
申请人： Michael Hale , Xiaoling Xie , Jeremy Green , Jingrong Cao , Christopher Baker , Francois Maltais , James Janetka , Guy Bemis , Michael Mullican , Judith Straub , Qing Tang , Robert Mashal
发明人： Michael Hale , Xiaoling Xie , Jeremy Green , Jingrong Cao , Christopher Baker , Francois Maltais , James Janetka , Guy Bemis , Michael Mullican , Judith Straub , Qing Tang , Robert Mashal
IPC分类号： A61K315377
CPC分类号： C07D401/14 , C07D231/38 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
摘要翻译：本文描述了可用作具有下式的蛋白激酶抑制剂的化合物：其中R1-4，Q和T在说明书中描述。该化合物可用于治疗由蛋白激酶抑制剂，特别是诸如癌症，炎症性疾病，再狭窄和心血管疾病等疾病减轻的哺乳动物的疾病状态。

4. 发明申请

US20090186394A1 Crystallizable JNK complexes 失效
标题翻译：可结晶JNK复合物
公开(公告)号：US20090186394A1
公开(公告)日：2009-07-23
申请号：US12150328
申请日：2008-04-25
申请人： Xiaoling Xie , Yong Gu , William Markland , Michael S. Su , Paul R. Caron , Edward Fox , Keith P. Wilson
发明人： Xiaoling Xie , Yong Gu , William Markland , Michael S. Su , Paul R. Caron , Edward Fox , Keith P. Wilson
IPC分类号： C12N9/12 , G06F17/50
CPC分类号： C12Q1/485 , C07K2299/00 , G01N2333/9121 , G01N2500/00 , G06F19/16
摘要： The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of JNK3. A computer comprising such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to JNK3 or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of JNK3 or close structural homologues of the active site binding pockets.
摘要翻译：本发明涉及用包含JNK3的活性位点结合口袋的分子和分子复合物的相应结构坐标编码的数据存储介质。包括这种数据存储材料的计算机能够在计算机屏幕上显示这样的分子和分子复合物或其结构同系物作为图形三维表示。本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。此外，本发明涉及使用结构坐标筛选和设计与JNK3或其同系物结合的化合物（包括抑制性化合物）的方法。本发明还涉及分子和分子复合物，其包含JNK3的活性位点结合口袋或活性位点结合口袋的紧密结构同源物。

5. 发明授权

US06994868B2 Compositions useful as inhibitors of ERK 失效
标题翻译：可用作ERK抑制剂的组合物
公开(公告)号：US06994868B2
公开(公告)日：2006-02-07
申请号：US10437419
申请日：2003-05-13
申请人： Guy Bemis , Xiaoling Xie
发明人： Guy Bemis , Xiaoling Xie
IPC分类号： A61F2/02 , A61K31/41
CPC分类号： A61K31/501 , A61K31/4155 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/53
摘要： This invention provides a method of treating a disease state in mammals that is alleviated by treatment with a protein kinase inhibitor, especially an ERK inhibitor, which method comprises administering a compound having the pharmacophoric features Grp 1, Grp 2 and Grp 3: Grp 1 is an optionally substituted aryl or aliphatic group; Grp 2 is a heteroaromatic ring having one to three nitrogens, said ring comprising a hydrogen bond acceptor HBA2 optionally bonded to a hydrogen bond donor HBD2, and Grp 3 is a heteroaromatic ring comprising a hydrogen bond donor HBD1, with distances between the pharmacophoric features defined in the specification. The method is useful for treating cancer, stroke, diabetes, hepatomegaly, cardiovascular disease, Alzheimer's disease, cystic fibrosis, viral disease, autoimmune diseases, atherosclerosis, restenosis, psoriasis, allergic reactions, inflammation, neurological disorders or a hormone-related disease.
摘要翻译：本发明提供了一种治疗哺乳动物疾病状态的方法，该方法通过用蛋白激酶抑制剂，特别是ERK抑制剂进行治疗来缓解，该方法包括给予具有药学特征的化合物Grp 1，Grp 2和Grp 3：化学物质 =“CHEM-US-00001”num =“000

6. 发明授权

US08827125B2 Clothing holders 有权
标题翻译：服装持有人
公开(公告)号：US08827125B2
公开(公告)日：2014-09-09
申请号：US13808294
申请日：2011-08-08
申请人： Xiaoling Xie
发明人： Xiaoling Xie
IPC分类号： A47G25/60 , A41D27/22
CPC分类号： A47G25/60 , A47G25/743
摘要： A holder for holding a clothing or apparel article, the holder comprises a main body for supporting a clothing article and a plug-in module carrying a scent treatment substance. The scent treatment substance is adapted for scent emission and/or odor absorption. The plug-in module is adapted to disseminate scent to the ambient and/or to absorb odor from the ambient so that scent can be disseminated by the holder to the clothing item supported on the holder or odor can be absorbed from the ambient.
摘要翻译：用于保持服装或服饰制品的持有人，所述保持器包括用于支撑衣物的主体和携带香味处理物质的插件模块。香味处理物质适于气味发射和/或气味吸收。插件模块适于将气味传播到环境中和/或吸收环境中的气味，使得香气可以由保持器散发到支撑在支架上的衣服物品，或者气味可以从环境中吸收。

7. 发明申请

US20130228598A1 CLOTHING HOLDERS 有权
标题翻译：服装夹具
公开(公告)号：US20130228598A1
公开(公告)日：2013-09-05
申请号：US13808294
申请日：2011-08-08
申请人： Xiaoling Xie
发明人： Xiaoling Xie
IPC分类号： A47G25/60
CPC分类号： A47G25/60 , A47G25/743
摘要： A holder for holding a clothing or apparel article, the holder comprises a main body for supporting a clothing article and a plug-in module carrying a scent treatment substance. The scent treatment substance is adapted for scent emission and/or odor absorption. The plug-in module is adapted to disseminate scent to the ambient and/or to absorb odor from the ambient so that scent can be disseminated by the holder to the clothing item supported on the holder or odor can be absorbed from the ambient.
摘要翻译：用于保持服装或服饰制品的持有人，所述保持器包括用于支撑衣物的主体和携带香味处理物质的插件模块。香味处理物质适于气味发射和/或气味吸收。插件模块适于将气味传播到环境中和/或吸收环境中的气味，使得香气可以由保持器散发到支撑在支架上的衣服物品，或者气味可以从环境中吸收。

8. 发明申请

US20120133830A1 Receiving Method, Terminal Equipment And Receiving Device For Mobile Digital Multimedia Service 有权
标题翻译：接收方式，移动数字多媒体业务的终端设备和接收设备
公开(公告)号：US20120133830A1
公开(公告)日：2012-05-31
申请号：US13380927
申请日：2010-08-10
申请人： Longan Xiao , Shiliang Guo , Xiaoling Xie
发明人： Longan Xiao , Shiliang Guo , Xiaoling Xie
IPC分类号： H04N7/00
CPC分类号： H04N7/1675 , H04N21/4143 , H04N21/4623
摘要： The present invention provides a method and a device for receiving a mobile digital multimedia service and terminal equipment for a mobile digital multimedia service, and the method for receiving the mobile digital multimedia service includes: a receiving device receiving multimedia broadcast data, and if the receiving device judges that a state of the multimedia broadcast data is a scrambling state, descrambling the multimedia broadcast data, and sending descrambled multimedia broadcast data to computer equipment, and the computer equipment receiving the descrambled multimedia broadcast data. The technical scheme of the present invention does not need to send key information needed in descrambling to the computer equipment, so that the security of the key information can be increased; and the receiving device re-encapsulates the multiplex subframe and retains the subframe header part in the multiplex subframe, so as to make the descrambled data code steam entirely retain the original information.
摘要翻译：本发明提供一种用于接收移动数字多媒体业务的移动数字多媒体业务的方法和装置，以及用于移动数字多媒体业务的终端设备，接收移动数字多媒体业务的方法包括：接收设备接收多媒体广播数据，设备判断多媒体广播数据的状态是加扰状态，对多媒体广播数据进行解扰，并向计算机设备发送解扰的多媒体广播数据，以及接收解扰的多媒体广播数据的计算机设备。本发明的技术方案不需要向计算机设备发送解扰所需的密钥信息，从而可以增加密钥信息的安全性; 并且接收装置重新封装多路复用子帧并将子帧头部分保留在多路复用子帧中，以便解密的数据代码蒸汽完全保留原始信息。

9. 发明授权

US06849267B2 Compositions useful as inhibitors of ERK 失效
标题翻译：可用作ERK抑制剂的组合物
公开(公告)号：US06849267B2
公开(公告)日：2005-02-01
申请号：US09971533
申请日：2001-10-05
申请人： Guy Bemis , Xiaoling Xie
发明人： Guy Bemis , Xiaoling Xie
IPC分类号： A61K31/4155 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , A61F2/02 , A61F6/06 , A61F13/02 , A61K9/70 , A61L9/04
CPC分类号： A61K31/501 , A61K31/4155 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/53
摘要： This invention provides a method of treating a disease state in mammals that is alleviated by treatment with a protein kinase inhibitor, especially an ERK inhibitor, which method comprises administering a compound having the pharmacophoric features Grp1, Grp2 and Grp3:Grp 1 is an optionally substituted aryl or aliphatic group; Grp 2 is a heteroaromatic ring having one to three nitrogens, said ring comprising a hydrogen bond acceptor HBA2 optionally bonded to a hydrogen bond donor HBD2, and Grp3 is a heteroaromatic ring comprising a hydrogen bond donor HBD1, with distances between the pharmacophoric features defined in the specification. The method is useful for treating cancer, stroke, diabetes, hepatomegaly, cardiovascular disease, Alzheimer's disease, cystic fibrosis, viral disease, autoimmune diseases, atherosclerosis, restenosis, psoriasis, allergic reactions, inflammation, neurological disorders or a hormone-related disease.
摘要翻译：本发明提供一种治疗哺乳动物疾病状态的方法，其通过用蛋白激酶抑制剂，特别是ERK抑制剂治疗而减轻，该方法包括给予具有药学特征的化合物Grp1，Grp2和Grp3：Grp1是任选取代的芳基或脂族基; Grp 2是具有一至三个氮的杂芳环，所述环包含任选地键合到氢键供体HBD2的氢键受体HBA2，Grp3是包含氢键供体HBD1的杂芳环，其中定义的药效特征之间的距离规格。该方法可用于治疗癌症，中风，糖尿病，肝肿大，心血管疾病，阿尔茨海默病，囊性纤维化，病毒性疾病，自身免疫性疾病，动脉粥样硬化，再狭窄，牛皮癣，过敏反应，炎症，神经障碍或激素相关疾病。

10. 发明授权

US06593357B1 Pyrazole compositions useful as inhibitors of ERK 有权
公开(公告)号：US06593357B1
公开(公告)日：2003-07-15
申请号：US10225719
申请日：2002-08-22
申请人： Jeremy Green , Jingrong Cao , Michael Hale , Christopher Baker , Francois Maltais , James Janetka , Michael Mullican , Guy Bemis , Xiaoling Xie , Judith Straub , Qing Tang
发明人： Jeremy Green , Jingrong Cao , Michael Hale , Christopher Baker , Francois Maltais , James Janetka , Michael Mullican , Guy Bemis , Xiaoling Xie , Judith Straub , Qing Tang
IPC分类号： A61K314155
CPC分类号： C07D401/14 , C07D231/38 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.

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